Low solubility of drugs is a constantly encountered problem for

pharmaceutical science in the field of parenteral dosage form

development. This requires the active use of solubilizers to
produce soluble forms of substances suitable for administration
via injection and infusion. Polysorbates or Tweens are often
used as surfactants with the same poly(oxyethylene) part and
different fatty acids that form the corresponding esters to
overcome the hydrophobic nature of drugs. The introduction of
polysorbates into pharmaceutical science and practice still
remains relevant due to their high solubilizing activity,
compatibility with other surfactants and electrolytes, and
insensitivity to pH changes. This review highlights the
properties of polysorbates and their use in pharmaceutical
development (for drugs used both in clinics and at various
stages of research), which makes it possible to assess the
prospects for using these excipients to create dosage forms with
new hydrophobic active substances.