PT1 + Pharmacology Exam 3 Review Questions

1. What is the pharmacodynamic basis for antimicrobial drug therapy? Provide two specific
examples:

2. Define bacteriostatic and bactericidal. Which do we prefer for drug therapy, and particularly in
which situations?

3. Differentiate time dependent and concentration dependent. What are the predictors of efficacy
for each?

4. What are the MOAs of the drugs in triple antibiotic ointment? How can their actions be
synergistic and what does this mean?

5. What kinds of antibodies or cells cause the inflammation associated with contact dermatitis?
6. How do glucocorticoid effects differ from mineralocorticoid effects?

7. Describe the actions of nAChRs and explain receptor desensitization. Why is the nicotine dose
response curve shaped differently?

8. Describe the MOAs of nicotine products, varenicline, and bupropion; explain why they may be
helpful in aiding smoking cessation:

9. How do azole antifungals (including clotrimazole) work?

10. What happens when phenylephrine binds to 1-adrenergic receptors?