Final BPKM KKI BBS TA 2019-2020 Ok

STUDENT GUIDEBOOK
BASIC BIOMEDICAL SCIENCE

MODULE
MEDICAL EDUCATION UNIT

INTERNATIONAL CLASS PROGRAM
FACULTY OF MEDICINE
UNIVERSITY OF INDONESIA
2019-2020
STUDENT GUIDEBOOK
BASIC BIOMEDICAL SCIENCE MODULE
Authors
Novi Silvia H
Rawina Winita
Reni Paramita
Asmarinah
Andi Yasmon
Sophie Yolanda
July Kumalawati
Ardiana Kusumaningrum
Editor:
Novi Silvia H
Published by
Medical Educatin Unit
Fakultas Kedokteran
Universitas Indonesia
Jalan Salemba Raya No.6 Jakarta Pusat
Phone/Fax : (021) 3908643
Email : meu.fkui@gmail.com
Copyright 2019 by Medical Education Unit Faculty of Medicine, Universitas Indonesia

All rights reserved.
This book or any parts thereof,
may not be used or reproduced in any manner
without written permission from the writer/publishers.
Printed in Jakarta, Indonesia
ISBN : 978-602-409-527-7
STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 2

TABLE OF CONTENT
Page
Foreword 4
Introduction 5
Student characteristics 6
Competency 7
Learning objective 7
Scope of study 8
Learning method 15
Resources
Time table 17
Human resource 20
References 26
Facility and infrastructure 28
Evaluation 29
Attachments
1. Question Based-Discussion – Guideline 30
2. QBD - List of Question 32
3. Job description of module's committee 38
4. Student's assessment 43
5. Evaluation sheet 45
Module Team 47

FOREWORD
Praise God for making it possible for us to create the Instructional Design Book of Basic Biomedical
Science Module, academic year 2019-2020. The book contains all materials necessary for staffs and
students in teaching and learning activities in this module.
The book may be far from complete; therefore criticisms or suggestions to improve this Instructional
Design Book are very welcome.
We thanked the Basic Biomedical Science team for their commitments and huge efforts in all
processes during the preparation of the book. We thanked all advices and supports from the Medical
Education Unit of the Faculty of Medicine University of Indonesia.
Jakarta, July 2019
Team of Basic Biomedical Science

INTRODUCTION
To be able to identify normal parameters of human body, structure and function, one should have
knowledge of Basic Biomedical Science. Understanding physico-chemical, structure and function of cell
including cell replication and proliferation, organization cell and human body, principles of homeostasis
and its parameters, and metabolism of cell are the foundation in the study of normal human body.
Various disorders may involve cells, tissues and organs which eventually lead to clinical signs and
symptoms, and these problems can only be understood by having knowledge of the normal
parameters of human body.
This module will provide such a comprehensive basic knowledge necessary as the foundation of
systematic research in medical field, and so students are adepts at managing medical and health
issues holistically and comprehensively.
This module is a first step knowledge to understand other modules in next semester. For examples,
Basic molecule of cell topic especially nucleic acid hereditary is a basic knowledge to understand
Molecular Cell Biology module in semester 2. Cell to cell communication topic is a basic knowledge for
Basic Human Neuroscience in semester 2. Fluid, electrolyte and acid balance in human body topic
plays a role to understand Renal and Body Fluids modul in semester 3. Metabolism process in cell topic
is a basic science to understand Metabolic Endocrine module in semester 5.
The Basic Biomedical Science is part of HEALTH SCIENCES stage, and held in first semester for 14
weeks, with 4-credit point load. All teaching and learning materials are accessible in SCeLE. By
the end of the module, student is expected to have the ability of explaining simulated healthy
conditions and have the skill to apply Basic Biomedical Science.

STUDENT
CHARACTERISTICS
STUDENT CHARACTERISTICS
Basic Biomedical Science module is intended for students in semester 1 who graduated from High
School and enrolled in International Class Program-Faculty of Medicine University of Indonesia

LEARNING OBJECTIVE
COMPETENCY
Competency to be achieved in this module is 1st and 2nd degree (KBK 2012).
The students are expected to have the ability of explaining simulated healthy conditions and have the
skill to apply Basic Biomedical Science in the practice of family medicine and manage medical and
health issues holistically and comprehensively.
The module will cover the achievement of several areas of competencies as stated in FMUI 2012
curriculum, especially in basic of medical sciences, effective communication skills and management of
information and technology.
LEARNING OBJECTIVE
Terminal
If given secondary clinical, laboratory, or epidemiologic data, the student of International Class of
Faculty of Medicine University of Indonesia (FMUI) in semester 1 is able to use principles of Basic
Biomedical Science to identify the normal parameters of human body.
Supporting
If given secondary data on clinical, laboratory, or epidemiologic problems, the student of FMUI in
semester 1 is able to explain normal parameters of human body, have the foundation necessary for
systematic research in medical field, and so will be able to address medical and health issues related
to science, clinical and community (details are shown in Scope of study, page 8).

SCOPE OF STUDY
LEARNING Level Bloom Learning
TOPIC SUBTOPIC CONTENT
OBJECTIVE methods
Explain medical Biophysics in Wave, Optics, and Properties of Wave C1=
biophysics medicine Sound - Electromagnetic vs. mechanical wave knowledge
and chemistry - Ionizing radiation
Properties of light wave
(Level Bloom: Focusing and imaging with lenses
C1=Knowledge) Refraction
Imaging and detection by eye
Week 1
Physiology of eye refraction
QBD 1
Types of vision impairment & correction
Properties of Sound
Functional anatomy of the human ear
Sound processing in the ear:
- Amplification
- Pitch recognition
(References: no.1, 2, 7)
Gas/fluid Fluids and hydrodynamics C1= Week 6
mechanics/hydrostatic Basic physics of pressure and flow of fluids knowledge QBD 5
pressure Pressure and flow in the body
Relationship between pressure, resistance, airflow:
Boyle’s, Poiseuille’s, La Place laws
Physiology of respiratory mechanics
Relationship between pressure, resistance, and blood
flow: Poiseuille’s law
Physical characteristics of blood vessels and their
physiological impact
Starling forces
Concept of blood pressure and mean arterial pressure
Physiology of blood pressure regulation
(References: no. 1, 2)
Microscope (in P1: microscope) C3= Week 2
application P1

Photometry Principles of photometry Week 1
Analysis methods of photometry L1
Spectroscopy for UV, visible light and infrared
Infrared spectroscopy
Core resonance spectroscopy
Mass spectroscopy
(References: no.4, 6)
Medical chemistry Atom, molecule Concept of atom, molecule and ion C1= Week 3
Atomic Structure and the Periodic Table knowledge QBD 2
The mole concept and stoichiometry
Chemical bonding
Free radical Free radical: basic chemistry, application and
formation
Free radicals in human body and their productions
Compound, acid, Redox chemistry C2=

base, ion, pH and Antioxidants and their sources comprehen
buffer Benefits and functions of antioxidant to maintain sion
homeostatic condition
(References: no.19, 21, 22)
Correlation of acid or base dissociation constant (Ka or
Kb), strength of acid or base
Relationship of acid strength and conjugate base
pH and pOH of a solution, correlation of pH or pOH,
acidity or basicity,
pH and pOH of aqueous solutions of weak and strong
acids and bases from molarity and Ka/Kbvalues,
acidity of a solution when a salt dissociates in water,
pH of an aqueous solution of salt
Measuring pH of a solution using a pH meter, provide
examples of the importance of pH in chemical and
biological systems
Basic principle of buffered solution and its functions in
blood chemistry
Regulation of blood pH in the lung and kidney
(References: no. 5, 6, 27, 28)
Explain normal Basic molecule of Organic: Carbohydrate: chemical characteristics and types C1= Week 1
structure and cell carbohydrate, protein, Carbohydrates: their functions in human body knowledge L4
function of cells lipid Protein: structures, types, sources
Lipid: definition, classification, physical and chemical Week 2
properties, reaction of lipid, function P2

Nucleic acid- Types and structures of nucleic acids C1= Week 1
hereditary Differences in the structure of the two types of knowledge L5
Molecule nucleic acid
Concept of base pairing of nucleic acid

Structure of single strand, double strand and 3D
conformation. Physico-chemical properties of nucleic
acids (denaturation, renaturation, melting point,
absorption of light)
Location and role of nucleic acids in cells
DNA as a hereditary molecule, transfer of genetic
information
Central dogma, replication, transcription and
translation
(References: no. 10, 11, 13)
Explain DNA as Cell biology Phylogeny-ontogeny, History and development of science about cell C1= Week 4
hereditary material, structure and function (conventional to present, including genetic knowledge L3
genome of cell engineering)
organization of
prokaryotes, Origin and evolution of cell
eukaryotes and Differences of Universal characteristics of life, structure prokaryotes
Viruses prokaryotes and and eukaryotes
eukaryotes (References: no. 8)
Structure and Structure and genome organization of eukaryotes, C1= Week 4

function of organelle, prokaryotes and viruses. knowledge L3
and cell components Nucleosome, chromatin and chromosome structures
in humans/other organism
Membrane systems and organelles: nucleus, RER,

