waktu (jam) kadar obat b.e C res 1 A.

e C res 2
0.1 4.7 41.2 -36.5 104 140.5
0.3 13.2 40.9 -27.7 101 128.7
0.5 20.8 40.6 -19.8 98.2 118
1 36.3 40 -3.7 91.5 95.2
2.5 61.4 38 23.4 74 50.6
5 68.1 35 33.1 51.9
7.5 61.1 32.2 28.9 36.5
10 52.1 29.7 22.4 25.6
15 37.3 25.2 12.1
20 27.5 21.3 6.2
25 21.1 18.1 3
30 16.9 15.4 1.5
40 11.4
50 8.2
60 5.9

waktu(Jam) Ln C res 1(mg/L)

15 12.1
20 6.2
25 3
30 1.5

waktu(jam) Ln Cres 2(mg/L)

0.1 140.5 Ka = 0.40 jam
0.3 128.7 Inter sep C = 146.3 mg/L
0.5 118 Kadar obat pada t = 0.1 jam adalah 41.2 mg/L
1 95.2 T1/2 Absorbsi = 0.693/0.40 = 1.73 jam
 2.5 50.6

persamaan model 2-kompartmen

dari data di atas : Ka>α>β

Nilai AUC (t = 0 sampai (t=∞)

waktu (jam) kadar obat AUC (mg.jam/L)

0 0 0
0.1 4.7 0.235
0.3 13.2 1.79
0.5 20.8 3.4
1 36.3 14.275
2.5 61.4 73.275
5 68.1 161.875
7.5 61.1 161.5
10 52.1 141.5
15 37.3 223.5
20 27.5 162
25 21.1 473.1
30 16.9 95
40 11.4 141.5
50 8.2 98
60 5.9 70.5
∞ 178.9
AUC total 1648.64

kadar obat C70 = 4.10 mg/L Vd area = 7.58 L

% Obat yang tersisa dalam tubuh =

 kadar obat
80
70
60
50
40
30
20
10
0
0 10 20 30 40 50 60 70

Chart Title
12
10 f(x) = 42.5587637797337 exp( − 0.0329330502244388 x )
R² = 0.99999993204362
8
6
4
2
0
35 40 45 50 55 60 65

Ln C res 1(mg/L)
14
12
f(x) = 99.5419488646634 exp( − 0.139783160737331 x )
10 R² = 0.999772576707831 Ln C res 1(mg/L)
8 Exponential (Ln C res
1(mg/L))
6
4
2
0
14 16 18 20 22 24 26 28 30 32

Ln Cres 2(mg/L)
160
140
f(x) = 146.138357100707 exp( − 0.424877585407378 x )
120 R² = 0.999958001143601
100
80
60
40
20
0
0 0.5 1 1.5 2 2.5 3
 80
60
40
20
0
0 0.5 1 1.5 2 2.5 3

nama: intan permata sari

nim: 2048201031