SwissTargetPrediction

Target Common Uniprot ChEMBL ID Target Class Probability* Known

name ID actives
(3D/2D)
Cytochrome P450 CYP11B1 P15538 CHEMBL1908 Cytochrome 0.0978745343258 228 / 0     
11B1 P450
Cytochrome P450 CYP11B2 P19099 CHEMBL2722 Cytochrome 0.0978745343258 263 / 0     
11B2 P450
Geranylgeranyl PGGT1B P53609 CHEMBL2095164 Enzyme 0.0978745343258 45 / 0     
transferase type I FNTA P49354
Cyclooxygenase-2 PTGS2 P35354 CHEMBL230 Oxidoreductase 0.0978745343258 343 / 0     
(by homology)
Cyclin-dependent CDK5R1 Q15078 CHEMBL1907600 Kinase 0.0978745343258 37 / 0     
kinase 5/CDK5 CDK5 Q00535
activator 1
Cyclin-dependent CCNB3 Q8WWL7 CHEMBL2094127 Other cytosolic 0.0978745343258 33 / 0     
kinase 1/cyclin B CDK1 P06493 protein
CCNB1 P14635
CCNB2 O95067
Glycogen synthase GSK3B P49841 CHEMBL262 Kinase 0.0978745343258 103 / 0     
kinase-3 beta
11-beta- HSD11B1 P28845 CHEMBL4235 Enzyme 0.0978745343258 251 / 0     
hydroxysteroid
dehydrogenase 1
Protein FNTA P49354 CHEMBL2094108 Enzyme 0.0978745343258 147 / 0     
farnesyltransferase FNTB P49356
Carbonic anhydrase I CA1 P00915 CHEMBL261 Lyase 0.0978745343258 224 / 0     
Serotonin 2b (5- HTR2B P41595 CHEMBL1833 Family A G 0.0978745343258 44 / 0     
HT2b) receptor protein-coupled
receptor
Serotonin 2a (5- HTR2A P28223 CHEMBL224 Family A G 0.0978745343258 88 / 0     
HT2a) receptor protein-coupled
receptor
Serotonin 2c (5- HTR2C P28335 CHEMBL225 Family A G 0.0978745343258 103 / 0     
HT2c) receptor protein-coupled
receptor
Glycine transporter 1 SLC6A9 P48067 CHEMBL2337 Electrochemical 0.0978745343258 27 / 0     
(by homology) transporter
Muscarinic CHRM2 P08172 CHEMBL211 Family A G 0.0978745343258 24 / 0     
acetylcholine protein-coupled
receptor M2 (by receptor
homology)
Muscarinic CHRM1 P11229 CHEMBL216 Family A G 0.0978745343258 19 / 0     
acetylcholine protein-coupled
receptor M1 (by receptor
homology)
Muscarinic CHRM3 P20309 CHEMBL245 Family A G 0.0978745343258 21 / 0     
acetylcholine protein-coupled
receptor M3 (by receptor
homology)
Metabotropic GRM5 P41594 CHEMBL3227 Family C G 0.0978745343258 258 / 0     
glutamate receptor 5 protein-coupled
(by homology) receptor
LXR-alpha NR1H3 Q13133 CHEMBL2808 Nuclear receptor 0.0978745343258 17 / 0     
LXR-beta NR1H2 P55055 CHEMBL4093 Nuclear receptor 0.0978745343258 18 / 0     
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
Carbonic anhydrase II CA2 P00918 CHEMBL205 Lyase 0.0978745343258 300 / 0     
PI3-kinase p110- PIK3CD O00329 CHEMBL2111432 Enzyme 0.0978745343258 4 / 0     
delta/p85-alpha PIK3R1 P27986
Carbonic anhydrase CA4 P22748 CHEMBL3729 Lyase 0.0978745343258 20 / 0     
IV
Cytochrome P450 CYP2A6 P11509 CHEMBL5282 Cytochrome 0.0978745343258 1 / 0     
2A6 P450
Monoamine oxidase MAOA P21397 CHEMBL1951 Oxidoreductase 0.0978745343258 132 / 0     
A
Acetylcholinesterase ACHE P22303 CHEMBL220 Hydrolase 0.0978745343258 68 / 0     
Cathepsin K CTSK P43235 CHEMBL268 Protease 0.0978745343258 61 / 0     
Cytochrome P450 CYP2C19 P33261 CHEMBL3622 Cytochrome 0.0978745343258 15 / 0     
2C19 P450
Serotonin 6 (5-HT6) HTR6 P50406 CHEMBL3371 Family A G 0.0978745343258 35 / 0     
receptor protein-coupled
receptor
P2X purinoceptor 7 P2RX7 Q99572 CHEMBL4805 Ligand-gated 0.0978745343258 126 / 0     
ion channel
