Critical Care >Principles of Neurosciences Critical Care

John M. Oropello, Stephen M. Pastores, Vladimir Kvetan+

Table 48A–1GPhysical findings in drug-induced coma.

Drug class Pupils Other changes

Opioids Miotic Hypopnea/apneic

Barbiturates and benzodiazepines Reactive Hypopnea, mild hypotension

Anticholinergics (scopolamine, etc) Mydriasis Tachycardia, seizures

Bradycardia, sweating, salivation, lacrimation, diarrhea, vomiting,

Anticholinesterases (organophosphates) Miotic
urination

Cocaine and amphetamine Mydriasis Tachycardia, hypertension, hypotension, arrhythmia

Neuroleptics Variable Motor rigidity, hypotension, hyperthermia

Antidepressants Mydriasis Rarely seizure

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