Chemokine Receptor Biology

04-0021-00

Bone Marrow HOMEOSTASIS Secondary Lymphoid Tissues

INFLAMMATION Periphery CXCL1, 8
CCL2, 5
CXCR4
Rolling Neutrophil T Progenitor
CXCR4 Specialized Stromal Cells Follicle DUFFY
CCR7 CCR9 T cell Zone
Sphingosine-1-Phosphate
LFA-1 Blood Vessel Gradient Bone Marrow
CXCR1, 2 CXCR5
ICAM-1 T Progenitor Niche Endothelium
Atypical
CXCL8 CCR7 CCR9 CXCL13 T cell
CCL21
E-Selectin CXCR5
Blood
Brain: CXCL12, CXCL14 B cell
PSGL-1 CCL19 CCL21 CCL25 CCR7
P-Selectin
Endothelium CXCL12
CCL19 D6
Endothelium CD34 + Lungs: CXCL12, CXCL17
CXCR4 T cell
HSC HEV CCL2, 3, 5, 7
IFN-γ
Pro-inflammatory CXCL8
Tissue Thymus Cortex Medulla Egress
G-CSF Bone Marrow: CXCL12 Lymph Nodes:
Cytokines TNF-α CCL19, CCL21, CXCL13
Sphingosine-
IL-1
Cortico-medullary
1-Phosphate Skin Spleen: CCL19, CCL21, CXCL13
Receptor
CXCR4+, CCR7+, CCR9+ Junction Liver: CXCL13
Chemokine Gradient CD4-CD8- CXCL17
CD4+ or CD8+
Thymocyte Single Positive Dermal Cells Small Intestine:
CXCL8
Mature CD4 or CD8 Naïve T Cell
+ +
CCL25, CXCL17
Thymocyte CCL27 ?
Positive Negative CCL25
CCR7+, CCR9+
Selection Selection CCR10
Injury, Infection
CD4+CD8+ Thymocyte Skin: CCL27, CXCL14 Small Intestine CCR9

Epithelium
CCL25 CCL27, 28 CLA+ T cell
CCL1, 4 CCL18 α4β7+ T cell
CCL19, 21 CCR9 CXCL17
CCR8 CCR10
VIROLOGY Chemokine Sink CCL20 CCR7
?
? CXCL14
Tumor Defense CANCER
HIV Entry CCR6
?
HIV CXCL11, 12
CXCR4 CXCL6, 8 Chemokine Receptor Signaling Oxysterols
CCR7
Dendritic Cell
Macrophage CXCR1
Chemokine CXCR7
CXCL16
CXCL1, 2, 3, CCL27, CXCL14
Chemokine Receptor Extracellular
5, 6, 7, 8 CXCR2 CXCR6
CD4 Tumor Cells
CCL28
T Cell CXCL13
CXCL1, CXCL8 CCR7, 10
CCR2 CXCL9, 10, 11 Membrane CXCR5 Block Recruitment of
CXCR3
Dendritic Cells,
Reduced Tumor Cell Proliferation
Lymphocytes
Recruitment CXCR4 CXCL12
HIV Intracellular
CCR5
CCL19, 21 CCR7 Treg Recruitment
Chemokine CCL2 CCL5 G Proteins XCR1 XCL 1,2 Metastasis/Angiogenesis Immunosuppression
Sequestration
US28
CCR5 PLCβ2, Arrestin, Hypothetical Primary Tumor Site
CD4 CCL3, 4, 5, CX3CR1 CCL26, CX3CL1
PLD, PKC PLCβ2
8, 14 CXCR4 Upregulation of
Macrophage
Cytomegalovirus CXCL12 Chemokine Receptors
Receptor VEGF
CCR4 Respiratory Burst STK’s, Ras
Endothelial Cell Internalization/
CCL2, 3, 5 Granule Release Desensitization
Cytoskeletal Remodeling CXCR4
ECRF3
17, 22
Shape Change CXCL1, 5, 7
HIV CCR3
Immunosuppression Firm Adhesion
CCR5 US28 Angiogenesis
Tumor Cells
CCL5, 7, 11,
CCR2
Immune Tolerance 13, 14, 15,
UL12
CCL2, 3,
4, 5, 7
24, 26 CCR1
B cell Viral CCL1, 2, 3 CCR4 CCR8 CCL2, 7, 8 E1
CD4 KSHV Blood Vessel
12, 13 CCL2, 3, 4, 5
CCL3, 4, 5, 7 Tumor Metastasis
Treg, Th2 Recruitment
Dendritic Cell 14, 15, 16 CXCL1, 8, CCL11 CCR7: Breast, Melanoma, Head and Neck, Colorectal, Chronic Lymphocytic
Recruitment Leukemia, Stomach, Non-Hodgkin’s Lymphoma, T Cell Leukemia
10, 12
CCR9: Melanoma