Golgi apparatus, lysosomes, microsomes,
mitochondria. Cytoskeleton: microtubule,
microfilaments, intermediate filaments and dynamic
motion of cells
Disorder and abnormality of cell structure and
function
Mechanism of movement: filament structure in
eukaryotic cells
Contact and interaction between cells in multicellular
organism

Protein and Role of protein in Concept of protein structures and functions. C2= Week 6
enzyme structure and function Universality of amino acid constituents for protein comprehensive QBD3
of Classification, general properties of amino acids,
Cell codons and amino acids relationship-protein
Concept of amino acids essential and non essential
Concept of protein denaturation
Concept of ligand-protein interactions
Physiological function of protein
Role of enzyme Enzymes: definition and classification C2= Week 4
comprehension P4
Various types and function of enzyme specificity
Distribution of enzymes in the cell Week 6
Concept of enzyme-substrate and enzyme specific L6
properties with inorganic catalysts
Role of coenzyme and cofactor
Concept of antienzyme and functions
(References no.17, 18, 19, 20))
Explain cycle of cell Eukaryotes cell Cell life cycle, mitosis, Cell cycle and its regulation C1= Week 5
replication, cell division meiosis Factors affecting bacterial growth (such as food, knowledge QBD 4
proliferation and Bacteria, virus and Bacteria proliferations moist, temperature, pH, oxygen). Media for bacterial
division, prion proliferation and factors affecting growth (intracellular and extracellular)
mitosis and meiosis the process
as the basis of Algae, fungi, Algae, fungi, Cellular mechanisms of bacterial cell division C1= Week 8
physiological or protozoa, and protozoa, and worm Characteristics of bacterial growth curve knowledge L7
pathological worm Relationship between bacteria and human host
processes Characteristics of algae, fungi, protozoa, and worm
Relationship between parasite and human host
(References: no. 15)
Proliferation of Characteristics and structures of bacteriophage, C1= Week 8
bacteriophage, virus virus and prion. knowledge L8
and prion Cellular mechanisms of bacteriophage and virus
replications. Characteristics of growth curve of
bacteriophage/virus
Growth media for bacteriophage and virus
Mechanisms of prion proliferation
Relationship between bacteriophage and bacterial
cell. Virus and prion relationship with human host
(References: no 13, 14, 15, 16)
Describe cell type, Cell and basic Four categories of Microscopic structure, function, histophysiology, Week
histo-physiology tissue basic tissues histodynamic: stem cell as the source of all cells in C2= L2
and histo-dynamic human body, epithelium cell and gland, including cell comprehension

of normal human surface and junctional specialization, connective Week 11
tissue as basic tissue cell including extracellular matrix, muscular P3
knowledge to study tissue cell, nervous tissue cell including supporting
the changes of cell
certain tissue in (Ref.no: 27, 28)
association with
disease and age
Explain structure Systems of human Systems of human Systems of human body: Anatomy overview C2= Week 9
and mechanism of body body (Reference: no. 26) comprehension L9
action of systems in
maintaining Week 10
homeostasis P7
Systems of human body: Physiology overview Week 9

(Reference: no. 1, 2) L 11
Membrane Membrane structure Membrane structure and functions: lipid bilayer, C2= Week 5
dynamics and function integral and peripheral protein, transport proteins: comprehension P5
gap junction, channel, carrier, pump Week 6
Amphipathic properties and fluid mosaic of plasma P6
membranes
Membrane transport Types of membrane transport: simple diffusion, C2= Week 7
osmosis, facilitated diffusion, active transport comprehension QBD 6
Concept of osmolarity
Membrane pump mechanisms (Na+, K+ - ATPase, Ca+
- ATPase)
Bioelectricity and Fundamentals of bioelectricity of the mammalian C2=
membrane polarity nervous system and other excitable tissues comprehension
Membrane potential: Nernst equation, Goldman-
Hodgkin-Katz equation
Homeostasis Principles of Concept of homeostasis: C1= Week 8
Homeostasis - Definition knowledge QBD 7
- Internal and external environment
- Cannon’s postulates Week 9
Reflex arc Components of reflex arc: sensor/receptor, C1= L 10
integrating center, effector knowledge
Function of each reflex arc component
How reflex arc maintains homeostasis
Homeostasis feedback Negative feedback C1=
Positive feedback knowledge
Feed forward mechanism

Cell to cell Principle and concept Levels of organization in the body C1= Week 9
communication of cell and tissue Definition of cells-tissues communication knowledge QBD8
communication Relation of cell communication with homeostasis
Cell to cell communication: chemical vs. electrical,
local vs. Systemic
Electrical Ionic movement through gap junction C1=

communication Graded potential: depolarization, hyperpolarization knowledge
Action potential: generation, propagation
Chemical Autocrine, paracrine C1=
communication Signal molecules: neurotransmitters, hormones knowledge
Signal transduction Cell receptors and signal transduction: C1=
transmembrane vs intracellular, ionotropic vs knowledge
metabotropic (second messenger system)
Humoral and electric Comparison of the nervous and endocrine system C1=
communications How the nervous and endocrine system maintain knowledge
homeostasis (neural, neuroendocrine, and endocrine
reflex)
Cell to cell Principle and concept Levels of organization in the body C1= Week 9
communication of cell and tissue Definition of cells-tissues communication knowledge QBD 8
communication Concept of intercellular communication: chemical
Membrane and vs. electric, direct versus indirect
membrane transport Membrane structure and functions: lipid bilayer,
integral and peripheral protein, transport proteins:
gap junction, channel, carrier, pump
Identify the Fluid, electrolyte, Body fluid Body compartments and their ionic contents: C1= Week 10
parameters of and acid-base composition intracellular and extracellular fluid knowledge QBD 9
homeostasis of balance in human Water as a polar molecule, hydrophilic and
human body body hydrophobic molecular interactions, roles and
functions of water in the human body
Functions and normal values of ions in the body:
sodium, potassium, calcium
Urine production Nephron: structure and function C1=
Urine production: filtration, reabsorption, secretion knowledge
Physiology of fluid Body fluid osmolarity and volume balance: water C1=
and electrolyte balance, salt balance knowledge
balance Water balance: osmolarity and tonicity, role of
vasopressin and countercurrent system
Salt balance: renin-angiotensin-aldosterone system
Physiology of acid- Definition and concept of acid, base, buffer, pH C1=
base balance Buffer system of the body: chemical, ventilation, renal knowledge

Acid-base imbalance: acidosis vs. alkalosis, metabolic
vs. respiratory
Hemorrheology Viscosity, osmolarity, Definition viscosity, osmolarity, osmolality, tonicity. C1= Week 10
parameters osmolality, tonicity Hemorrheology parameters: their relation in medical knowledge L12
applications
Component of
homeostasis and their Coagulation, coagulation factor, platelet function.
function Production & metabolism of coagulation factor
Activation of coagulation factor: intrinsic, extrinsic,
common pathway, adhesion & aggregation of
Vascular component platelets
of hemostasis
Vasocontriction to prevent bleeding, vascular as
thrombo-regulator
(References: no. 21, 22, 23, 24, 25)
Metabolism and Energy and The law of thermodynamics C1= Week 12
body temperature metabolism Energy balance: energy input (food intake regulation) knowledge QBD10
regulation and energy output (metabolic rate)
Energy storage and usage: carbohydrate, protein, fat
ATP production: phosphagen system, glycolysis, citric
acid cycle, oxidative phosphorylation
Anaerobic vs. aerobic metabolism
Explain various Normal Carbohydrate Glycolysis, glycogenesis, gluconeogenesis. Essential- C1= Week 12
metabolism metabolism: metabolism Protein non essential amino acids, catabolism of carbon knowledge L 13
processes in cell carbohydrate, metabolism structure, formation of ammonia, urea cycle, nitrogen
protein, lipid Lipid metabolism balance, synthesis nitrogen compound
Fatty acid oxidation, ketogenesis, lipolysis,
biosynthesis of triacylglycerol
(References: no.17, 18, 19, 20)

LEARNING METHOD
The main principal of learning strategy in Basic Biomedical Science module is student centered and
integrated with Question Based-Discussion (QBD) approach and self-directed learning (SDL). Sharing
and feedback from tutors as subject experts will follow the discussion. Lectures and practicals will
also be used systematically to facilitate the understanding of basic concepts.
METHOD
1.1. Lectures
This module will have 13 lectures (L1-L13), including Interactive Lectures (7 hours). Total
duration are 21 hours.
See List of Lecture (page 23).
1.2. Question Based-Discussion (QBD)

There are 10 QBDs (QBD 1-10) with total duration of 30 hours.
Each QBD will be conducted in Group Discussion (GD) consists of 10 students and 1 tutor
(subject expert). Prior to QBD that is the Day-2, students will access the questions
according to the topic provided in the Student Guide Book in SCeLE. Students
should at all time refer to SCOPE OF STUDY.
Students in each QBD will be divided into smaller groups consist of 2-3 people, to work out
the questions. On the day of the QBD, students will discuss their findings with their partners
within the small group, then later share with all students involved in the QBD. The tutor may
give inputs (See QBD-Guidelines: Attachment 1 page 34, and QBD-List of Questions:
Attachment 2 page 36).
1.4. Self-Directed Learning (SDL)

SDL is a free time allocated within the program that allows students to work out the
tasks. During SDL students can work individually or with their peers in the library
to access textbooks, journals, or others and can also browse the Internet. Some lecture
and reading materials are provided in SCeLE, which can be used during this time
Total SDL provided is 58 hours (SDL1 – SDL52).
1.5. Practical
Laboratory practice will be held in 7 occasions (P1-P7) with total of 21 hours.
The departments involved are Biology integrated with Microbiology and
Parasitology; Chemistry, Biochemistry, Physiology, Histology and Anatomy.

