Professional Documents
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Scientific Research
Radiology department
By
Safaaaldin Ahmed Sultan
Supervised by
2022-2023
بسم هللا الرحمن الرحيم
for the exceptional efforts, and the valuable directions and advices to
The researchers
Recognition and
appreciation
Titles Pages
(1)
1. Introduction
The Urinary system tract is your body’s drainage system for removing wastes and
extra fluids. The urinary tract includes two kidneys, two ureters, a bladder, and
a urethra.
The kidneys filter wastes and fluids to produce urine. The urine travels from the
kidneys down two narrow tubes called the ureters. The urine is then stored in a
hollow, muscular, balloon-shaped organ called the bladder. When the bladder
empties, urine flows out of the body through a tube called the urethra at the bottom
of the bladder.
All parts of the urinary tract—the kidneys, ureters, bladder, and urethra—must
work together to urinate normally.
(2)
Imaging could be required for symptoms such as:-
Imaging can also help your health care professional identify, evaluate,
follow up, and monitor problems such as
● Kidney diseases
● Tumors
● Small bladder capacity
● Backward flow of urine, known as vesicoureteral reflux (VUR)
● Hydronephrosis, or urine blockage, in new born following suspicious or
abnormal imaging during the pregnancy
Before ordering imaging tests, your health care professional will consider your
general medical history, including any major illnesses or surgeries, perform a
physical exam, obtain blood test results, and may ask
● About your specific urinary tract symptoms, when they began, how often
they occur, and how severe they are
● If you take any prescription or over-the-counter medicines
(3)
● How much fluid you take in each day
● About your use of alcohol and caffeine
● Whether you are allergic to any foods or medicines
● Whether you could be pregnant, if you are a female patient
Your health care professional can use several different imaging techniques,
depending on factors such as your general medical history and urinary tract
symptoms.
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Chapter Two
Aim of work
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2. Aim of work:
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Chapter Three
Review of literature
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3. Literature Review
3.1 Anatomy of urinary tract
It is the group of organs that make, store and excrete urine.Urinary system
consisted of :-
1-Kidneys
2-Ureters
3-Bladder
4-Urethra
1-Kidneys
The kidneys are two bean-shaped organs located on the left and right in the
retroperitoneal space.
1-Renal capsule
2-Renal cortex
3-Renal medulla
4-Renal Calyx
5-Renal Pelvis
2- Ureters
• The ureters are tubes made of smooth muscle
fibers that push the urine from the kidneys to the urinary bladder.
• In the human adult, the ureters are usually 2 around 3–4 mm (0.12–0.16 in) in
diameter
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3- Bladder
that collects and stores urine from the kidneys before removal by urination.
. The bladder is a hollow muscular, and distensible (or elastic) organ, that sits on the
pelvic base.
. Urine enters the bladder via the ureters and exits via the urethra.
. The typical human bladder will hold between 300 and 500 ml.
4- Urethra
The urethra is a thin, fibromuscular tube that begins at the lower opening of the
bladder and extends through the pelvic and urogenital diaphragms to the outside
3.2 Technique
3.2.1.ULTRASOUND
The most common indication for a point-of-care ultrasound (PoC US) of the
urinary tract in the emergency department (ED) is flank pain, responsible for
approximately 2 million ED visits in the United States annually. About 20% of
patients presenting with flank pain have nephrolithiasis .
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The kidneys are located in the retroperitoneum between the 12th thoracic
and fourth lumbar vertebrae. The right kidney is more inferior than the left due to
the position of the liver. Grossly, the kidneys consist of a cortex, medulla, and hilum.
On ultrasound, the cortex is homogeneous and should be isoechoic relative to the
liver parenchyma. The medullary pyramids appear as hypoechoic triangular
structures with intervening tissue that is contiguous with the cortex. The central
collecting system is formed of small minor and major calyces that are buried within
the hyperechoic fat of the renal pelvis when no obstruction is present. At the renal
pelvis, the ureters (also indistinguishable in the absence of obstruction) travel
slightly medially and inferiorly in the retroperitoneal space. Distally, the ureters
enter the posterior-inferior aspect of the bladder at the ureterovesical junctions
(UVJs). Occasionally, the UVJs can be seen in a transverse view of the bladder as
“humps” that protrude into the bladder lumen bilaterally from the posterior wall. In
this view, the bladder appears rectangular, contains anechoic urine, and is just
superior to the pubic symphysis. In a sagittal plane, the bladder appears more
triangular.
