COMPLETE BLOOD COUNT

3 cell types : WBC, RBC and platelets

WBC 4.6 x10 4.6-11

RBC
-Hemoglobin
4.89 4.70-6.10

- Neutrophils -Hematocrit
- Lymphocytes
- Monocytes
- Eosinophils RBC
- Basophils -Most abundant cell in blood
Polymorphonuclear cells (PMNs) : Neutrophils, Eosinophils, Basophils -transportation in O2 and CO2 transportation
The nucleus is multilobed -cell membrane, filled with hemoglobin
-no nucleus
Neutrophils -Biconcave disc
- Part of PMNs
- Most abundant of WBCs in blood Polycythemia (increase RBC)
- major part in acute inflammation (specially bacterial infections) -Polycythemia vera :disease where our body produce too much RBC- problem in regulatin
of BM
Netrophilia (increase neutrophil) Neutropenia (decrease neutrophil) -High altitutde
-Acute bacterial infection -Folate/ b12 deficiency -congenital heart diseaes
-Acute stress -Aplastic anemia -COPD
-Burns -Chemotherapy
-Leukemia -Chloramphenicol/ Sulfonamides Anemia (decrease RBC)
-Steroid use -Aplastic anemia
-Rheumatoid Arthritis -Chronic renal failure
-Iron deficiency
-Pernicious anemia
-pregnancy
Eosinophil
-

Eosinophilia Eosinopenia HEMOGLOBIN

-Allergies -Nutritional deficiency - oxygen transport
-Parasitic infections -Glucocorticoids - >95% of the dry weight of RBCs
-Leukemia - Quaternary structure
-Polyateritis disease - 4 globular proteins : heme group & FE2+

Increase & decrease : SAME AS RBC

BASOPHIL
-very blue color HEMATOCRIT
-Participate in allergic symtomps -PACKED CELL VOLUME
-MEASURED IN PERCENTAGE
Basophilia Basopenia -Volumes % of RBCs in blood
-Allergic reactions -measured by centrifugation of blood cells
-CML
-Hodkin’s disease
- Oral contraceptive pills

MEAN CORPUSCULAR VOLUME

-average volume of the red blood cells
MONOCYTE - Hct = MCV
-Largest of the WBC RBC
-Chronic inflammation
-stored in spleen Macrocytosis (increase volume of RBC) Microcytosis (dec)
- very motile -Reticulocytosis -Iron deficiency
-What they do -Folate deficiency -Thalassemia
-Phagocytosis -B12 deficiency -Anemia of chronic disease
-helps T cells -Methotrexate -Hemolytic anemia
-cytokine production -Phenytoin -Hereditary Spherocytosis
-Lead poisoning
Monocytosis Monocytopenia
-Chronic inflammation state -Aplastic anemia
-stress -AML MEAN CORPUSCULAR HEMOGLOBIN
-cushing’s syndrome -Glucocorticoids -Average MASS of hemoglobin
-sarcoidosis -Myelotoxic drugs - Hbg = MCH
RBC

MCH increase MCH decrease

-alcoholism -Sideroblastic anemi
Three main types of lymphocytes : T,B, NK -B12 deficiency -Lead poisoning
-folate deficiency -Iron deficiency anemia
T cells - (mature in the thymus) -liver disease -Anemia of Chronic disease
1. Helper : help other cells mature and activate and function (through cytokine production) -hemochromatosis -Thalassemia
2. Cytotoxic : destroy cells infected with viruses
3. Memory : remember the antigens of past infections

B cells -(formed in the bone)

1. Plasma : produce large amounts of antibodies MEAN CORPUSULAR HEMOGLOBIN CONCENTRATION
2. Memory : remember past infections -concentration of Hgb in a given volume of RBCs
- hgb. = MCHC
NK cells - hcct
play a role similar to “Cytotoxic T cells”.. they kill virus-infected cells and tumor cells
Hyperchromic (increase) Hypochromicc (decr
-Hereditary spherocytosis -same as MCH
Lymphocytosis (increase) Lymphocytopenia (decrease) -hemolysis
-Viral infection -HIV - destroy T cells (CD4) -sickle cell disease
-Leukemia: CLL,, ALL -Glucocorticoids
-Adrenal insuficiency -Rheumatoid arthritis
-SLE
-Aplastic anemia RED CELL DISTRIBUTION WIDTH (RDW)
-The variation in RBC size or volume

INCREASE
-Anisocytosis
-Vit B12 def
-Folate def
-iron def
-Hemolytic anemia
-RBC fragmentation
-liver disease