Scribd Logo
Upload

Welcome to Scribd!

  • Blood Coagulation

    Uploaded by

    Johanna Marie
    12 views2 pages
    The document lists the 13 coagulation factors and groups them into the intrinsic pathway, extrinsic pathway, and common pathway. It then further categorizes the factors into four coagulation groups: contact group, prothrombin group, and fibrinogen group. The contact group involves factors that are activated through contact with a foreign surface and includes factors XII, XI, prekallikrein, and high molecular weight kininogen. The prothrombin group contains vitamin K dependent factors II, VII, IX, and X. The fibrinogen group consists of factors I, V, VIII, and XIII, with factor VIII requiring von Willebrand factor as a cofactor.

    Original Description:

    Original Title

    blood coagulation.docx

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    The document lists the 13 coagulation factors and groups them into the intrinsic pathway, extrinsic pathway, and common pathway. It then further categorizes the factors into four coagulation groups: contact group, prothrombin group, and fibrinogen group. The contact group involves factors that are activated through contact with a foreign surface and includes factors XII, XI, prekallikrein, and high molecular weight kininogen. The prothrombin group contains vitamin K dependent factors II, VII, IX, and X. The fibrinogen group consists of factors I, V, VIII, and XIII, with factor VIII requiring von Willebrand factor as a cofactor.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    12 views2 pages

    Blood Coagulation

    Uploaded by

    Johanna Marie
    The document lists the 13 coagulation factors and groups them into the intrinsic pathway, extrinsic pathway, and common pathway. It then further categorizes the factors into four coagulation groups: contact group, prothrombin group, and fibrinogen group. The contact group involves factors that are activated through contact with a foreign surface and includes factors XII, XI, prekallikrein, and high molecular weight kininogen. The prothrombin group contains vitamin K dependent factors II, VII, IX, and X. The fibrinogen group consists of factors I, V, VIII, and XIII, with factor VIII requiring von Willebrand factor as a cofactor.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    Factor Name Notes

    Factor I Fibrinogen
    Factor II Prothrombin Vitamin K dependent
    Factor III Tissue thromboplastin/ Tissue
    factor
    Factor IV Calcium
    Factor V Labile Factor; unstable in heat
    and storage
    Factor VI Unassigned
    Factor VII Stable factor; proconvertin Vitamin K dependent
    Factor VIII Antihemophilic factor
    Factor IX Plasma thromboplastin Vitamin K dependent
    component; Christmas factor
    Factor X Stuart prower factor Vitamin K dependent
    Factor XI Plasma thromboplastin
    antecedent
    Factor XII Hageman factor
    Factor XIII Fibrin stabilizing factor

    Intrinsic

    ● Factor XII
    ● Factor XI
    ● Factor IX
    ● Factor VIII
    ● Tested by aPTT

    Extrinsic

    ● Factor III
    ● Factor VII
    ● Tested by PT

    Common pathway

    ● Factor X
    ● Factor V
    ● Factor II
    ● Factor XIII
    ● Factor I

    Coagulation groups

    Contact group

    ● Prekalikrin
    o Activates HMWK
    ▪ Makes it into bradykinin.
    o Activates Factor XII
    ▪ Starts intrinsic pathway
    ● HMWK (high molecular weight kinin
    ● Factor XI
    ● Factor XII
    ● Contact with foreign surface for activation

    Prothrombin group

    ● Factor II
    ● Factor VII
    ● Factor IX
    ● Factor X
    ● Vitamin Ka dependent factor

    Fibrinogen group

    ● Factor I
    ● Facotr V
    ● Factor VIII
    o Needs a cofactor; VWF
    o VWF protects it from degradation
    ● Factor XIII

    You might also like