Indications
1- Ureteral Obstruction
The most common indication for PoC US of the urinary system in the ED is
concern for ureteral obstruction caused by nephrolithiasis. Patients classically
present with sudden-onset, unilateral, colicky flank pain that may radiate anteriorly
or to the groin, often with microscopic or gross hematuria, nausea, and vomiting.
2- Urinary Retention
3-Foley Placement
Contraindications
Equipment
Preparation
Technique
Complications
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3.2.2 Computed Tomography(CT) of urinary tract
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Fig. 1—36-year-old man with right renal colic due to distal ureteric calculus. Imaging
of pelvis was performed with patient prone to ascertain whether stone was in distal
ureter or in bladder. Because of its size (< 3 mm), stone should pass spontaneously.
A, Unenhanced pelvic CT urogram shows calculus (arrow) in region of vesicoureteric
junction on right. B, Sagittal reconstruction of unenhanced CT urogram confirms that
calculus (arrowhead) is not in dependent portion of bladder and is therefore in distal
ureter, not in bladder.
Fig. 2—52-year-old man with renal cysts. Coronal reformation of pyelographic phase
CT urogram shows multiple bilateral parapelvic renal cysts (arrows).
Malignant urologic tumors, such as renal cell carcinoma and transitional cell
carci- noma, are potentially detectable during un- enhanced imaging examinations.
(13)
Renal cell carcinoma and transitional cell carcinoma typically appear solid on
unenhanced images and have higher attenuation (5–30 HU) than urine [7]. Possible
malignant tumors are further characterized with contrast-enhanced CT urography.
Malignant renal and urothelial tumors both exhibit early enhancement and washout
after IV contrast administration, which assists in characterization [8]. Because of this
property, an enhancing urothelial lesion can be detected in the nephrographic
phase, in which urine has low attenuation (Fig. 4). Greater than 10 HU lesion
enhancement compared with the findings on unen-
Fig. 4—68 year-old man with transitional cell carcinoma of bladder and congenital
absence of left kidney. Heterogeneous lymph node mass is present on right side.
A, CT scan through pelvis shows soft-tissue mass (arrowhead) in bladder that
contrasts with low- attenuation urine in bladder.
B, Nephrographic phase CT urogram shows soft- tissue mass (arrow) to left of
midline near dome of bladder and absence of left kidney.
Advantages of CT Urography
Three-dimensional reformations with coronal and sagittal maximum intensity
projections of the kidneys and urinary collecting systems facilitate thorough
examination for renal and urothelial malignancy. The advantages of unenhanced CT
over excretory urography in the detection of urinary tract calculi are well
established. Reports have shown sensitivity ranging from 98% to 100% and
specificity of 92–100% for unenhanced CT in the detection of urinary tract calculi [4].
Unlike excretory urography, CT for the evaluation of urinary tract calculi (stone
proto- col) does not require IV contrast administration in most circumstances, and
the risk of nephrotoxicity associated with excretory urography is therefore
eliminated.
It is widely accepted that CT urography outperforms ultrasound, excretory urog-
raphy, and radiography in the evaluation of renal parenchymal masses and urinary
tract calculi. Study results [10] suggest that CT urography has excellent sensitivity
(89– 100%) and specificity in the detection of pelvicaliceal and ureteric transitional
cell carcinoma. Data have prompted investigators in the field to conclude that CT
urography is more sensitive and specific than excretory urography in the detection
(14)
of urothelial tumors. It has been suggested [1] that CT urography be performed as a
first-line technique in the evaluation of hematuria when the risk of disease
outweighs the risk of radiation exposure, as in the care of patients at high risk of
urologic cancer.
The debate continues, however. A 2006 systematic review [11] of diagnostic
tests and algorithms used for investigating hematuria concluded that the available
evidence was insufficient to draw
firm conclusions about the diagnostic accuracy of imaging studies in determining the
cause of hematuria.
Introduction
Investigates how MR imaging has become one of the essential modalities for
evaluating the urinary tract, especially by providing exquisite and unique soft tissue
contrast and allowing accurate assessment of a wide range of pathology. Existing
and emerging applications, including renal mass characterization, evaluation of the
collecting systems and bladder, staging of malignancies, depiction of anomalies of
the urinary system, MR angiography, are discussed, along with its use for guidance
of percutaneous tumour ablation and post-procedural follow-up. Functional MR
nephron-urography as a developing technique combining structural and functional
data within a single examination is also discussed, along with the use of multi-coil
array body surface coils to increase the signal-to-noise ratio (SNR) and obtain high-
resolution images.
