A critical analysis: Analysis of shared heritability in

common disorders of the brain

 This abstract highlight the importance of common genetic

variation as a risk factor for brain disorders and the value of
heritability-based methods in understanding their etiology and
how it was quantified with the wide assessment done on a
number of subjects and their relationships
 It also shows us the results of the assessment done on all the
patients and the correlations among different disorders
 It is concluded in the abstract the high degree of genetic
correlation among many of the psychiatric disorders adds
further evidence that their current clinical boundaries do not
reflect distinct underlying pathogenic processes, at least on the
genetic level
 How Brain disorders has evolved over the past century has
been explained with respect to as behavioural change, loss of
motor function, spontaneous movements, or alterations of
consciousness has been explained in detail
 Details has been provided with respect to Brainstorm
Consortium, a collaboration among GWAS meta-analysis
consortia for 25 disorders assembled to perform a
comprehensive heritability and correlation analysis of brain
disorders
 Linkage disequilibrium score has been mentioned in the
abstract as being developed by the author which was used to
calculate heritability estimates and correlations, as well as to
estimate their statistical significance from block jackknife–
based standard errors.
 Detailed explanation has been provided on the Heritability
estimates and their error sources. The common variant
 heritability’s estimates for the psychiatric and neurological
disorders were generally somewhat lower than previously
reported estimates from common variants has been explained
 Author has provided details on different discussions that has
happened over the analysis and the correlation among brain
disorders
 Downside of this abstract is that it is very difficult to
understand from a common person’s perspective
 While reading this abstract, I had to go through most of the
statements more than once to understand on what the author
is intending to tell in the abstract with too detailed
explanations