Students will be divided into small group consisting approximately 10 people.
Prior to the laboratory practice, students should have read the Laboratory Guidebook.
During Laboratory session, each student should be actively involved, work out the
tasks and have discussions with the tutor. Student should also take Post-test at the end
of laboratory session. Pre-test is maybe held prior to laboratory practice. See List of Practical
page 26.
1. Feedback
Aimed to provide input toward both students and the module team by assessing the
process and results gained by the students.
3.1. Formative evaluations: 2 sessions (computer based, allocated time, independent)

3.2. Observations: students activity during QBD and students task are evaluated by tutors
3.3. Reports of laboratory exercises
No. Learning method Hour Credit points

1 Lecture 21 16 1.31
2 QBD 30 32 0,94
3 Practical laboratorium 21 32 0,7
4 Online discussion 8 32 0,25
(SceLe)
5 Self Directed Learning 52 64 0,8
TOTAL 4,00
LEARNING SOURCES
Learning sources include:
 Textbooks
 Resource persons, tutor
 E books, scientific journals, information from internet
 Module Instructional Design
 Tutor and Student Guidebook
 Lecture slides
 SCeLE
INSTRUCTIONAL MEDIA
Lecture slides, SCeLE

RESOURCES
TIME TABLE
Week 1 2
Time Wed Thurs Wed Thurs
18-Sept-19 19-Sept-19 25-Sept-19 26-Sept-19
07.00-08.00 SDL1 SDL2 SDL4 SDL6
08.00 - 09.00 Introduction QBD1 P1 L3
09.00 - 10.00 L1 L3
10.00 - 11.00 L2 L4
11.00 - 12.00 L2 SDL3 SDL5 L4
12.00 - 13.00 Break Break Break Break
Week 3 4
02-Oct-19 03-Oct-19 9-Oct-19 10-Oct-19
07.00-08.00 SDL7 SDL9 SDL11 SDL13
08.00 - 09.00 P2 QBD2 P3 QBD3
09.00 - 10.00
10.00 - 11.00
11.00 - 12.00 SDL8 SDL10 SDL12 SDL14
Week 5 6
16-Oct-19 17-Oct-19 23-Oct-19 24-Oct-19
07.00-08.00 SDL15 SDL16 SDL18 SDL20
08.00 - 09.00 L5 QBD4 P4 QBD5
Rescheduled
to Fri, 4-Oct-
09.00 - 10.00 19, 13.00-
15.00
10.00 - 11.00 L6
11.00 - 12.00 L6 SDL17 SDL19 SDL21
Online Online
17.00 - 21.00 discussion discussion
(SCeLE) (SCeLE)

Week 7 8
30-Oct-19 31-Oct-19 06-Nov-19 07-Nov-19
07.00-08.00 SDL22 SDL23 SDL25 SDL27
08.00 - 09.00 L7 QBD6 P5
09.00 - 10.00 L8 Progress Test
10.00 - 11.00 L8
11.00 - 12.00 L9 SDL24 SDL26
Formative-1
Week 9 10
13-Nov-19 14-Nov-19 20-Nov-19 21-Nov-19
07.00-08.00 SDL28 SDL29 SDL31 SDL33
08.00 - 09.00 Summative1 QBD7 P6
QBD8
09.00 - 10.00
10.00 - 11.00 L10
11.00 - 12.00 L11 SDL30 SDL32 SDL34
Self Directed Learning (SDL): Friday, 22 November 2019, 13.00-16.00: Visit i-Museum
Week 11 12
27-Nov-19 28-Nov-19 04-Dec-19 05-Dec-19
07.00-08.00 SDL35 SDL37 SDL39 SDL41
P7, Practical
08.00 - 09.00 QBD10
Reschedul-ed Examination
09.00 – 10.00 to: Friday, QBD9
29 Nov-19,
10.00 – 11.00 13.00-16.00
11.00 – 12.00 SDL36 SDL38 SDL40 SDL42
12.00 – 13.00 Break Break Break Break

Week 13 14
11-Dec-19 12-Dec-19 18-Dec-19 19-Dec-19
07.00-08.00 SDL43 SDL44 SDL47 SDL50
08.00 – 09.00 L12 Summative 2 Coaching Remedial
09.00 - 10.00 L12
10.00 - 11.00 L13 SDL45 SDL48 SDL51
11.00 - 12.00 L13 SDL46 SDL49 SDL52
Formative 2
L: Lecture
QBD: Question Based-Discussion
P: Practical
SDL: Self Directed Learning
Formative: computer based (independent)
Summative & practical exam: computer based (in the classroom)
Formative- Summative 1: L1-L7, QBD1-5,
Formative- Summative 2: L8-L13, QBD6-10,
Practical examination: P1-P7

HUMAN RESOURCES
BASIC BIOMEDICAL SCIENCE

MODULE’S TEAM 2019-2020
Name Department Phone Email
Chair DR. dr. Novi Silvia H, Biochemistry 08159930181 novi_s_h@yahoo.com
Mbiomed novish98@gmail.com
Vice Dra. Rawina Winita, Parasitology 08161605281 rawinaw@yahoo.com
MS, DAP&E
Secretary DR. dr. Reni Paramita, Biochemistry 081310186573 paramitareni@yahoo.com
MBiomed
PIC of dr. Ardiana Microbiology 085295523315 ardiana.dr@gmail.com
SCeLE Kusumaningrum,
M.Biomed
Member Dr. rer. nat. Dra. Biology 081381472194 asmarinah.si@gmail.com

Asmarinah, MS
DR.Andi Yasmon, SPi, Microbiology 081318307123 andiyasmon@gmail.com
Mbiomed
dr. July Kumalawati, Clinical 0816971383 july.kumalawati@ui.ac.id
DMM, SpPK(K) Pathology
dr. Sophie Yolanda, Physiology 08161958138 sophie.y@ui.ac.id
M.Biomed

LIST OF LECTURE
AND RESOURCE PERSON
Date Activity Resource Person Department
Hour
18 Sep 2019 Introduction Dr. dr. Novi Silvia H, Biochemistry
Wed MBiomed
08.00–09.00
18 Sep 2019 L1 Photometry Dr. Ade Arsianti, SSi Chemistry
Wed 1
09.00–10.00
18 Sep 2019 L2 Four categories of basic Prof. dr. Jeanne Pawitan, Histology
Wed tissues PhD 2
10.00–12.00
26 Sep 2019 L3 Cell Biology Drs. Dwi Ari Pujianto, PhD Biology
Thurs 2
08.00-10.00
26 Sep 2019 L4 Basic molecule of cell Dr. Ade Arsianti, SSi Chemistry
Thurs (organic) 2
10.00-12.00
04 Oct 2019 L5 Nucleic acid-hereditary Prof. Dr. rer. physiol dr. Biochemistry
Fri Molecule (Interactive Septelia Inawati Wanandi 2
13.00-15.00 lecture)
16 Oct 2019 L6 Role of Enzyme Prof.Dr.Mohamad Sadikin, Biochemistry
Wed DSc 2
10.00–12.00
30 Oct 2019 L7 Introduction of Dr. Ika Puspasari, Parasitology
Wed Parasitology (protozoa, MBiomed, Sp.Park, PhD 1
08.00–09.00 worm)
30 Oct 2019 L8 Proliferation of bacteria, dr. Tjahyani Mirawati S, Microbiology
Wed virus, prion. PhD 2
09.00–11.00
30 Oct 2019 L9 Systems of human body: dr. Rahmadini, MBiomed Anatomy
Wed Anatomy overview 1
11.00–12.00
13 Nov 2019 L 10 Principles and concept of DR. dr. Minarma Siagian, Physiology
Wed homeostasis MS, AIFO 1
10.00–11.00
13 Nov 2019 L 11 Systems of human body: dr. Sophie Yolanda, Physiology

Wed Physiology overview M.Biomed 1
11.00–12.00 (flipped class room)
11 Dec 2019 L 12 Hemorrheology Dr. Ninik Sukartini, DMM, Clinical
Wed parameters SpPK(K) Pathology 2
08.00–10.00
11 Dec 2019 L 13 Normal metabolism Prof. DR. dr. Sri Widia AJ, Biochemistry
Wed (carbohydrate, protein, MS 2
10.00–12.00 lipid) (Interactive Lecture)

