Hospital no DOB Age when started zoledronate/denosumab

41161480 3/10/1962 56
41446832 2/19/1940 77
41303734 8/17/1937 80
40488869 7/16/1944 74
40467527 5/19/1947 71
41068119 12/23/1947 70
40907939 6/27/1944 73
40999596 11/17/1962 55
40854975 6/8/1938 80
40931890 2/6/1932 86
40860746 3/10/1931 86
40457779 7/22/1944 74
40000045 12/3/1943 74
41025627 4/25/1942 76
41007187 3/11/1960 59
40747072 2/9/1960 59
40815863 11/4/1931 85
40866371 5/6/1945 74
40716973 7/28/1953 65
40630908 6/11/1944 75
40657054 4/24/1940 79
40523262 9/13/1942 77
40444348 12/5/1957 61
41061509 12/11/1939 80
40788170 2/13/1934 85
41182367 9/13/1947 72
40486747  3/16/1955 65
40688703 11/24/1958 61
40470263 11/5/1943 76
40311026 5/30/1962 58
40913876 3/17/1951 69
40699669 7/11/1941 77
40049061 4/27/1939 79
40498261 2/17/1937 82
41007169 1/28/1946 72
40628960 8/11/1946 71
41074216 3/22/1955 64
40146556 9/30/1950 68
40757492 1/15/1946 72
40490673 11/28/1936 81
40459411 6/16/1935 83
40703884 11/27/1950 68
40482245 7/30/1933 85
40826375 12/29/1959 59
40890294 2/25/1945 74
40487568 9/24/1947 71
41754401 10/1/1953 65
40124148 7/4/1957 59
40648546 21//11/49 67
40478547 12/30/1950 68
40657798 7/11/1930 88
40498709 7/27/1947 70
40905738 8/4/1942 76
40697336 6/18/1950 59
40714687 3/15/1953 65
40742760 1/11/1940 78
40787770 12/28/1967 50
40866401 11/9/1949 69
40978842 10/15/1939 78
41283740 6/22/1959 60
40504441 10/22/1951 67
40370145 11/10/1941 77
40692036 10/17/1964 53
40777561 3/1/1944 74
40821864 3/1/1942 76
40876540 8/25/1952 66
40917225 9/7/1935 83
40953385 12/17/1938 79
40316919 7/17/1934 82
40478818 6/1/1933 85
40519856 3/1/1930 88
40530078 1/14/1958 60
40679207 3/26/1932 86
40831436 11/18/1928 88
40867882 8/6/1945 73
40935322 11/4/1943 74
40970713 12/25/1945 72
40984826 4/3/1929 90
40968205 8/4/1945 74
40653941 10/30/1939 79
40857995 7/13/1933 85
40489150 6/8/1940 79
41059606 1/24/1958 61
40637572 5/16/1937 81
40874800 6/30/1943 75
40799456 11/6/1935 83
40085940 2/18/1961 58
40448247 1/26/1955 64
41263610 8/6/1942 77
40258218 7/12/1943 76
40533643 8/22/1938 81
40657481 1/22/1951 67
40515539 6/8/1947 72
40538685 2/11/1933 86
40654686 1/28/1929 89
40717829 9/29/1956 63
40852097 10/24/1949 70
40039744 8/31/1932 85
40707244 3/27/1953 66
40938246 3/21/1949 70
41696891 5/17/1959 60
41470610 1/1/1957 61
41255409 7/25/1933 85
40518830 10/25/1960 59
40760553 10/8/1956 62
40933654 1/14/1951 66
40807909 9/12/1942 76
40939779 1/29/1947 72
40995625 3/23/1946 72
40657539 8/9/1942 76
40081010 12/20/1946 71
41310000 10/25/1952 65
40916435 7/9/1938 81
40176741 7/9/1945 74
40686567 2/19/1933 86
40080444 1/8/1948 71
40202834 8/20/1941 78
41729710 2/27/1948 71
40458771 5/25/1939 80
40537818 1/20/1947 72
40972822 6/13/1942 72
40678607 8/12/1930 89
40406756 10/9/1947 72
40667986 4/22/1949 69
40365796 7/21/1951 68
40310162 2/9/1939 79
40178806 10/28/1964 55
40815133 2/21/1933 86
40665769 7/16/1946 72
40524014 6/15/1948 71
40699855 1/11/1947 73
40885805 1/21/1943 77
41437980 1/8/1959 59
40936485 4/26/1937 82
40668474 10/19/1952 67
41337660 10/7/1952 67
40635731 6/14/1938 81
40520135 11/20/1936 83
40629132 4/14/1937 83
40477851 6/2/1943 77
40901264 11/13/1937 79
40732742 6/29/1941 79
40693816 8/14/1939 79
40826375 12/29/1959 59
40541203 11/29/1935 RIP
40524730 7/19/1943 77
41710424 1/6/1940 80
40146980 8/3/1933 87
40468669 11/8/1950 70
40716527 3/14/1962 58
40756877 3/20/1957 62
40078124 9/26/1948 71
40117841 10/8/1940 68
40244375 10/30/1959 59
40069233 6/26/1959 59
41723551 6/26/1945 73
41224321 1/27/1972 46
40270641 10/11/1947 71
40043550 8/9/1960 58
41165304 5/25/1942 76
41078803 4/15/1958 61
40140579 7/6/1940 69
40267614 8/1/1947 72
40390768 9/17/1952 66
40146850 5/14/1939 79
40194752 7/4/1955 52
40066444 1/28/1937 80
40025492 11/25/1946 72
40054846 5/17/1943 75
40132099 2/6/1932 86
40178996 9/19/1931 88
40355845 4/26/1934 84
40359872 3/23/1957 62
40398867 9/6/1954 65
40413387 5/10/1943 75
40161499 7/7/1940 79
41372022 10/17/1939 79
40248430 6/19/1949 70
40016989 5/31/1932 77
40058259 3/30/1943 74
40064359 1/27/1956 62
40275328 11/11/1930 79
 40125793 4//1/1959 59
40226530 11/19/1957 62
40256684 1/22/1944 74
40400906 6/26/1936 82
40997181 2/1/1971 48
41004748 9/23/1934 85
41156712 10/23/1938 79
41304067 3/27/1936 80
40089609 4/6/1947 71
40124042 8/4/1952 66
40173836 11/16/1959 59
40259848 2/15/1933 82
40313048 3/13/1935 84
40533981 17/1//1942 77
41010975 1/1/1951 68
41535922 1/27/1940 79
40073814 4/4/1953 66
40045842 10/18/1938 89
40098494 7/11/1946 74
40070115 3/1/1931 88
40070063 9/14/1936 84
40101002 7/4/1946 74
40528424 8/13/1942 77
40235507 4/18/1944 74
41543112 3/17/1936 84
40219154 1/3/1942 77
40338320 3/7/1952 67
40184022 1/25/1939 79
40128636 9/9/1947
40001880 4/12/1942 78
40087156 2/23/1939 81
40681781 4/18/1936 79
40373168 1/31/1940
40300258 5/3/1937 82
40300258 5/3/1937
40128847 9/1/1938 75
40139804 11/12/1947
40906196 7/26/1933 85
40532389 10/16/1929 91
 41094733 1/13/1958 62
40908146 8/21/1927 93
40673544 1/26/1956 64
40711174 1/12/1933 87
40941263 3/28/1944 76
40481025 3/8/1927 91
40107999 4/8/1949 71
 40355051 8/7/1961
40047169 5/2/1938 80
40804648 2/13/1934 86
40021548 9/29/1961 59
40940481 6/11/1971 69
40192536
40012887
40200524
40204111
41181192 5/28/1955 64
41067022 12/1/1949 71
40156124 12/25/1934
41639545 10/24/1961
40483358 5/4/1943 76
40016929 5/1/1949
41569044 6/5/1968 52
41311282 12/29/1952 68
40532955 4/29/1937 83
40938537 7/21/1947 72
40670414 11/26/1958 62
40654252 12/3/1933 87
41015337 10/4/1951 69
40229866 11/6/1941 79
41084654 6/26/1961 59
40105662 1/21/1964 56
41004153 8/1/1937 83
40230400 10/1/1937
41008318 10/6/1956 64
40053422 3/24/1940
40679516 6/26/1952 68
40482225 1/19/1934 86
40781919 10/21/1934 86
41825765
40257747 3/27/1949
40742760 1/11/1940 78
40468374 2/23/1955 65
41565527 9/25/1948 69
40109128 10/4/1943 75
41460344 5/21/1935 83
41703079 10/16/1959 69
40281902 8/25/1941 77
40030669 9/17/1938 80
40222731 3/27/1951 67
40017705 12/28/1953 66
40077111 4/3/1944 74
41511998 2/16/1941 77
40001986 1/3/1943 75
40197652 3/4/1928 90
40080379​  2/4/1952 66
40222756 12/23/1946 77
40378219 10/31/1950 69
40423782 9/14/1955 63
40031516 9/19/1951 67
40037332 11/17/1938 81
41326965 1/11/1941 77
40329003 4/26/1952 67
40013371 7/17/1938 78
41299061 5/28/1951 69
40000050 6/26/1933 83
 Baseline bloods
Drug administed (zoledronate/denosumab) PTH Vit D Adjusted calcium Phosphate
Denosumab 8.8 2.39 1.06
Denosumab 7.5 2.44 1.17
Denosumab 2.9 2.43 1.13
Denosumab 5.1 2.42 1.24
Denosumab 6.2 2.43 1.08
Denosumab 4.7 2.49 1.09
Denosumab 10.3 2.29 1.37
Denosumab not done 2.41 1.01
Denosumab 8.8 2.42 1.12
Denosumab 4.3 2.5 1
Denosumab 4.5 2.31 1.33
Denosumab 6.1 2.27 0.97
Denosumab 9.5 2.37 1.38
Denosumab 3.1 2.53 1.25
Denosumab 4.9 2.34 1.45
Denosumab not done 2.36 1.3
Denosumab 5.8 2.39 1.24
Denosumab 12.4 56 2.46 0.75
Denosumab 4.6 2.56 1.22
Denosumab 3.9 2.44 1.11
Denosumab 7.5 2.5 0.81
Denosumab 9 2.42 1.38
Denosumab 1.7 2.14 haemolysed
Denosumab 6.3 2.53 0.95
Denosumab 9.9 2.36 0.89
Denosumab not done 2.31 1.26
Denosumab 4.2 2.29 1.09
Denosumab 6.8 2.38 0.91
Denosumab 6.2 2.39 1.09
Denosumab not done 2.38 haemolysed
Denosumab 4.8 2.4 1.3
Zoledronate 7.4 2.52 1.08
Zoledronate not done 2.55 1.22
Zoledronate 10.3 2.66 1.16
Zoledronate 7 2.34 1.11
Zoledronate 4.5 2.38 1.24
Zoledronate 14.5 47 2.43 1.09
Zoledronate 7.1 2.38 1.15
Zoledronate 4.2 2.35 1.23
Zoledronate 2.6 2.38 1.06
Zoledronate 29.4 2.57 1
Zoledronate 12.3 2.35 1.09
Zoledronate not done 2.37 1.11
Zoledronate not done 2.35 1
Zoledronate 4.6 2.41 1.17
Zoledronate 2.6 2.43 0.96
Zoledronate 5.4 2.32 1.01
Zoledronate 10.2 2.35 1.21
Zoledronate 6.4 2.39 1.31
Zoledronate 4.5 2.5 1.18
Zoledronate 6 2.41 0.77
Zoledronate 7 2.37 1.2
Zoledronate not done 2.4 1.14
Zoledronate not done 2.34 1.13
Zoledronate 11.7 2.4 1.1
Zoledronate 5.8 2.32 1.17
Zoledronate 3.7 2.35 1.18
Zoledronate 5 2.42 1.39
Zoledronate 4.8 2.36 1.21
Zoledronate 10.2 2.41 1.2
Zoledronate 5.4 2.57 1.33
Zoledronate 3.9 2.31 1.62
Zoledronate 6.1 2.46 0.85
Zoledronate 2.9 2.45 1.1
Zoledronate 6.2 2.38 1.06
Zoledronate not done 2.3 1.02
Zoledronate 4.3 2.38 0.9
Zoledronate 5.1 2.46 1.06
Zoledronate 6.6 2.32 1.11
Zoledronate 6.2 2.29 1.17
Zoledronate 2.5 2.56 1.16
Zoledronate 5.8 2.42 1.26
Zoledronate 11.9 2.63 0.92
Zoledronate not done 2.4 1.04
Zoledronate not done 2.4 1.27
Zoledronate not done 2.39 0.75
Zoledronate not done 2.55 1.04
Zoledronate not done 2.49 1.02
Zoledronate 4.2 2.59 1.32
Zoledronate not done 2.48 1
Zoledronate 6.1 2.38 1.33
Zoledronate 3.5 2.32 1.09
Zoledronate not done 2.38 1.37
Zoledronate 11.7 2.37 1.17
Zoledronate 5.1 2.44 1.22
Zoledronate 4.7 2.52 1.42
Zoledronate 5.2 2.48 1.1
Zoledronate 5.1 2.48 0.95
Zoledronate 3.5 2.36 1.1
Zoledronate 11.2 2.53 1.08
Zoledronate 12.8 2.46 1.04
Zoledronate 8.8 2.41 1.22
Zoledronate 3.5 2.54 1.46
Zoledronate 6.9 2.31 1.09
Zoledronate 10.8 2.49 0.93
Zoledronate 3.8 2.43 1.37
Zoledronate 8.6 2.33 1.16
Zoledronate 3.9 2.39 1.2
Zoledronate 4.9 2.4 1.26
Zoledronate 4.6 2.43 1.12
Zoledronate 8.7 2.4 1.4
Zoledronate 14.3 51 2.42 1.02
Zoledronate 11.8 2.35 1.3
Zoledronate 6.5 2.22 1.09
Zoledronate 10.6 2.48 1.3
Zoledronate not done 2.42 1.09
Zoledronate 4 2.65 1.05
Zoledronate 6.4 2.46 1.13
Zoledronate 5.6 2.43 1.34
Zoledronate 5.3 2.38 1.03
Zoledronate 5.4 2.41 1.2
Zoledronate 4 2.46 1.38
Zoledronate not done 2.4 1.29
Zoledronate 4.9 2.41 1.39
Zoledronate not done 2.35 1.3
Zoledronate 5.1 2.37 1.31
Zoledronate 4.8 2.32 1.1
Zoledronate not done 2.15 1.2
Zoledronate 8.4 2.33 1.31
Zoledronate 4.2 2.39 1.15
Zoledronate not done 2.22 1.51
Zoledronate 9.5 2.43 1.26
Zoledronate 10.6 2.41 1.39
Zoledronate 7.4 2.4 1.16
Zoledronate 6.5 2.39 1.05
Zoledronate 3.5 2.34 1.06
Zoledronate not done 2.36 1.2
Zoledronate nor done 2.27 1.18
Zoledronate 7.3 2.6 1.04
Zoledronate 6.9 2.53 1.3
Zoledronate 6.1 2.32 1.29
Zoledronate 5.5 2.37 1.21
Zoledronate 4.3 2.36 1.23
Zoledronate not done 2.27 1.16
Zoledronate 4.1 2.48 1.2
Zoledronate 13.9 2.39 1.19
Zoledronate 7.7 2.37 1.11
Zoledronate 2.6 2.6 1.24
Zoledronate 13.1 2.33 1.07
Zoledronate 10.7 2.41 1.23
Zoledronate 6.1 2.31 1.42
Zoledronate 6.7 2.29 1.35
Zoledronate 3.6 2.49 1.06
Zoledronate not done 2.35 1
Zoledronate
Zoledronate 4.3 2.3 1.17
Zoledronate 9 2.22 1.41
Zoledronate 13 2.51 1.06
Zoledronate 5.8 2.25 1.06
Zoledronate 2.37 1.27
Zoledronate 3.1 2.43 0.89
Zoledronate 6 2.52 1.12
Zoledronate 7.3 2.46 1.23
Zoledronate 6.3 2.44 1.49
Zoledronate 3.7 2.34 0.78
Zoledronate
Zoledronate 4.8 2.44 1.18
Zoledronate 5.9 2.38 1.19
Zoledronate 4.7 2.43 0.9
Zoledronate 4 2.52 1.25
Zoledronate 7 2.49 1.15
Zoledronate 1.8 2.6 1.14
Zoledronate 3.3 2.54 1.19
Zoledronate 6.1
Zoledronate
Zoledronate 2.47 1.17
Zoledronate 2.44 1.23
Zoledronate 2.5 1.01
Zoledronate 10.4 2.46 1.06
Zoledronate 2.46 0.93
Zoledronate 2.47 1.18
Zoledronate 7.7 2.36 0.66
Zoledronate 7.4 2.56 1.02
Zoledronate 6.7 2.44 0.98
Zoledronate 11.1 2.14 0.89
Zoledronate 6.9 2.51 1.2
Zoledronate 10.9 2.65 1.03
Zoledronate 2.2 2.48 1.3
Zoledronate 4.7 2.56 1.09
Zoledronate 2.45 1.02
Zoledronate 2.44 1.1
Zoledronate 2.36 1.07
Zoledronate 7.3 2.62 1.06
Zoledronate 6.4 2.54 1.09
Zoledronate 3.9 2.46 0.98
Zoledronate 14.6 55 2.56 1.08
Zoledronate 2.8 2.44 0.83
Zoledronate 2.28 1.03
Zoledronate 12 2.52 0.96
Zoledronate 8.1 2.33 1.43
Zoledronate 4.4 2.28 1.34
Zoledronate 2.46 1.22
Zoledronate 2.21
Zoledronate 13 2.46 1.17
Zoledronate 2.39 1.11
Zoledronate 4.5 2.47 1.16
Zoledronate 14.6 66 2.76 0.94
Zoledronate 10.5 2.53 0.89
Zoledronate 2.42 1.21
Zoledronate 9.9 2.6 0.96
Zoledronate 4.6 2.43 1.19
Zoledronate 17.2 2.39 1.21
Zoledronate 9.5 2.5 0.86
Zoledronate 2.43 1.22
Zoledronate 2.41 1.21
Zoledronate 15 2.69 0.8
Zoledronate 7.9 2.24 1.23
Zoledronate 3.3 2.2 1.07
Zoledronate 4.6 2.46 1.17
Zoledronate 6.2 2.45 1.16
Zoledronate
Zoledronate 7.7 2.57 1.19
Zoledronate 4.8 2.65 1.11
Zoledronate 7.5 2.34 1.02
Zoledronate
Zoledronate
Zoledronate
Zoledronate 8.5 2.41 0.94
Zoledronate
Zoledronate
Zoledronate 2.3 0.95
Zoledronate 6.8 2.28 1.26
Zoledronate 5.2 2.34 1.14
Zoledronate 9.4 2.46 1.2
Zoledronate 7.1 2.27 1.23
Zoledronate 6 2.42 1.06
Zoledronate 11.3 2.47 0.91
Zoledronate 2.43 1.3
Zoledronate
Zoledronate 4.9 2.36 1.26
Zoledronate 2.32 1.07
Zoledronate
Zoledronate 5.1 2.37 1.24
Zoledronate
Zoledronate
Zoledronate
Zoledronate
Zoledronate 7.5 2.46 1.19
Zoledronate 17.9 2.36 1.08
Zoledronate
Zoledronate
Zoledronate
Zoledronate
Zoledronate 2.38 1.13
Zoledronate 8.8 2.54 1.16
Zoledronate 4.9 2.49 1.05
Zoledronate
Zoledronate 5.9 2.29 1.27
Zoledronate 2.24 1.41
Zoledronate 5.7 2.22 1.15
Zoledronate 13.1 2.56 0.94
Zoledronate 11.1 2.28 1.21
Zoledronate 7 2.27 53
Zoledronate 4.3 2.39 1.22
Zoledronate
Zoledronate 6.7 2.31 1.15
Zoledronate
Zoledronate 4.2 2.33 1.27
Zoledronate 4.7 2.39 1.05
Zoledronate
Zoledronate
Zoledronate
Zoledronate 5.8 2.32 1.17
Zoledronate 6.6 2.36 0.71
Zoledronate 8.3 2.35 1.58
Denosumab 10.3 2.39 1.2
Denosumab 6.6 2.61 1.05
Denosumab 5 2.27 0.89
Denosumab 8.8 2.3 1.07
Denosumab 8.2 2.52 1.21
Denosumab 6.3 2.37 0.96
Denosumab 2.37 0.98
Denosumab 3.2 2.49 1.16
Denosumab 7.5 2.29 0.79
Denosumab 2.34 1.11
Denosumab 7.9 2.5 1.94
Denosumab 2.33 1.09
Denosumab 8.6 2.46 1.22
Denosumab 5.3 2.67 1.3
Denosumab
Denosumab 2.5 2.55 1.31
Denosumab 2.34 1.31
Denosumab 7.3 2.35 1.14
Denosumab 4.5 2.37 1.28
Denosumab 2.46 1.19
Denosumab 7.2 1.12 1.33
Denosumab 2.8 2.46 1.31