MR Urography
MRU is performed by pursuing two different imaging strategies. On the one
hand, heavily T2-weighted turbo spin-echo sequences are employed for obtaining
unenhanced static-water images of the urinary tract. On the other, the T1-weighted
MRU technique imitates conventional intravenous pyelography and is, therefore,
referred to as excretory MR urography. For this reason, a gadolinium contrast agent
is injected intravenously and, after its renal excretion, the gadolinium-enhanced
urine is imaged with fast T1-weighted gradient-echo sequences. Use of these two
(15)
techniques, either individually or in combination, permits investigation of all
relevant aspects in the diagnosis of urinary tract disease.
Although MR imaging is not recommended during the first trimester and use of
contrast material is not recommended in pregnant patients, fast MR imaging is
useful in various obstetric settings and can provide more specific information with
excellent tissue contrast and multiplanar views. In pregnant patients with
hydronephrosis, MRU can demonstrate the site of obstruction and the cause (e.g., a
ureteral stone. A report on the application of standard 2D-FT (fiber tracking) MR
combined with RARE (rapid acquisition with relaxation enhancement) - MRU in a
pregnant woman with right sided abdominal pain, dilated upper urinary tract and
possible stone or inflammatory disease. This technique visualized the complete
obstructed ureter in relation to the surrounding organs (uterus, vessels), allows
precise diagnosis of the cause of the obstruction and avoids ionizing.
In a study with 74 patients, fast 3D gradient echo type echo planar imaging
(GRE EPI) sequences improve the clinical practicability of excretory MRU especially
in old or critically ill patients unable to suspend breathing for more than 20 second.
Susceptibility effects were more pronounced on GRE-EPI MRU and calculi measured
0.8-21.7% greater in diameter compared with conventional GRE .
If you are scheduled for an MR urography exam, you may be asked to wear a gown
during the exam or you may be allowed to wear your own clothing if it is loose-
fitting and has no metal fasteners.
In order to distend your urinary bladder, you may be asked to drink water prior
to the examination, and also not to urinate until after the scan is complete.
However, guidelines about eating and drinking before an MRI exam vary with the
specific exam and also with the facility. For some types of exams, you will be asked
to fast for eight to 12 hours. Unless you are told otherwise, you may follow your
regular daily routine and take medications as usual.
If you are scheduled to undergo MR urography, you may have contrast material
injected intravenously for the exam. The radiologist or technologist may ask if you
have asthma or allergies of any kind, such as an allergy to gadolinium drugs, certain
foods or the environment.
The radiologist should also know if you have any serious health problems or if
you have recently had surgery. Some conditions, such as severe kidney disease, may
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prevent you from being given gadolinium for an MRI. If there is a history of severe
kidney disease, it may be necessary to perform a blood test to determine whether
the kidneys are functioning adequately.
Women should always tell their doctor and technologist if they are pregnant.
MRI has been used since the 1980s with no reports of any ill effects on pregnant
women or their unborn babies. However, the baby will be in a strong magnetic field.
Therefore, pregnant women should not have an MRI in the first trimester unless the
benefit of the exam clearly outweighs any potential risks. Pregnant women should
not receive gadolinium contrast unless absolutely necessary. See the MRI Safety
During Pregnancy
patient preparations
If you have claustrophobia (fear of enclosed spaces) or anxiety, ask your doctor
to prescribe a mild sedative prior to the date of your exam.
With advance notice and planning, some medical centers can provide conscious
sedation for patients with claustrophobia. Patients will typically need to avoid eating
for six hours and drinking for two hours prior to sedation. Consult with your
referring physician and imaging center if conscious sedation may be required.
Leave all jewelry and other accessories at home or remove them prior to the MRI
scan. Metal and electronic items are not allowed in the exam room. They can
interfere with the magnetic field of the MRI unit, cause burns, or become harmful
projectiles. These items include:
jewelry, watches, credit cards, and hearing aids, all of which can be damaged
pins, hairpins, metal zippers, and similar metallic items, which can distort MRI
images, removable dental work pens, pocketknives, and eyeglasses
(17)
pelvicalyceal system, ureters and the urinary bladder. This exam has been largely
replaced by CT urography.
Terminology
Some prefer the term "urogram" to refer to visualisation of the kidney parenchyma,
calyces, and pelvis after intravenous injection of contrast, and reserve the term
"pyelogram" to retrograde studies involving the collecting system. In practice, both
terms are often used interchangeably.