LIST OF QBD AND TUTOR
Date QBD TUTOR Department
Thurs 1 Wave, Optic & Prasandhya Astagiri Yusuf, S.Si., M.T., PhD Physics
19-Sept-19 Sound Dr. Anindya Pradipta Susanto, B.Eng.,M.M. Physics
08.00–11.00 Ir. Muhammad Hanif Nadhif, S.T. Physics

dr. Sophie Yolanda, MBiomed * Physiology
DR. dr. Minarma S, MS, AIFO Physiology
dr. Dewi Irawati, MS, AIFM Physiology
Standby Tutor DR. dr. Neng Tine Kartinah,MKes Physiology
Thurs 2 Medical DR. Ade Arsianti, SSi, Msi Chemistry

Chemistry
03-Oct-19 Dr. rer. physiol. dr. Septelia IW Biochemitry
08.00–11.00 DR. dr. Ani Retno P, MS Biochemistry
dr. July K, DMM, SpPK (K) Clin. Pathology
Prof. DR. dr. Sri Widia A Jusman, MS Biochemistry
DR. dr. Novi Silvia H, MBiomed * Biochemistry
Standby Tutor DR. dr. Reni Paramita, MBiomed Biochemistry
Thurs 3 Role of protein Dr. dr. Ani Retno Prijanti, MBiomed Biochemistry
10-Oct-19 in structure Prof. Dr. dr. Sri Widia A. Jusman, MS Biochemistry
08.00 – 11.00 and function Prof. DR. rer. Physiol dr. Septelia Inawati Biochemistry
of Wanadi
Cell Dr. dr. Syarifah Dewi, MBiomed
Dr. dr. Novi Silvia Hardiany, MBiomed Dr. Biochemistry
dr. Febriana Catur Iswanti, MBiomed Biochemistry
Standby Tutor Dr. dr. Reni Paramita, MBiomed Biochemistry
Thurs 4 Cell cycle and Andriansyah, SSi, MBiomed, PhD Microbiology

17-Oct-19 its regulation Dr.dr. Ika Puspasari, M.Biomed Parasitology
08.00 -11.00 DR. Andi Yasmon, SPi, Mbiomed* Microbiology
Drs. Dwi Ari P, MS, PhD Biology
Dr. rer. nat. Asmarinah, MS Biology
Luluk Yuniani, SSi, MBiomed Biology
Standby Tutor Dr. Ardiana Kusumaningrum, SpMK Microbiology
Thurs 5 Gas/fluid/ DR. dr. Neng Tine Kartinah,MKes Physiology

24-Oct-19 hydrostatic dr. Dewi Irawati, MS, AIFM Physiology
08.00 -11.00 pressure DR. dr. Ermita Ilyas, MS, AIFO Physiology
dr. Sophie Yolanda, MBiomed* Physiology
dr. Imelda Rosalyn Sianipar, MBiomed, PhD Physiology
Standby Tutor dr. Nurul Paramita, MBiomed, SpKFR Physiology
Thurs 6 Membrane DR. dr. Neng Tine Kartinah,MKes Physiology

31-Oct-19 dynamics dr. Dewi Irawati, MS, AIFM Physiology
08.00 -11.00 DR. dr. Ermita Ilyas, MS, AIFO Physiology

Date QBD TUTOR Department
Thurs 7 Homeostasis DR. dr. Neng Tine Kartinah,MKes Physiology

14-Nov-19 dr. Dewi Irawati, MS, AIFM Physiology
08.00 -11.00 DR. dr. Ermita Ilyas, MS, AIFO Physiology
Thurs 8 Cell to cell DR. dr. Neng Tine Kartinah,MKes Physiology

21-Nov- communication dr. Dewi Irawati, MS, AIFM Physiology
2019 dr. Sophie Yolanda, MBiomed Physiology
08.00-11.00
DR. dr. Novi Silvia H,MBiomed Biochemistry
DR. dr. Ani Retno P, MS* Biochemistry
Standby Tutor DR. dr. Syarifah Dewi,MBiomed Biochemistry
Thurs 9 Fluid balance, dr. Dewi Irawati, MS, AIFM Physiology

28-Nov-19 acid-base and Dr. July K, DMM, SpPK(K) Clin. Pathology
08.00 -11.00 electrolytes dr. Sophie Yolanda, MBiomed * Physiology
DR. dr. Syarifah Dewi, MBiomed Biochemistry
Prof. DR. dr. Sri Widia AJ, MS Biochemistry
Standby Tutor dr. Nuri Dyah I, SpPK Clin. Pathology
Thurs 10 Metabolism & DR. dr. Neng Tine Kartinah,MKes Physiology

05-Dec-19 Body dr. Dewi Irawati, MS, AIFM Physiology
08.00 – 11.00 temperature dr. Sophie Yolanda, MBiomed * Physiology
regulation DR. dr. Minarma S, MS, AIFO Physiology
DR. dr. Ermita Ilyas, MS, AIFO Physiology
*PIC of QBD

PERSON IN CHARGE (PIC)
Sep. Oct. Nov. Des.
PIC HARI
2019 2019 2019 2019
Rabu 18 2 6 4
DR. dr. Novi Silvia H, MBiomed
Kamis 3 7 5
Rabu 9 13
DR.dr. Reni Paramita, MBiomed. Kamis 19 10 14
Rabu 16 11
Kamis 17 12
Dra. Rawina Winita, MS Rabu 25 23 20
Kamis 24 21
Rabu 30 27 18
dr. Ardiana Kusumaningrum, M.Biomed
Kamis 26 31 28 19
LIST OF PRACTICAL AND PIC

Date Practical PIC Department
Wed P1: Microscope (integrated) Dwi Ari P, Ssi, MBiomed, Biology
25 Sept PhD
2019 Dr. Andi Yasmon, Microbiology
08.00–11.00 M.Biomed
Dra. Rawina Winita, MS, Parasitology
DAP&E
Wed P2: Composition of basic Drs. Surya Dwira, M.Si Chemistry
02 Oct 2019 molecule: Protein, lipid,
08.00–11.00 carbohydrate
Wed P3: Basic Histology: Four dr. Radiana Dewayani, Histology
09 Oct 2019 Basic Tissues PhD
08.00-11.00
Wed P4: Enzyme activity Dr.dr. Reni Paramita, Biochemistry
23 Oct 2019 M.Biomed
08.00–11.00
Wed P5: Membrane transport Gulshan Fahmi El Bayani, Physiology
06 Nov 2019 and tonicity, membrane SGz, MBiomed
08.00–11.00 potential
Wed P6: Introduction to Gulshan Fahmi El Bayani, Physiology
20 Nov 2019 PowerLab SGz, MBiomed
08.00–11.00
Friday Anatomy-2: dr. Rahmadini, MBiomed Anatomy
29 Nov 2019 Systems of human body:
13.00-16.00 Anatomy overview

LIST OF TUTOR FOR PRACTICAL
Departement Tutor
Biology Drs. Dwi Ari P, MS, PhD
DR. dr. Sylvia WL, Mbiomed
Microbiology DR. Andi Yasmon, SPi, Mbiomed
dr. Ardiana Kusumaningrum, SpMK
Parasitology Dra. Rawina Winita, MS, DAP&E
dr. Ika Puspasari, PhD
Chemistry Drs. Surya Dwira, Msi
DR. Ade Arsianti, SSi, MSi
Dr.Fadilah, SSi, MSi
Aryo Tedjo, SSi, MSi
Dra. Fatmawaty, Msi
Biochemistry DR. dr. Reni Paramita, MBiomed

DR. dr. Sri Widia AJ, MS
Dr. rer. physiol. Septelia IW
DR. dr. Ani Retno P, MS
dr. Syarifah Dewi, MBiomed
DR. dr. Novi Silvia Hardiany, Mbiomed
Physiology DR. dr. Minarma S, MS, AIFO
dr. Dewi Irawati, MS, AIFM
DR. dr. Ermita Ilyas, MS, AIFO
DR. dr. Neng Tine Kartinah,MKes
dr. Imelda Rosalyn Sianipar, MBiomed, PhD
dr. Sophie Yolanda, MBiomed
Anatomy dr. Rahmadini, MBiomed

dr. Ria Margiana, MBiomed
Sasanthy Kusumaningtyas, SSi, MBiomed
Deswaty Furqonita, SSi, MBiomed
dr. Isabela Kurnia Liem, PhD
dr. Gondo S Gozali, PAK
Histology dr. Radiana D Antarianto, MBiomed, PhD
Prof. dr. Jeanne A Pawitan, MS, PhD
dr. Lia Damayanti, SpPA
dr. Atikah C Barasila, MS
dr. Ahmad Aulia Jusuf, PhD

REFERENCES
Department Book/ Authors Publisher/
Journal Edition
Physiology 1. Human physiology: Sherwood L Brooks/Cole, Cengage
from cells to systems Learning, Canada, 9th ed, 2016
2. Human physiology: an Silverthorn D Pearson Education, Inc, San
integrated approach Fransisco, 6th ed, 2012
Chemistry 3. Carbohydrate Sinnot M RSC Publishing, 2nd ed,

Chemistry and Cambridge, 2013.
Biochemistry: Structure
and Mechanism.
4. Essentials of Medical Bhagavan NV and Elsevier Inc. All rights reserved.
Biochemistry, Second Chung-Eun H 2nd ed, 2015
Edition: With Clinical
Cases.
5. Lipids Paolo GD and Wenk Elsevier Inc. All rights reserved.
MR. 1st ed, 2012.
6. Spectrofotometry: Germer TA, Elsevier Inc. All rights reserved.
Accurate Measurements Zwinkels JC and 1st ed, 2014.
of Optical Properties of Tsai BK
Materials.
Physics 7. Physics in biology and Davidovits P 4th ed. London: Elsevier; 2013
medicine
Biology 8. Molecular biology of Bruce Alberts, et al Garland Publishing Inc., 6th ed,
the cell 2015
9. Pinciples of genetics D. Peter Snustad Wiley & Sons, 3rd ed, 2003
and Michael J.
Simmons
10. Emery's Elements of Peter Turnpenny Churchill Livingstone, 13th ed,
Medical Genetics and Sian Ellard 2007
11. Genetics in medicine Nussbaum, Mc Saunders Elsevier, 7th ed. 2007
Immes, Willard
12. Human Molecular Tom Strachan and John Willey & Sons, 2nd ed,
Genetics Andrew P. Read 1999
Microbiology 13. Molecular Biology of B Alberts, A Garland Science.
the cell, 5th ed, 2008, Johnson, J Lewis et
Chapter 24 al.,
14. Foundation in KP Talaro. McGraw Hill.

