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Drug Administration - 0
Drug Administration - 0
Introduction on Drugs
Pharmacology
Greek: pharmakon means “drugs” and logos means “science”
the study of the effect of drugs on living organisms
Pharmaceutical Drug
any chemical substance intended for use in the medical diagnosis, cure,
treatment, or relief of a symptom or for prevention of diseases
Sources of Drugs
Natural Sources – drugs derived from plants and animals (found in nature)
Ex: opium, digitalis, iron, NaCl, Insulin, and Vaccines
Synthetics – drugs that are produced and comes from starting materials not
found in nature
Ex: Sulfonamides (antibiotic), Propoxyphene HCl
Drug Classifications
OTC (Over-the-Counter) Drugs – may be available without special restrictions or
doesn’t need any prescription from the doctors for it to be purchased; legally safe
for the layperson to use when taken according to directions provided by the
manufacturer
Ex: Paracetamol, Acetaminophen, Aspirin
POM (Prescription Only Medicine) Drugs – must be prescribed by a licensed
medical practitioner
Ex: Antibiotics
BTC (Behind-the-Counter) – BTCs do not require a prescription, but must be kept
in the dispensary, not visible to the public, and only be sold by a pharmacist or
pharmacy technician. Unlike a prescription medication, BTC would allow a
patient to access drugs after an assessment and decision by a pharmacist.
Ex: Birth Control Pills
Drug Names
Chemical Name – describes the drugs molecular structure and identifies its
chemical structure
Generic Name – is the drug’s official name; it is also the complete copy the
branded drugs
Trade Name (Brand Name) – Name given by the drug manufacturer; it also
known as “the first of its kind”
Note: Branded drugs are produced first before the generic drug. That is why generic
drugs are much cheaper compared to branded drugs. Brand-name drugs are
typically more expensive because of the higher initial costs to develop, market, and
sell a brand-new drug while generic drugs will not undergo the same process as
compared with branded drugs.
Note: generic names are written with a small initial letter while brand names are written
with a capital initial letter as seen on the image above.
Drug Effects
Therapeutic effect is always accompanied with unlikely effect
Local Drug Effect – point of contact & generally does not affect tissues in other
areas
Ex: Topical (skin/mucous membranes) application of anti-inflammatory drugs
(Hydrocortisone) on inflamed area of the skin.
Systemic Drug Effect – drug affects the different body systems; administration of
medication so that the entire body is affected
Ex: Oral medications usually causes systemic effects.
Therapeutic Effects – these are desired effects, intended effects, and or primary
effects; this effect is the reason why the drug is prescribed
Ex: Decongestants are prescribed to decongest the airway
Side Effects
“secondary effects”
An effect that are not intended but are usually predictable
Ex: (1) Digitalis – this drug is given to improve myocardial contractions while its
side effects are feeling nauseous and vomiting. (2) Antibacterial – this drug is
given to kill bacteria while its side effects are diarrhea and stomach upset.
Adverse Effects
“Adverse Reactions”
More severe side effects
Ex: Digitalis – a/r: visual problems, including blurry vision and yellow halos
Toxicity
Deleterious effects of a drug to an organism; results from:
o Overdosage
o Ingestion
o Buildup of drug due to impaired excretion/metabolism (cumulative effect). It is
common to patients with kidney (organ for excretion) and liver (organ for
metabolism) problems.
Ex: Morphine Sulfate (narcotic analgesic) – overdosage of this drug results to
respiratory depression (s/sx: decreased respiratory rate)
Idiosyncratic Effects
An unexpected and may be individualized effect
An unexplainable effect
Idiosyncratic drug reactions are adverse drug reactions that do not occur in most
patients at any dose and do not involve the known pharmacological properties of
the drug. These are drug reactions that occur rarely and unpredictably amongst
the population.
Ex: Idiosyncratic drug-induced liver injury (DILI) is a significant adverse effect of
antitubercular therapy with isoniazid (INH)
Drug Interaction (when two or more drugs are being given to the patient)
o occurs when the administration of one drug, alters the effect of one or both
o Effect: increased (potentiating effect) or decreased (inhibiting effect)
Ex: There are drugs that when they are combined together would either have a
potentiating effect (means that a drug can amplify the effect of another drug) or
inhibiting effect (means that a drug can prevent/stop the effect of another drug
from taking place).
