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Crow’s feet
and Fine lines Droopy eyelid
Consumer seek safe products that can protect their eye contour, limiting
signs of fatigue, dark circles and
puffiness
44% 23%
of Thai consumers* would of UK women say their
like their diet to help eyes are their biggest
improve their eye health concern when it
comes to maintaining
their skin
Puffiness focus
Flavagrum ® instantly reduce bags thanks to
immediate tissue draining and free radical
scavenging
èNEW Seanactiv
Seanactiv
S E A N AC T I V
new bioactive using the power of
fucoidans to help decrease the signs of I n as few as 7 d ay s !
aging around the eye and help create a 2 Dark circles are reduced
healthier & fresher look.
3 1
Crow’s feet are fading
The eye contour looks
healthier & fresher
Seanactiv Agenda
Extremophile Superfood
Photosynthetic organisms that can grow under extreme
conditions and retain high concentrations of a wide variety of
health-sustaining ingredients
| Sources : Literature
consumers’ interests for algae
What are the main benefits of algae? In food? In fashion? What are the
properties for beauty?
What do people need/want/wish when it comes to skin?
Of skincare
launches in the High and growing interest of
last 12 months
with algae inside consumer for algae
â
Existing BASF solution from algae
Shadownyl Clear with Fucus Vesiculosus Extract
Slim-Excess with Hydrolyzed Rhodophycea Extract
Medicinal uses
Anti-cancer properties, enhance therapeutic effects of
conventional therapy for example, works on inflammation,
helping patient to reduce fatigue after chemotherapy,
boosting key immune cells.
| Sources : Literature
Seanactiv
Fucus vesiculosus algae
Criteria to s e l e c t s p e c i m e n s to be harvested
based on their size
Corresponding
Concentration approximately to
Separation & Filtration 20-36%
of fucose
~50%
Standardization in dry matter Of
fucoidan
~ 1.6
mol of
Characterization in fucoidan sulfate/mol
of fucose
Seanactiv FIGHT FIGHT
DARK CIRCLES SIGNS OF AGING
will act in
3-steps 1 2 3
to DARK CIRCLES CROW’S FEET V I TA L I T Y
REDUCER REMOVER ENHANCER
Q U I C K LY Boosting HO-1 enzyme for a Collagen I stimulation Even skin tone by reducing
lighter and healthier eye for a younger skin dullness, improving eye
contour area appearance luminosity
improve
the eye-
contour
area ä HO-1 ä COLLAGEN I ä SIRT-1
Conce
pt pro
of
FOCUS
Activit y of fucoidan
We have evaluated a standard pure
molecule of fucoidan on the 3 biomarkers
linked to eye contour improvement.
In vivo
In vitro
Application period
Clinical assessment
Panel inclusion 3 Parameters:
criteria - Dark circles
Evaluation of § 24 females / 18-65 years old - Crows’ feet wrinkles
Seanactiv § Crow’s Feet Wrinkles - Luminosity of the skin
efficacy on the 3 § Dark circles
proteins : Measurement points every day:
- HO-1 - Short period application (D1 to D7)
Test products - Long period application (D1 to D28)
- COL I § Placebo emulsion
- SIRT-1 § Emulsion with 1% Seanactiv Methodology:
At home, day-to-day image acquisition with connected
SkinCam Device measurements @ wake up, (before
morning product application).
