Table A.1.

Causes of death with an established causal association with tobacco use.

Equivalence with the International Classification of Diseases-9th and 10th revisions
(ICD-9 and10) codes.
Cause of death ICD-9 Code ICD-10
Code
Tumours
Cancer of trachea-bronchus-lung 162 C33-34
Other cancers
Lip, oral cavity and pharynx 140–149 C00-14
Oesophagus 150 C15
Stomach 151 C16
Pancreas 157 C25
Larynx 161 C32
Cervix uteri 180 C53
Kidney and renal pelvis 189.0,189.1 C64-65
Bladder 188 C67
Liver and intrahepatic bile ducts 155 C22
Colon and rectum 153-154 C18-20
Acute myeloid leukaemia 204.0 C92.0
Cardiovascular diseases-diabetes mellitus
Ischaemic heart disease 410-414, 429.2 I20-25
Other heart diseases
Rheumatic heart diseases 390-398 I00-02 /
I05-09
Cardiopulmonary diseases and other types of 415-429.1, 429.3- I26-28 /
heart disease 429.9 I30-51
Cerebrovascular disease 430–434,436–438 I60-69
Other vascular diseases
Atherosclerosis 440 I70
Aneurysms and others 441–448 I71-78
Diabetes mellitus 250 E10-14
Respiratory diseases
Chronic obstructive pulmonary disease 490,491,492,494 J40-44
Influenza, pneumonia 480–487 J09-18
Tuberculosis 010–018 A15-19
The causes included are those with an established causal association with tobacco use in
accordance with the Centers for Disease Control and Prevention [1].
Table A.2. Annual crude rates of smoking-attributable mortality (SAM) in men per
100,000 population, by sex and cause of death: Spain, 1990-2018.

Men
 All Ischae Other Other
Other Diabe
Lung remai mic Cerebrov vascula respirat
heart tes CO
Year cance ning heart ascular r ory
diseases mellit PD
r cance diseas disease diseases diseases
ᶲ us
rs* e ¶ §

99.
1990 126.9 84.5 95.0 51.5 53.0 34.2 5.5 12.7
7
102
1991 130.3 86.5 99.0 52.2 54.2 32.7 5.2 11.1
.9
98.
1992 134.0 89.1 98.3 49.6 51.9 32.2 4.9 10.9
6
104
1993 136.7 92.9 100.5 50.5 51.3 30.9 5.0 11.4
.8
101
1994 138.6 93.6 97.1 47.4 50.4 29.5 4.9 10.6
.4
110
1995 139.9 93.5 98.0 47.2 49.8 27.5 5.0 10.9
.3
113
1996 134.9 89.6 98.6 47.4 45.4 26.7 4.6 10.6
.2
110
1997 134.5 91.1 96.0 45.2 43.5 25.4 4.2 10.5
.0
117
1998 137.1 90.8 96.3 46.1 43.2 25.8 4.5 10.8
.2
120
1999 139.0 92.1 98.4 43.8 41.6 26.2 4.4 16.1
.2
104
2000 134.6 89.4 92.0 39.5 37.2 24.1 4.1 13.4
.9
95.
2001 139.1 93.0 89.8 39.1 37.7 24.2 4.0 12.8
2
102
2002 132.8 87.2 85.3 38.1 35.0 23.0 3.8 13.0
.5
101
2003 133.8 87.4 85.6 38.8 35.1 22.1 3.8 13.0
.6
90.
2004 131.0 85.9 78.4 37.0 31.3 20.4 3.6 11.1
2
99.
2005 127.1 81.9 76.5 37.0 30.9 19.4 3.7 13.6
3
79.
2006 125.5 80.0 70.6 34.5 28.2 18.2 3.3 10.9
4
84.
2007 124.0 78.8 68.3 35.6 27.7 17.3 3.2 11.6
5
77.
2008 120.2 76.1 62.6 34.3 25.1 16.6 3.0 11.7
3
80.
2009 118.4 75.1 59.9 31.7 23.7 15.7 2.7 10.7
7
77.
2010 116.0 76.1 57.3 30.5 21.6 14.5 2.5 8.6
2
76.
2011 115.0 75.2 54.8 30.2 20.3 13.9 2.4 9.5
8
2012 114.3 75.6 53.8 30.9 20.2 14.0 2.3 80. 9.8
 4
72.
2013 112.2 73.6 51.5 29.4 18.4 13.4 2.1 8.9
0
71.
2014 108.4 69.7 48.9 28.7 17.6 12.8 2.2 9.3
5
76.
2015 107.5 69.1 48.9 30.8 18.0 12.7 2.2 10.3
9
67.
2016 108.9 69.6 47.7 30.6 17.4 12.9 2.1 10.0
9
68.
2017 105.5 67.2 46.2 30.6 16.8 13.0 2.1 10.4
3
63.
2018 104.0 65.1 43.6 30.6 16.2 12.8 1.9 11.2
6
COPD: chronic obstructive pulmonary disease
*All remaining cancers: include lip, oral cavity, pharynx, oesophagus, stomach, colon and rectum, liver and intrahepatic bile ducts, pancreas, larynx, cervix uteri, urinary
bladder, kidney-renal pelvis and acute myeloid leukaemia.
ᶲOther heart diseases: include rheumatic heart diseases, cardiopulmonary diseases and other types of heart disease.
¶Other vascular diseases: atherosclerosis, aneurysms and others.
§Other respiratory diseases: influenza-pneumonia-tuberculosis
Table A.3. Annual crude rates of smoking-attributable mortality (SAM) in women per 100,000 population, by sex and cause of death: Spain,
1990-2018.