o Potentiating effect
Additive – When two of the same type of drug increase the action of each
other
Ex: Codeine (narcotic analgesic) + Aspirin (Nonsteroidal Anti-
inflammatory drug) = pain killer and anti-inflammatory
Synergistic – When two different drugs increase the action of one or
another drug
Ex: ampicillin (antibiotic) + sulbactam (beta-lactamase inhibitor) =
prolonged action of the antibiotic
Parts of Prescription
Superscription
o Descriptive patient information (name, age, address)
o Date prescribed
o Rx symbol
Inscription
o Name & dosage strength of prescribed medication
Subscription
o Dispensing instructions for the pharmacist
Signatura
o Directions for the client
Prescriber’s signature
o Signature of the one who prescribed the drug
SUPERSCRIPTION
INSCRIPTION
SUBSCRIPTION
SIGNATURA
PRESCRIBER’S
SIGNATURE
Superscription:
Inscription:
Subscription:
Signatura:
Prescriber’s Signature:
Types of Medication Order
Stat Order – medication should be given immediately & only once
Ex: Morphine sulfate 10mg IV STAT
Single Order – (One-Time Order) medication to be given once at a specified time
Ex: Diphenhydramine 10mg slow IV push 30 mins prior to transfusion of 1st unit
of PRBC (packed red blood cells)
Standing Order – may or may not have a termination date; may be carried out
indefinitely
Kalium Durule 2 tabs p.o three times a day after meals x 3 days
PRN Order – (As-Needed Order) permits the nurse to give a medication when, in the
nurse’s judgment, the client requires it.
Ex: Paracetamol 500mg/tab 1tab p.o. every 4hrs PRN for fever (to be given for
temperature >37.8 C) this means that you are only allowed to administer
Paracetamol if the client is febrile with an interval of at least 4 hours (if you have
given paracetamol at around 4pm, you should not give paracetamol before 8pm
even if the patient is febrile therefore you can perform tepid sponge bath to the
patient).
Note: Always make sure to verify the medication ticket to your patient’s chart specifically
to the Medical Order Sheet then to the Medication Sheet (both of which can be found in
the patient’s chart) just to be sure that you are administering the right drug to the right
patient with the right dose.
6 – 12 – 6
p.o.
6 – 12 – 6 – 12
IVTT
5 – 11 – 5 – 11
p.o.
Semi Solids
1. Suppository – One or several drugs
mixed with a firm base such as a
gelatin and shaped for insertion into
the body (e.g. rectum); the base
dissolves gradually at body
temperature, releasing the drug 5. Gel (Jelly) – A clear or translucent
semisolid that liquefies when applied
to the skin
3. Liniments – a medication mixed with
alcohol, oil, or soapy emollient and
applied to the skin
Liquids
1. Lotions – a medication in a liquid
suspension applied to the skin
5. Tinctures – An alcoholic or water-
and-alcohol solution prepared from
drugs derived from plants
Administering Medication
The doctor by written order will indicate:
o drug name;
o amount of the drug per dose;
o the number of doses (tables, capsules, etc.);
o the route by which to administer the drug; and
o the frequency or number of times a day the drug is to be taken
Ex.: Demerol 100 mg IM q4˚ x 5 days
Consideration in Administration
1. The general principles related to drug administration.
2. The various types of drugs and their uses.
3. The minimum and maximum dosage of drugs.
4. The most effective means of administration and its expected effect.
5. S/sx (signs and symptoms) which would indicate patient idiosyncrasy or allergy.
6. Various factors which must be considered in determining the method and time of
administration of drugs.
7. Those factors which may modify the drug action.
8. The nurse should also know the new drugs which are continually appearing in the
market.
Note: You ONLY write your initials on the boxes which corresponds to the date and time
you have administered the drug. Never write your initials on the blank spaces if it does
not correspond to the date and time you administered the drug. If you see another initial
written on your supposed to be box, report to the Clinical Instructor or verify if that
person (who owns the initial) gave the drug to the patient to avoid doubling of drug
administered. If all of the boxes have been filled-up with initials, it is your prerogative to
add another medication sheet on top of the previous medication sheet. Do not discard
the used-up medication sheet.
If you have noticed the encircled series of numbers on the MEDICATION
column, that indicates the number of doses the patient received amoxicillin. The only
time that you can encircle the particular number is that if the patient completed the dose.
Based on the doctor’s order, the patient should receive amoxicillin 500mg for 4 times in
a day. So, on the fourth administration of the medication, you encircle the number using
the appropriate color of pen – who ever administers the fourth dose should be the one
encircling the number. This will help identify if the patient already completed the required
number of doses.
Note: Antibiotics, when ordered by a physician, should be completed in a specific
number of days.
This part of the medication sheet contains PRN medications (see image below).
Let’s discuss first the PRN medication portion. Remember that PRN medications are
drugs which are prescribed by the physician and are given to the patient when a certain
condition is met. In the example below, the physician ordered paracetamol i tab. q4° for
temperature > 37.6°C. This means that you will only administer the medication if the
patient’s temperature is above 37.6°C with an interval of 4 hours every administration. In
the example below, there are times wherein you are tasked to monitor the patient’s vital
signs (VS) every two hours. Paracetamol was initially given at 2pm. Now let’s say the
patient got febrile or had a temperature of more than 37.6°C when you checked his VS
at 4pm. You will not administer paracetamol to the patient because it increases the risk
of acetaminophen toxicity. Instead of administering paracetamol, you can help decrease
the patient’s temperature by performing tepid sponge bath (TSB) until the 4-hour-interval
elapses.