Min Ca 1.12
Max Ca 2.76
Baseline bloods
Alkaline phosphatase Creatinine eGFR Date of first treatment Date of bloods
70 57 >90 6/27/2018 11/28/2018
87 65 79 1/31/2018 5/1/2018
80 82 58 8/15/2018 1/22/2019
59 41 >90 8/29/2018 3/13/2019
72 72 73 10/10/2018 4/3/2019
99 57 >90 5/16/2018 10/22/2018
136 87 76 2/13/2018 7/16/2018
54 65 >90 8/29/2018 3/5/2019
76 62 82 6/27/2018 10/18/2018
88 68 71 9/19/2018 2/26/2019
52 56 81 8/29/2018 3/27/2019
59 47 >90 8/29/2018 6/28/2019
92 55 89 10/31/2018 3/12/2019
57 97 49 11/7/2018 4/8/2019
69 75 >90 1/2/2019 6/17/2019
62 62 >90 2/20/2019 6/20/2019
65 78 60 7/12/2017 12/22/2017
137 153 29 5/15/2019 10/23/2019
71 60 >90 5/22/2019 10/18/2019
70 54 89 9/10/2019 1/13/2020
69 135 32 10/7/2019 2/11/2020
81 90 53 10/30/2019 5/4/2020
91 62 >90 11/7/2019 1/31/2020
61 42 >90 12/12/2019 5/29/2020
57 83 55 1/16/2020 7/6/2020
48 47 >90 3/19/2020 8/27/2020
93 43 >90 4/23/2020 8/11/2020
65 56 >90 Brompton (bloods from Oc 8/28/2020
153 71 71 10/13/2020
92 84 66 12/15/2020
56 69 78 11/6/2020
95 53 89 9/28/2018 8/1/2019
129 68 74 5/3/2018 5/21/2019
94 49 87 7/10/2019 11/6/2020
44 60 88 6/6/2018 5/21/2019
71 67 79 7/25/2018 5/15/2019
55 56 >90 6/5/2019 5/22/2020
85 59 >90 7/10/2019 7/7/2020
88 73 71 10/3/2018 7/23/2019
122 74 65 11/16/2018 11/22/2019
130 98 46 12/6/2018 7/1/2019
94 51 >90 2/7/2019
120 41 >90 4/3/2019 7/3/2019
97 50 >90 3/13/2019 3/17/2020
118 70 74 5/2/2019 3/9/2020
102 66 >90 5/2/2019 10/20/2020
43 65 86 5/15/2019 3/17/2020
71 67 86 9/29/2016 7/20/2017
92 61 >90 2/24/2017 12/13/2017
65 50 >90 7/12/2019 6/30/2020
100 71 66 11/22/2018 9/9/2019
83 58 90 1/11/2018 1/2/2019
50 87 56 9/12/2018 8/9/2019
45 54 >90 8/9/2019 8/20/2020
133 54 >90 2/20/2019 1/17/2020
81 62 83 4/13/2018 4/3/2019
38 49 >90 1/1/2018 7/3/2019
66 72 74 2/22/2019 1/7/2020
82 62 83 5/3/2018 5/16/2019
61 78 72 12/18/2019 12/31/2020
174 112 44 7/26/2019 10/12/2020
77 55 87 4/18/2019 6/12/2019
211 50 >90 1/26/2018 1/23/2019
83 56 88 1/16/2019 10/10/2019
80 67 76 1/10/2019 11/27/2019
84 64 87 2/15/2019 12/11/2019
57 50 87 10/10/2018 8/12/2019
106 54 86 3/15/2018 12/3/2018
61 61 81 7/12/2017 5/9/2018
85 62 79 2/15/2019 1/21/2020
68 52 82 2/7/2019 9/23/2019
49 79 70 1/11/2019 1/28/2020
210 121 35 10/19/2018 2/14/2019
137 63 76 9/15/2017 4/17/2018
108 79 64 6/13/2019 12/15/2020
162 64 >90 7/20/2018 8/20/2019
64 90 55 22/11/2018 - no record of pt having infusion on sys
80 69 67 6/21/2019 7/1/2019
376 79 85 9/4/2019 12/2/2020
107 71 70 9/5/2019 11/16/2020
60 61 79 10/3/2018 7/24/2019
91 51 88 11/21/2019 1/31/2020
70 66 87 7/25/2019 6/16/2020
46 78 61 9/12/2018 8/6/2019
75 50 >90 11/15/2018 8/20/2019
55 67 73 9/27/2019 10/14/2020
80 59 >90 8/14/2019 10/9/2020
64 67 83 9/27/2019 9/23/2020
97 148 39 9/26/2019 11/21/2019
65 48 >90 10/24/2019 3/3/2020
 54 80 60 10/9/2019 1/9/2020
67 53 >90 11/15/2018 9/4/2019
71 65 >90 10/3/2019 9/14/2020
43 57 81 11/14/2019 10/2/2020
62 59 78 11/23/2018 10/11/2019
125 49 >90 11/1/2019 10/19/2020
58 81 64 11/6/2019 10/2/2020
119 50 85 7/27/2018 10/1/2019
97 80 66 11/15/2019 12/10/2020
80 64 85 11/8/2019
82 68 84 7/26/2019 11/8/2019
109 78 71 9/27/2018 12/18/2018
63 123 34 4/11/2019 12/6/2019
105 87 63 12/12/2019 12/16/2020
87 59 >90 3/14/2019 2/7/2020
72 73 74 3/9/2017 2/5/2019
102 58 86 6/26/2019 12/9/2020
79 58 88 5/16/2019 10/5/2020
55 71 73 5/28/2019 9/11/2020
53 63 82 11/16/2018 10/25/2019
135 74 70 7/11/2018 5/21/2019
75 46 >90 5/3/2018 3/26/2019
87 81 59 11/14/2019 10/19/2020
95 74 69 11/15/2019 9/29/2020
42 73 64 11/20/2019 11/26/2020
55 51 >90 11/21/2019 10/19/2020
75 60 84 11/21/2019 11/17/2020
62 48 >90 12/11/2019 11/12/2020
93 59 83 12/12/2019 2/10/2020
88 74 70 12/4/2019 11/23/2020
34 75 66 12/13/2019 1/25/2021
77 93 47 2/26/2020 4/20/2020
65 88 57 10/2/2020 10/29/2020
66 55 >90 11/15/2018 9/24/2019
83 84 62 12/19/2019
83 97 64 12/20/2018 12/2/2019
63 78 74 1/22/2020 1/4/2021
70 110 39 1/16/2020 1/21/2020
126 48 >90 1/30/2019 11/6/2019
134 57 90 1/31/2020 9/21/2020
73 53 >90 1/23/2020
148 58 86 1/30/2020 12/15/2020
75 76 74 11/9/2018 1/9/2020
79 78 61 2/26/2020 12/30/2020
78 74 72 2/26/2020 2/18/2021
131 100 50 2/24/2020 2/26/2020
 57 47 90 3/13/2020 7/2/2020
75 67 73 2/27/2020 4/2/2020
58 80 59 10/2/2020
89 81 60 10/16/2020
69 71 70 3/31/2017 11/2/2017
91 60 83 10/2/2020
94 54 86 7/31/2019 8/30/2019
97 50 >90 3/13/2019 3/17/2020