Microbiology, 8th ed.,
2012, Chapter 1-8, 12,
13,
15. Medical Microbiology, C Mims, HM Mosby-Elsevier.
4th ed, 2008, Chapter Dockrell, RV Goring,
17, et al.
16. Cellular and CJ Sigurdson, JC Annu. Rev. Pathol. Mech. Dis.
Molecular Mechanisms of Bartz, and M
Prion Disease. 2019. Glatzel.
14:497–516.

Department Book/ Authors Publisher/
Journal Edition
Biochemistry 17. Textbook of Devlin TM Wiley-Liss, A John Wiley &
Biochemistry with Clin Sons Inc Publ, 6th ed, 2009
Correl
18. Biokimia: Eksperimen Departemen Widya Medika
Laboratorium Biokimia FKUI
19. Marks Basic Medical Smith C et al Wiliiams & Wilkins, A Waverly
Biochemistry Company, 4th ed, 2009
20. Harper's Illustrated Murray RK The McGraw Hill Comp, 28th

Biochemistry ed, 2009
Clinical 21. Control of Griffin JH Lichtman MA, Beutler E, Kipps
Pathology coagulation reactions TJ, Seligsohn U, Kaushansky K,
Prchal JT eds. Williams
hematology. McGraw-Hill, New
York, 7th ed, 2006
p. 1695-714.
22. Molecular biology Roberts HR, Lichtman MA, Beutler E, Kipps
and biochemistry of the Monroe-III DM, TJ, Seligsohn U, Kaushansky K,
coagulation factors and Hoffman MR Prchal JT eds. Williams
pathways of hemostasis: hematology. McGraw-Hill, New
Overview. York, 7th ed. 2006
p. 1665-94.
23. Platelet morphology, Parise LV, Smyth Lichtman MA, Beutler E, Kipps
biochemistry and SS, Shet AS and TJ, Seligsohn U, Kaushansky K,
function Coller BS Prchal JT eds.
Williamshematology. McGraw-
Hill, New York, 7th ed, 2006
p. 1587-664
24. Vascular function in Hajjar KA, Esmon Lichtman MA, Beutler E, Kipps
hemostasis NL, Marcus AJ and TJ, Seligsohn U, Kaushansky K,
Muller W Prchal JT eds
Williams hematology. McGraw-
Hill, New York, 7th ed, 2006
p. 1715-40.
25. Diagnostic Approach Rodgers GM and Greer JP, Foerster J, Rodgers
to the Bleeding Disorders Lehman CM GM, Paraskevas F, Glader B,
Arber DA, et al., eds.
Wintrobe’s Clinical Hematology.
Lippincott Williams & Wilkins,
Philadelphia, 12th ed, 2009
p. 1273-88.
Anatomy 26. Human Anatomy Elaine N Marieb, Pearson Education Inc., 2012
Patricia Brady
Wilhelm, John
Mallatt
Histology 27. Color textbook of Gartner LP and Saunders, Elsevier, 3rd ed,
Histology Hiatt JL 2007
28.Bloom & Fawcett’s Fawcett DW and Arnold Publishing, London,
concise histology Jensh RP 2nded, 2002

FACILITY AND INFRASTRUCTURE
LECTURE
Lecture room (1), equipped with LCD (infocus) and audio system
GROUP DISCUSSION
Group discussion room (6) equipped with flipchart, stationery and LCD (infocus)
Internet connection
PRACTICAL
Laboratory and equipment provided by the department: Biology, Chemistry, Biochemistry Physiology
and Anatomy. Consumables as required
SCeLE
All teaching and learning materials (Tutor and Student Guidebook, Laboratory Practice Guidebook,
Lecture materials, Reading materials) are accessible in SCeLE (academic year 2017-2018, BBS)
EXAMINATION
Computer based examination will be held in at Facility in RIK Building, UI Depok
LIBRARY

EVALUATION
Student Evaluation
Assessments will be carried out in written examinations, observations, and student notes.
Written examination will be held twice
Observations will be performed using a checklist covering activity, argumentations, interaction, as
well as courtesy in communication during discussions.
Student’s note will checked by tutor/facilitator
Prerequisites to attend summative examination are as follow:

80% attendance in Lecture, QBD, and Practical
Formative examination is done
Instruments for Student Evaluation:

a. MCQ
1. Type 1 questions (vignette MCQ with one best answer-type questions)
b. Daily Observations
1. Observations during QBD carried out by the tutors (Evaluation sheet)
2. Observations during practical
c. Student assignment assessment sheet
d. Laboratory post test
Summative Evaluation
Student grade is based on the process and outcome of learning using the following instruments:
 60% knowledge-based assessment consisting of
o Summative 1 20%
o Summative-2 20%
o Practical examination 20%
 40% process-based assessment consisting of
o Observations during QBD 15%
o Observations during Practical 15%
o Student’s note 10%
Students will pass the module if each component’s grade at least 55 (C) Program Evaluation
The parameters of success of Basic Biomedical Science are:
- Program Evaluation
90% of the students pass with a minimum grade of B minus and a Grade Point Average
(GPA) of 2.7.
- Process Evaluation
 All teaching-learning activities run according to schedule
 Changes in schedule, time and activity do not exceed 10%
 All teaching-learning activities are be attended by at least 90% of the students, tutors,
resource persons, and tutors/facilitators

ATTACHMENTS
Attachment 1
QUESTION BASED-DISCUSSION GUIDELINES
Question Based-Discussion (QBD) is a learning method used in this module in which the design is
according to Collaborative Learning
As per definition, Collaborative learning is an umbrella term for a variety of approaches in education
that involve joint intellectual effort by students or students and teachers. It refers to methodologies
and environments in which learners engage in a common task in which each individual depends on
and is accountable to each other. It involves use of small groups so that all students can maximize
their learning and that of their peers. It is a process of shared creation: two of more individuals
interacting to create a shared understanding of a concept, discipline or area of practice that none
had previously possessed or could have come to on their own. Collaborative learning activities can
include collaborative writing, group projects, and other
activities.http://sydney.edu.au/education_social_work/learning_teaching/ict/theory/collaborative_lear
ning.shtml(cited on16 July 2012)
Basically, in the Collaborative Learning, student is the center of learning process and so it is expected
that the student will develop active learning and independent learning skills through small group
discussion. Each of individual in the small group has responsibility as well as the opportunity to
contribute the information, knowledge, experience, ideas, opinions, and skills to the member of the
group. Also, they have the responsibility to advance the learning process for other group members.
Interconnection and interdependence are the main character in this learning method.
Module Basic Biomedical Science will employ student active learning approach that is Question
Based-Discussion (QBD) ©Lucky H Moehario.
In each QBD, students will be given some tasks/questions in order to learn and gain knowledge
about particular topic(s).
The procedures of the QBD are as follow:
Tasks/questions should be accessed from the SCeLE (BBS module) 2 days prior to the
discussion.
Students will be divided into small group contain 2-3 people. Each individual in the small group is
responsible to work out a question or some questions.

The QBD session is 3 hours.
The First hour: students will complete the information of his/her tasks, have the discussion on the
specific topics, and understand the topics. Students may find through textbooks, journals, or
websites.
The second hour: students of the small group will share the information/knowledge about
particular topics to other members of the other small group. This is an open discussion; every
student should actively participate in it. The tutor will observe the discussion and make some notes.
The third hour: tutor will give clarification and feed back
During all times in the discussion, students will be observed and monitored by the tutor and
evaluated. Students’ self-assessment will also be evaluated.
Finally, students should always check the timetable for incoming QBD and make some preparations
prior to the QBD.

