Collegiate hookups often involve sexual behaviors that place students at risk for unwanted
pregnancies and for contracting HIV and other sexually transmitted infections (STIs) with African American women at disparate risk. While several studies have shown adequate sexual knowledge does not necessarily translate into safer sexual behaviors, the relationship between sexual risk and sexual satisfaction has remained unexplored despite sexual satisfaction being a major motivator of sexual conduct. The current study examines the association between sexual knowledge, sexual satisfaction, and sexual risk among undergraduate students at Historically Black Colleges and Universities in the Southeastern United States based on a sex positive approach to STI prevention. Gender, history of partnered sex, and “virginity” pledges were explored as possible moderators. Three hundred African American/Black, predominantly freshmen, and Christian students completed related surveys. Overall participants had low sexual knowledge with women better than men. Males reported more sexually risky behaviors but students without history of partnered sex reported fewer. “Virginity” pledges were unrelated to sexual risk taking. Overall, participants were more sexually satisfied than dissatisfied with no gender differences. There was no significant relationship between sexual knowledge and sexual satisfaction for either gender, with varying degrees of sexual satisfaction at all risk levels. Gender weakly moderated the relationship between sexual risk and sexual satisfaction regardless of history of partnered sex. Results bode well for the development of a sex positive approach to STI and unwanted pregnancy prevention.