Use of Skincam Imagery Device for at-home
Tracking Skin Daily Change
Tool of in vivo study
Multi-mode acquisition
Cross-polarized, standard acquisitions Using technologies
Skin measurement and innovations
2 cm diameter
HO-1
Heme oxygenase
Hemoglobin Heme
Blood vessel
Stimulation of HO -1 protein
Seanactiv
increases
the HO -1
protein by
+598%
Method: Application of a treatment on keratinocyte monolayers ; 72h treatment with Seanactiv or standard
molecule of fucoidan 0.001% (w/w); Measurement: HO-1 synthesis by Western blot
1. DARK CIRCLE REDUCER – In Vivo
Seanactiv demonstrates a fast decrease of Dark circle reduction of
dark circle color vs placebo - 8%
vs Pl from the first week
Seanactiv
helps to reduce
dark circle
discoloration
1. DARK CIRCLE REDUCER
Placebo
© BASF BCS © BASF BCS © BASF BCS
Seanactiv 1%
ä COLLAGEN I
Increase synthesis of Collagen
to improve crow's feet appearance
2. WRINKLE REMOVER – In Vitro The a
cti
Seana vity of
suppo ctiv is
richne r ted by it
ss in s
Seanactiv strongly stimulates Collagen I production fucoid
an
+485%
Seanactiv
helps to reduce
c r ow ’s fe e t
Placebo
© BASF BCS © BASF BCS © BASF BCS
Seanactiv 1%
SkinCam Representative
Images, Crow’s Feet – Parallel S ea na cti v s hows v i s i bl e benef i ts on crow’s feet reducti on
Polarized
from the first week of application and after
3. VITALITY ENHANCER
V I TA L I T Y
D u l l n e s s a n d t i r e d n e s s are linked to cell senescence, lack of cell ENHANCER
energy and lack of skin defense due to aging. A decrease of SIRT-1 could be one
factor making the eye appearing devitalized, lack of energy. Even skin tone by
reducing dullness,
improving eye luminosity
ä SIRT-1
S t i m ul at i ng S I RT-1 to rem ove epigenet ic m ar k
accumulations will help to decrease cell senescence
and to improve eye energy and luminosity
3. VITALITY ENHANCER – In Vitro The a
cti
Seana vity of
suppo ctiv is
richne r ted by it
ss in s
Seanactiv strongly stimulates the longevity protein fucoid
an
S I R T- 1 p r o d u c t i o n
+42%
Method: Application of a treatment on fibroblasts monolayers ; 24h treatment with Seanactiv ; Measurement: SIRT-1
synthesis with Sally Sue Western blot ;
Mitoc
hondr
produ ial ac
ction tiv
3. VITALITY ENHANCER – In Vitro to the a r e c l i t y a n d AT
to hel histone mo
p to m
osely
d
relate
d
P
a i n t a i i f i e r S I R T-
1
dynam n the cellu
Seanactiv strongly stimulates cellular dynamism ism lar
system
Seanactiv
Mitochondrial activity AT P p r o d u c t i o n Increases
mitochondrial activit y by
+138%
+ AT P P r o d u c t i o n o f
+258%
Method: Application of a treatment on fibroblasts monolayers ; 24h Method: Application of a treatment on fibroblasts monolayers ; 24h
treatment with Seanactiv ; Measurement: mitochondrial activity with treatment with Seanactiv ; Measurement: ATP production with luminescent
spectrometry assay
3. VITALITY ENHANCER – In Vivo
Seanactiv shows an express improvement of eye
area luminosity vs placebo
+2% vs Pl
from the first week
Significant improvement of the average of
the skin luminosity parameter
Seanactiv
helps to improve
eye contour
luminosity
3. VITALITY ENHANCER
Placebo
8% vs Pl - 7% vs Pl +2% vs Pl
Q U I C K LY Reduction of -
from the first week from the first week from the first week
enhance
the eye-
contour
area HO-1 +598% COLLAGEN I +485% SIRT-1 +42%
#menwomen
UNIVERSAL EYE PERFECTOR
The pe
rfe
recove ct ally to
r a hea
look in lth
D0 D7 only 7 d y
ays,
- Remove crow’s feet [-7%]
with a t
o
matchi uch of
ng colo
r!
