Scribd Logo
Upload

Welcome to Scribd!

  • CH 14

    Uploaded by

    김예진
    8 views67 pages
    The gene encoding the mRNA contains introns. R-looping experiments involve hybridizing mRNA to its DNA template. The results show areas where the mRNA is hybridized to the DNA (loops), which indicates where exons are located. Introns will appear as single-stranded loops not hybridized to the mRNA. The electron micrograph from this experiment shows multiple single-stranded loops, demonstrating the presence of introns in the gene.

    Original Description:

    Original Title

    ch14

    Copyright

    © © All Rights Reserved

    Available Formats

    RTF, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    The gene encoding the mRNA contains introns. R-looping experiments involve hybridizing mRNA to its DNA template. The results show areas where the mRNA is hybridized to the DNA (loops), which indicates where exons are located. Introns will appear as single-stranded loops not hybridized to the mRNA. The electron micrograph from this experiment shows multiple single-stranded loops, demonstrating the presence of introns in the gene.

    Copyright:

    © All Rights Reserved
    Download as RTF, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    8 views67 pages

    CH 14

    Uploaded by

    김예진
    The gene encoding the mRNA contains introns. R-looping experiments involve hybridizing mRNA to its DNA template. The results show areas where the mRNA is hybridized to the DNA (loops), which indicates where exons are located. Introns will appear as single-stranded loops not hybridized to the mRNA. The electron micrograph from this experiment shows multiple single-stranded loops, demonstrating the presence of introns in the gene.

    Copyright:

    © All Rights Reserved
    Download as RTF, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 67

    ch14

    Student: ___________________________________________________________________________

    1.  Which of the following is not true concerning eukaryotic mRNA processing?  
    A.  addition of a 3¢ poly-A tail
    B.  addition of a 5¢ cap
    C.  intron splicing
    D.  occurs in the nucleus
    E.  occurs in the cytoplasm

    2.  Which of the following experiments was useful in determining the existence of introns in the adenovirus
    genome?  
    A.  DNA/DNA hybridization
    B.  RNA/RNA hybridization
    C.  R-looping experiments
    D.  RT-PCR
    E.  cDNA cloning experiments

     
    3.  You have isolated a new species of mRNA using an oligo-dT column. You then perform an R-looping
    experiment to determine if the gene encoding for your mRNA contains introns. Below is a representation of the
    electron micrograph results. Which of the following can you conclude from your experiment?
     010009000003b878000000009178000000000400000003010800050000000b0200000000050000000c025e00d
    a000400000004010d0004000000070103000500000014020000000091780000410b2000cc005e00da000000000
    05e00da000000000028000000da0000005e0000000100180000000000e0f000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    00000000000000000000000000000000000030000000000    
    A.  The gene contains no introns.
    B.  The gene contains one intron.
    C.  The gene contains two introns.
    D.  The gene contains three introns.
    E.  The results are inconclusive.

    4.  The first two bases and the last two bases in the splicing signal consensus sequence are  
    A.  GT-AG.
    B.  GU-AG.
    C.  CU-AG.
    D.  GU-AC.
    E.  GT-TG.

    5.  Which of the following is the name for the Yeast 40S particle where mRNA splicing takes place?  
    A.  ribosome
    B.  nucleolus
    C.  spliceosome
    D.  hnRNA
    E.  R-loop

     
    6.  "Snurps" are composed of  
    A.  RNA.
    B.  protein.
    C.  DNA.
    D.  RNA and protein.
    E.  DNA and RNA.

    7.  Which of the following snRNP is mismatched with its function?  


    A.  U1: base pairs with 5¢ splice site of mRNA.
    B.  U2: base pairs with the conserved sequence at splicing branch point.
    C.  U4: base pairs with 3¢ splice site of mRNA.
    D.  U5: associates with last nucleotide in one exon and the first nucleotide in the next exon.
    E.  U6: base pairs with 5¢ end of the intron.

    8.  Which of the following complexes found in the spliceosome cycle is mismatched with its snRNP(s)?  
    A.  commitment complex: U6/U4
    B.  A complex: U1 and U2
    C.  B1 complex: all snRNPs
    D.  B2 complex: U2, U5 and U6
    E.  I complex: U2, U5 and U6

    9.  Which of the following splicing factors is required for the correct 3¢ splice site selection?  
    A.  SC35
    B.  Slu7
    C.  U11
    D.  SF2
    E.  SRp55

    10.  The catalytic center of the spliceosome appears to include  


    A.  Mg2+.
    B.  U2 and U6 snRNP.
    C.  the branch point region of the intron.
    D.  Mg2+ and the branch point region of the intron.
    E.  Mg2+, U2, and U6 snRNP, and the branch point region of the intron.

