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Elimination Part 1 PDF

1) Biotransformation, also known as metabolism, is the chemical conversion of one form to another within the body, usually through enzymatic processes. This is a major elimination process for removing drugs from the body. 2) Elimination occurs through two main processes: biotransformation and excretion. Biotransformation involves chemical changes to drugs through metabolic pathways, while excretion is the removal of drug and metabolites from the body. 3) Biotransformation can deactivate drugs through conversion to water-soluble metabolites that can be excreted, but can also activate prodrugs or produce toxic metabolites in some cases. This is an important detoxification process in the body.

Uploaded by

Kaushlendra chaudhary
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© © All Rights Reserved
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Topics covered

  • Chemical Transformation,
  • Biliary Excretion,
  • Clinical Pharmacology,
  • Research Methodologies,
  • Drug Development,
  • Phase I Metabolism,
  • Drug Regulation,
  • Metabolites,
  • Metabolism,
  • Drug Safety
385 views3 pages

Elimination Part 1 PDF

1) Biotransformation, also known as metabolism, is the chemical conversion of one form to another within the body, usually through enzymatic processes. This is a major elimination process for removing drugs from the body. 2) Elimination occurs through two main processes: biotransformation and excretion. Biotransformation involves chemical changes to drugs through metabolic pathways, while excretion is the removal of drug and metabolites from the body. 3) Biotransformation can deactivate drugs through conversion to water-soluble metabolites that can be excreted, but can also activate prodrugs or produce toxic metabolites in some cases. This is an important detoxification process in the body.

Uploaded by

Kaushlendra chaudhary
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Topics covered

  • Chemical Transformation,
  • Biliary Excretion,
  • Clinical Pharmacology,
  • Research Methodologies,
  • Drug Development,
  • Phase I Metabolism,
  • Drug Regulation,
  • Metabolites,
  • Metabolism,
  • Drug Safety

Biophamauuhcs PhammacokingHs

liminalton Dr. Parjanya Shukla

Eliminalion is tke oT
major ro ceM or Dr. M.P. Singh Clases

emoval a drug from body and


terminahon its achon

" sdalinad as he imeversibl lom odrug


/Tom Ki body.

Emi nahon OCCs by two proasnas

Bioronsfomakan ExcraHon

Biotanaformahon 4} is dainsd a

chemica comuATAIoD oone Pom to onother


also known as metabolism)
Th chemi cal chongas au
uAually olfeckad
nzy mahically inbody.
or Axamplh » penicillin convantad to þenicilloit acid

by bocterial aniilinasi and mommalb'un


Rhay mLs.
By- Dr Mahundro Praab Singh.
NdoT DTug/otronsfovmahon
xA chemical ubstonus (ofkr than nudrients for th body)
enter h
body thraugh inqeshion, inhalahon or abaorpHon
callkd as anobfohes OY exogenous Compouncls.

Drugs ant also XenobioHcs» enter by lipophibeiky


xTh ellechiva absovphon odu9nLs ds
Dr. Parjanya Shukla

ulfi'uiant bpo phibiit [Link] Clases

asitis som physiologieal popurty that


[Link] tobypas Axihon
water solubl 09ehta'undugo unal RxCTAHon)

Lipid 6olubl Aubslonas»basiuA y siabsorhed rom


unal tubulss

dvug iprtatt
dvug a cCumulafe in t body.
toxic uochon

To puvent Auch toxic t achons body tis ormsd wik


matabolbic Ayakam
which trons fovms HKe waer Insalubls, hophilic,
hon polor drus

into water solubl produck a can


ROily xYatad by krdnays
Drug biotrons mahon is Kus o

Detoxificakon prow.
By-Dy. Mahtndra Aralab Sing
Xenobio tics

Highly bopbiic Liho phibie PolaY Hydhephibie


mifabolirally stdhlu
Accu muaHon Phass I melabalism Polor
Phast-D Malabalism
Hydophilic
StoYs in
body himu)Cbioac Hivakjon oY ingchvaion) ^v

Melabalism
Cinochvahon)
Excrehon
Cunal or biliary)
iotranformaion :
Dr. Parjanya Shukla
&
Normally Xsuta in phmoralogital Dr. M.P.8ingh lases
inachvahkon odrugs

omahon o metabolihes toih H or no


phoma calog ieal acivi

e9
2.9 ConvaTsion o phanytointo - bydroxy þhanyBoin .

Occasionally yialds metabolites oith eqpal achvit


eg ComveYAIon phenylhufazont to oxybhenbutozona.
Kovaly uads to toxicological achivahion o drugs
ormaion ometabalites wih bigh iau mativihy.
Comversion paroutomos to uathvu meabolites

Causes hupakc neYosiS.

[Link] dra Pahp Singh


Via -prinupal, Aso. Pro
Krishorpik Imhitubs of Phomaoy
rayoqra .P

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