Attachment 2
QBD - LIST OF QUESTIONS
QBD Content QUESTIONS

1 Properties of wave Vignette
Thurs - Electromagnetic vs. mechanical wave
19-Sept-19 - Ionizing radiation A woman was diagnosed with myopia and cerumen prop during a routine
08.00 - 11.00
Properties of light wave medical checkup.
Focusing and imaging with lenses
Refraction 1. What is the definition and classification of wave?
Imaging and detection by eye 2. What are the properties and spectrums of electromagnetic wave?
Physiology of eye refraction 3. How do lenses form images?
Types of vision impairment & correction 4. Explain the physiology of eye refraction.
Properties of Sound 5. Explain the refractive disorders and their correction.
Functional anatomy of the human ear 6. What are the properties of mechanical wave?
Sound processing in the ear 7. Explain the structure and function of each component of the human
- Amplification ear.
Pitch recognition 8. Explain the process of hearing: sound transmission, impedance
matching, sound transduction, and pitch recognition.
9. Explain the pathophysiology of the disorders experienced by the patient
in the vignette.
2 Concept of atom, molecule and ion 1. Define concept of atom, molecule and ion!
Thurs Atomic Structure and Periodic Table 2. Identify group of atoms according Mendeleev's system!
03-Oct-19 The mole concept and stoichiometry 3. What is molarity, molality, and normality of chemical compound?
08.00 - 11.00 Chemical bonding 4. Define and describe chemical bonding!
Free radical: basic chemistry, application and formation 5. How molecules are constructed and degraded? Explain the
transamination reaction!
Free radicals in human body and their productions 6. What are free radicals and antioxidants?
Redox chemistry 7. Explain the principles of oxidation and reduction reactions!
Antioxidants and their sources 8. Explain their association and impact on human body!
Benefits and functions of antioxidant to maintain
homeostatic condition
Correlation of acid or base dissociation constant (Kaor 9. How does human body maintain the pH?
Kb), strength of acid or base

Relationship of acid strength and conjugate base 10. Define and explain the concept of acid, base, buffer and their
mechanisms of action in maintaining the pH of human body!
pH and pOH of a solution, correlation of pH or pOH,
acidity or basicity,
pH and pOH of aqueous solutions of weak and strong

acids and bases from molarity and Ka/Kbvalues, acidity
of a solution when a salt dissociates in water, pH of an
aqueous solution of salt
Concept of protein structures and functions.

3 Universality of amino acid constituents for protein 1. What is protein?
Thurs 2. Describe amino acid as the constituents of protein (structure and
10-Oct-19
Classification, general properties of amino acids, classification)
08.00 - 11.00
codons and amino acids relationship-protein 3. Describe of the protein structure (primer, secondary, tertiary,
quaternary)!
Concept of amino acids essential and nonessential 4. Describe the classification of protein (globular protein, fibrous
protein, simple protein, conjugated protein)
Concept of protein denaturation 5. Describe the concept of protein denaturation!
6. Describe of ligand and protein interactions!
Concept of ligand-protein interactions 7. Explain physiological function of protein!
8. Describe the glycoprotein (definition, structure, classification and
Physiological function of protein function)
Glycoprotein
4 Cell cycle and its regulation 1. Define phases of one cell cycle!
Thurs 2. What cell activities occur during each phase of cell cycle?
17-Oct-19 3. What is the importance of karyokinesis and cytokinesis?
08.00 - 11.00
Factors affecting bacterial growth (such as food, moist, 4. What is the role of CDK and cyclines in the regulation of cell cycle?
temperature, pH, oxygen). Media for bacterial growth 5. How is MPF activated, and what is the consequence of MPF activation?
(intracellular and extracellular) 6. Describe various factors that affect bacterial growth!
7. Explain the bacterial growth curve!
Cellular mechanisms of bacterial cell 8. Explain cellular mechanism of bacterial division!
division.Characteristics of bacterial growth curve. 9. How is the relationship between bacteria and human host?
Relationship between bacteria and human host. 10. How is the relationship between parasites ahuman host?

11. Describe characteristics of algae, fungi, protozoa and worm!
Characteristics of algae, fungi, protozoa, and worm.
Relationship between parasite and human host
5  Fluids and hydrodynamics Vignette:

Thurs  Basic physics of pressure and flow of fluids
24-Oct-19  Pressure and flow in the body A man was involved in an accident. He was bleeding profusely from his
08.00 - 11.00
 Relationship between pressure, resistance, broken leg.
airflow: Boyle’s, Poiseuille’s, La Place laws
 Physiology of respiratory mechanics 1. What is fluid? What is hydrodynamics?
 Relationship between pressure, resistance, and 2. Describe the pressure and flow of fluid in human body!
blood flow 3. What do you know about Boyle’s, Poiseuille’s, and LaPlace laws?
 Physical characteristics of blood vessels and their 4. Describe the mechanics of respiration based on Boyle’s and LaPlace
physiological impact laws.
 Starling forces 5. Explain the influence of Poiseuille’s law on pressure, resistance and
 Concept of blood pressure and mean arterial blood flow.
pressure 6. Explain the physical characteristics of blood vessels, and their impact
 Physiology of blood pressure regulation on intravascular hydrodynamics.
7. Explain the exchange happening in the capillary based on Starling
forces.
8. What is mean arterial pressure (MAP)? Name the two main factors
affecting MAP.
9. Explain the physiology of blood pressure regulation.
in the vignette.
6  Membrane structure and functions Vignette:

Thurs  Amphipathic properties and fluid mosaic of
31-Oct-19 plasma membranes A few medical students were watching the movie “five feet apart” and later
08.00-11.00
 Types of membrane transport discovered that cystic fibrosis is a channel protein disorder.
 Concept of osmolarity
 Membrane pump mechanisms 1. Explain the structure of cell membrane, and what are the physiological
 Fundamentals of bioelectricity of the mammalian impacts of these structures?
nervous system and other excitable tissues 2. Explain the types and function of membrane proteins.
 Membrane potential 3. Explain the types of membrane transport. Why do molecules need

different methods of membrane transport?
4. What is osmolarity? How does membrane transport affect osmolarity?
5. Define excitable cells. Relate to the changes that may occur in
membrane potential. Explain how resting membrane potential is
formed.
in the vignette.
7 Levels of organization in the body Vignette:

Thurs Concept of homeostasis
14-Nov-19 - Definition A bare-foot person stepped on shattered glass. He instantly pulled his leg
08.00 - 11.00
- Internal and external environment because of pain. The wound bled then stopped.
Components of reflex arc
Function of each reflex arc component 1. Explain the level of organization in human body.
How reflex arc maintains homeostasis 2. What are the basic cell functions?
Negative feedback 3. What are the four primary tissue types?
Positive feedback 4. Name the systems that make up a human and their primary function.
Feed forward mechanism 5. What is internal and external environment?
6. Define and explain homeostasis in human body.
7. How is homeostasis maintained?
8. What are the components and function of the reflex arc?
9. What are the components to the control pathway? Give examples of
each pathway.
10. Give an example of two body systems that work together to maintain a
homeostatic parameter. Explain the mechanism briefly.
11. What type of reflex arc is described in the vignette? Explain the
pathway.
8  Cell to cell communication Vignette:

Thurs  Concept of intercellular communication: chemical
21-Nov-19 vs. electrical, local vs. systemic A baby was suckling on his mother’s breast for breastmilk.
08.00 - 11.00
 Electrical communication: ionic movement
through gap junction, graded potential, action 1. Explain the relation of systems of the body, homeostasis, and cell to
potential cell communication.
2. Explain the classification of cell to cell communication based on

 Chemical communication: autocrine, paracrine, distance and signal type.
neurotransmitters, hormones 3. Explain the methods of electrical communication in human body: ion
 Cell receptors and signal transduction movement through gap junction, graded potential, action potential.
 Comparison of the nervous and endocrine system 4. Explain the chemical signals in cell to cell communication: autocrine,
 How the nervous and endocrine system maintain paracrine, neurotransmitter, hormone.
homeostasis (neural, neuroendocrine, and 5. Explain the types of membrane receptors.
endocrine reflex) 6. Explain intracellular cell transduction.
7. Compare and contrast the nervous system and the endocrine system;
how do they contribute to reflex arc and maintenance of homeostasis?
Give examples of neural, neuroendocrine, and endocrine reflexes.
8. What type of reflex arc is described in the vignette? Explain the pathway.
9  Body compartments and their ionic contents Vignette:

Thurs  Water as a polar molecule, hydrophilic and
28-Nov-19 hydrophobic molecular interactions, roles and After heavy exercise, a person sweats profusely. He became very thirsty
08.00 - 11.00
functions of water in the human body and drank a bottle of water.
 Functions and normal values of ions in the body
 Nephron & urine production 1. Explain the compartment and composition of body fluids.
 Body fluid osmolarity and volume balance: water 2. Explain physico-chemical properties and function of water in human
balance, salt balance body.
 Definition and concept of acid, base, buffer, pH 3. Explain the function of ions in the body: sodium, potassium, calcium.
 Buffer system of the body 4. Explain the structure and function of each component of the nephron.
 Acid-base imbalance 5. Explain the 3 processes of urine production.
6. Explain about water balance and its role in maintaining osmolarity and
tonicity.
7. Explain the role of vasopressin and countercurrent system in water
balance.
8. Explain about salt balance and its role in maintaining body volume.
9. Explain the role of renin-angiotensin-aldosterone system in salt
balance.
10. Define the following terms: acid, base, buffer, pH.
11. Explain 3 systems maintaining acid-base balance in human body.
12. Explain the types of acid base imbalance.
13. Explain the mechanism of thirst in the vignette.