Cytochrome P450 CYP19A1 P11511 CHEMBL1978 Cytochrome 0.0978745343258 277 / 0     
19A1 P450
Aldo-keto-reductase AKR1C3 P42330 CHEMBL4681 Enzyme 0.0978745343258 16 / 0     
family 1 member C3
Cathepsin S CTSS P25774 CHEMBL2954 Protease 0.0978745343258 58 / 0     
Heat shock protein HSP90AA1 P07900 CHEMBL3880 Other cytosolic 0.0978745343258 14 / 0     
HSP 90-alpha protein
Leucine-rich repeat LRRK2 Q5S007 CHEMBL1075104 Kinase 0.0978745343258 16 / 0     
serine/threonine-
protein kinase 2
Transitional VCP P55072 CHEMBL1075145 Primary active 0.0978745343258 8 / 0     
endoplasmic transporter
reticulum ATPase
Epoxide hydrolase 1 EPHX1 P07099 CHEMBL1968 Protease 0.0978745343258 44 / 0     
Receptor protein- ERBB2 P04626 CHEMBL1824 Kinase 0.0978745343258 46 / 0     
tyrosine kinase
erbB-2
Epidermal growth EGFR P00533 CHEMBL203 Kinase 0.0978745343258 201 / 0     
factor receptor erbB1
Arachidonate 5- ALOX5 P09917 CHEMBL215 Oxidoreductase 0.0978745343258 32 / 0     
lipoxygenase
Anandamide FAAH O00519 CHEMBL2243 Enzyme 0.0978745343258 71 / 0     
amidohydrolase
Monoglyceride lipase MGLL Q99685 CHEMBL4191 Enzyme 0.0978745343258 42 / 0     
Androgen Receptor AR P10275 CHEMBL1871 Nuclear receptor 0.0978745343258 79 / 0     
Thromboxane A2 TBXA2R P21731 CHEMBL2069 Family A G 0.0978745343258 13 / 0     
receptor protein-coupled
receptor
Dopamine D2 DRD2 P14416 CHEMBL217 Family A G 0.0978745343258 40 / 0     
receptor protein-coupled
receptor
Histamine H3 HRH3 Q9Y5N1 CHEMBL264 Family A G 0.0978745343258 100 / 0     
receptor protein-coupled
receptor
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
Monoamine oxidase MAOB P27338 CHEMBL2039 Oxidoreductase 0.0 246 / 0     
B
Metabotropic GRM1 Q13255 CHEMBL3772 Family C G 0.0 49 / 0     
glutamate receptor 1 protein-coupled
receptor
Neuropeptide Y NPY5R Q15761 CHEMBL4561 Family A G 0.0 129 / 0     
receptor type 5 protein-coupled
receptor
Heme oxygenase 1 HMOX1 P09601 CHEMBL2823 Enzyme 0.0 7 / 0     
(by homology)
Tyrosine-protein FLT3 P36888 CHEMBL1974 Kinase 0.0 28 / 0     
kinase receptor FLT3
Cannabinoid receptor CNR1 P21554 CHEMBL218 Family A G 0.0 252 / 0     
1 protein-coupled
receptor
Cannabinoid receptor CNR2 P34972 CHEMBL253 Family A G 0.0 227 / 0     
2 protein-coupled
receptor
Multidrug resistance- ABCC1 P33527 CHEMBL3004 Primary active 0.0 7 / 0     
associated protein 1 transporter
ATP-binding cassette ABCG2 Q9UNQ0 CHEMBL5393 Primary active 0.0 14 / 0     
sub-family G member transporter
2
5-lipoxygenase ALOX5AP P20292 CHEMBL4550 Other cytosolic 0.0 88 / 0     
activating protein protein
Trace amine- TAAR1 Q96RJ0 CHEMBL5857 Family A G 0.0 44 / 0     
associated receptor 1 protein-coupled
(by homology) receptor
Melatonin receptor MTNR1A P48039 CHEMBL1945 Family A G 0.0 233 / 0     
1A protein-coupled
receptor
Melatonin receptor MTNR1B P49286 CHEMBL1946 Family A G 0.0 203 / 0     
1B protein-coupled
receptor
Glutamate [NMDA] GRIN2B Q13224 CHEMBL1904 Ligand-gated 0.0 7 / 0     
receptor subunit ion channel
epsilon 2
LDL-associated PLA2G7 Q13093 CHEMBL3514 Enzyme 0.0 11 / 0     
phospholipase A2
Fibroblast growth FGFR1 P11362 CHEMBL3650 Kinase 0.0 14 / 0     
factor receptor 1
Smoothened SMO Q99835 CHEMBL5971 Frizzled family G 0.0 35 / 0     
homolog protein-coupled
receptor
Thromboxane-A TBXAS1 P24557 CHEMBL1835 Cytochrome 0.0 18 / 0     