Temp>37.6°C
Lastly, I present to you the Single Order and STAT medications portion of the
medication sheet. This part of the medication sheet contains urgent medications to be
administered without delay and single order medications. In this example,
diphenhydramine (an antihistamine drug) is administered to the patient 30 minutes prior
to blood transfusion of PRBC. This is a case of Single Order medication – it doesn’t
necessarily mean that the nurse will administer it immediately once the drug is available
but should be given 30 minutes prior to transfusion of the PRBC considering that it is
ready to be transfused to the patient.
of PRBC
For STAT medication order, make sure that it is carried out immediately right
after the order is given by the physician. Do not forget to write the date and time at the
back of the Red Medication Ticket once the drug is administered so as not to forget the
details when transcribing in the medication sheet. Remember to use the appropriate
color of pen when writing your initial.
The last two columns basically contain the initials and last name of the nurse
administrating the medication. This will help identify whoever administered the drug at a
given time and date.
ANA VGY
8pm
500mg i tabfor MKR
Temp>37.6°C
MEDICATION SHEET
NAME: WD: RM & BED NO:
DATE FREQUENCY/
MEDICATION DATE ADMINISTERED/SINATURE
ORDERED TIME
DATE FREQUENCY/
PRN MEDICATION DATE ADMINISTERED/SINATURE
ORDERED TIME
DATE/TIME
DATE SINGLE ORDER/STAT ADMINISTERED/ SIGNATURE NURSES PRINTED
ORDERED MEDICATION SIGNATURE (INITIAL) NAME
Drug Computation Step 1: Identify the variables
Safe nursing care mandates accuracy in Desired dose (D) = 1gm
the calculation of dosages and solution Drug on hand (H) = 250mg
rates. In this section you will get a brief Vehicle (V) = (1) capsule
review of basic arithmetic calculations
Step 2: convert the necessary
and a review of the ratio and proportion
measurement
method that is used for the calculation
1gm = 1000mg
of dosages and solutions.
Step 3: use the formula
Basic Formula
Amount to give = 1000mgx (1) capsule
_D_x V = Amount to give
250mg
H
where: D = desired dose
1000mg_ x (1) capsule = 4 capsules
H = drug on hand; dose on hand
250mg
V = vehicle; form and amount in
Note: always indicate the unit of which
which drug comes (tablet,
you are going to administer to your
capsule, liquid)
patient.
Note: Your desired dose is basically what
the doctor ordered; drug on hand is the
available drug; and vehicle is the type of
preparation of the drug.
o Kinds of Syringes
Tuberculin Syringe – originally
designed to administer tuberculin
(TB exposure); narrow, calibrated in
tenths and hundredths of ml; used in
administering drugs that needs
precise measurements or in small
doses
3 Variable Characteristics of a
Needle:
1. Slant or Length of Needle. The bevel
of the needle may be short or long.
Longer bevels provide the sharpest
needles and cause less discomfort.
They are commonly used for
subcutaneous or intramuscular
injections. Short bevels are used for
intradermal and intravenous
injections because a long bevel can
become occluded if it rests against
the side of a blood vessel.
Vials
o Are small glass bottle with a
sealed rubber cap
o Can some in single dose or
multi-dose
o Reconstitution – Technique of
adding a solvent to a powdered
o A glass container usually drug to prepare it for
designed to hold a single dose of administration
a drug
o Made of clear glass; has a
constricted neck
o Some may have colored marks
or dots which indicate where
they are pre-scored
o Vials with plastic cap
o Dorsogluteal site
composed of thick gluteal
muscles of the buttocks
not to be used for children below
3 y.o. unless the child has been
walking for at least 1 year
Nursing Alert: Locate the site
carefully to avoid striking the
sciatic nerve, major blood
vessel, and bone. o Rectus Femoris
Position: prone or side-lying with situated on the anterior aspect of
the upper knee flexed and in the thigh
front of the lower leg advantage: good for patients
who administer their own
injections for they can reach the
site easily
Z-Track Technique Note: Z-track technique prevents
used for Parenteral iron preparation leakage into subcutaneous tissue and
(to seal the drug deep into the decreases the chance of local irritation.
muscle & prevent staining of the
skin) Intravenous Medications
Retract skin laterally (use the ulnar Injecting medications into the vein
side of the non-dominant hand to has a rapid effect on the patient’s
pull skin appx. 1 inch to the side) body
Don’t massage injection site. lessens discomfort