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SA Adme Poster

Charles River offers a complete range of in vitro and in vivo ADME and DMPK services with a team of over 400 scientists. Their services include absorption, distribution, metabolism, and excretion studies using in vitro assays with cell and tissue models as well as in vivo studies in animals. They provide metabolic stability testing, metabolite identification, and assessment of transporters, protein binding, and drug-drug interactions to support drug discovery and development. More details can be found at their website www.criver.com/ADME.

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240 views1 page

SA Adme Poster

Charles River offers a complete range of in vitro and in vivo ADME and DMPK services with a team of over 400 scientists. Their services include absorption, distribution, metabolism, and excretion studies using in vitro assays with cell and tissue models as well as in vivo studies in animals. They provide metabolic stability testing, metabolite identification, and assessment of transporters, protein binding, and drug-drug interactions to support drug discovery and development. More details can be found at their website www.criver.com/ADME.

Uploaded by

Uzy
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

ADME/DMPK Services

With a team of more than 400 dedicated ADME scientists, Charles River offers a complete range of in vitro and in vivo metabolism studies in support of hit-to-lead,
candidate discovery, and selection for preclinical testing and clinical development programs. To explore services in depth, visit www.criver.com/ADME.

IN VITRO IN VIVO
Absorption Absorption
Permeability/drug transport Pharmacokinetics, (non-)radiolabelled
Dermal absorption Dermal absorption

Distribution Distribution
Plasma protein binding Tissue distribution/QWBA
RBC partitioning (blood/plasma ratio)
Cerebral fluid collection
Melanin binding Distribution
Metabolite profiling/identification
Uptake/Efflux transporters
Barrier tissue models Pharmacokinetics, (non-)radiolabelled

Metabolism Metabolism Metabolism


Metabolic stability Metabolite profiling/identification
Metabolite profiling/identification Pharmacokinetics, (non-)radiolabelled
Drug-drug interaction Absorption
CYP/UGT characterization Excretion
CYP/UGT inhibition Metabolism cages
CYP induction Bile cannulation
Excretion
Reactive metabolite assessment Expired air collection

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