FARMAKOLOGI DAN

TOKSIKOLOGI

ANIEK SETIYA BUDIATIN

DEPARTEMEN FARMASI PRAKTIS
FAKULTAS FARMASI UNIVERSITAS AIRLANGGA
1.OSTEOPOROSIS (OP)
2.OSTEOARHTRITIS (OA)
3.RHEUMATIC (RA)
4.GOUT
Reference
1. Michael J. Neal-Medical Pharmacology at a Glance-Wiley (2016)
2. Bertram G Katzung, Basic and Clinical Pharmacology 15th Edition pdf
3. Aniek Setiya Budiatin, Muhammad Zainuddin, Junaidi Khotib. 2014.
Biocompatable Composite as Gentamicin delivery System for
Osteomyelitis and Bone Regeneration. International Journal Of
Pharmacy and Pharmaceutical Sciences. Vol 6, Issue3.,223-226
4. Heinz Luellmann, Klaus Mohr, Lutz Hein - Color Atlas of Pharmacology-
Georg Thieme Verlag (2018)
 Human Anatomy
Function of bone tissue :
- Support soft tissue and provides
attachment for skeletal muscle.
- Protect internal organ.
- Asssist in movement together
with skeletal muscle
- Store and release mineral
- Contain red bone marrow which
produce blood cell.
The structure of synovial join
 BONE
 Extracellular Matrix :

Anorganic compound(mineralHA) 50%;

organic (proteincolagen/gelatin)25 %,
water 25%
 Cell:

Osteoprogenitor  osteoblast
Osteoblast (Bone formation)
Osteoclast (bone resorption)
Osteocyte
Homeostasis Calsium

CT=Calcitonin; DBP =Vit D

Binding Protein

HA=hydroxyapatite
Ca10(PO4)6(OH)2
 OSTEOPOROSIS (OP)
1. Kelainan
multifactorial dengan kepadatan
tulang rendah (low bone mass) dan
meningkatnya fragilitas skeletal.
2. Banyak dialami oleh wanita lansia
(Estrogen <<; PTH >>)
3. Dapatdisebabkan oleh penggunaan obat
golongan glukokortikoid dalam jangka
panjang, kelainan GIT, RA, liver, ginjal,
myeloma
OSTEOPOROSIS

T-score between
-1 and -2.5

T-score <-3.5
T-score <- 2.5

T score merupakan standar dari WHO adalah perbandingan

bone density pasien dengan bone density puncak rata rata
dewasa normal dari populasi
 1. Osteoclast 
creates an acidic
milieu enabling
minerals to
solubilized
+phagocytoses the
organic matrix
2. After a certain
amount of bone
mass has been
broken down,
osteoblast take
1. Osteoblast  RANKL over bone
2. RANK - Osteoclast progenitor formation
Osteoclast
3. PTH  actvation Osteoclast
4. OB OPG
5. Estrogen  increase OPG FPPS=farnesyl pyrophosphatesynthase
inactivation Osteoclast
Estradiol (ERT/HRT) + Progestin  menurunkan
endometriosis Cancer
Cinacalcet (Calsium sensing Receptor, inh PTH)
Golongan bifosfonaf

Ca10(PO4)6(OH)2
HA

FPPS=farnesyl pyrophosphatesynthase
vsbv
Osteoarthritis
Cartilage:
Extracellular matrix Compound :
• Water ; collagens; Protein; proteoglycans ( Glycosaminoglycan:
Chondroitin Sulfat; Keratan Sulfat; Dermatan Sulfat)
Cellulair : chondrocytes Osteoarthritis (OA) is a long-term chronic
disease characterized by the deterioration
of cartilage in joints which results in bones
rubbing together and creating stiffness,
pain, and impaired movement. Treatment
can help, but this condition can't be cured
Treatment :
1. PO: Glucosamine; NSAID; tramadol,
opioid; Diacerein
2. Injection:Corticosteroid
(Triamcinolone); Hyaluronic
3. Topical agent: Cream Diclofenak,
Glucosamine/Chondroitin, Capsaicin
4. ImplantasionCartilage (from Bovine
cartilage; cartilage from other place)
or Scaffold : Chitosan; chondroitin;
Collagen; Gelatin + NSAID
Rheumatoid Arthritis
Rheumatoid
NSAIDs
Gout (Hiperuresemia)
 PMN=polymorphonuclear
MNP=mononuclear phagocyt
Gout therapy
TERIMAKASIH