71 50 90 9/3/2020
43 65 77 9/11/2020
102 91 49 9/3/2020
70 63 87 10/9/2020
92 48 >90 9/25/2020
58 58 >90 10/17/2019 2/4/2021
137 101 49 11/27/2019 1/3/2001
41 41 >90 8/31/2018 9/28/2018
60 55 >90 9/13/2018 1/27/2020
107 49 >90 11/15/2018 12/18/2018
10/15/2018 11/11/2018
85 54 >90 10/22/2018 7/3/2019
78 76 68 9/17/2018 8/12/2019
70 73 79 9/28/2018 9/25/2019
78 94 51 9/14/2018 8/15/2019
118 54 >90 3/28/2019 3/13/2020
93 72 69 1/23/2019 31/11/20
83 70 75 7/15/2019 10/3/2019
61 50 >90 3/28/2018 11/12/2018
60 76 65 8/8/2018 12/5/2018
79 54 >90 5/4/2017 4/12/2018
78 12/7/2017 10/30/2018
73 56 >90 2/26/2018 2/26/2019
54 75 68 5/14/2019 12/11/2019
110 60 79 11/28/2018 9/17/2019
68 67 71 2/14/2019 9/3/2020
78 87 53 12/18/2018 8/5/2019
121 54 >90 8/15/2019 9/18/2020
60 64 88 2/5/2019 9/24/2019
115 50 >90 1/11/2018 10/22/2018
116 51 88 9/13/2019 9/9/2020
87 49 89 2/4/2019 10/10/2019
70 43 >90 10/7/2019 10/13/2020
68 76 61 1/29/2019 7/29/2019
47 53 90 10/27/2017 4/10/2018
99 75 74 11/26/2018 3/25/2019
77 71 65 9/11/2019 10/1/2020
 61 73 78 12/14/2018 10/24/2019
65 74 76 3/1/2019 11/29/2019
94 66 80 5/31/2018 7/24/2019
129 52 86 7/20/2018 6/4/2019
75 58 >90 4/12/2019 8/17/2020
57 72 81 4/2/2019 9/14/2020
98 114 40 3/15/2018 2/26/2019
67 71 69 12/5/2016 6/13/2017
26 56 >90 5/31/2018 11/20/2018
135 55 >90 4/13/2018 2/1/2019
285 72 80 6/14/2018 4/17/2019
69 92 50 12/3/2015 6/27/2016
75 43 >90 5/16/2019 9/16/2020
91 70 73 4/18/2019 10/10/2020
105 58 >90 4/12/2019 5/13/2020
65 74 67 3/26/2019 3/5/2020
52 63 81 10/11/2019 11/10/2020
164 73 68 12/7/2017 5/29/2018
70 76 74 2/3/2020 4/16/2020
137 56 80 12/12/2019 9/4/2020
90 64 77 2/3/2020 3/10/2020
88 51 >90 2/5/2020
78 45 >90 7/29/2019 1/5/2021
105 46 >90 10/8/2018 9/3/2019
65 68 72 3/11/2020 12/3/2020
80 77 64 11/28/2019 11/10/2020
72 57 >90 7/12/2019 10/14/2020
65 72 69 11/2/2018 1/23/2020

59 72 69 9/18/2020
84 81 59 9/3/2020
87 62 82 1/7/2016 9/7/2017

11/3/2015

119 73 >60 3/20/2014 3/18/2015

6/28/2019 2/8/2020
81 72 64 6/17/2020 9/2/2020
89 68 83 7/16/2020
227 81 72 9/3/2020
68 63 90 9/11/2020
59 62 78 8/21/2020
76 56 88 9/25/2020 12/17/2019
45 74 61 3/7/2019 3/26/2019
94 66 81 9/11/2020
 87 58 84 12/5/2018 12/10/2020
153 75 63 5/19/2020 11/11/2020
? May 2020 8/4/2020
60 67 87 10/2/2020 16/1//20

Needs OPD

63 74 74 2/28/2019 9/8/2020
128 57 >90 9/17/2020 2/2/2021

5/9/2019 1/7/2020

209 67 >90 9/11/2020 12/10/2020

111 79 67 9/25/2020 2/3/2021
73 62 81 9/11/2020 8/25/2020
2/15/2019 1/15/2020
73 58 >90 9/25/2020
105 44 88 10/2/2020
53 73 73 10/15/2020
86 58 85 10/15/2020
105 65 >90 10/8/2020 8/14/2020
46 >90 10/16/2020 2/1/2021
188 79 60 11/4/2020

97 52 >90 10/28/2020

87 54 >90 10/28/2020
62 58 80 10/22/2020
6/12/2020 9/2/2020

81 62 83 4/13/2018 2/20/2019
76 59 >90 10/28/2020 10/14/2020
100 79 66 2/7/2017 1/12/2018
45 64 82 11/23/2018 4/8/2019
78 109 90 9/17/2018 1/25/2019
55 87 84 11/16/2018 2/12/2019
107 50 >90 5/14/2018 11/9/2018
89 122 36 6/18/2018 8/21/2018
59 68 80 8/1/2018 11/25/2018
62 66 85 8/22/2018 2/21/2018
446 76 67 11/23/2018 5/2/2019
50 55 87 11/21/2018 6/11/2019
 51 51 >90 11/22/2018 4/12/2019
81 112 37 8/26/2018 1/14/2019
122 45 >90 11/16/2018 4/23/2019
72 12/19/2018 6/4/2019
70 57 >90 4/15/2019
12/11/2018 5/7/2019
64 90 57 6/17/2019 1/20/2020
55 3/5/2020 9/2/2020
59 55 87 6/11/2018 6/20/2018
50 70 77 9/3/2019 1/21/2020
59 58 85 7/13/2016 12/22/2016
95 55 >90 11/3/2020
50 68 72 GP 7/18/2017
 Bloods after treatment #1
PTH Vit D Adjusted calcium Phosphate Alkaline phosphatase Creatinine eGFR
4.5 2.49 1.03 49 52 >990
not done 2.39 1.31 56 65 78
2.8 2.58 1.08 101 75 64
5.3 2.55 1.23 69 40 >90
not done 2.4 1.09 75 66 81
7.8 2.39 1.01 53 52 >90
8.2 2.27 1.41 87 85 77
5.3 2.36 0.96 63 76 76
not done 2.51 1.22 61 73 67
3.4 2.38 1.15 61 63 76
5.3 2.24 1.17 58 54 81
6 2.35 1.03 44 47 >90
5.1 2.37 1.23 66 70 73
not done 2.52 1.27 46 107 43
4.9 2.33 1.39 45 65 >90
4.2 2.55 1.48 47 61 >90
not done 2.5 1.15 59 75 62
16.8 31 2.35 0.84 111 139 32
3.8 2.47 1.09 73 62 >90
4.7 2.37 1 83 58 87
not done 2.45 1.17 50 126 35
6.4 2.49 1.4 60 79 62
not done 2.27 1.37 117 68 >90
5 2.39 1.35 52 53 86
5.8 2.39 1.51 60 79 58
6.2 2.23 1.29 49 50 >90
not done 2.2 1.05 89 44 >90
9.3 2.29 1.12 56 64 90
none on system none on system none on systnone on system none on sys none on system
none on system none on system none on systnone on system none on sys none on system
none on system none on system none on systnone on system none on sys none on system
not done 2.57 1.24 71 60 84
not done 2.52 1 93 73 67
8.2 2.4 1.19 59 39 >90
3 2.52 1.46 37 74 69
4 2.53 1.43 66 70 75
11.6 2.25 1.14 56 56 >90
7.1 2.34 1.32 71 66 82
5.8 2.46 1.12 101 75 68
7.3 2.34 1.16 147 73 66
17.1 85 2.66 0.97 96 85 55
none on system none on system none on systnone on system none on sys none on sy
not done 2.39 1.33 102 54 83
2.4 2.28 1.01 110 51 >90
 5.7 2.25 1.13 102 77 65
not done 2.13 1.1 87 58 >90
4.2 2.39 1.22 46 67 82
not done 2.42 1.31 59 65 89
4.2 2.52 1.08 73 62 89
4.7 2.19 1.12 41 48 >90
5.2 2.28 1.05 76 68 69
not done 2.37 1.07 54 71 74
not done 2.36 1.1 44 68 75
8.8 2.32 1.37 46 58 90
13.9 2.48 1.05 143 51 >90
5.4 2.34 1.11 73 72 69
not done 2.21 0.79 30 36 >90
not done 2.29 1.26 45 81 63
7 2.22 1.03 54 62 82
21.4 30 2.17 1.33 48 79 70
6.7 2.44 1.18 138 109 45
not done 2.23 1.33 74 60 84
9.8 2.28 1.25 128 54 >90
2.6 2.59 1.5 87 73 69
5.6 2.45 1.17 65 65 79
not done 2.27 1.16 76 67 81
4.7 2.46 1.05 49 48 87
5.5 2.45 0.99 87 55 86
9.2 2.32 1.03 58 51 85
5.5 2.36 1.12 88 63 77
1.3 2.49 0.93 77 51 82
6.6 2.36 0.96 55 90 59
19.9 2.59 0.97 135 126 33
not done 2.61 1.05 84 76 60
8.1 2.12 1.03 76 80 62
not done 2.44 1 107 73 86
none on system none on system none on systnone on system none on sys none on sy
not done 2.3 0.7 116 55 79
2.7 2.4 1.32 440 67 89
7.8 2.41 1.21 127 70 70
6.3 2.44 1.46 58 72 65
not done 2.26 1.15 89 41 >90
5.3 2.23 1.12 57 69 81
7.6 2.5 1.27 58 86 54
6 2.4 1.34 76 45 >90
2.8 2.26 1.17 33 71 67
5.6 2.28 1.14 66 64 >990
4 2.3 1.08 74 62 >90
5.2 2.3 0.92 101 127 47
8.3 2.47 1.08 60 46 >90
not done 2.47 1.22 35 88 53
7.7 2.36 1.31 46 60 90
3 2.32 1.38 62 67 >90
3 2.22 1.21 48 60 79
9.4 2.38 1 54 60 77
6.4 2.38 1.26 186 43 >90
6.6 2.35 1.24 66 78 66
3.4 2.4 1.02 123 47 85
6.1 2.28 1.25 66 90 57
none on system none on system none on systnone on system none on sys none on sy
not done 2.29 1.41 69 69 83
16.3 45 2.42 1.01 102 88 61
not done 2.38 1.26 65 122 35
8.5 2.22 1.11 68 86 63
10.7 2.35 1.04 55 55 >90
9.3 2.4 1.05 74 68 79
10.5 2.47 1.16 87 81 60
6 2.23 1.1 52 61 86
7.2 2.24 1.19 46 66 79
4.8 2.29 1.2 40 64 80
6..6 2.56 1.17 134 89 56
4.8 2.43 1 59 61 >90
not done 2.16 1.1 57 77 62
not done 2.36 1.31 67 77 65
not done 2.23 1.44 32 65 73
5.7 2.3 1.25 45 48 >90
5 2.35 1.14 59 60 83
not done 2.36 1.22 51 56 89
not done 2.33 1.34 79 56 85
4.6 2.28 1.28 64 72 72
4.1 2.27 1.6 40 81 60
not done 2.23 1.27 64 90 49
not done 2.5 1.26 67 86 58
9.7 2.33 0.96 49 61 88
none on system none on system none on systnone on system none on sys none on sy
2.2 2.33 1.43 68 93 67
not done 2.22 1.16 55 80 71
not done 2.19 0.98 65 99 44
6.2 2.62 1.01 77 51 >90
not done 2.23 1.23 134 53 >90
none on system none on system none on systnone on system none on sys none on sy
5.1 2.25 1.23 130 61 84
4.5 2.35 1.31 71 73 77
not done 2.34 1.19 79 79 60
5.9 2.25 1.12 78 75 71
27.4 65 2.31 0.91 133 84 62
not done 2.2 1.28 62 41 >90
not done 2.32 1.26 68 66 74
none on system none on system none on systnone on system none on sys none on system
none on system none on system none on systnone on system none on sys none on sy
not done 2.37 1.3 68 66 76
none on system none on system none on systnone on system none on sys none on system
12.1 2.39 1.15 96 46 >90
2.4 2.28 1.01 110 51 >90

