General

1. Routes of drug administration – advantages and disadvantages of each route

2. Factors modifying drug action – examples
3. Factors affecting drug absorption – enumerate and discuss
4. Prolongation of drug action - SN
5. Bioavailability
6. First Pass metabolism – clinical significance
7. Plasma Protein Binding of drugs
8. Plasma half-life
9. Volume of distribution
10. Zero and first order kinetics - difference
11. Drug antagonism – describe with examples
12. G-Protein coupled receptor
13. Potency and efficacy – define with examples
14. Enzyme induction
15. Therapeutic window
16. Tachyphylaxis
17. Idiosyncrasy
18.Mechanism of drug action with example
19.Half life;how half life is related to attain steady state plasma concentration &elimination of drug.
20.ADR;Difference b/w typeA and typeB with examples
21.Tolerance
22.Drug interactions

ANS
1. Cholinesterase inhibitors
2.succinylcholine causes prolonged apnea?
3.Beta2 agonists- uses and Action
4.Difference b/w D tubocurarine and succinylcholine
5. Pharmacotherapy of Myasthenia gravis
5. Open angle glaucoma ;pharmacology of glaucoma
6. Pilocarpine in glaucoma – rationale of using
7. Use of anticholinergics
8. Atropine
9. Pharmacotherapy of Atropine poisoning
10. Uses of sympathomimetics
11. Adrenaline in anaphylactic shock – rationale of using
12. Beta-blockers – classification, uses, S/E and c/i
13. Cardioselective beta blockers – pharmacological actions and therapeutic advantages
14. Use of adrenaline-ADR
15.Difference b/w Adrenaline and Nor Adrenaline
17.16.Carbamazepine
18.Ibuprofen
19.Terbutaline
20 Pancuronium as skeletal muscle retanant
21Dopamine vs dobutamine
22.MOA inhibitors-Difference b/w MOA A & MOA B inhibitors
23. Dopamine receptors
24.Organophosphate poisonings
Autacoids
1. Levocetrizine - SN
2. NSAIDS – enumerate, uses, MOA, ADR
3. Aspirin – Uses and S/E2
4. Misoprostol; why is it used in induction of labour
5. Migraine - pharmacotherapy
6 Prophylaxis of Migraine
7 Acute gout – drug treatment
8 Colchicine in acute gout
9. DMARDS – describe with suitable example
10.Nimesulide
11.SSRIs
12.Tegaserod
13.Methylergometrine
14.Drug therapy for ulcerative colitis

CNS
1. Benzodiazepine – MOA
2.Diazepam – uses and ADR
3. Pharmacotherapy of Parkinsonism- Selegiline in Parkinsonism
4. Treatment of drug induced Parkinsonism
5. Rationale of combining Levodopa with carbidopa
6 Alzheimer's disease - pharmacotherapy
7. Atypical antipsychotics
8. Diphenylhydantoin – MOA and S/E
9. Antidepressants – classification
10. SSRIs; rationale of using in Depression
11. Fluoxetine – MOA, adverse effects, therapeutic uses
12. MAO inhibitors- in depression
13. Anti epileptics – classification;
14. Grand mal epilepsy - pharmacotherapy
15.Phenytoin – MOA, ADR and uses
16. Sodium valproate
17. Disulphiram in alcohol abuse
18.Non opioid analgesics-classification
19. Narcotic analgesics – classification
20. Morphine –MOA, uses, ADR, withdrawal symptoms
21 Morphine poisoning – pharmacotherapy
22.Opioid overdose management
23Differences b/w morphine and pentazocine
24 Difference b/w opioid and belladonna poisoning
25. Lindocaine
26.Halothane
27.Xylocaine
28.Pharmacology of acute attack of migraine
29.Propofol
30.Drug interactions-verapamil and propranolol
-pyridoxin with levodopa
31.ACE inhibitors in CHF
Anesthesia
1. Local anaesthetics – classification
2. Adrenaline with Lignocaine - rationale
3. Lignocaine – uses and ADR
4. Tetracaine
5. Diethyl ether
6. D-tubocurarine and succinylcholine - difference
7. Rationale for ultrashort action of thiopentone sodium
7. Pre-anaesthetic medications - SN

