Unit 2

1. Enlist types of receptors. Discuss various transduction mechanism of a protein coupled receptor.
2. Discuss factors modifying drug action in detail.
3. Write detail note on pharmacovigilance.
4. Explain various phases of clinical trials in brief.
5. Classify adverse drug reactions with example.
6. Explain the role of enzyme in metabolism.
7. Write short note on plasma protein binding.
8. Classify various types of drug interaction. discuss pharmacokinetic drug interaction with suitable
example.
9. Define ADR. Classify ADR’s as per Rawlins Thomson system with suitable examples.
10. What is drug interactions. Give the explanation of drug interaction on the basis of
pharmacokinetic with example.
11. Classify the receptors and give in detail about drug receptor interactions signal transaction
mechanism.
12. Note on: therapeutic index, combined drug effects, ADRs.
13. Give in detail about drug discovery phase of preclinical evaluation phase, clinical trial phase.
14. Write cause of drug interactions. Discuss pharmacodynamic drug interactions.
15. Explain: dose response relationship.
16. Differentiate between phase 1 and phase 2 biotransformation reaction.
17. Describe pharmacokinetic type of drug-drug interaction.