4.8 2.28 1.21 62 57 >90

2.28 1.01 78 85 59
2.42 1.13 47 42 >90
5 2.51 1.29 46 49 >90
2.31 0.5 108 51 >90
9.1 2.49 1.23 113 57 88
2.29 1.02 78 50 >90
2.36 1.34 59 91 55
2.48 1.04 72 72 79
3.39 2.69 1.27 55 93 51
9.5 2.4 1.17 88 52 >90
3.2 2.49 1.1 80 73 68
62 55 90
2.3 1.04 46 52 >90
7.9 2.46 1.13 48 72 69
3.2 2.52 1.18 56 55 >90
6.6 2.38 1.16 66 76 63
2.3 1.15 73 58 88
8.6 2.27 1.06 32 90 54
109 51 83
8.7 2.24 1.2 52 63 76
5.7 2.57 0.97 77 113 38
2.39 1.29 79 53 >90
2.46 67 59 >90
15.9 2.39 1.15 141 74 68
9.2 2.27 1.16 97 51 87
2.67 0.93 73 43 >90
2.27 1.27 41 44 >90
2.49 1.2 78 68 70
2.35 1.16 38 52 90
2.38 1.12 58 72 >90
2.26 0.99 68 68 69
 8.3 2.46 1.12 41 69 83
2.49 0.96 44 69 81
2.48 0.89 76 84 59
2.72 0.91 70 61 81
64 >90
5.1 2.32 1.09 75 75 80
7.3 2.6 0.97 51 123 36
2.36 1.59 62 77 62
4.1 2.38 1.34 17 54 >90
6 2.69 1.25 54 73 74
4.4 2.35 0.8 68 78 72
85 55
44 88
8.2 2.19 1.18 82 77 64
14.9 51 2.64 0.91 89 56 >90
12.5 2.5 1.11 68 85 56
2.07 1.19 48 61 >90
10.8 2.59 0.7 115 63 81
2.4 0.96 60 70 74
2.27 0.63 416 37 >90
2.46 1.21 84 63 78

6.5 2.32 1.29 44 53 87

15 2.55 0.94 102 46 >90
3.7 2.24 1.29 78 54 83
5.6 2.03 1.02 55 62 83
2.2 1.02 55 59 >90
14.7 2.41 1.06 75 70 71

2.23 0.95 56 57 83

9 2.35 1.04 81 71 >60

18.1 2.27 1.18 135 96 61

2.39 0.66 78 83 54

10.6 2.34 1.11 89 57 87

16.7 82 54
 4.1 2.24 1.09 57 57 83
73 65
5 2.39 1.37 189 60 >90
2.46 1.1 57 63 >90

6.1 2.37 1.28 54 60 >90

2.28 0.86 83 65 82

6 2.34 1.13 13 63 82

2.33 1.37 86 65 >90

2.2 1.17 93 69 78
4.8 2.44 1.22 72 59 81
4 2.36 1.15 61 63 85

2.3 1.25 102 62 >90

2.21 1.24 43

2.15 1.01 96 88 52

5.4 2.34 1.11 73 72 69

5.8 2.42 1 59 62 >90
6.8 2.35 1.41 57 77 68
10.8 2.44 1.09 46 70 75
5.1 2.67 1.22 76 94 48
2.22 1.18 51 87 84
2.35 1.18 78 48 >90
6.3 2.53 1.13 84 129 34
2.48 1.3 6.2 67 81
2.37 0.98 62 66 85
3.2 2.58 1.55 450 95 50
6.9 2.35 1.01 42 58 85
 6.6 2.38 1.46 47 67 79
5.4 2.56 1.12 62 116 36
6.9 2.3 1.3 103 50 >90
10.3 2.49 1.03 58 54 90

10.3 2.36 1.01 41 55 >90

4.9 2.43 1.08 48 88 58
6.1 2.27 1.36 54 83 57
2.36 1.1 59 60 84
5.3 2.33 1.15 58 63 88
3.7 2.38 1.12 37 62 83

2.47 1.17 36 51 85

Min Ca 2.03
Max Ca 2.72
 Bloods after treatme
Date of second treatment Date of bloods PTH Vit D Adjusted calcium
1/2/2019 6/4/2019 12.2 2.44
7/3/2018 12/24/2018 6.2 2.54
2/13/2019 7/30/2019 3.7 2.44
4/10/2019 8/6/2019 4.6 2.53
4/10/2019 10/22/2019 4.5 2.42
11/7/2018 4/1/2019 8.8 2.36
7/19/2018 1/31/2019 6.5 2.42
4/10/2019 8/7/2019 not done 2.19
12/19/2018 5/23/2019 8.8 2.55
4/10/2019 8/22/2019 4.7 2.35

7/31/2019 1/8/2020 4.5 2.47

4/29/2019 10/14/2019 12.3 2.46
5/29/2019 10/15/2019 4.7 2.34
7/31/2019 12/11/2019 6.3 2.15
1/2/2020 6/16/2020 not done 2.31
1/3/2018 6/25/2018 7.9 2.26
4/30/2020 10/28/2020 12.4 47 2.38
11/14/2019 4/21/2020 not done 2.41
2/20/2020 7/20/2020 not done 2.39
6/10/2020 10/13/2020 not done 2.43
5/11/2020 11/16/2020 7.8 2.3
4/22/2020 10/9/2020 not done 2.22
6/12/2020 11/30/2020 4.6 2.54
7/10/2020 1/11/2021 7.2 2.34
9/9/2020 1/27/2021 not done 2.24
10/27/2020 none on system none on system
9/11/2020 none on system none on system
none on system
none on system
none on system
9/19/2019 8/26/2020 not done 2.36
6/10/2019 2/24/2020 15.2 70 2.44
11/19/2020 none on system none on system
7/5/2019 10/23/2020 not done 2.32
6/27/2019 none on system none on system
10/22/2020 none on system none on system
9/3/2020 none on system none on system
9/11/2019 none on system none on system
10/8/2020 none on system none on system
2/5/2020 none on system none on system
stopped after first dose - atypical fem #
8/21/2020 none on system none on system
9/25/2020 11/20/2020 not done 2.21
COVID-19 Delay
LOW CA
9/3/2020 none on system none on system
2/9/2018 11/20/2018 11.3 2.45
3/9/2018 2/4/2019 6.1 2.43
7/10/2020 none on system none on system
on hold
3/27/2019 8/27/2020 11.9 2.34
9/20/2019 12/3/2020 4.4 2.17
9/11/2020 none on system none on system
11/6/2020 none on system none on system
6/12/2019 7/4/2019 none on system 2.24
8/7/2019 none on system none on system
2/26/2020 none on system none on system
6/14/2019 12/27/2019 not done 2.24

LOW VIT D

2/20/2019 9/9/2019 not done 2.38

1/23/2020 12/4/2020 8.4 2.28

7/29/2020 8/19/2020 not done 2.29
1/16/2020 1/14/2021 2.1 2.47
4/11/2019 2/28/2020 6.6 2.43
7/26/2018 1/13/2020 6.7 2.39
2/27/2020 none on system none on system
2/7/2020
2/24/2020 8/10/2020 not done 2.33
11/6/2019 12/3/2019 not done 2.58
Held pre OGD, then pt DNA'd appts

on hold
lost to follow up
LOW VIT D
Paget's ?exclude. Did not wish for further zol
next dose awaited
10/2/2019 12/2/2019 not done 2.3
11/11/2020 11/19/2020 not done 2.25
ON HOLD
9/13/2019 none on system none on system
11/14/2019 11/12/2020 5.6 2.32
11/6/2020 none on system none on system
11/5/2020 none on system none on system
postponed as P1NP low
10/28/2020 2/2/2021 not done 2.21
12/3/2020 none on system none on system
2nd dose delayed due to Covid 19
11/15/2019 12/31/2020 12.8 2.31
10/8/2020 none on system none on system
11/11/2020 none on system none on system
11/22/2019 11/26/2019 8.1 2.48
11/19/2020 none on system none on system
2nd infusion awaited
12/4/2019 11/15/2020 not done 2.08
2nd infusion awaited
2nd infusion awaited, pending dental review
9/10/2020 none on system none on system
12/11/2019 11/19/2020 10 53( 133 Sep 2 2.39
12/6/2019 11/3/2020 11.3 2.29
Due Dec 2020, awaited
10/8/2020 none on system none on system
3/1/2019 7/26/2019 not done 2.46
DECEMBER
10/28/2020 1/9/2021 not done 2.35
not yet seen in clinic again ?for further dose
11/20/2019 11/17/2020 4.2 2.21
6/26/2019 11/9/2020 9.7 2.37
5/15/2019 3/17/2020 6.7 2.3
2nd infusion awaited
11/11/2020 none on system none on system
2nd infusion awaited
11/27/2020 none on system none on system
12/21/2020 none on system none on system
12/11/2020 none on system none on system
12/12/2020 12/16/2020 not done 2.2
12/23/2020 none on system none on system
2nd infusion awaited
2/26/2021
10/2/2021
12/11/2019 12/21/2020 10 2.29
2nd infusion awaited
12/19/2019 12/7/2020 4.1 2.35
22/01/2021 - hasn't yet had
16/01/2021 - hasn't yet had
2/4/2020 10/27/2020 6.3 2.4
31/01/2121 -hasn't yet had
23/01/2021 - hasn't yet had
30/01/2021 - hasn't yet had
12/11/2020 none on system none on system
2/26/2021
2/26/2021
2/24/2021
 3/13/2021
2/27/2021
none on system
10/16/2021
3/21/2018 7/29/2019 8.6 2.33
none on system
10/9/2020 none on system none on system
9/25/2020 3/16/2021 1.8 2.2

9/3/2021
9/11/2021
9/3/2021
10/9/2021
9/25/2021

10/30/2019 10/22/2020 10 2.23

2/26/2020
11/27/2019 11/2/2020 5.4 2.27
Declined 2nd
10/30/2019 10/7/2020 8.8 2.22
10/3/2019 11/23/2020 2.12
9/28/2019 6/10/2020 6.6 2.43
9/11/2019 8/21/2020 3.5 2.41
10/22/2020
2/4/2020 12/29/2020 4.4 2.3
7/15/2020 12/21/2020 2.31
on hold
on hold
8/10/2018 4/18/2019 2.2 2.52
12/18/2018 10/29/2019 6.2 2.41
5/2/2019 9/15/2020 5.6 2.29
10/29/2020 2/24/2021
1/13/2020 10/22/2020 2.37
10/1/2020 1/11/2021 2.35
2/24/2020 12/12/2020
10/29/2020
10/29/2020
1/3/2020 12/14/2020 20.4 2.21
10/8/2020 1/13/2021
2/25/2020 1/29/2021 2.48

2/5/2020 2/25/2020 2.42

1/8/2019 11/6/2019 2.44
1/14/2020 8/27/2020 2.45
 12/12/2019 10/14/2020 6.2 2.32

on hold
10/17/2019 11/10/2020 13.8 2.49

10/15/2020 2/17/2021

10/1/2020
5/17/2019 10/21/2020 3.4 2.12
4/5/2019 4/17/2020 9.5 2.39
5/14/2019 10/1/2020 6 2.25
11/15/2017 9/2/2019 12.1 2.44
DELAYED COVID

10/8/2020 2/10/2021 16.7 58 2.57

LOW VIT D
2/3/2021
12/12/2020 12/16/2020 16.2 2.44
2/3/2021
2/5/2021

1/6/2020 3/4/2021 15.2 2.73

3/11/2021

11/12/2020
10/15/2020 12/8/2020

9/18/2021
9/3/2021

10/24/2016 3/26/2018 14.7 2.68

DELAYED

ON ORAL TABS
6/17/2021
7/16/2021

9/11/2021
8/21/2021
9/25/2021

9/11/2021
 5/19/2021
May-21
10/2/2021

10/8/2020
9/17/2021

9/11/2021
9/25/2021
9/11/2021
10/2/2020 1/28/2021 2.32
9/25/2021
10/2/2021
10/15/2021
10/15/2021
10/8/2021
10/16/2021
11/4/2021

10/28/2021

10/28/2021
10/22/2021
11/20/2020 1/4/2021

6/12/2019 12/13/2019 2.25

10/28/2021
7/6/2018 2/12/2019 2.44
5/29/2019 9/4/2019 2.5
3/8/2019 9/16/2019 5.5 2.62
6/13/2019 10/7/2019 5 2.29
12/11/2018 5/7/2019 9.3
12/17/2018 2/19/2019 7.1 2.44
2/13/2019 7/30/2019 8.9 2.45
3/20/2019 8/28/2019 3.8 2.43
5/25/2020 11/10/2020 6.9 2.38
7/1/2019 2/13/2020 7.6 2.4
 6/17/2019 10/4/2019 7.7 2.24
8/12/2019 5/7/2020 9 2.33
5/31/2019 11/5/2019 6.7 2.41
7/3/2019

