Your Ref.

: -Please Advise-
Our Ref. : PT/7080/UIAM/19 (azreen)

23rd November 2022

Patent, Trademark, Industrial
Design Registration & Copyright
INTERNATIONAL ISLAMIC UNIVERSITY MALAYSIA Protection
Innovation and Commercialization Unit, International Intellectual Property
Registration & Enforcement
Level 2, Research Management Centre, Technology Transfer &
International Islamic University Malaysia, Commercialisation
Jalan Gombak, 53100 Kuala Lumpur . By email (amiluq@iium.edu.my) Intellectual Property Strategy &
Incentives Facilitation
Attn : En. Ami Nordin Bin Ismail & Confirmation by Post

Dear Sirs,

NOTICE OF GRANT FOR PATENT APPLICATION NO. PI 2019006842

OWNER : INTERNATIONAL ISLAMIC UNIVERSITY MALAYSIA
INVENTION : A SYNBIOTIC ORAL CARE COMPOSITION
DATE OF GRANT : 26TH APRIL 2022

1. We refer to the above matter.

2. CONGRATULATIONS. We are pleased to inform you that the aforesaid application has been
GRANTED with the following particulars:

GRANT NO. : MY-190505-A

DATE OF GRANT : 26TH APRIL 2022
PUBLICATION DATE : 26TH APRIL 2022
OWNER : INTERNATIONAL ISLAMIC UNIVERSITY MALAYSIA
EXPIRATION DATE : 21ST NOVEMBER 2039

3. Please find enclosed the original copy of the Certificate of Grant of A Patent for your reference and
record. Copies of the patent were made available to the public on the date of grant and will be
published in the Gazette as soon as possible.

4. Your attention is drawn to the need to pay annual fees in order to keep the patent in force. A patent first
fee (2nd Year) is payable before the first anniversary of the date of Grant i.e. 25th April 2023.

5. We thank you for entrusting us with this application and look forward to serve you better. If we can be
of any further assistance, please do not hesitate to contact Ms. Azreen or Ms. Zarina at
patent4@pintas-ip.com.

6. Please acknowledge receipt of this Certificate of Registration.

Thank you.

Yours faithfully,
Acknowledgement
PINTAS CONSULTING GROUP SDN BHD
Lok Choon Hong
Director
..............................................
Signature

Name
Date

MALAYSIA OFFICE URL: www.pintas-ip.com SINGAPORE OFFICE

PINTAS CONSULTING GROUP SDN BHD 199801004930 PINTAS PTE LTD 200104671-N
No. 19, Jalan SS 1/36, 151, Chin Swee Road, #12-14 Manhattan House
47300 Petaling Jaya, Selangor, Malaysia Singapore 169876
T: (603) 7876 5050 F: (603) 7876 2678 T: (65) 6250 2070 F: (65) 6737 1805
E : pintas.my@pintas-ip.com E : pintas.sg@pintas-ip.com
(12) MALAYSIAN PATENT (11) MY-190505-A

(21) Application No. : PI2019006842 (56) Prior Art :

WO 2015127311 A1
(22) Filing Date : 21 November 2019 WO 2018106845 A1

(47) Date of Publication and Grant : (72) Inventors :

26 April 2022 Mohd Hafiz Bin Arzmi

(30) Priority Data : (73) Patent Owner :

None International Islamic University Malaysia
Jalan Gombak
(51) Classification, INT CL : 53100 Kuala Lumpur
A61K 8/99 Malaysia
A61K 35/744
A61K 36/88 (74) Agent :
Lok Choon Hong
C/o Pintas Consulting Group Sdn. Bhd.

(54) Title : A Synbiotic Oral Care Composition

(57) Abstract :

The present invention relates to a synbiotic composition for promoting oral health in a
recipient comprising Streptococcus salivarius K12 and Musa acuminata fruit peel extract.
 1

A SYNBIOTIC ORAL CARE COMPOSITION

FIELD OF INVENTION

5 The present invention relates to an oral care composition and more particularly to a
composition comprising a probiotic and a prebiotic for promoting oral health.

BACKGROUND OF THE INVENTION

10 Oral cavity comprises microbiome that is consists of bacteria, fungal and virus. Any
perturbation of oral environment may lead to dysbiosis thus induce oral diseases
including oral candidiasis and dental caries.

