Section #: Med 1-Dekwaneh

Group#: 2
Group Members:

Group 2
Bechara, Julie Tracy Youssef
Afara, Imad Naji
Kfoury, Karl Abdo
Serhal, Sara Hani
Milan, Joelle Dib
Abi Kheir, Venise Gergi
Akil, Hussein Mohamad
Sourani, Lea Hisham
Moussa, Ghadi Mike

Case Presentation Date: November 1, 2022

Case# 2
A 27-year-old mother of a 4-year old boy was expecting her second child. At 35 weeks’ gestation,
a girl was delivered by emergency cesarean section due to preeclampsia. Routine group B.
Streptococcus (GBS) testing of the mother was negative. The neonate was 40.8 cm and 1.75 kg at
birth (both below the second percentile). Upon physical examination, the baby appeared to be
jaundiced with elevated alanine aminotransferase and bilirubin levels. Petechiae were seen on the
baby’s face and trunk and hepatosplenomegaly was also noted. The mother did not have any
additional medical issues at the time of delivery. However, the mother did report having a flu-like
illness at 13 weeks of gestation (during the first trimester) that resolved spontaneously. She had
not mentioned that illness to her obstetrician at that time because it seemed minor. At that time,
several children at her son’s day care had typical illnesses, such as upper respiratory infections and
enteroviruses. Blood cultures from the newborn were negative.
Note: Group members should be prepared to discuss and answer any of the following
questions since each member will be selected randomly to answer and discuss one of the
questions. Present your answers in the form of a Power Point Presentation
Questions
Q#1: Which virus most likely contributed to the baby girl condition? Justify your answer
Q#2: Is there any consequence on the mother as a result of her baby girl condition?
Q#3: Is the baby girl at an increased risk of developing long-term health problems? If yes,
what would be the most common health problem(s) to develop?
Q#4: What is the best and most accurate diagnostic test to confirm the viral infection in the
baby girl?
Q#5: Once the suspected viral infection is confirmed. What would be the most appropriate
therapy for the baby girl to prevent progression of the disease and improve the outcome?
Q#6: Is there any role/association between the virus that caused the disease in the infant and
one of the neural derived cancers? Briefly mention what does the recent literature indicate
Q#7: What would be the optimal treatment for the causative virus?
Q#8: Is there any attempt to develop an mRNA-based vaccine against the causative agent?
If yes, provide a brief summary?
Q#9: Is there any non-invasive method to predict congenital infection with the causative
virus? If yes, give a brief background about this method