8/9/2019 1/23/2020 4.1 2.41

5/5/2020 11/12/2020 5.4 2.25
9/14/2020
3/12/2019 6/17/2019 2.42
4/23/2020 9/1/2020 9.8 2.3
3/9/2017 1/23/2018 4.2 2.41

11/5/2020
Min Ca 2.08
Max Ca 2.73
Bloods after treatment #2
Phosphate Alkaline phosphatase Creatinine eGFR Date of third treatment
1.09 48 54 >90 6/26/2019
1.18 102 72 69 1/3/2019
1.13 79 82 58 8/14/2019
1.42 71 46 >90 11/14/2019
1.22 77 71 73 11/7/2019
1.01 70 46 >90 10/2/2019
1.49 98 82 81 2/25/2019
0.91 52 68 86 11/14/2019
1.37 61 76 64 6/19/2019
1.04 69 57 80 10/31/2019

1.04 46 40 >90 1/23/2020

0.76 102 68 76 11/21/2019
1.24 54 88 55 11/21/2019
1.25 49 60 >90 1/16/2020
1.28 52 60 >90 6/24/2020
1.05 56 67 71 6/27/2018
0.9 115 139 32
1.06 71 64 87 5/12/2020
1.17 62 59 85 8/17/2020
0.94 47 143 30
1 66 82 59
1.55 107 62 >90
1.26 51 51 87
1.01 62 72 65
1.32 49 46 >90
none on syst none on system none on sys none on system
none on syst none on system none on sys none on system

1.25 66 55 86 not yet had

1.1 127 86 55 not yet had
none on syst none on system none on sys none on system
1.34 47 66 79 P1NP suppressed, no need for further infusion
none on syst none on system none on sys none on synot yet had
none on syst none on system none on sys none on sy 10/22/2021
none on syst none on system none on sys none on sy 9/3/2021
none on syst none on system none on sys none on syon hold
none on syst none on system none on sys none on sy 10/8/2021
none on syst none on system none on sys none on sy 2/5/2021
on hold
none on syst none on system none on sys none on sy 8/21/2021
1.02 56 42 >90 9/25/2021
none on syst none on system none on sys none on sy 9/3/2021
1.21 73 69 82 on hold
1.28 55 59 90 on hold
none on syst none on system none on sys none on sy 7/10/2021

1.3 82 70 74 17/11/2020 - on hold, pt shielding

1.09 56 77 64
none on syst none on system none on sys none on sy 9/11/2021
none on syst none on system none on sys none on system
1.2 64 73 68
none on syst none on system none on sys none on sy Feb 2021
none on syst none on system none on sys none on sy 2/26/2021
1.21 62 63 80

1.24 91 70 85 on hold

1.37 63 58 85 1/23/2021
1.22 71 70 77 7/29/2021
1.5 86 53 83 1/16/2021
1.45 89 60 82
haemolysed 50 52 84
none on syst none on system none on sys none on sy 2/27/2021

1.08 52 97 54 2/24/2021
0.89 124 125 33 on hold
on hold

0.77 131 55 82 ON HOLD

1.22 138 44 >90

none on syst none on system none on sys none on syON HOLD

1.22 90 43 >90
none on syst none on system none on sys none on system
none on syst none on system none on sys none on system

1.17 89 122 49 10/28/2021

none on syst none on system none on sys none on system
 1.51 49 53 >90
none on syst none on system none on sys none on sy 10/8/2021
none on syst none on system none on sys none on system
1.03 52 not done not done
none on syst none on system none on sys none on system
DELAYED
1.07 112 43 87

none on syst none on system none on sys none on sy 9/10/2021

1.05 106 79 69 12/11/2020
1.33 72 144 28 12/6/2020

none on syst none on system none on sys none on sy 10/8/2021

0.97 78 68 79 DECLINED

1.26 59 61 86 10/28/2021

1.13 54 52 88 12/4/2020
1.13 168 81 62 12/17/2020
1.2 63 62 89 course completed

none on syst none on system none on sys none on system

none on syst none on system none on sys none on system

none on syst none on system none on sys none on system
none on syst none on system none on sys none on system
1.06 81 97 47
none on syst none on system none on sys none on system

1.27 57 64 84 3rd infusion awaited

1.3 128 96 64 3rd infusion awaited

1 62 44 >90 04/02/2021 - postponed

none on syst none on system none on sys none on system

 1.31 65 65 77 9/5/2019

none on syst none on system none on sys none on sy 10/9/2021

1.16 74 43 >90 9/25/2021

1.49 45 50 88
2/26/2021
0.75 63 57 >90

1.31 79 51 >90
1.38 60 75 68
0.93 76 76 74 on hold
1.3 56 87 55 on hold

0.9 91 67 74 2/4/2021
1.21 93 51 >90

1.28 56 64 89 on hold
1.31 42 67 73 on hold
0.94 66 56 89 11/5/2020
28 80 61 10/29/2021
0.89 79 46 85 1/13/2021
1.2 43 62 77 10/1/2021
119 108 40 2/24/2021
10/29/2021
10/29/2021
1.16 122 83 59 SEPT
111 54 86 10/8/2021
0.99 67 48 88 2/25/2021

1.13 80 57 2/5/2021
1.29 50 48 >90 1/8/2020
0.97 57 81 66 1/14/2021
0.76 29 75 75

1.04 68 49 86

68 82 10/15/2021
ON HOLD
10/1/2021
1.4 22 56 89 LOW CA
1.03 57 50 >90
0.85 61 71 80
0.89 55 74 63

1.13 76 10/8/2021

1.15 199 46 85

0.88 156 47 >90 1/6/2021

74 65 10/15/2021

0.99 80 60 83 2/14/2019
 10/8/2021

1.22 67 58 88 10/2/2021

92 49

1.21 77 78 62

1.4 42 83 61 11/20/2020
1.06 52 64 81 12/2/2019
1.32 82 93 49 10/1/2019
0.91 42 84 87 12/12/2019
56 86 6/3/2019
0.86 80 113 40 6/27/2019
0.98 56 63 87 8/14/2019
1.17 63 63 89 9/10/2019
1.07 490 76 66
1.06 50 52 88 4/21/2020
1.15 44 52 89 12/16/2019
1.3 71 109 38 8/28/2020
1.32 74 50 >90 12/12/2019
1/3/2020
6/15/2020
1.01 48 53 >90 9/15/2020
0.98 47 93 54

1.37 67 56 86
1.55 59 57 >90 9/10/2020
1.02 45 56 85 1/31/2018

36 55 83
 Bloods after treatment #3
PTH Vit D Adjusted calcium Phosphate Alkaline phosphatase
11/29/2019 not done 2.66 1.18 50
7/31/2019 12 2.4 1.09 51
1/7/2020 2.8 2.36 1.13 116
5/6/2020 not done 2.51 1.39 70
4/28/2020 not done 2.38 1.08 66
1/21/2020 not done not done not done not done
8/22/2019 8.2 2.23 1.49 98
1/15/2020 not done not done not done 45
11/18/2019 9 2.43 1.27 72
11/28/2019 not done 2.31 1.18 61

8/26/2020 10.1 2.19 1.01 39

4/17/2020 12.9 2.38 1.23 90
4/17/2020 not done 2.56 1.57 49
7/10/2020 not done 2.07 1.24 55
6/21/2020 not done 2.31 1.35 50
1/30/2019 not done not done not done not done

11/10/2020 not done 2.35 1.31 72

not done not done not done not done

ed, no need for further infusion

n hold, pt shielding
none on system none on system none on syst none on system
none on system none on system none on syst none on system

none on system none on system none on syst none on system

none on system none on system none on syst none on system
10/13/2020 5.5 2.22 1.37 62

12/29/2020 65

3/4/2021

10/13/2020
6/10/2019 2.61 1.13 84
1/28/2021 2.26 1.26 46
5/29/2020 2.42 1.2 50
3/9/2020 10.2 2.53 1.18 81
8/17/2020 3 2.3 1.41 57
1/24/2020 2.38 1.2 115
8/20/2019 13.2 2.56 1.26 78
1/24/2020 6.1 2.46 1.22 58
2/12/2020 2.9 2.36 1.31 67

10/2/2020 7.3 2.17 1.02 42

 6/8/2020 7.6 2.26 1.04 45
9/17/2020 70
6/12/2020 2.25 1.51 101

6/27/2018 2.38 1.13 39

Min Ca 2.07
Max Ca 2.66
 Bl
Creatinine eGFR Date of fourth treatment Date of bloods PTH Vit D
62 >90 12/19/2019 5/29/2020 7.3
70 71 10/30/2020 10/8/2020 3.7
95 48 1/21/2020 7/13/2020 2.7
37 >90 5/21/2020 11/11/2020 not done
75 69 4/30/2020 11/2/2020 3.8
48 >90 4/23/2020 10/7/2020 not done
86 76 8/27/2019 1/20/2020 7.8
64 >90 6/2/2020 11/5/2020 not done
73 67 12/31/2019 none on system
65 73 4/27/2020 6/2/2020 not done

43 >90 9/4/2020 10/12/2020 not done

73 69 4/30/2020 10/23/2020 8.2
81 60 5/1/2020 10/22/2020 4.5
64 >90
61 >90
71 66 1/30/2019 7/25/2019 5.1

54 >90
not done not done
none on sys none on system
none on sys none on system

none on sys none on system

none on sys none on system
67 73 11/24/2020 none on system

51 >90

55 80

44 >90
62 81
 92 54
79 63 6/9/2020 11/2/2020
106 42 4/21/2020 10/7/2020
87 83 8/27/2020
56 86 5/3/2020 7/16/2020 16.9
132 33 1/7/2020 6/23/2020
64 86 3/9/2020 8/28/2020 4.7
65 85 5/7/2020 11/10/2020

53 87
 57 86 6/19/2020 11/27/2020 6.9
107 39
44 >90 6/17/2020 12/2/2020 5.9
8/21/2020

62 82 7/30/2018 1/7/2019 2.8

Min Ca
Max Ca
 Bloods after treatment #4
Adjusted calcium Phosphate Alkaline phosphatase Creatinine eGFR Date of fifth treatment
2.35 1.05 57 57 >90 6/10/2020
2.38 1.38 98 65 77
2.33 1.08 93 86 54 7/24/2020
2.49 1.26 79 44 >90
2.43 1.24 76 70 74
not done not done not done 49 >90
2.41 1.3 105 84 75 2/20/2020
2.08 0.96 55 71 81
none on system none on syst none on system none on sys none on sy 6/2/2020
2.33 1.23 59 62 87

not done not done not done 44 >90

2.41 1.45 79 70 73 11/2/2020
2.4 1.3 49 85 57 11/3/2020

2.35 1.04 55 72 65 9/4/2019

none on system none on syst none on system none on system
2.38 1.06 47 72 70
2.43 1.33 112 90 50 10/21/2020

2.11 1.14 70 57 85
2.52 1.52 86 137 31 6/29/2020
2.41 0.95 54 65 83 9/14/2020
2.1 1.2 56 58 >90
2.33 1.17 37 51 89

2.31 1.22 94 44 >90

2.48 1.08 40 57 84 2/12/2019

2.08
2.52
 Bloods after treatment #5
Date of bloods PTH Vit D Adjusted calcium Phosphate Alkaline phosphatase
none on system none on system none on syst none on system

none on system none on system none on syst none on system

7/13/2020 not done 2.24 1.31 99

none on system none on system none on syst none on system

none on system none on system none on syst none on system

12/1/2020 not done 2.08 1.23 43

5/5/2020 4.1 2.37 1.32 70

7/24/2019 4.8 2.47 1.26 42

Min Ca 2.08
Max Ca 2.47
 Blood
Creatinine eGFR Date of sixth treatment Date of bloods PTH Vit D
none on sys none on system

none on sys none on system

83 79 8/17/2020 10/6/2020 not done

none on sys none on system

none on sys none on system

74 67

78 58 5/13/2020 11/9/2020 8.5

62 81 8/20/2019 2/27/2020 5.3

Min Ca
Max Ca
 Bloods after treatment #6
Adjusted calcium Phosphate Alkaline phosphatase Creatinine eGFR

not done not done 101 86 75

2.23 1.23 55 69 67
2.43 1.11 42 53 86

2.23
2.43
 Bloods after treatment #7
Date of seventh treatment PTH Vit D Adjusted calcium Phosphate
10/28/2020
ds after treatment #7 Bloods
Alkaline phosphatase Creatinine eGFR Date of eighth treatment PTH Vit D
 Bloods after treatment #8
Adjusted calcium Phosphate Alkaline phosphatase Creatinine eGFR Date of ninth treatment
 Bloods after treatment #9
PTH Vit D Adjusted calcium Phosphate Alkaline phosphatase Creatinine eGFR
 Bloods after treatment #10
Date of tenth treatment PTH Vit D Adjusted calcium Phosphate Alkaline phosphatase
 Other Comments
Creatinine eGFR Denosumab
Zoledronate
Temporary pause in denosumab because of Covid 19 situation

