‘equation. by are the relative, 2 1H1PO,- ble pai s 6.8. What oO a a hp impede ape poy Heo, Pi = tog HO 48-68 +1og HPO" 4PQ,' For this buffer pair, HPO,-? is A~ and 1,20, Thus, the Henderson—Hasselbaleh equation can be used to calculate that the cr >» Of HPO, is 100 times that of HPO, in a.urine sample of pH. 4. Titration curves (Figure 5-18) = describe how the pH of a buffered soli. je 69 HY fons are added to itor removed from it. A ihe A Penate cided tothe solution, the HA form is produced; as Hviona are removed, the A~ form is produced. A buffer is most effective inthe lin removal of H* portion of the titration curve, where the addition oF in pH. when the pH of the solution equals:Tiere ee es = ee To pa 1 In metabolic acidosis, the serum (HCO, dec is depleted in buffering fixed acid For electroneutrality, the concentration of another anion must increas® to replace HCO; That anion can be Cr-or it can be an unmeasured anion. (1) The serum snion gop is increased if the concentration of an unmeasured anio® He, Picephate lctat, f-hydrenybutyrate, and formate) is increased to replace (2) The serum anion gap is normal if the concentration of Cl- is increased to replace HCO, (hyperchloremic metabolic acidosis) 2 Metabolic. 4. Loss of fixed H’ or gain of base produces a decrease in arterial [H*] (alkalemie). ', As aresult, arterial [HCO;;] increases. This increase is the primary disturbance. = For example, in vomiting, H* is lost from Fi inthe See from the stomach, HCO, remains behind in