Procedure
Indications
4- Assess for synchronous upper tract disease in those with bladder transitional cell
carcinoma (TCC).
Patient preparation
2- On the day of the procedure take a scout/pilot film to check patient preparation
and also for radiopaque calculi.
3- Check serum creatinine level to be within the normal range (as per hospital
guidelines)
4- Take a history of the patient for any known drug allergies followed by written
informed consent for the procedure.
Technique
(18)
Exposures are generally in the 65-75 kV range, mA of 600-1000, with exposure
of <0.1 sec. Higher kV ranges reduce contrast of the renal parenchyma.
3- Dose will vary as per the weight of the patient; generally up to 1.5 ml/kg body
weight is well tolerated by patient
5- The calyces are usually visualised in <2 minutes following contrast administration
- this is the nephrogram
6-Serial images are taken at 5-20 minutes for visualisation of the pelvicalyceal
systems and ureters when required and with operator preference
8-The full length 10-15 minute film is performed with a compression band applied to
the patient
1-Scout images
3- Early and late images of the upper collecting system (abdominal compression
then applied) (>3 minutes)
5- Supine, after release of compression, images of the upper collecting system and
proximal ureters (10-15 minutes)
(19)
6- Supine image (20 minutes)
Chapter four
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Practical cases
Case1
(21)
Intravenous pyelography (IVP) of Female 12 years With Rt. PUJ Obstruction
Case2
(22)
Non contrast abdominal CT axial section shows left renal stone 10 x 13mm with
PCS dilatation
Case3
(23)
a b
a. Non contrast abdominal CT axial section shows left renal staghorn stone b.
coronal 3d CT showing the same finding
Case4
(24)
contrast enhanced abdominal CT coronal sections shows left renal simple cortical
cyst in the upper pole
Case 5
(25)
Intravenous pyelography (IVP) showing left hydrouretronephrosis
Case 6
(26)
Intravenous urography ( I V U) of a Child 1 y and 3 months
Left kidney : significantly delayed and faint excretion of contrast , severe PCS
and ureteric dilatation down to the urinary bladder , tortuous ureter ....... DX :
severe VU reflux .
Case 7
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Inter venues urography ( I V U)
(28)
Case 8
(29)
Case 9
(30)
Chapter five
Summary and conclusion
(31)
5. Summary and Conclusion
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Chapter Six
References
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References
1. Body, V. (no date) Urinary system structures, Visible Body Learn Anatomy.
Available at: https://www.visiblebody.com/learn/urinary/urinary-system-
structures (Accessed: December 7, 2022).
2. CT urography - ajronline.org (no date). Available at:
https://www.ajronline.org/doi/pdfplus/10.2214/AJR.10.4198 (Accessed:
December 21, 2022).
3. Hiorns, M.P. (2011) Imaging of the urinary tract: The role of CT and MRI,
Pediatric nephrology (Berlin, Germany). U.S. National Library of
Medicine. Available at:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991216/ (Accessed:
December 24, 2022).
4. Home - books - NCBI National Center for Biotechnology Information. U.S.
National Library of Medicine. Available at:
https://www.ncbi.nlm.nih.gov/books (Accessed: December 9, 2022).
5. Niknejad, M. (2022) Intravenous urography: Radiology reference article,
Radiopaedia Blog RSS. Radiopaedia.org. Available at:
https://radiopaedia.org/articles/intravenous-urography (Accessed:
December 22, 2022).
6. Radiological Society of North America (RSNA) and American College of
Radiology (ACR) (no date) Urography, Radiologyinfo.org. Available at:
https://www.radiologyinfo.org/en/info/urography (Accessed: December 24,
2022).
7. Urinary tract imaging (no date) National Institute of Diabetes and
Digestive and Kidney Diseases. U.S. Department of Health and Human
Services. Available at:
https://www.niddk.nih.gov/health-information/diagnostic-tests/urinary-
tract-imaging (Accessed: December 6, 2022).
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وزارة التعليم العالي والبحث العلمي
كلية الهادي الجامعة
قسم تقنيات االشعة والسونار
مشروع تخرج مقدم الى قسم تقنيات األشعة و السونار كجزء من متطلبات الحصول على درجة
البكالوريوس في تقنيات االشعة و السونار
أعــــداد
صفاء الدين أحمد سلطان
شمس األصيل علي غضبان
بالل ابراهيم فرحان
بإشـــراف
2022-2023
)(1