Has denosumab in nursing home

(seen by endo, primary hyperparathyroidism)

seen by endo -differentials between parathyroid adenoma and raised PTH 2dary to CKD
endo felt 2dary to vit D deficiency

referred to endo
endo felt 2dary to vit D deficiency
H 2dary to CKD
 Age when started Drug administed
Hospital no DOB zoledronate/denosumab (zoledronate/denosumab) Baseline PTH
41161480 ### 56 Denosumab 8.8
41446832 ### 77 Denosumab 7.5
41303734 ### 80 Denosumab 2.9
40488869 ### 74 Denosumab 5.1
40467527 ### 71 Denosumab 6.2
41068119 ### 70 Denosumab 4.7
40907939 ### 73 Denosumab 10.3
40999596 ### 55 Denosumab not done
40854975 6/8/1938 80 Denosumab 8.8
40931890 2/6/1932 86 Denosumab 4.3
40860746 ### 86 Denosumab 4.5
40457779 ### 74 Denosumab 6.1
40000045 ### 74 Denosumab 9.5
41025627 ### 76 Denosumab 3.1
41007187 ### 59 Denosumab 4.9
40747072 2/9/1960 59 Denosumab not done
40815863 ### 85 Denosumab 5.8
40866371 5/6/1945 74 Denosumab 12.4
40716973 ### 65 Denosumab 4.6
40630908 ### 75 Denosumab 3.9
40657054 ### 79 Denosumab 7.5
40523262 ### 77 Denosumab 9
40444348 ### 61 Denosumab 1.7
41061509 ### 80 Denosumab 6.3
40788170 ### 85 Denosumab 9.9
41182367 ### 72 Denosumab not done
40486747  ### 65 Denosumab 4.2
40688703 ### 61 Denosumab 6.8
40470263 ### 76 Denosumab 6.2
40311026 ### 58 Denosumab not done
40913876 ### 69 Denosumab 4.8
40699669 ### 77 Zoledronate 7.4
40049061 ### 79 Zoledronate not done
40498261 ### 82 Zoledronate 10.3
41007169 ### 72 Zoledronate 7
40628960 ### 71 Zoledronate 4.5
41074216 ### 64 Zoledronate 14.5
40146556 ### 68 Zoledronate 7.1
40757492 ### 72 Zoledronate 4.2
40490673 ### 81 Zoledronate 2.6
40459411 ### 83 Zoledronate 29.4
40703884 ### 68 Zoledronate 12.3
40482245 ### 85 Zoledronate not done
40826375 ### 59 Zoledronate not done
40890294 ### 74 Zoledronate 4.6
40487568 ### 71 Zoledronate 2.6
41754401 ### 65 Zoledronate 5.4
40124148 7/4/1957 59 Zoledronate 10.2
40648546 21//11/49 67 Zoledronate 6.4
40478547 ### 68 Zoledronate 4.5
40657798 ### 88 Zoledronate 6
40498709 ### 70 Zoledronate 7
40905738 8/4/1942 76 Zoledronate not done
40697336 ### 59 Zoledronate not done
40714687 ### 65 Zoledronate 11.7
40742760 ### 78 Zoledronate 5.8
40787770 ### 50 Zoledronate 3.7
40866401 ### 69 Zoledronate 5
40978842 ### 78 Zoledronate 4.8
41283740 ### 60 Zoledronate 10.2
40504441 ### 67 Zoledronate 5.4
40370145 ### 77 Zoledronate 3.9
40692036 ### 53 Zoledronate 6.1
40777561 3/1/1944 74 Zoledronate 2.9
40821864 3/1/1942 76 Zoledronate 6.2
40876540 ### 66 Zoledronate not done
40917225 9/7/1935 83 Zoledronate 4.3
40953385 ### 79 Zoledronate 5.1
40316919 ### 82 Zoledronate 6.6
40478818 6/1/1933 85 Zoledronate 6.2
40519856 3/1/1930 88 Zoledronate 2.5
40530078 ### 60 Zoledronate 5.8
40679207 ### 86 Zoledronate 11.9
40831436 ### 88 Zoledronate not done
40867882 8/6/1945 73 Zoledronate not done
40935322 ### 74 Zoledronate not done
40970713 ### 72 Zoledronate not done
40984826 4/3/1929 90 Zoledronate not done
40968205 8/4/1945 74 Zoledronate 4.2
40653941 ### 79 Zoledronate not done
40857995 ### 85 Zoledronate 6.1
40489150 6/8/1940 79 Zoledronate 3.5
41059606 ### 61 Zoledronate not done
40637572 ### 81 Zoledronate 11.7
40874800 ### 75 Zoledronate 5.1
40799456 ### 83 Zoledronate 4.7
40085940 ### 58 Zoledronate 5.2
40448247 ### 64 Zoledronate 5.1
41263610 8/6/1942 77 Zoledronate 3.5
40258218 ### 76 Zoledronate 11.2
40533643 ### 81 Zoledronate 12.8
40657481 ### 67 Zoledronate 8.8
40515539 6/8/1947 72 Zoledronate 3.5
40538685 ### 86 Zoledronate 6.9
40654686 ### 89 Zoledronate 10.8
40717829 ### 63 Zoledronate 3.8
40852097 ### 70 Zoledronate 8.6
40039744 ### 85 Zoledronate 3.9
40707244 ### 66 Zoledronate 4.9
40938246 ### 70 Zoledronate 4.6
41696891 ### 60 Zoledronate 8.7
41470610 1/1/1957 61 Zoledronate 14.3
41255409 ### 85 Zoledronate 11.8
40518830 ### 59 Zoledronate 6.5
40760553 ### 62 Zoledronate 10.6
40933654 ### 66 Zoledronate not done
40807909 ### 76 Zoledronate 4
40939779 ### 72 Zoledronate 6.4
40995625 ### 72 Zoledronate 5.6
40657539 8/9/1942 76 Zoledronate 5.3
40081010 ### 71 Zoledronate 5.4
41310000 ### 65 Zoledronate 4
40916435 7/9/1938 81 Zoledronate not done
40176741 7/9/1945 74 Zoledronate 4.9
40686567 ### 86 Zoledronate not done
40080444 1/8/1948 71 Zoledronate 5.1
40202834 ### 78 Zoledronate 4.8
41729710 ### 71 Zoledronate not done
40458771 ### 80 Zoledronate 8.4
40537818 ### 72 Zoledronate 4.2
40972822 ### 72 Zoledronate not done
40678607 ### 89 Zoledronate 9.5
40406756 ### 72 Zoledronate 10.6
40667986 ### 69 Zoledronate 7.4
40365796 ### 68 Zoledronate 6.5
40310162 2/9/1939 79 Zoledronate 3.5
40178806 ### 55 Zoledronate not done
40815133 ### 86 Zoledronate nor done
40665769 ### 72 Zoledronate 7.3
40524014 ### 71 Zoledronate 6.9
40699855 ### 73 Zoledronate 6.1
40885805 ### 77 Zoledronate 5.5
41437980 1/8/1959 59 Zoledronate 4.3
40936485 ### 82 Zoledronate not done
40668474 ### 67 Zoledronate 4.1
41337660 ### 67 Zoledronate 13.9
40635731 ### 81 Zoledronate 7.7
40520135 ### 83 Zoledronate 2.6
40629132 ### 83 Zoledronate 13.1
40477851 6/2/1943 77 Zoledronate 10.7
40901264 ### 79 Zoledronate 6.1
40732742 ### 79 Zoledronate 6.7
40693816 ### 79 Zoledronate 3.6
40826375 ### 59 Zoledronate not done
40541203 ### RIP Zoledronate
40524730 ### 77 Zoledronate 4.3
41710424 1/6/1940 80 Zoledronate 9
40146980 8/3/1933 87 Zoledronate 13
40468669 ### 70 Zoledronate 5.8
40716527 ### 58 Zoledronate
40756877 ### 62 Zoledronate 3.1
40078124 ### 71 Zoledronate 6
40117841 ### 68 Zoledronate 7.3
40244375 ### 59 Zoledronate 6.3
40069233 ### 59 Zoledronate 3.7
41723551 ### 73 Zoledronate
41224321 ### 46 Zoledronate 4.8
40270641 ### 71 Zoledronate 5.9
40043550 8/9/1960 58 Zoledronate 4.7
41165304 ### 76 Zoledronate 4
41078803 ### 61 Zoledronate 7
40140579 7/6/1940 69 Zoledronate 1.8
40267614 8/1/1947 72 Zoledronate 3.3
40390768 ### 66 Zoledronate 6.1
40146850 ### 79 Zoledronate
40194752 7/4/1955 52 Zoledronate
40066444 ### 80 Zoledronate
40025492 ### 72 Zoledronate
40054846 ### 75 Zoledronate 10.4
40132099 2/6/1932 86 Zoledronate
40178996 ### 88 Zoledronate
40355845 ### 84 Zoledronate 7.7
40359872 ### 62 Zoledronate 7.4
40398867 9/6/1954 65 Zoledronate 6.7
40413387 ### 75 Zoledronate 11.1
40161499 7/7/1940 79 Zoledronate 6.9
41372022 ### 79 Zoledronate 10.9
40248430 ### 70 Zoledronate 2.2
40016989 ### 77 Zoledronate 4.7
40058259 ### 74 Zoledronate
40064359 ### 62 Zoledronate
40275328 ### 79 Zoledronate
40125793 4//1/1959 59 Zoledronate 7.3
40226530 ### 62 Zoledronate 6.4
40256684 ### 74 Zoledronate 3.9
40400906 ### 82 Zoledronate 14.6
40997181 2/1/1971 48 Zoledronate 2.8
41004748 ### 85 Zoledronate
41156712 ### 79 Zoledronate 12
41304067 ### 80 Zoledronate 8.1
40089609 4/6/1947 71 Zoledronate 4.4
40124042 8/4/1952 66 Zoledronate
40173836 ### 59 Zoledronate
40259848 ### 82 Zoledronate 13
40313048 ### 84 Zoledronate
40533981 17/1//194 77 Zoledronate 4.5
41010975 1/1/1951 68 Zoledronate 14.6
41535922 ### 79 Zoledronate 10.5
40073814 4/4/1953 66 Zoledronate
40045842 ### 89 Zoledronate 9.9
40098494 ### 74 Zoledronate 4.6
40070115 3/1/1931 88 Zoledronate 17.2
40070063 ### 84 Zoledronate 9.5
40101002 7/4/1946 74 Zoledronate
40528424 ### 77 Zoledronate
40235507 ### 74 Zoledronate 15
41543112 ### 84 Zoledronate 7.9
40219154 1/3/1942 77 Zoledronate 3.3
40338320 3/7/1952 67 Zoledronate 4.6
40184022 ### 79 Zoledronate 6.2
40128636 9/9/1947 Zoledronate
40001880 ### 78 Zoledronate 7.7
40087156 ### 81 Zoledronate 4.8
 40681781 ### 79 Zoledronate 7.5
40373168 ### Zoledronate
40300258 5/3/1937 82 Zoledronate
40300258 5/3/1937 Zoledronate
40128847 9/1/1938 75 Zoledronate 8.5
40139804 ### Zoledronate
40906196 ### 85 Zoledronate
40532389 ### 91 Zoledronate
 41094733 ### 62 Zoledronate 6.8
40908146 ### 93 Zoledronate 5.2
40673544 ### 64 Zoledronate 9.4
40711174 ### 87 Zoledronate 7.1
40941263 ### 76 Zoledronate 6
40481025 3/8/1927 91 Zoledronate 11.3
40107999 4/8/1949 71 Zoledronate
40355051 8/7/1961 Zoledronate
40047169 5/2/1938 80 Zoledronate 4.9
40804648 ### 86 Zoledronate
40021548 ### 59 Zoledronate
40940481 ### 69 Zoledronate 5.1
40192536 Zoledronate
40012887 Zoledronate
40200524 Zoledronate
40204111 Zoledronate
41181192 ### 64 Zoledronate 7.5
41067022 ### 71 Zoledronate 17.9
40156124 ### Zoledronate
41639545 ### Zoledronate
40483358 5/4/1943 76 Zoledronate
40016929 5/1/1949 Zoledronate
41569044 6/5/1968 52 Zoledronate
41311282 ### 68 Zoledronate 8.8
40532955 ### 83 Zoledronate 4.9
40938537 ### 72 Zoledronate
40670414 ### 62 Zoledronate 5.9
40654252 ### 87 Zoledronate
41015337 ### 69 Zoledronate 5.7
40229866 ### 79 Zoledronate 13.1
41084654 ### 59 Zoledronate 11.1
40105662 ### 56 Zoledronate 7
41004153 8/1/1937 83 Zoledronate 4.3
40230400 ### Zoledronate
41008318 ### 64 Zoledronate 6.7
 40053422 ### Zoledronate
40679516 ### 68 Zoledronate 4.2
40482225 ### 86 Zoledronate 4.7
40781919 ### 86 Zoledronate
41825765 Zoledronate
40257747 ### Zoledronate
40742760 ### 78 Zoledronate 5.8
40468374 ### 65 Zoledronate 6.6
41565527 ### 69 Zoledronate 8.3
40109128 ### 75 Denosumab 10.3
41460344 ### 83 Denosumab 6.6
41703079 ### 69 Denosumab 5
40281902 ### 77 Denosumab 8.8
40030669 ### 80 Denosumab 8.2
40222731 ### 67 Denosumab 6.3
40017705 ### 66 Denosumab
40077111 4/3/1944 74 Denosumab 3.2
41511998 ### 77 Denosumab 7.5
40001986 1/3/1943 75 Denosumab
40197652 3/4/1928 90 Denosumab 7.9
40080379​  2/4/1952 66 Denosumab
40222756 ### 77 Denosumab 8.6
40378219 ### 69 Denosumab 5.3
40423782 ### 63 Denosumab
40031516 ### 67 Denosumab 2.5
40037332 ### 81 Denosumab
41326965 ### 77 Denosumab 7.3
40329003 ### 67 Denosumab 4.5
40013371 ### 78 Denosumab
41299061 ### 69 Denosumab 7.2
40000050 ### 83 Denosumab 2.8
 PTH values
PTH post Rx #1 PTH post Rx #2 PTH post Rx #3 PTH post Rx #4 PTH post Rx #5 PTH post Rx #6
4.5 12.2 not done 7.3 none on system
not done 6.2 12 3.7
2.8 3.7 2.8 2.7 none on system
5.3 4.6 not done not done
not done 4.5 not done 3.8
7.8 8.8 not done not done
8.2 6.5 8.2 7.8 not done not done
5.3 not done not done not done
not done 8.8 9 none on system none on system
3.4 4.7 not done not done
5.3
6 4.5 10.1 not done
5.1 12.3 12.9 8.2 none on system
not done 4.7 not done 4.5 not done
4.9 6.3 not done
4.2 not done not done
not done 7.9 not done 5.1 4.1 8.5
16.8 12.4
3.8 not done not done
4.7 not done not done
not done not done
6.4 7.8
not done not done
5 4.6
5.8 7.2
6.2 not done
not done none on system
9.3 none on system
none on system
none on system
none on system
not done not done
not done 15.2
8.2 none on system
3 not done
4 none on system
11.6 none on system
7.1 none on system
5.8 none on system
7.3 none on system
17.1 none on system
none on system
not done none on system
2.4 not done
5.7
not done
4.2 none on system
not done 11.3
4.2 6.1
4.7 none on system
5.2
not done 11.9
not done 4.4
8.8 none on system
13.9 none on system
5.4 none on system
not done none on system
not done none on system
7 not done
21.4
6.7
not done
9.8 not done
2.6
5.6 8.4
not done not done
4.7 2.1
5.5 6.6
9.2 6.7
5.5 none on system
1.3
6.6 not done
19.9 not done
not done
8.1
not done
none on system
not done
2.7
7.8
6.3 not done
not done not done
5.3
7.6 none on system
 6 5.6
2.8 none on system
5.6 none on system
4
5.2 not done
8.3 none on system
not done
7.7 12.8
3 none on system
3 none on system
9.4 8.1
6.4 none on system
6.6
3.4 not done
6.1
none on system
not done none on system
16.3 10 none on system
not done 11.3 none on system
8.5
10.7 none on system
9.3 not done
10.5
6 not done
7.2
4.8 4.2 none on system
6..6 9.7 none on system
4.8 6.7
not done
not done none on system
not done
5.7 none on system
5 none on system
not done none on system
not done not done
4.6 none on system
4.1
not done
not done
9.7 10
none on system
2.2 4.1
not done
not done
6.2 6.3
not done
none on system
5.1
4.5 none on system
not done
5.9
27.4
not done
not done
none on system
none on system
not done 8.6 5.5 none on system
none on system
12.1 none on system
2.4 1.8