CVS
1. Dopamine and dobutamine – difference
2 Dopamine in caridogenic shock – rationale of using
3. Enumerate Drugs of angina and rational use of each
4. Nitrate – MOA in angina
5. Glyceryl trinitrate – actions, uses, ADR
6 Nitroglycerine – Uses and ADR
7Pharmacotherapy of MI
8 Digoxin – mechanism of action; rationale for giving in congestive heart failure(pharmacology)
9 Loading and maintenance dose of digoxin
11 Enumerate drugs of Congestive heart failure
12.Furosemide MOA uses and ADR
13. Antiarrhythmic drugs – classification- treatment of PSVt
14. Pharmacotherapy of Supra ventricular tachycardia
15 Pharmacotherapy of Atrial flutter
16. Xylocaine therapy in ventricular tachycardia
17. Antihypertensive – classification
18. Captopril – MOA, uses, ADR
19.ACE inhibitors in Diabetic nephropathy – rationale of using
20.Losartan in hypertension – rationale of using
21. Thiazide diuretic in hypertension – rationale of using
22.Drug for treatment of essential hypertension
23. Amlodipine- uses and ADR
24.Nifedipine
25. Verapamil in PSVT- rationale for using
26. Statins
Hematology
1.Thrombolytic agents
2. Fibrinolytics
3.Low molecular weight heparin
4.Difference b/w anti thrombotic sand fibrolytics
5.Pharmacotherapy of leukemia
6. Anti platelet drugs
7.Warfarin sodium
8. Hypolipidemic drugs -enumerate
-Atorvastatin- MOA,ADR,USES.

Kidney
1. Diuretics – classification
2. Potassium sparing diuretics
3. Thiazide diuretics in hypertension
4 Loop diuretics – SN;
5.Furosemide – pharmacology, ADR and uses

Endocrine
1.Anti diabetic drugs- SN
- Type 2 DM Pharmacology
2.Insulin preparation -advantage uses ADR
3.Types of insulin
4.Biguanides and sulfonylurea as oral anti diabetic drug
5. Sulfonylurea – SN; uses and side effects
6.ACE inhibitors in diabetic nephropathy
7. Metformin therapy in DM
8. Insulin and metformin - difference
9. Biguanides and sulfonylurea
10. Diabetic ketoacidosis – drug treatment
11. Glucocorticoids – enumerate, pharmacological actions, therapeutic uses, ADR
12.Antithyroid drugs – classification
13. Pharmacotherapy of Thyrotoxicosis; drugs uses and their adverse effects
14. Propranolol in thyrotoxicosis - rationale
15. Radioactive Iodine
16 Tamoxifen
17.Tolbutamide-ADR
18. Raloxiphene
19. Oral contraceptives – actions, uses and ADR
20.Mesoprostol in labor induction
21. Combines pill as an oral contraceptive
22. Methylergometrine in PPH – rationale of using
23.Dutasteride in BPH

Antibiotics –
General
1. Penicillin-penicillamine
2.Anti pseudomonal penicillin
3. Beta-lactamase inhibitors
4. Amoxycillin given with clavulanic acid – rationale
5. Aminoglycosides – uses and side effects
6. Quinolones; flouroquinolone
7 Pyrimethamine with sulphamethoxazole – rationale
8. Acute UTI – pharmacotherapy
9 Streptomycin MOA USES ADR C/Is
10.Omeprazole
11.Metronidazole

Antibiotics – Antitubercular
12. DOTs regimen – advantages and disadvantages
13. Rifampicin – uses, s/e and c/i
14. Categories of tuberculous chemotherapy
15. Define MDR-TB- regimen
Antibiotics – Antiamoebic
16. Antiamoebic drugs – classification,
17. Metronidazole – uses and ADR3
18. Pharmacology of amebic hepatitis and. Pharmacotherapy of amebiasis
19. Pharmacotherapy of amoebic colitis
20. Albendazole
21.Round worm infestations

Antibiotics – Antiviral
22.Acyclovir-SN
23. Zidovudine

Antibiotics - Antimalarial
24 Pharmacotherapy of malaria
25. Acute relapsing malaria – drug treatment
26. Antimalarial drugs – classification
27. Chloroquine – MOA, Uses, S/E4

Antibiotics – Miscellaneous
28. Drugs used in treatment of Enteric fever; discuss management of enteric fever.
29.Drug interactions-sulfamoyl oxazole and irimethoprim

Chemotherapy – Antineoplastic
30. Methotrexate – uses, s/e and c/i; rationale of using methotrexate in malignancy2
31.Leukaemia treatment

Respiratory
1. Bronchial Asthma – drugs and pharmacotherapy
3. Acute attack of bronchial asthma – drug treatment
4. Pharmacological actions and uses of beta-2 agonist
5. Role of in bronchial asthma
6. Pharmacotherapy of Status asthmaticus

GIT
1. Peptic ulcer – drug treatment
2. Pharmacotherapy of ulcerative colitis
3. Sulfasalazine; rationale for using in ulcerative colitis2
4. Osmotic purgatives
5. Tegaserod
6. Ondansetron as anti-emetic
7.Sucralfate
8.Pro kinetic agents
9.Omeprazole in peptic ulcer
10.Metoclopramide

Miscellaneous
1. Dopamine receptors
2. Penicillamine