Women

All Ischaemic Other

Lung Other heart Cerebrovascular Other vascular Diabetes
Year remaining heart COPD respiratory
cancer diseasesᶲ disease diseases¶ mellitus
cancers* disease diseases§

1990 0.7 0.8 1.6 1.4 1.6 2.4 0.1 4.7 0.3
1991 1.0 0.9 1.7 1.0 1.3 1.3 0.2 3.7 0.2
1992 0.8 0.7 1.3 0.6 0.8 0.6 0.1 2.5 0.1
1993 1.1 1.2 2.6 2.1 2.3 3.1 0.1 6.8 0.4
1994 1.2 1.1 1.4 0.5 0.8 0.2 0.2 2.0 0.1
1995 1.7 1.4 2.8 1.8 2.0 1.8 0.2 6.0 0.4
1996 1.3 1.1 1.9 1.1 1.2 0.9 0.1 3.8 0.3
1997 2.0 1.6 2.9 1.7 1.8 1.3 0.2 5.6 0.4
1998 2.6 2.0 4.1 2.9 2.8 2.5 0.3 8.7 0.7
1999 2.7 2.0 3.7 2.1 2.2 1.6 0.3 7.4 0.8
2000 3.3 2.1 3.5 2.1 2.1 1.5 0.3 5.8 0.8
2001 3.5 2.1 3.4 1.9 2.0 1.1 0.3 4.5 0.6
2002 4.5 2.9 4.7 2.8 2.8 1.9 0.3 7.3 1.0
2003 5.3 3.5 5.9 3.9 3.7 2.4 0.4 9.1 1.3
2004 6.4 4.0 5.9 3.9 3.5 2.2 0.4 7.8 1.2
2005 6.2 4.0 6.1 4.2 3.7 2.3 0.4 9.4 1.5
2006 7.0 4.3 5.8 3.9 3.6 2.0 0.4 6.9 1.3
2007 7.8 4.9 6.5 5.0 4.2 2.5 0.5 8.8 1.6
2008 9.2 6.0 7.5 6.3 4.9 3.1 0.5 9.8 2.0
2009 9.3 5.9 6.6 5.2 4.3 2.3 0.5 9.0 1.9
 2010 11.1 7.3 7.5 5.9 4.7 2.4 0.6 9.6 1.7
2011 11.6 8.2 8.7 7.4 5.3 2.9 0.6 11.4 2.3
2012 12.9 8.6 8.9 7.9 5.5 3.2 0.5 12.1 2.3
2013 14.5 10.1 9.8 8.7 6.2 3.6 0.6 11.9 2.5
2014 13.9 9.4 8.7 8.1 5.6 3.2 0.6 11.7 2.5
2015 15.7 10.5 9.9 9.6 6.3 3.3 0.7 12.6 2.9
2016 16.6 11.2 9.7 9.8 6.3 3.5 0.7 11.7 3.1
2017 18.2 12.5 11.1 11.9 7.1 3.9 0.7 13.1 3.6
2018 18.6 12.4 10.7 11.7 7.1 3.9 0.7 12.1 4.1
COPD: chronic obstructive pulmonary disease
*All remaining cancers: include lip, oral cavity, pharynx, oesophagus, stomach, colon and rectum, liver and intrahepatic bile ducts, pancreas, larynx, cervix uteri, urinary
bladder, kidney-renal pelvis and acute myeloid leukaemia.
ᶲOther heart diseases: include rheumatic heart diseases, cardiopulmonary diseases and other types of heart disease.
¶Other vascular diseases: atherosclerosis, aneurysms and others.
§Other respiratory diseases: influenza-pneumonia-tuberculosis
Table A.4. Annual percentage change (APC) with its periods of change, by sex, age group (35-64, 65 years and over) and cause (all-cause, lung
cancer), accompanied by their 95% confidence intervals (95%CI).