4.8

10
5
5.4
9.1
8.8

6.6
3.39 3.5
9.5
3.2 4.4

7.9
3.2 2.2
6.6 6.2
5.6
8.6
 8.7
5.7

15.9 20.4
9.2

8.3 6.2

13.8

5.1
7.3

4.1 3.4
6 9.5
4.4 6
12.1

8.2
14.9 16.7
12.5

10.8

16.2

6.5
15 15.2
3.7
5.6

14.7
 14.7

18.1

10.6
16.7

4.1

6.1

4.8
4
 5.4
5.8
6.8
10.8
5.1 5.5 10.2
5 3
9.3 16.9
6.3 7.1 13.2
8.9 6.1 4.7
3.8 2.9
3.2 6.9
6.9 7.6 7.3
6.6 7.7 7.6 6.9
5.4 9
6.9 6.7 5.9
10.3

10.3 4.1
4.9 5.4
6.1

5.3 9.8
3.7 4.2 2.8 4.8 5.3
Hospital n Rx Baseline PTH PTH post Rx #1 T test pre vs post Rx#1
41161480 Denosumab 8.8 4.5 0.172624105796669
41303734 Denosumab 2.9 2.8
40488869 Denosumab 5.1 5.3
41068119 Denosumab 4.7 7.8
40907939 Denosumab 10.3 8.2
40931890 Denosumab 4.3 3.4
40860746 Denosumab 4.5 5.3
40457779 Denosumab 6.1 6
40000045 Denosumab 9.5 5.1
41007187 Denosumab 4.9 4.9
40866371 Denosumab 12.4 16.8
40716973 Denosumab 4.6 3.8
40630908 Denosumab 3.9 4.7
40523262 Denosumab 9 6.4
41061509 Denosumab 6.3 5
40788170 Denosumab 9.9 5.8
40688703 Denosumab 6.8 9.3
40498261 Zoledronate 10.3 8.2
41007169 Zoledronate 7 3
40628960 Zoledronate 4.5 4
41074216 Zoledronate 14.5 11.6
40146556 Zoledronate 7.1 7.1
40757492 Zoledronate 4.2 5.8
40490673 Zoledronate 2.6 7.3
40459411 Zoledronate 29.4 17.1
40890294 Zoledronate 4.6 5.7
41754401 Zoledronate 5.4 4.2
40648546 Zoledronate 6.4 4.2
40478547 Zoledronate 4.5 4.7
40657798 Zoledronate 6 5.2
40714687 Zoledronate 11.7 13.9
40742760 Zoledronate 5.8 5.4
40978842 Zoledronate 4.8 7
41283740 Zoledronate 10.2 21.4
40504441 Zoledronate 5.4 6.7
40692036 Zoledronate 6.1 9.8
40777561 Zoledronate 2.9 2.6
40821864 Zoledronate 6.2 5.6
40917225 Zoledronate 4.3 4.7
40953385 Zoledronate 5.1 5.5
40316919 Zoledronate 6.6 9.2
40478818 Zoledronate 6.2 5.5
40519856 Zoledronate 2.5 1.3
40530078 Zoledronate 5.8 6.6
40679207 Zoledronate 11.9 19.9
40968205 Zoledronate 4.2 2.7
40857995 Zoledronate 6.1 6.3
40637572 Zoledronate 11.7 7.6
40874800 Zoledronate 5.1 6
40799456 Zoledronate 4.7 2.8
40085940 Zoledronate 5.2 5.6
40448247 Zoledronate 5.1 4
41263610 Zoledronate 3.5 5.2
40258218 Zoledronate 11.2 8.3
40657481 Zoledronate 8.8 7.7
40515539 Zoledronate 3.5 3
40538685 Zoledronate 6.9 3
40654686 Zoledronate 10.8 9.4
40717829 Zoledronate 3.8 6.4
40852097 Zoledronate 8.6 6.6
40039744 Zoledronate 3.9 3.4
40707244 Zoledronate 4.9 6.1
41470610 Zoledronate 14.3 16.3
40518830 Zoledronate 6.5 8.5
40760553 Zoledronate 10.6 10.7
40807909 Zoledronate 4 10.5
40939779 Zoledronate 6.4 6
40995625 Zoledronate 5.6 7.2
40657539 Zoledronate 5.3 4.8
40081010 Zoledronate 5.4 6.6
41310000 Zoledronate 4 4.8
40080444 Zoledronate 5.1 5.7
40202834 Zoledronate 4.8 5
40537818 Zoledronate 4.2 4.6
40667986 Zoledronate 7.4 9.7
40310162 Zoledronate 3.5 2.2
40665769 Zoledronate 7.3 6.2
40885805 Zoledronate 5.5 5.1
41437980 Zoledronate 4.3 4.5
40668474 Zoledronate 4.1 5.9
41337660 Zoledronate 13.9 27.4
40693816 Zoledronate 3.6 12.1
40756877 Zoledronate 3.1 4.8
40244375 Zoledronate 6.3 5
41165304 Zoledronate 4 3.39
41078803 Zoledronate 7 9.5
40140579 Zoledronate 1.8 3.2
40054846 Zoledronate 10.4 8.6
40355845 Zoledronate 7.7 5.7
40413387 Zoledronate 11.1 15.9
40161499 Zoledronate 6.9 9.2
40125793 Zoledronate 7.3 8.3
41156712 Zoledronate 12 7.3
40089609 Zoledronate 4.4 4.1
40533981 Zoledronate 4.5 8.2
41010975 Zoledronate 14.6 14.9
41535922 Zoledronate 10.5 12.5
40045842 Zoledronate 9.9 10.8
40235507 Zoledronate 15 15
41543112 Zoledronate 7.9 3.7
40219154 Zoledronate 3.3 5.6
40184022 Zoledronate 6.2 14.7
40128847 Zoledronate 8.5 9
40941263 Zoledronate 6 10.6
40481025 Zoledronate 11.3 16.7
40047169 Zoledronate 4.9 4.1
41181192 Zoledronate 7.5 6.1
40532955 Zoledronate 4.9 4.8
40742760 Zoledronate 5.8 5.4
40468374 Zoledronate 6.6 5.8
41565527 Zoledronate 8.3 6.8
40109128 Denosumab 10.3 10.8
41460344 Denosumab 6.6 5.1
40030669 Denosumab 8.2 6.3
40077111 Denosumab 3.2 3.2
41511998 Denosumab 7.5 6.9
40197652 Denosumab 7.9 5.4
40222756 Denosumab 8.6 10.3
40031516 Denosumab 2.5 4.9
40329003 Denosumab 4.5 5.3

120
Hospital n Rx Baseline PTH PTH post Rx #1
41161480 Denosumab 8.8 4.5
41303734 Denosumab 2.9 2.8
40488869 Denosumab 5.1 5.3
41068119 Denosumab 4.7 7.8
40907939 Denosumab 10.3 8.2
40931890 Denosumab 4.3 3.4
40860746 Denosumab 4.5 5.3
40457779 Denosumab 6.1 6
40000045 Denosumab 9.5 5.1
41007187 Denosumab 4.9 4.9
40866371 Denosumab 12.4 16.8
40716973 Denosumab 4.6 3.8
40630908 Denosumab 3.9 4.7
40523262 Denosumab 9 6.4
41061509 Denosumab 6.3 5
40788170 Denosumab 9.9 5.8
40688703 Denosumab 6.8 9.3
40109128 Denosumab 10.3 10.8
41460344 Denosumab 6.6 5.1
40030669 Denosumab 8.2 6.3
40077111 Denosumab 3.2 3.2
41511998 Denosumab 7.5 6.9
40197652 Denosumab 7.9 5.4
40222756 Denosumab 8.6 10.3
40031516 Denosumab 2.5 4.9
40329003 Denosumab 4.5 5.3
0.38635036685451