     
    11.  Which of the following is the first snRNP to bind during the assembly stage of the spliceosome cycle?  
    A.  U1
    B.  U2
    C.  U4
    D.  U5
    E.  U6

    12.  The binding of which of the following snRNPs to spliceosome requires ATP?  
    A.  U1
    B.  U2
    C.  U4
    D.  U5
    E.  U6

    13.  The expressed regions of genes are referred to as ________ while the noncoding regions are called_______.

    ________________________________________

    14.  The process by which introns are removed from immature mRNA is called _____________.  
    ________________________________________

    15.  _______________ disrupting the normal splicing consensus sequence are one way to obtain abnormal
    splicing patterns.  
    ________________________________________

    16.  Joan Steitz was one of the researchers who used __________ studies to demonstrate that U6 snRNP binds
    to the 5¢ end of the intron.  
    ________________________________________

    17.  Some introns, such as Group II introns, are self splicing. These types of introns contain catalytic RNA's,
    also referred to as __________.  
    ________________________________________

    18.  Exon definition involves the use of the ________ subunit of RNA polymerase II.  
    ________________________________________

     
    19.  Alternative splicing is involved in _________ determination in fruit flys.  
    ________________________________________

    20.  There are a common set of ___________ Sm proteins that are specific to each snRNA.  
    ________________________________________

    21.  Introns are regions found in DNA sequences and mature mRNA sequences.  
    True    False

    22.  RNA polymerase II does not transcribe through introns, instead it jumps over them.  
    True    False

    23.  Heterogeneous nuclear RNA (hnRNA) is thought to be a precursor of mRNA.  


    True    False

    24.  Pre-mRNA splicing occurs in the cytoplasm.  


    True    False

    25.  Experimental evidence demonstrates that mRNA precursors are spliced via a lariat-shaped intermediate.  
    True    False

    26.  Base pairing between the 5¢ splice site and U1 snRNA is the only interaction essential for splicing.  
    True    False

    27.  The spliceosome cycle is one way for a cell to regulate gene expression.  
    True    False

    28.  Immature mRNA splicing can be established by either exon definition or intron definition.  
    True    False

     
    29.  Alternative splicing patterns can lead to the production of different protein products from the same gene.  
    True    False

    30.  SC35 is an RNA binding protein that is responsible for the commitment to splice the b-globin pre-mRNA.  
    True    False

    31.  The discovery of alternate splicing helped prove the "one gene, one protein" theory.  
    True    False

     
    ch14 Key
     

    1.  Which of the following is not true concerning eukaryotic mRNA processing?  
    A.  addition of a 3¢ poly-A tail
    B.  addition of a 5¢ cap
    C.  intron splicing
    D.  occurs in the nucleus
    E.  occurs in the cytoplasm

    Blooms Level: 2. Understand


    Section: 14.01
    Weaver - Chapter 14 #1
     

    2.  Which of the following experiments was useful in determining the existence of introns in the adenovirus
    genome?  
    A.  DNA/DNA hybridization
    B.  RNA/RNA hybridization
    C.  R-looping experiments
    D.  RT-PCR
    E.  cDNA cloning experiments

    Blooms Level: 2. Understand


    Section: 14.01
    Weaver - Chapter 14 #2
     
    3.  You have isolated a new species of mRNA using an oligo-dT column. You then perform an R-looping
    experiment to determine if the gene encoding for your mRNA contains introns. Below is a representation of the
    electron micrograph results. Which of the following can you conclude from your experiment?
     010009000003b878000000009178000000000400000003010800050000000b0200000000050000000c025e00d
    a000400000004010d0004000000070103000500000014020000000091780000410b2000cc005e00da000000000
    05e00da000000000028000000da0000005e0000000100180000000000e0f000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000
    00000000000000000000000000000000000030000000000    
    A.  The gene contains no introns.
    B.  The gene contains one intron.
    C.  The gene contains two introns.
    D.  The gene contains three introns.
    E.  The results are inconclusive.

    Blooms Level: 5. Evaluate


    Section: 14.01
    Weaver - Chapter 14 #3
     

    4.  The first two bases and the last two bases in the splicing signal consensus sequence are  
    A.  GT-AG.
    B.  GU-AG.
    C.  CU-AG.
    D.  GU-AC.
    E.  GT-TG.

    Blooms Level: 1. Remember


    Section: 14.01
    Weaver - Chapter 14 #4
     
    5.  Which of the following is the name for the Yeast 40S particle where mRNA splicing takes place?  
    A.  ribosome
    B.  nucleolus
    C.  spliceosome
    D.  hnRNA
    E.  R-loop

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #5
     

    6.  "Snurps" are composed of  


    A.  RNA.
    B.  protein.
    C.  DNA.
    D.  RNA and protein.
    E.  DNA and RNA.

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #6
     

    7.  Which of the following snRNP is mismatched with its function?  


    A.  U1: base pairs with 5¢ splice site of mRNA.
    B.  U2: base pairs with the conserved sequence at splicing branch point.
    C.  U4: base pairs with 3¢ splice site of mRNA.
    D.  U5: associates with last nucleotide in one exon and the first nucleotide in the next exon.
    E.  U6: base pairs with 5¢ end of the intron.