D0 D7 UNIVERSAL CC
EYE PERFECTOR
- Improve eye luminosity Dark circles
Crow’s feet
#Identity Radiance
D0 D7
SILKY CONCENTRATE
#personnalization
in
The richness of fucoidans r esults
g
to reveal eye beauty ath takin week
Bre nly one
o
y
Dark circle remedy to
f a ging b
o ntity
optimize eye area e signs id e
Eras ing own
keep
SILKY EYE
CONCENTRATE
When waking-up, eye area
Dark circles
Crow’s feet is visibly younger, brighter,
Radiance
more rested
Rich in fucoidan
#keepsmiling
#selfesteem
Seanactiv
Re gu l at o r y d at a
BC10113 Seanactiv ™
INCI Water (and) Fucus Vesiculosus Extract (and) Gluconolactone (and) Xanthan gum (and) Sodium chloride
Dose of Use 1%
Regulatory data
JP QD
PCPC IECSC IECIC 2015 REACH
cosmetics additive
On going ü ü ü ü x
Seanactiv
Fo r m u l at i o n & s t o r ag e c o n d i t i o n s
Color impact
Formulation Storage
method conditions
Incorporated below
40°C or at room In its original
temperature for a packaging at
cold process. 10-30°C
pH 3-11
Shelf life:
OK at Room T°, 18 months
slight color change
at 45°C
Formulation of the clinical study
Phase Trade Name INCI Name %
A Eau osmosée Water 76,23
Euxyl PE 9010 (Schülke) Phenoxyethanol, Ethylhexylglycerin 1,00
Glycerine 99-5 Glycerin 3,00
EDETA® BD Disodium EDTA 0,05
B Cosmedia® SP Sodium Polyacrylate 0,20
C Emulgade® PL 68/50 Cetearyl Glucoside, Cetearyl Alcohol 5,00
Cutina® PES Pentaerythrityl Distearate 1,50
Cutina® HVG Hydrogenated Vegetable Glycerides 1,50
Myritol® 331 Cocoglycerides 3,00
Cetiol® CC Dicaprylyl Carbonate 5,00
Cegesoft® PFO Passiflora Incarnata Seed Oil 3,00
Xiameter PMX-
200 Silicone Fluid 350CS (Dow Dimethicone 0,50
Corning)
D Seanactiv BC10113 See composition sheet 0,00
Sodium Hydroxide solution 16% Sodium Hydroxide, Water 0,020
Process
Specifications:
pH = 6,27
Viscosity = 70 000 mPas (Brookfield RVT, spindle C, 20 rpm)
EMB180604_10129 Seanactiv
#menwomen
UNIVERSAL EYE PERFECTOR
Phase Ingredients INCI % by weight Function
A Dehymuls® PGPH Polyglyceryl-2 Dipolyhydroxystearate 5.00 Emulsifier (W/O)
Lameform® TGI Polyglyceryl-3 Diisostearate 2.00 Emulsifier (W/O)
Cutina® PES Pentaerythrityl Distearate 1.50 Structurant
Cosmedia® Gel CC Dicaprylyl Carbonate, Stearalkonium Hectorite, 7.00 Rheology modifier
Propylene Carbonate
Cetiol® Sensoft Propylheptyl Caprylate 7.00 Emollient
DOWSIL 9041 Silicone Elastomer Blend Dimethicone, Dimethicone Crosspolymer 2.00 Skin feel modifier
(Dow Corning)
D Chione™ M SVA Synthetic Fluorphlogopite, Lauroyl Lysine 2.00 Skin feel modifier
Timica® Terra Yellow MN4502 Mica, Iron Oxides, Titanium Dioxide 1.10 Effect pigment
Timica® Terra Red MN4506 Mica, Iron Oxides, Titanium Dioxide 0.33 Effect pigment
Timica® Terra Black MN4498 Mica, Iron Oxides, Titanium Dioxide 0.13 Effect pigment
Seanactiv™ BC10113 See Composition Sheet 1.00 Active ingredient
Specifications
Viscosity 17000 mPa s
(Brookfield; RVT; spindle TC, Helipath; 20 rpm; 20°C)
#Identity Appearance
-
Beige fluid
Process
CC-FR-21-BC-50872-05
Seanactiv
Use the power of fucoidan to quickly erase
eye -aging and improve healthy radiance
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