10  The law of thermodynamics Vignette
Thurs  Energy balance
05-Dec-19  Energy storage and usage A man was joining a marathon in his city.
08.00 - 11.00
 ATP production
 Anaerobic vs. aerobic metabolism 1. Explain the law of thermodynamics.
 Mechanics of skeletal muscle contraction and 2. Explain the physiology of energy balance.
relaxation 3. Explain the physiology of energy storage and usage.
 Muscle metabolism 4. Explain the processes of ATP production, and whether the process is
 Muscle fatigue anaerobic of aerobic.
 Relation of metabolism and body temperature 5. Explain the mechanism of skeletal muscle contraction and relaxation.
regulation 6. Explain the metabolism of skeletal muscle and how it relates to muscle
 Heat balance and heat transfer fatigue.
 Reflex arc of body temperature regulation 7. Explain heat balance. How does energy balance related to heat
 Response reflex in hot and cold environment balance?
 Pathophysiology of Fever 8. Explain the types of heat transfer.
9. Explain about reflex arc of body temperature. What happens in hot and
cold environment?
10. Explain the pathophysiology of fever!
11. What is the primary source of ATP for the person in the vignette?
12. How is his body temperature during the marathon?

Attachment 3
JOB DESCRIPTION OF MODULE’S TEAM
The Module Committee consists ofchairman, vice chairman, secretary and members of committee
and administration staffs.
PRE-IMPLEMENTATION PERIOD
1. Re-evaluates the schedule/activities matrix by synchronizing with:

a. Official holidays
b. The availability of facilities such as, laboratory rooms/skill lab rooms, etc
c. The availability of resource persons for lectures
a. The availability of teaching facilities in Centers of Excellence Hospitals, such as
Persahabatan General Hospital, Dr. SuliantiSaroso Hospital for Infectious Diseases,
Harapan Kita Children’s and Women’s Hospital, and Harapan Kita National Heart
Center
2. Accepts reports from the Year Coordinator on:

a. List of students and groups (source: Coordinators of Programs for Regular and
International classes)
b. Forms for evaluation of group discussions by tutors (source: MEU)
c. List of facilitators (source: Human Resources Manager cq Coordinator Of Undergraduate
Medical Education)
3. Holds preparation meetings

a. Together with resource persons on:
i. Lectures: the readiness of the timetable and material, including the continuity
between the lectures, if any
ii. Plenary and summary/feedback sessions: the readiness of 3 – 4 resource persons for
each plenary sessions, and provide feedback after the plenary sessions
iii. Teaching material that will be uploaded to the virtual class. (The material should be
prepared as LECTURE OUTLINES/HANDOUTS and submitted to the MEU Secretariat
to be uploaded by the Labkom staff – Wahyono/Syafei)
iv. Examination grid and the timetable forpreparing the examination document
b. Together with facilitators on:

i. The objectives of the module
ii. Important information regarding group discussions: Trigger and pointers/
keywords/list of questions/answers
iii. Evaluations to be carried out by the facilitators and instructions on how to do the
evaluations
iv. Confirmation of availability and substitution mechanism if unavailable during the
module
v. Discussion groups and room allocations
vi. Things to do on the first day of discussions (go directly to the discussion room
allocated or report to the secretariat first to receive the facilitator kit, fill the
attendance form directly or wait for the attendance rounds/direct control)
vii. The willingness to be examination supervisors
viii. Remuneration
4. Upload Student Guidebook prepared by the MEU to Scele

5. Upload required references needed for group discussion.
IMPLEMENTATION PERIOD
1. Prepare rooms for the various activities:

a. Lectures/Plenary/Feedback sessions: Lecture room + AVA + 3 sets of wireless
microphones for the students
b. Discussions: discussion rooms + all in one board (IP board)
2. Monitors implementation
a. Lectures/Plenary/Feedback sessions
b. Group Discussions
3. Monitors student attendance and any problems that arise and report to the student guidance
counselors
4. Holds weekly evaluation meetings, together with the resource persons, facilitators and
instructors
5. Carries out student evaluation/assessments

a. Preparation:
i. Timetable & location of examinations: Date, rooms, dividing the students, assigning
examination monitors to the exam rooms
ii. Evaluation material & supporting kit: exam documents, answer sheets, rules and
regulations, attendance form for students & monitors, & report forms
b. Implementation:
i. Carry out the examination according to the schedule
ii. Mark/grade the examination (written MCQ exams will be graded and analyzed by the
MEU)
c. Follow-up:
i. Calculate the grades according to the MEU guidelines. The list of grades must be
signed by the Chairman of the Module and the Subprogram
ii. Discuss the results of item analysis with the resource persons
Note:
The Module committee together with the Coordinators of Programs for Regular and
International classes secures the examination rooms, and if needed they can coordinate
with the General Facilities Manager.
d. Support the MEU program evaluation by distributing and collecting questionnaires on
program evaluation to the students and teaching staff.

POST-IMPLEMENTATION PERIOD
1. Prepares written reports on

a. IMPLEMENTATION
i. Information on the timetable and feasibility
ii. The teaching staff and students involved, summary of staff attendance (reports are
also forwarded to the Human Resources Manager) and student attendance (reports
are also given to the Subprogram chairman) in every planned activity
iii. Special note should be made to:
1. evaluate the attendance of the facilitators
2. evaluate the attendance of the resource persons for lectures
3. evaluate the attendance of the resource persons for plenary & feedback sessions
4. evaluate the preparation for facilities and resources
iv. Evaluation reports should include
1. the type of evaluation
2. the list of grades for each student*)
v. Closing: conclusions and suggestions
The report on module implementation must be submitted to the appropriate Year

Coordinator 2 weeks after the end of the module, except in the case of the last module
of an even semester, then the report must be submitted 1 week after the end of the
module.
b. BUDGET
Written reports (include proof of purchase or other accounts of expenditures) are
submitted to the Financial Manager. A copy of the report is also submitted to the
Coordinator of Undergraduate Medical Education.
2. Presents the module report during module evaluation meeting held by the Year Coordinator
3. Submit the final grades in the module*) after Remedial-1 to the Year Coordinator, at the least 2
(two) days before the first academic evaluation meeting. The module grade is a letter that is
converted from the mark according to the conversion calculations of the March 2006 Kurfak
revision (suratWadek I FKUI no. 1791/PT02.M1 FK/Q/2006).
4. Attend the academic evaluation meeting held by the Year Coordinator, and recheck the yearly
module grades summary.
*)
The Grades must be submitted in printed and electronic forms

THE DUTIES OF TUTOR and RESOURCE PERSON
TUTOR
A. Question Based-Discussion (QBD)

- Tutor is a subject expert and has the responsibility that the discussion is going into the
correct direction as expected (refer to SCOPE OF STUDY in the Tutor Guide Book).
- Should have some preparation prior to the discussion and make sure that he or she has the
expertise on the topics.
- Should bring the SCOPE OF STUDY sheet from the Tutor Guide Book when he or she will
attend the discussion
- Should fill in the attendance sheet
Opening Session
- Divide students into small group consists of 2-3 people
- Students introduce themselves
- Tutor introduces him or herself
- Tutor will check students’ presence and give general explanations of the process and aims
of the QBD and the evaluation
- Ask the group to select a chairman and secretary for the QBD
- Explain the duties of the chairman and secretary during the QBD
Discussion Session
In the first hour:

- Tasks or questions are distributed among the small group. Students are advised to access
the SCeLE on Day-2 to get the tasks/questions and start working on it.
- Allow students within the small group to complete or finish up their findings by searching
or browsing internet or reading the references and have a discussion on specific topics, and
understand the topics before entering the second hour for sharing
- Observe/monitor the activity of the students within the small groups
In the second hour:

- Students will share the information/knowledge about particular topics in the group. Tutor
will observe the students’ activities and their presentations, and make notes
In the third hour:

- Tutor will give clarification and feed back
Closing Session
- Fill out the evaluation sheet for the discussion
- Fill out the evaluation sheet for student assignment assessment sheet or the soft copy
- Remind the students to check the incoming QBD and access the tasks or questions from
SCeLE
- Remind the students to use effectively the allocated time of Self Directed Learning (SDL) to
work out their tasks
B. Other
Attend all meetings held by the module committee for the preparation and evaluation of the
module
RESOURCE PERSONS

- Prepare materials for lectures and hand a softcopy to the module committee
- Give the lecture according to the schedule
- Construct questions for the examinations and hand them to the module committee cq
person in charge of the examinations, according to the agreed timetable
- Attend all meetings called by the module committee for the preparation and evaluation of
the module
- Mark the exam papers that cannot be marker by the computer
- Be an examiner for skills examination
LABORATORY INSTRUCTOR
- Accept the agreed schedule from the person in charge of laboratory session
- Prepare the resources and facilities for the laboratory activities, aided by the laboratory
technician
- Provide instruction and exercise for the students according to the objectives of the
practicals
- Fill in the process evaluation form for laboratory activities and hand them to the person in
charge of laboratory activities at the end of the lab sessions. The forms are in duplicates,
the first should be given to the Module Chairman, and the second to the students. The
person in charge of laboratory activities submits the evaluation forms to the module
chairman.