synthase P450
Progesterone PGR P06401 CHEMBL208 Nuclear receptor 0.0 168 / 0     
receptor
Adenosine A1 ADORA1 P30542 CHEMBL226 Family A G 0.0 128 / 0     
receptor (by protein-coupled
homology) receptor
Matrix MMP13 P45452 CHEMBL280 Protease 0.0 24 / 0     
metalloproteinase 13
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
Glutamate receptor GRIA4 P48058 CHEMBL3190 Ligand-gated 0.0 4 / 0     
ionotropic, AMPA 4 ion channel
Matrix MMP9 P14780 CHEMBL321 Protease 0.0 17 / 0     
metalloproteinase 9
Matrix MMP2 P08253 CHEMBL333 Protease 0.0 19 / 0     
metalloproteinase 2
ADAM17 ADAM17 P78536 CHEMBL3706 Protease 0.0 10 / 0     
Glutaminyl-peptide QPCT Q16769 CHEMBL4508 Enzyme 0.0 68 / 0     
cyclotransferase
Matrix MMP8 P22894 CHEMBL4588 Protease 0.0 9 / 0     
metalloproteinase 8
Diacylglycerol O- DGAT1 O75907 CHEMBL6009 Enzyme 0.0 11 / 0     
acyltransferase 1
Vascular endothelial KDR P35968 CHEMBL279 Kinase 0.0 227 / 0     
growth factor
receptor 2
Cytochrome P450 CYP17A1 P05093 CHEMBL3522 Cytochrome 0.0 156 / 0     
17A1 (by homology) P450
Tyrosine-protein ABL1 P00519 CHEMBL1862 Kinase 0.0 70 / 0     
kinase ABL
Isocitrate IDH1 O75874 CHEMBL2007625 Enzyme 0.0 49 / 0     
dehydrogenase
[NADP] cytoplasmic
Monoacylglycerol ABHD6 Q9BV23 CHEMBL2189127 Enzyme 0.0 2 / 0     
lipase ABHD6
Lymphocyte CD38 P28907 CHEMBL4660 Enzyme 0.0 31 / 0     
differentiation
antigen CD38
Inhibitor of nuclear IKBKB O14920 CHEMBL1991 Kinase 0.0 29 / 0     
factor kappa B kinase
beta subunit
Inhibitor of NF-kappa- CHUK O15111 CHEMBL3476 Kinase 0.0 19 / 0     
B kinase (IKK)
Alpha-2a adrenergic ADRA2A P08913 CHEMBL1867 Family A G 0.0 8 / 0     
receptor protein-coupled
receptor
Serine/threonine- RAF1 P04049 CHEMBL1906 Kinase 0.0 14 / 0     
protein kinase RAF
Thyroid hormone THRB P10828 CHEMBL1947 Nuclear receptor 0.0 9 / 0     
receptor beta-1
Norepinephrine SLC6A2 P23975 CHEMBL222 Electrochemical 0.0 3 / 0     
transporter transporter
Serotonin transporter SLC6A4 P31645 CHEMBL228 Electrochemical 0.0 9 / 0     
transporter
Dual-specificity DYRK1A Q13627 CHEMBL2292 Kinase 0.0 53 / 0     
tyrosine-
phosphorylation
regulated kinase 1A
Cytochrome P450 CYP1A2 P05177 CHEMBL3356 Cytochrome 0.0 8 / 0     
1A2 P450
Carbonic anhydrase CA9 Q16790 CHEMBL3594 Lyase 0.0 232 / 0     
IX
Histamine H4 HRH4 Q9H3N8 CHEMBL3759 Family A G 0.0 59 / 0     
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
receptor protein-coupled
receptor
Cathepsin L CTSL P07711 CHEMBL3837 Protease 0.0 45 / 0     
Muscarinic CHRM4 P08173 CHEMBL1821 Family A G 0.0 12 / 0     
acetylcholine protein-coupled
receptor M4 receptor
Muscarinic CHRM5 P08912 CHEMBL2035 Family A G 0.0 7 / 0     
acetylcholine protein-coupled
receptor M5 receptor
Bromodomain BAZ2B Q9UIF8 CHEMBL1741220 Reader 0.0 3 / 0     
adjacent to zinc
finger domain protein
2B
Kinesin-like protein KIF20A O95235 CHEMBL2021753 Other cytosolic 0.0 6 / 0     
KIF20A protein
MAP kinase p38 MAPK14 Q16539 CHEMBL260 Kinase 0.0 150 / 0     
alpha
Bromodomain BAZ2A Q9UIF9 CHEMBL3108642 Reader 0.0 2 / 0     
adjacent to zinc
finger domain protein
2A
Melanin- MCHR1 Q99705 CHEMBL344 Family A G 0.0 10 / 0     
concentrating protein-coupled
hormone receptor 1 receptor
Tyrosine-protein LCK P06239 CHEMBL258 Kinase 0.0 40 / 0     
kinase LCK