40498261 Zoledronate 10.3 8.2

41007169 Zoledronate 7 3
40628960 Zoledronate 4.5 4
41074216 Zoledronate 14.5 11.6
40146556 Zoledronate 7.1 7.1
40757492 Zoledronate 4.2 5.8
40490673 Zoledronate 2.6 7.3
40459411 Zoledronate 29.4 17.1
40890294 Zoledronate 4.6 5.7
41754401 Zoledronate 5.4 4.2
40648546 Zoledronate 6.4 4.2
40478547 Zoledronate 4.5 4.7
40657798 Zoledronate 6 5.2
40714687 Zoledronate 11.7 13.9
40742760 Zoledronate 5.8 5.4
40978842 Zoledronate 4.8 7
41283740 Zoledronate 10.2 21.4
40504441 Zoledronate 5.4 6.7
40692036 Zoledronate 6.1 9.8
40777561 Zoledronate 2.9 2.6
40821864 Zoledronate 6.2 5.6
40917225 Zoledronate 4.3 4.7
40953385 Zoledronate 5.1 5.5
40316919 Zoledronate 6.6 9.2
40478818 Zoledronate 6.2 5.5
40519856 Zoledronate 2.5 1.3
40530078 Zoledronate 5.8 6.6
40679207 Zoledronate 11.9 19.9
40968205 Zoledronate 4.2 2.7
40857995 Zoledronate 6.1 6.3
40637572 Zoledronate 11.7 7.6
40874800 Zoledronate 5.1 6
40799456 Zoledronate 4.7 2.8
40085940 Zoledronate 5.2 5.6
40448247 Zoledronate 5.1 4
41263610 Zoledronate 3.5 5.2
40258218 Zoledronate 11.2 8.3
40657481 Zoledronate 8.8 7.7
40515539 Zoledronate 3.5 3
40538685 Zoledronate 6.9 3
40654686 Zoledronate 10.8 9.4
40717829 Zoledronate 3.8 6.4
40852097 Zoledronate 8.6 6.6
40039744 Zoledronate 3.9 3.4
40707244 Zoledronate 4.9 6.1
41470610 Zoledronate 14.3 16.3
40518830 Zoledronate 6.5 8.5
40760553 Zoledronate 10.6 10.7
40807909 Zoledronate 4 10.5
40939779 Zoledronate 6.4 6
40995625 Zoledronate 5.6 7.2
40657539 Zoledronate 5.3 4.8
40081010 Zoledronate 5.4 6.6
41310000 Zoledronate 4 4.8
40080444 Zoledronate 5.1 5.7
40202834 Zoledronate 4.8 5
40537818 Zoledronate 4.2 4.6
40667986 Zoledronate 7.4 9.7
40310162 Zoledronate 3.5 2.2
40665769 Zoledronate 7.3 6.2
40885805 Zoledronate 5.5 5.1
41437980 Zoledronate 4.3 4.5
40668474 Zoledronate 4.1 5.9
41337660 Zoledronate 13.9 27.4
40693816 Zoledronate 3.6 12.1
40756877 Zoledronate 3.1 4.8
40244375 Zoledronate 6.3 5
41165304 Zoledronate 4 3.39
41078803 Zoledronate 7 9.5
40140579 Zoledronate 1.8 3.2
40054846 Zoledronate 10.4 8.6
40355845 Zoledronate 7.7 5.7
40413387 Zoledronate 11.1 15.9
40161499 Zoledronate 6.9 9.2
40125793 Zoledronate 7.3 8.3
41156712 Zoledronate 12 7.3
40089609 Zoledronate 4.4 4.1
40533981 Zoledronate 4.5 8.2
41010975 Zoledronate 14.6 14.9
41535922 Zoledronate 10.5 12.5
40045842 Zoledronate 9.9 10.8
40235507 Zoledronate 15 15
41543112 Zoledronate 7.9 3.7
40219154 Zoledronate 3.3 5.6
40184022 Zoledronate 6.2 14.7
40128847 Zoledronate 8.5 9
40941263 Zoledronate 6 10.6
40481025 Zoledronate 11.3 16.7
40047169 Zoledronate 4.9 4.1
41181192 Zoledronate 7.5 6.1
40532955 Zoledronate 4.9 4.8
40742760 Zoledronate 5.8 5.4
40468374 Zoledronate 6.6 5.8
41565527 Zoledronate 8.3 6.8
0.0796770388374343
Hospital n Rx PTH post Rx #1 PTH post Rx #2 T-test post dose 1 vs 2
41161480 Denosumab 4.5 12.2 0.067755
41303734 Denosumab 2.8 3.7
40488869 Denosumab 5.3 4.6
41068119 Denosumab 7.8 8.8
40907939 Denosumab 8.2 6.5
40931890 Denosumab 3.4 4.7
40457779 Denosumab 6 4.5
40000045 Denosumab 5.1 12.3
41007187 Denosumab 4.9 6.3
40866371 Denosumab 16.8 12.4
40523262 Denosumab 6.4 7.8
41061509 Denosumab 5 4.6
40788170 Denosumab 5.8 7.2
40648546 Zoledronate 4.2 6.1
40821864 Zoledronate 5.6 8.4
40953385 Zoledronate 5.5 6.6
40316919 Zoledronate 9.2 6.7
40874800 Zoledronate 6 5.6
41470610 Zoledronate 16.3 10
40657539 Zoledronate 4.8 4.2
40081010 Zoledronate 6.6 9.7
41310000 Zoledronate 4.8 6.7
40667986 Zoledronate 9.7 10
40310162 Zoledronate 2.2 4.1
40665769 Zoledronate 6.2 6.3
40826375 Zoledronate 2.4 1.8
41165304 Zoledronate 3.39 3.5
40140579 Zoledronate 3.2 4.4
40194752 Zoledronate 3.2 2.2
40066444 Zoledronate 6.6 6.2
40413387 Zoledronate 15.9 20.4
40125793 Zoledronate 8.3 6.2
40089609 Zoledronate 4.1 3.4
40124042 Zoledronate 6 9.5
40173836 Zoledronate 4.4 6
41010975 Zoledronate 14.9 16.7
40235507 Zoledronate 15 15.2
41460344 Denosumab 5.1 5.5
40030669 Denosumab 6.3 7.1
40077111 Denosumab 3.2 6.9
41511998 Denosumab 6.9 7.6
40001986 Denosumab 6.6 7.7
40197652 Denosumab 5.4 9
40080379​  Denosumab 6.9 6.7
40423782 Denosumab 10.3 4.1
40031516 Denosumab 4.9 5.4
40329003 Denosumab 5.3 9.8
40013371 Denosumab 3.7 4.2

48

Baseline post-dose 2 T-test baseline vs post dose 2

41161480 Denosumab 8.8 12.2 0.012224
41446832 Denosumab 7.5 6.2
41303734 Denosumab 2.9 3.7
40488869 Denosumab 5.1 4.6
40467527 Denosumab 6.2 4.5
41068119 Denosumab 4.7 8.8
40907939 Denosumab 10.3 6.5
40854975 Denosumab 8.8 8.8
40931890 Denosumab 4.3 4.7
40457779 Denosumab 6.1 4.5
40000045 Denosumab 9.5 12.3
41025627 Denosumab 3.1 4.7
41007187 Denosumab 4.9 6.3
40815863 Denosumab 5.8 7.9
40866371 Denosumab 12.4 12.4
40523262 Denosumab 9 7.8
41061509 Denosumab 6.3 4.6
40788170 Denosumab 9.9 7.2
40124148 Zoledronate 10.2 11.3
40648546 Zoledronate 6.4 6.1
40498709 Zoledronate 7 11.9
40821864 Zoledronate 6.2 8.4
40917225 Zoledronate 4.3 2.1
40953385 Zoledronate 5.1 6.6
40316919 Zoledronate 6.6 6.7
40874800 Zoledronate 5.1 5.6
40657481 Zoledronate 8.8 12.8
40654686 Zoledronate 10.8 8.1
41470610 Zoledronate 14.3 10
41255409 Zoledronate 11.8 11.3
40657539 Zoledronate 5.3 4.2
40081010 Zoledronate 5.4 9.7
41310000 Zoledronate 4 6.7
40667986 Zoledronate 7.4 10
40310162 Zoledronate 3.5 4.1
40665769 Zoledronate 7.3 6.3
40901264 Zoledronate 6.1 8.6
40117841 Zoledronate 7.3 10
40069233 Zoledronate 3.7 5.4
41224321 Zoledronate 4.8 8.8
40043550 Zoledronate 4.7 6.6
41165304 Zoledronate 4 3.5
40140579 Zoledronate 1.8 4.4
40413387 Zoledronate 11.1 20.4
40400906 Zoledronate 14.6 13.8
40089609 Zoledronate 4.4 3.4
40259848 Zoledronate 13 12.1
41010975 Zoledronate 14.6 16.7
40070115 Zoledronate 17.2 16.2
40235507 Zoledronate 15 15.2
41460344 Denosumab 6.6 5.5
41703079 Denosumab 5 5
40281902 Denosumab 8.8 9.3
40030669 Denosumab 8.2 7.1
40222731 Denosumab 6.3 8.9
40077111 Denosumab 3.2 6.9
41511998 Denosumab 7.5 7.6
40197652 Denosumab 7.9 9
40329003 Denosumab 4.5 9.8

59 7.3796610169492 8.2
Hospital n Rx PTH post RPTH post Rx #2
41161480 Denosuma 4.5 12.2
41303734 Denosuma 2.8 3.7
40488869 Denosuma 5.3 4.6
41068119 Denosuma 7.8 8.8
40907939 Denosuma 8.2 6.5
40931890 Denosuma 3.4 4.7
40457779 Denosuma 6 4.5
40000045 Denosuma 5.1 12.3
41007187 Denosuma 4.9 6.3
40866371 Denosuma 16.8 12.4
40523262 Denosuma 6.4 7.8
41061509 Denosuma 5 4.6
40788170 Denosuma 5.8 7.2
41460344 Denosuma 5.1 5.5
40030669 Denosuma 6.3 7.1
40077111 Denosuma 3.2 6.9
41511998 Denosuma 6.9 7.6
40001986 Denosuma 6.6 7.7
40197652 Denosuma 5.4 9
40080379​  Denosuma 6.9 6.7
40423782 Denosuma 10.3 4.1
40031516 Denosuma 4.9 5.4
40329003 Denosuma 5.3 9.8
40013371 Denosuma 3.7 4.2
0.13566

40648546 Zoledronat 4.2 6.1

40821864 Zoledronat 5.6 8.4
40953385 Zoledronat 5.5 6.6
40316919 Zoledronat 9.2 6.7
40874800 Zoledronat 6 5.6
41470610 Zoledronat 16.3 10
40657539 Zoledronat 4.8 4.2
40081010 Zoledronat 6.6 9.7
41310000 Zoledronat 4.8 6.7
40667986 Zoledronat 9.7 10
40310162 Zoledronat 2.2 4.1
40665769 Zoledronat 6.2 6.3
40826375 Zoledronat 2.4 1.8
41165304 Zoledronat 3.39 3.5
40140579 Zoledronat 3.2 4.4
40194752 Zoledronat 3.2 2.2
 40066444 Zoledronat 6.6 6.2
40413387 Zoledronat 15.9 20.4
40125793 Zoledronat 8.3 6.2
40089609 Zoledronat 4.1 3.4
40124042 Zoledronat 6 9.5
40173836 Zoledronat 4.4 6
41010975 Zoledronat 14.9 16.7
40235507 Zoledronat 15 15.2
0.312178

Hosp no Rx Baseline post-dose 2

41161480 Denosuma 8.8 12.2
41446832 Denosuma 7.5 6.2
41303734 Denosuma 2.9 3.7
40488869 Denosuma 5.1 4.6
40467527 Denosuma 6.2 4.5
41068119 Denosuma 4.7 8.8
40907939 Denosuma 10.3 6.5
40854975 Denosuma 8.8 8.8
40931890 Denosuma 4.3 4.7
40457779 Denosuma 6.1 4.5
40000045 Denosuma 9.5 12.3
41025627 Denosuma 3.1 4.7
41007187 Denosuma 4.9 6.3
40815863 Denosuma 5.8 7.9
40866371 Denosuma 12.4 12.4
40523262 Denosuma 9 7.8
41061509 Denosuma 6.3 4.6
40788170 Denosuma 9.9 7.2
41460344 Denosuma 6.6 5.5
41703079 Denosuma 5 5
40281902 Denosuma 8.8 9.3
40030669 Denosuma 8.2 7.1
40222731 Denosuma 6.3 8.9
40077111 Denosuma 3.2 6.9
41511998 Denosuma 7.5 7.6
40197652 Denosuma 7.9 9
40329003 Denosuma 4.5 9.8
0.257841

40124148 Zoledronat 10.2 11.3

40648546 Zoledronat 6.4 6.1
40498709 Zoledronat 7 11.9
40821864 Zoledronat 6.2 8.4
40917225 Zoledronat 4.3 2.1
40953385 Zoledronat 5.1 6.6
40316919 Zoledronat 6.6 6.7
40874800 Zoledronat 5.1 5.6
40657481 Zoledronat 8.8 12.8
40654686 Zoledronat 10.8 8.1
41470610 Zoledronat 14.3 10
41255409 Zoledronat 11.8 11.3
40657539 Zoledronat 5.3 4.2
40081010 Zoledronat 5.4 9.7
41310000 Zoledronat 4 6.7
40667986 Zoledronat 7.4 10
40310162 Zoledronat 3.5 4.1
40665769 Zoledronat 7.3 6.3
40901264 Zoledronat 6.1 8.6
40117841 Zoledronat 7.3 10
40069233 Zoledronat 3.7 5.4
41224321 Zoledronat 4.8 8.8
40043550 Zoledronat 4.7 6.6
41165304 Zoledronat 4 3.5
40140579 Zoledronat 1.8 4.4
40413387 Zoledronat 11.1 20.4
40400906 Zoledronat 14.6 13.8
40089609 Zoledronat 4.4 3.4
40259848 Zoledronat 13 12.1
41010975 Zoledronat 14.6 16.7
40070115 Zoledronat 17.2 16.2
40235507 Zoledronat 15 15.2
0.024089
7.86875
Hospital n Rx PTH post Rx #2 PTH post Rx #3 T-test post dose 2 vs 3
41446832 Denosumab 6.2 12 0.24839
41303734 Denosumab 3.7 2.8
40907939 Denosumab 6.5 8.2
40854975 Denosumab 8.8 9
40457779 Denosumab 4.5 10.1
40000045 Denosumab 12.3 12.9
40901264 Zoledronate 8.6 5.5
41460344 Denosumab 5.5 10.2
41703079 Denosumab 5 3
40030669 Denosumab 7.1 13.2
40222731 Denosumab 8.9 6.1
40017705 Denosumab 3.8 2.9
41511998 Denosumab 7.6 7.3
40001986 Denosumab 7.7 7.6

14

baseline post dose 3 T-test baseline vs post dose 3

41446832 Denosumab 7.5 12 0.113851
41303734 Denosumab 2.9 2.8
40907939 Denosumab 10.3 8.2
40854975 Denosumab 8.8 9
40457779 Denosumab 6.1 10.1
40000045 Denosumab 9.5 12.9
40901264 Zoledronate 6.1 5.5
41460344 Denosumab 6.6 10.2
41703079 Denosumab 5 3
40030669 Denosumab 8.2 13.2
40222731 Denosumab 6.3 6.1
41511998 Denosumab 7.5 7.3

12
Hospital n Rx PTH post Rx #3 PTH post Rx #4 T-test post Rx 3 vs 4
41446832 Denosumab 12 3.7 0.107924
41303734 Denosumab 2.8 2.7
40907939 Denosumab 8.2 7.8
40000045 Denosumab 12.9 8.2
40222731 Denosumab 6.1 4.7
40001986 Denosumab 7.6 6.9
Hospital n Rx PTH post Rx #4 PTH post Rx #5
40815863 Denosumab 5.1 4.1
40013371 Denosumab 2.8 4.8

Too few fior T test, same for dose 5 vs 6 - 2 pts only