There have been many approaches developed to overcome the oral diseases
15 aforementioned. These approaches include using chemical-based mouthwash such as
chlorhexidine (CHX), cetylpryidinium chloride (CPC) and alcohol. Nevertheless,
concern on the side effect of using chemical-based mouthwash is recently raised due
to the activity of these active ingredients which is able to cause dysbiosis by killing all
the good and bad oral microorganisms.
20
As such, it is desirable to develop an alternative oral care formulation that does not
adversely affect balance in the oral microbiome.

SUMMARY OF INVENTION
25
The main aspect of the present invention is to provide an oral care composition
comprising a probiotic and a prebiotic, in which the oral care composition is able to
promote oral health by enhancing growth of beneficial oral microorganisms while
inhibiting the growth of the pathogenic oral microorganisms in oral cavity of a
 2

recipient. In accordance with a preferred embodiment, the pathogenic microorganism

includes Candida species.

At least one of the preceding objects is met, in whole or in part, by the present
5 invention, in which one of the embodiments of the present invention is an oral care
composition comprising Streptococcus salivarius K12 and Musa acuminata fruit peel
extract.

In accordance with a preferred embodiment, the oral care composition

10 aforementioned is administered to oral cavity of a recipient in the forms of drops,
tablet or capsule.

The present preferred embodiment of the invention consists of novel features and a
combination of parts hereinafter fully described and illustrated in the accompanying
15 drawings and particularly pointed out in the appended claims; it being understood that
various changes in the details may be effected by those skilled in the arts but without
departing from the scope of the invention or sacrificing any of the advantages of the
present invention.

20 BRIEF DESCRIPTION OF THE DRAWINGS

For the purpose of facilitating an understanding of the invention, there is illustrated in

the accompanying drawing the preferred embodiments from an inspection of which
when considered in connection with the following description, the invention, its
25 construction and operation and many of its advantages would be readily understood
and appreciated.

Figure 1 shows the effect of Musa acuminata fruit skin aqueous extract on growth of
Candida albicans (A, B, C) and Streptococcus salivarius K12 (D).
 3

DETAILED DESCRIPTION OF THE INVENTION

Hereinafter, the invention shall be described according to the preferred embodiments

5 of the present invention and by referring to the accompanying description and
drawings. However, it is to be understood that limiting the description to the preferred
embodiments of the invention and to the drawings is merely to facilitate discussion of
the present invention and it is envisioned that those skilled in the art may devise
various modifications without departing from the scope of the appended claim.
10
The present invention relates to an oral care composition comprising Streptococcus
salivarius K12 and Musa acuminata fruit peel extract.

The oral care composition can be used for promoting oral health by inducing the
15 growth of beneficial oral bacteria and inhibiting plaque accumulation by oral
pathogen. According to a preferred embodiment, the oral pathogen includes Candida
species.

The oral composition may be administered to oral cavity of a recipient in the form of
20 of drops, tablet or capsule.

According to the preferred embodiment, the Musa acuminata fruit peel extract is used
as prebiotic in the oral care composition of the present invention. As shown in Figure
1, based on a biofilm assay, the Musa acuminata extract inhibited biofilm formation
25 of both lab and clinical strains of Candida albicans while promoting growth of the
probiotic including Streptococcus salivarius K12. In one embodiment, it is preferable
that about 700-900 mg/mL of the Musa acuminata fruit peel extract is included in the
oral care composition aforementioned.
 4

Although the invention has been described and illustrated in detail, it is to be

understood that the same is by the way of illustration and example, and is not to be
taken by way of limitation. The scope of the present invention is to be limited only by
the terms of the appended claims.
5

10

15

20

25
 5

CLAIMS

1. An oral care composition comprising Streptococcus salivarius K12 and Musa

acuminata fruit peel extract.
5
2. The synbiotic composition according to claim 1 is administered to oral cavity
of a recipient in the forms of drops, tablet or capsule.

3. Use of the oral care composition according to claim 1 or 2 for inhibiting

10 growth of pathogenic microorganism in the oral cavity of the recipient.

4. Use of the oral care composition according to claim 3, wherein the pathogenic
microorganism includes Candida species.

15

20

25
 6

ABSTRACT

A SYNBIOTIC ORAL CARE COMPOSITION

5 The present invention relates to a synbiotic composition for promoting oral health in a
recipient comprising Streptococcus salivarius K12 and Musa acuminata fruit peel
extract.

No illustration for abstract.

10
 1/1

Figure 1