ANS

1. Define tachyphylaxis and give example of two drugs which show

this phenomenon.
2. Mention two differences between tachyphylaxis and tolerance.
3. Write the differences between Ach esterase and butyryl
cholinesterase.
4. Describe difference between directly and indirectly acting
sympathomimetic drugs.
5. What is uptake 1 (Axonal) and uptake 2 (extra neuronal) in
adrenergic transmission?
6. What is COMT and MAO? Describe their importance in adrenergic
transmission?
7. Enumerate types of adrenergic receptors with its distribution.
8. Mention the effects of adrenaline, noradrenaline, isoprenaline on
heart rate and blood pressure.
9. What is the pharmacological basis for use of adrenaline in
anaphylactic shock?
10. Why adrenaline is not given by SC or IV route in anaphylactic
shock?
11. What is the pharmacological basis for use of Chlorpheniramine
maleate and corticosteroid in anaphylactic shock?
12. Why adrenaline is combined with lignocaine? Mention its
indication.
13. Explain the pharmacological basis of Adrenaline in cardiac arrest.
14. Explain the pharmacological basis of dobutamine in cardiogenic
shock.
15. Explain dose dependent actions of Dopamine on different
receptors.
16. Mention triggering factors for release of catecholamine.
17. What is cheese reaction?
18. Why Phenylpropanolamine is banned as an anorectic agent?
19. What is first dose effect with Prazosin? What instruction will you
give to the patient to prevent it?
20. What is Phentolamine test for pheochromocytoma?
21. Explain the pharmacological basis of Finasteride in BPH.
22. Mention beta blockers having intrinsic sympathomimetic activity
with its clinical significance.
23. Enumerate non cardiac uses of beta blockers.
24. Explain the pharmacological basis of dipivefrine in open angle
glaucoma.
25. Name the drug used by oral route in open angle glaucoma.
 Autacoids
1. What is MOA of histaminic receptor H1 and H2 on blood vessels?
2. Name of the drug which is first generation anti histamine drug?
3. What are the uses of H1 blocker drug (first generation)?
4. Why we not prefer anti histamine dug for truck driver or
machinery operator?
5. Difference between first and second generation of histamine drug.
6. Which anti histamine drug causes QT prolongation?
7. What is triphasic response of serotonin?
8. Name of the drug of choice for chemotherapy, post operative and
radiation induced nausea and vomiting. Tell about MOA of that
drug.
9. Which drug of serotonin receptor use as a anti anxiety drug. Name
the drug of anti anxiety drug.
10. Drug of choice to abort acute attack of migraine?
11. What are the contraindication of use of triptan in migraine?
12. Mention the class of drug use for a prophylaxis of migraine.
13. Why we never give triptan and ergotamine together ?
14. Name of drug used to keep ductus arteriosus patent and
Name of drug used for treatment of patent ductus arteriosus.
15. What is batter syndrome? Which drug is use for treatment of
this syndrome?
16. Which drug causes Mobious syndrome?
17. What is reason behind the aspirin can result in precipitation
of asthma attacks?
18. By which mechanism prostaglandins decrease intra ocular
pressure? Name the drug use for it.
19. By which way we inhibit the action of leukotriene?
20. Paracetamol is metabolise into which compound? and write
the anti dote for paracetamol poisoning .
21. What are the dose dependent action of aspirin?
22. What are the adverse effects of aspirin?
23. Rafecoxib and valdecoxib were withdrawn from market
because of which reason?
24. Name of drug which is selective cox-2 inhibitor.

RS
1. What is pharmacological action of expectorants? And give
examples of expectorants.
2. What is mechanism of action of antitussive drug? and give
example of it?
3. Which drugs are use in dry cough?
4. Which drugs are use in productive cough?
5. What is mechanism of action of dextromethorphan?
6. Name the drug which is peripherally act as an antitussive.
7. How would you manage patient with ACE inhibitor associated
cough?
8. Which sympathomimetic drug use in bronchial asthma and tell
about mechanism of action of it?
9. Which are three distinct cellular action of methylxanthine?
10. What is relation between efficacy and toxicity of
theophylline with it’s plasma concentration?
11. Drug which enhance theophylline metabolism and which
drug inhibit theophylline metabolism?
12. What is mechanism of action and use of montelukast?
13. Which are the mast cell stabilizers drug and uses of it?
14. Which drug is anti IgE monoclonal antibody and it
administrated by which route?
15. Which drug is use in seasonal asthma and exercise induced
asthma?