All causes* Lung cancer

Group Period APC 95%CI Period APC 95%CI
1990 - 1999 -1.1 -1.6 -0.7 1990 - 1999 0.3 -0.3 0.9
Men 35-64 years 1999 - 2008 -3 -3.5 -2.5 1999 - 2010 -1.6 -2 -1.1
2008 - 2018 -3.8 -4.2 -3.5 2010-2018 -4.1 -4.8 -3.5
1990 - 1998 -0.1 -0.9 0.7 1990 - 1994 2.5 1.2 3.8
Men 65 years and over 1998 - 2018 -2.6 -2.8 -2.4 1994 - 2003 -0.2 -0.6 0.2
      2003 - 2018 -1.3 -1.5 -1.1
1990 - 2001 25 20.3 29.9 1990 - 2002 29.7 24.9 34.6
Women 35-64 years
2001 - 2018 6.1 4.1 8.3 2002 - 2018 7.4 4.9 10.1
Women 65 years and
1990 - 2018 7.1 5.7 8.6 1990 - 2018 11.6 10.7 12.5
over
*All causes include: cancers (trachea-bronchus-lung, lip, oral cavity, pharynx, oesophagus, stomach, colon and rectum, liver and intrahepatic bile ducts, pancreas, larynx,
cervix uteri, urinary bladder, kidney-renal pelvis and acute myeloid leukaemia), cardiovascular diseases-diabetes mellitus (ischaemic heart disease, rheumatic heart diseases,
cardiopulmonary diseases, and other types of heart disease, cerebrovascular disease, atherosclerosis, aortic aneurysm, other arterial diseases and diabetes mellitus), respiratory
diseases (influenza-pneumonia-tuberculosis and chronic obstructive pulmonary disease).
Figure A.1. Trends in smoking attributable lung cancer mortality rates adjusted by the joinpoint regression model, by sex (men and women) and

age group (35-64 and 65 years and over) across the period 1990-2018 in Spain: rates per 100,000 population.

Adjusted rates were adjusted by the direct method using the European standard population proposed by Eurostat's task force [2].
REFERENCES

1. U.S Department of Health and Human Services. The Health Consequences of

Smoking: 50 Years of Progress. A Report of the Surgeon General. Atlanta, GA:

Centers for Disease Control and Prevention; 2014.

2. European Comission. Revision of the European Standard Population Report of

Eurostat’s task force. Brussels; 2013.