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #7
     

    8.  Which of the following complexes found in the spliceosome cycle is mismatched with its snRNP(s)?  
    A.  commitment complex: U6/U4
    B.  A complex: U1 and U2
    C.  B1 complex: all snRNPs
    D.  B2 complex: U2, U5 and U6
    E.  I complex: U2, U5 and U6

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #8
     
    9.  Which of the following splicing factors is required for the correct 3¢ splice site selection?  
    A.  SC35
    B.  Slu7
    C.  U11
    D.  SF2
    E.  SRp55

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #9
     

    10.  The catalytic center of the spliceosome appears to include  


    A.  Mg2+.
    B.  U2 and U6 snRNP.
    C.  the branch point region of the intron.
    D.  Mg2+ and the branch point region of the intron.
    E.  Mg2+, U2, and U6 snRNP, and the branch point region of the intron.

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #10
     

    11.  Which of the following is the first snRNP to bind during the assembly stage of the spliceosome cycle?  
    A.  U1
    B.  U2
    C.  U4
    D.  U5
    E.  U6

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #11
     

    12.  The binding of which of the following snRNPs to spliceosome requires ATP?  
    A.  U1
    B.  U2
    C.  U4
    D.  U5
    E.  U6

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #12
     
    13.  The expressed regions of genes are referred to as ________ while the noncoding regions are called_______.

    exons, introns

    Blooms Level: 1. Remember


    Section: 14.01
    Weaver - Chapter 14 #13
     

    14.  The process by which introns are removed from immature mRNA is called _____________.  
    RNA splicing

    Blooms Level: 1. Remember


    Section: 14.01
    Weaver - Chapter 14 #14
     

    15.  _______________ disrupting the normal splicing consensus sequence are one way to obtain abnormal
    splicing patterns.  
    Mutations

    Blooms Level: 2. Understand


    Section: 14.01
    Weaver - Chapter 14 #15
     

    16.  Joan Steitz was one of the researchers who used __________ studies to demonstrate that U6 snRNP binds
    to the 5¢ end of the intron.  
    cross-linking

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #16
     

    17.  Some introns, such as Group II introns, are self splicing. These types of introns contain catalytic RNA's,
    also referred to as __________.  
    ribozymes

    Blooms Level: 1. Remember


    Section: 14.03
    Weaver - Chapter 14 #17
     
    18.  Exon definition involves the use of the ________ subunit of RNA polymerase II.  
    Rpb1

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #18
     

    19.  Alternative splicing is involved in _________ determination in fruit flys.  


    sex

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #19
     

    20.  There are a common set of ___________ Sm proteins that are specific to each snRNA.  
    seven

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #20
     

    21.  Introns are regions found in DNA sequences and mature mRNA sequences.  
    FALSE

    Blooms Level: 2. Understand


    Section: 14.01
    Weaver - Chapter 14 #21
     

    22.  RNA polymerase II does not transcribe through introns, instead it jumps over them.  
    FALSE

    Blooms Level: 2. Understand


    Section: 14.01
    Weaver - Chapter 14 #22
     

    23.  Heterogeneous nuclear RNA (hnRNA) is thought to be a precursor of mRNA.  


    TRUE

    Blooms Level: 1. Remember


    Section: 14.01
    Weaver - Chapter 14 #23
     
    24.  Pre-mRNA splicing occurs in the cytoplasm.  
    FALSE

    Blooms Level: 2. Understand


    Section: 14.01
    Weaver - Chapter 14 #24
     

    25.  Experimental evidence demonstrates that mRNA precursors are spliced via a lariat-shaped intermediate.  
    TRUE

    Blooms Level: 2. Understand


    Section: 14.02
    Weaver - Chapter 14 #25
     

    26.  Base pairing between the 5¢ splice site and U1 snRNA is the only interaction essential for splicing.  
    FALSE

    Blooms Level: 2. Understand


    Section: 14.02
    Weaver - Chapter 14 #26
     

    27.  The spliceosome cycle is one way for a cell to regulate gene expression.  
    TRUE

    Blooms Level: 2. Understand


    Section: 14.02
    Weaver - Chapter 14 #27
     

    28.  Immature mRNA splicing can be established by either exon definition or intron definition.  
    TRUE

    Blooms Level: 2. Understand


    Section: 14.02
    Weaver - Chapter 14 #28
     

    29.  Alternative splicing patterns can lead to the production of different protein products from the same gene.  
    TRUE

    Blooms Level: 2. Understand


    Section: 14.02
    Weaver - Chapter 14 #29
     
    30.  SC35 is an RNA binding protein that is responsible for the commitment to splice the b-globin pre-mRNA.  
    TRUE

    Blooms Level: 1. Remember


    Section: 14.02
    Weaver - Chapter 14 #30
     

    31.  The discovery of alternate splicing helped prove the "one gene, one protein" theory.  
    FALSE

    Blooms Level: 2. Understand


    Section: 14.02
    Weaver - Chapter 14 #31
     
    ch14 Summary

    Category # of Questions
    Blooms Level: 1. Remember 18
    Blooms Level: 2. Understand 12
    Blooms Level: 5. Evaluate 1
    Section: 14.01 11
    Section: 14.02 19
    Section: 14.03 1
    Weaver - Chapter 14 31

    You might also like