biolegend.com
CCR10: Melanoma
Other Reported HIV Co-Receptors CXCR3: Acute Lymphoblastic Leukemia
Kaposi Sarcoma Virus CXCR4: Breast, Ovarian, Prostate, Pancreatic, Melanoma, Oesophageal,
CCR2 CCR8 CXCR7 Interactive Poster: biolegend.com/chemokinebiology Non-small Cell Lung, Head and Neck, Bladder, Colorectal, Osteosarcoma, Hypothetical
CCR3 CXCR6 CX3CR1 We would like to thank Dr. Albert Zlotnik, University of California, Irvine for his contributions to this poster. Neuroblastoma, Acute Lymphoblastic Leukemia, Chronic Lymphocytic Secondary
Leukemia, Stomach
Immunosuppression 9727 Pacific Heights Blvd. San Diego, CA 92121 | Email: cs@biolegend.com Tumor Site
CXCR5: Head and Neck Cancer
US & Canada Toll-Free: 1.877.246.5343 (877-BIOLEGEND) | International: 1.858.768.5800

Chemokine Nomenclature
CXCL1: GRO1, GROα, MGSA, NAP3,
SCYB1, MGSA-α
CXCL2: CINC-2α, GRO2, GROβ,
GROB, MGSA-β, MIP2
CXCL3: GRO3, GRO-γ, MGSA-γ, CXCL7: NAP-2 CXCL12: SDF-1 CXCL17: DMC, VEGF Co-regulated CCL1: I-309, TCA-3, SCYA1 CCL6: C10, MRP1 CCL12: MCP-5 CCL17: TARC, ABCD 2 CCL22: MDC, ABCD 1 CCL27: CTACK, ESKine, ILC, Skinkine Th17: CCR4, 6 Cell Expression Dendritic Cells: CCR1, 2, 5, 6, 7; CXCR1, 2, 4 Eosinophils: CCR3, CXCR4
MIP-2β, SCYB3 CXCL8: IL-8 CXCL13: BCA-1, BLC Chemokine 1 CCL2: MCP-1, MCAF, JE CCL7: MCP-3, MARC CCL13: MCP-4 CCL18: DC-CKA1, PARC, MIP-4, AMAC-1 CCL23: MIP-3, CKb-8, MPIF-1 CCL28: MEC, CCK1 Th22: CCR4, 6, 10 Natural Killer Cells: CCR2, 4, 5, 8; Mast Cells: CCR1, 3, 4, 5; CXCR1-4
Hematopoietic Stem Cells: CXCR4
CXCL4: PF-4 CXCL9: CMK, MIG, SCYB9 CXCL14: BRAK, Bokeline CX3CL1: Fractalkine, Neurotactin CCL3: MIP-1α CCL8: MCP-2, HC14 CCL14: HCC-1, HCC-3, MCIF, NCC2 CCL19: ELC, MIP-3β, Exodus-3 CCL24: MPIF-2, Eotaxin-2, CKβ-6 Tfh: CXCR5 CXCR1, 3, 4; CX3CR1 Endothelial Cells: CCR1-4; CXCR1-4
T Helper Cell Expression Naïve T Cells: CCR7, CXCR4
CXCL5: ENA-78, LIX CXCL10: IP-10 CXCL15: LUNGKINE, SCYB15 XCL1: Lymphotactin, ATAC, SCM-1α CCL4: MIP-1β, ACT-2, H400 CCL9: CCL10, MRP-2, MIP-1γ, CCF18 CCL15: MIP-1δ, MIP 5, MRP-2B, NCC3, HCC-2 CCL20: LARC, MIP-3α, Exodus-1 CCL25: TECK, CKβ-15 Treg: CCR2, 4, 5, 6, 8-10; CXCR4-6 Neutrophils: CCR1; CXCR1, 2, 4 Epithelial Cells: CCR1-8; CXCR1, 4
Th1: CCR5, CXCR3 B Cells: CCR7, CXCR4, 5; CX3CR1
CXCL6: SCYB6, GCP 2, CKA-3 CXCL11: I-TAC CXCL16: SCYB16, SR-PSOX XCL2: SCM-1β CCL5: RANTES CCL11: Eotaxin, Eotaxin 1 CCL16: HCC-4, LEC, LCC-1 CCL21: SLC, 6Ckine, Exodus-2 CCL26: Eotaxin-3 Basophils: CCR1-4, CXCR4
Th2: CCR3, 4, 8; CXCR5 Macrophages: CCR1, 2, 5; CXCR1, 4