Attachment 4
STUDENT ASSESSMENTS
ASSESSMENT
Assessments will comprise of 2 aspects:
1. Cognitive and skills will be 60%
2. Process, behavior and attitude will be 40%
Remedial
Remedial is eligible for the students who get D score in summative, NOT for students who get E
score. E score means that the students must repeat the module next year. Remedial examination will
be given at end of module or end of semester. Maximal grade for remedial is C. The score will be
presented during evaluation. The score that has been evaluated in the meeting is FINAL.
ASSESSMENT CATEGORY
1. Pass
2. Repeating the module
3. Fail the program
LEVEL OF ACADEMIC DISTINCTION

GP/GPA SEMESTER LEVEL GRADUATE LEVEL
2.00 – 2.75 Satisfactory Satisfactory
2.76 – 3.50 Very satisfactory Very satisfactory
3.51 – 4.00 Excellent Cum laude
GP/GPA PROFESSIONAL LEVEL

2.50 – 3.00 Satisfactory
3.01 – 3.50 Very satisfactory
3.51 – 4.00 Cum laude
Note:
1. Pass: the final grade is ≥ 55 (C) for each module
2. Repeat a module: the final grade for the module is ≤ C
a. The student will be summoned by the Evaluation Committee after designated as
failing a module
b. Failing a module means the student must repeat the module at the earliest
according to the Curriculum 2012 schedule
c. The student is allowed to continue with modules in the following semester
d. The timetable to take a repeat module in one academic year will be arranged by the
head of the subprogram
e. The student is sent to the Evaluation Committee (MEU) for further assessment if the
grade for the repeated module is still < 55 (C)
3. Failing the program: Dropout (Academic Regulation UI SK no 478/SK/R/UI/2004)

a. If during evaluation in the first 2 (two) semesters, the student does not achieve a
minimal Grade Point of 2.0 (two point zero) from at least 24 credits of his best
subject
b. If during evaluation in the first 4 semesters, the student does not achieve a minimal
Grade Point of 2.0 (two point zero) from at least 48 credits of his best subject

c. If during evaluation in the first 8 semesters, the student does not achieve a minimal
Grade Point of 2.0 (two point zero) from at least 96 credits of his best subject
d. If during evaluation at the end of his study, the student does not achieve a minimal
Grade Point of at least C in the required study load
e. If the student cannot complete his study in 1½ n time
ASSESSMENT GUIDELINES
INTEGRATED MEDICAL SCIENCES SUBPROGRAM
CURRICULUM 2012 FACULTY OF MEDICINE UNIVERSITAS INDONESIA
1. Summative assessments will be held at the end of the module and weighted as follows:
a. 60% knowledge-based assessment from (the types and combination can be
determined accordingly)
i. Multi-format MCQ examinations
ii. MEQ examinations
iii. Essay examinations
iv. Systematic Problem Solving examinations
v. Practical examinations
b. 40% process evaluation from (the types and combination can be determined
accordingly)
i. Observation in Group Discussions (MEU evaluation forms)
ii. Student’s notes (MEU evaluation forms)
iii. Peer assessments
2. Formative assessments will be carried out twice in each module. The assessment will cover
the same area as the summative assessment (point 1a and 1b)
3. Progress tests (formative tests) will be carried out twice a year in semesters 3 and 4. At the
end of semester 6, there will be a summative comprehensive examination before the student
continues to semester 7. The Coordinator of Undergraduate Medical Education of Curriculum
2012 will prepare progress test.

Attachment 5
EVALUATION SHEET
MEDICAL EDUCATION UNIT

FACULTY OF MEDICINE UI
MEMBER EVALUATION SHEET IN QBD
(TO BE SUBMITTED TO THE MODULE ORGANIZER)
Group : Module : Basic Biomedical Science
Tutor Name : ______________ Academic year: 2019-2020
Question Based Discussion : ______________
Involvement Behaviour Sum

(Max:
Sharing
Argumentation
Activity
Dominant
Collaboration
Attendance
Discipline/
Communication
Manners
50)
No Name
1
2
3
4
5
6
7
8
9
10
Note:
Score Score
0-5 6-7 8-10 -5 -3 0
Sharing minimum sometimes always Dominant yes sometimes No
Argumentation poor fair good Discipline/ late>1 late<15’ on time
Attendance 5’
Activity poor fair good Manners none sometimes always
show good
manners
Communication poor fair good
Collaboration poor fair good
Definition on evaluation term:

Sharing :sharing opinion/information related to the topic discussed between group member ____,_____________201..
Argumentation :giving logical knowledge and argumentation based on literature
Activity : active in discussion without tutor intervention
Dominant : dominating the forum in a group discussion
Communication : listening, explaining and asking questions using appropriate language
systematically
Collaboration : ability to collaborate with others and manage conflict
Manners : demonstrate respectful behavior (__________________)
Tutor’s name

FACULTY OF MEDICINE, UNIVERSITY OF INDONESIA
SUBPROGRAM GENERAL EDUCATION
SUBPROGRAM INTEGRATED MEDICAL SCIENCES
STUDENT ASSIGNMENT ASSESSMENT SHEET*
BASIC BIOMEDICAL SCIENCE – ACADEMIC YEAR 2019-2020
QBD**: 1 – 2 – 3 – 4 – 5 – 6 – 7 – 8 – 9 – 10
(**Circle the right Question Based Discussion)
Group : ..............................................
STUDENT NAME SCORE ***
*** Not Submitted: Score 0

*** Submitted : Score 10-100
- Contents are complete
- References are listed
Jakarta, ………………., 201..
TUTOR
(.........................................)

Module Team
Novi Silvia H
Biochemistry & Molecular Biology Department
Rawina Winita
Parasitology Department
Reni Paramita
Biochemistry & Molecular Biology Department
Asmarinah
Biology Department
Andi Yasmon
Microbiology Department
Sophie Yolanda
Physiology Department
July Kumalawati
Clinical Pathology Department
Ardiana Kusumaningrum
Microbiology Department
Medical Education Unit Reviewers
Medical Education Department

Final BPKM KKI BBS TA 2019-2020 Ok

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STUDENT GUIDEBOOK

BASIC BIOMEDICAL SCIENCE

MEDICAL EDUCATION UNIT

BASIC BIOMEDICAL SCIENCE MODULE

Copyright 2019 by Medical Education Unit Faculty of Medicine, Universitas Indonesia

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 2

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 3

Jakarta, July 2019

Team of Basic Biomedical Science

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 4

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 5

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 6

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 7

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 8

Compound, acid, Redox chemistry C2=

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 9

Concept of base pairing of nucleic acid

Structure and Structure and genome organization of eukaryotes, C1= Week 4

Membrane systems and organelles: nucleus, RER,

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 10

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 11

Systems of human body: Physiology overview Week 9

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 12

Electrical Ionic movement through gap junction C1=

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 13

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 14

1.2. Question Based-Discussion (QBD)

1.4. Self-Directed Learning (SDL)

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 15

3.1. Formative evaluations: 2 sessions (computer based, allocated time, independent)

No. Learning method Hour Credit points

Learning sources include:

Lecture slides, SCeLE

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 16

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 17

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 18

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 19

BASIC BIOMEDICAL SCIENCE

Member Dr. rer. nat. Dra. Biology 081381472194 asmarinah.si@gmail.com

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 20

13 Nov 2019 L 11 Systems of human body: dr. Sophie Yolanda, Physiology

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 21

08.00–11.00 Ir. Muhammad Hanif Nadhif, S.T. Physics

Thurs 2 Medical DR. Ade Arsianti, SSi, Msi Chemistry

Thurs 4 Cell cycle and Andriansyah, SSi, MBiomed, PhD Microbiology

Thurs 5 Gas/fluid/ DR. dr. Neng Tine Kartinah,MKes Physiology

Thurs 6 Membrane DR. dr. Neng Tine Kartinah,MKes Physiology

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 22

Thurs 7 Homeostasis DR. dr. Neng Tine Kartinah,MKes Physiology

Thurs 8 Cell to cell DR. dr. Neng Tine Kartinah,MKes Physiology

Thurs 9 Fluid balance, dr. Dewi Irawati, MS, AIFM Physiology

Thurs 10 Metabolism & DR. dr. Neng Tine Kartinah,MKes Physiology

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 23

LIST OF PRACTICAL AND PIC

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 24

Biochemistry DR. dr. Reni Paramita, MBiomed

Anatomy dr. Rahmadini, MBiomed

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 25

Chemistry 3. Carbohydrate Sinnot M RSC Publishing, 2nd ed,

14. Foundation in KP Talaro. McGraw Hill.

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 26

20. Harper's Illustrated Murray RK The McGraw Hill Comp, 28th

STUDENT GUIDEBOOK BASIC BIOMEDICAL SCIENCE MODULE, FMUI 2019-2020 27