Pharma 2nd LE

1. Activation of metabotropic receptors located presynaptically causes inhibition by decreasing the inward flux of
Calcium

2. Which neurotransmitter does not change membrane excitability by decreasing K conductance

 Dopamine

3. which of the following chemicals does not satisfy the criteria for a neurotransmitter
 cyclic amp

4. cyclic AMP functions as diffusible second messenger after activation of

 beta 1 adrenoceptors

5. Neurotransmitter may
 exert all of the above actions

6. which of the following chemicals is most likely to function as neurotransmitter in hierarchical systems?
 GABA

7. which of the following statements about B-endorphins is most accurate

 its action are mainly inhibitory

8. this transmitter is mostly located in diffuse neuronal systems in the CNS, with cell bodies particularly in the
raphe nuclei. It appears to play a major role in the expression of mood states, and many antidepressant drugs are
thought to increase its functional activity.
 serotonin

9. Which of the following mechanisms underlying the actions of CNS drugs is likely to be useful in the
management of Parkinson’s disease
A) Activation of dopamine receptors
B) Antagonism of acetylcholine receptors
C) Increase in dopamine synthesis
D) Inhibition of Dopamine metabolism
E) All the above

Reference:
https://quizlet.com/71552351/pharmacology-chapter-21-intro-to-cns-flash-cards/
https://quizlet.com/60505151/pharm-exam-3-old-exam-quesitons-flash-cards/

10. which of the following is not a neurotransmitter in diffuse systems?

 peptides

11. the following local anesthetics are clinically useful as infiltrative and regional anesthesia, EXCEPT?
 tetracaine

12. which of the following local anesthetics produces methemoglobinemia?

 prilocaine

13. it is used for obstetric epidural anesthesia

 bupivacaine

14. the following are adverse effects of local anesthetics, EXCEPT?

 hypertension

15. the following statements are TRUE regarding local anesthetics, EXCEPT?
 lidocaine has a greater potency and shorter duration of action than procaine

16. all of the following statements are CORRECT concerning general anesthetics, EXCEPT?
 it produces slow propagation of nerve impulses by reducing the rate of action potential and the rate of
repolarization

17. which of the following statements regarding local anesthetics is/ are INCORRECT?
 none of the above

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18. correct statements regarding cocaine are the following, EXCEPT?
 none of the above

19. the following are characteristics of procaine, EXCEPT?

 Causes no local irritation

20. the local anesthetic with the shortest duration of action?

 Procaine

24. inhalation anesthetics are characterized by the following statements, EXCEPT?

 Enflurane depresses laryngeal reflexes

25. the following are cardiovascular effects of halothane, EXCEPT?

 none of the above

26. which of the following general anesthetics is contraindicated in patient disorder?

a. halothane
b. enflurane
c. isoflurane
d. nitrous oxide
e. none of the above

27. pharmacologic effects of enflurane, EXCEPT?

 bronchoconstriction

28. it is the most nephrotoxic inhaled anesthetic agent

 halothane

29. inactivation of vitamin B12 is common adverse effect of

 nitrous oxide

30. it is the newest and widely used inhaled anesthesia?

 Sevoflurane

31. Which of the following statements regarding epinephrine is INCORRECT?

 enhances the absorption of local anesthetic agent in the blood stream

32. “loss of blink reflex and regular respiration” is observed during this stage of anesthesia
 Stage 2

33. which of the following statements is INCORRECT regarding Dopamine precursor

 dopamine precursor can cross the blood brain barrier

34. the following agents reduces the beneficial effects of Levodopa, EXCEPT?
 Domperidone

35. which of the following statement/s is/are TRUE regarding drug interaction associated with L-dopa?
 phenothiazines enhance the metabolism of levodopa because decarboxylation of levodopa to dopamine

36. which of the following agents reduces the peripheral conversion of levodopa to dopamine?
 Carbidopa

37. which of the following statements regarding Antiparkinsonism is INCORRECT?

 levodopa offers rapid and complete alleviation of bradykinesiam, rigidity, tremors in Parkinson’s disease

38. it mimics the action of dopamine

 Bromocriptine

39. what is the most effective drug to alleviate the symptoms of Parkinson’s Disease?
 Carbidopa + Levodopa (Sinemet)

40. Which of the following agents reduces the dose requirement of Levodopa?
 Carbidopa

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41. the following statements are TRUE regarding Dopamine-receptor- agonists, EXCEPT?
 none of the above

42. the therapeutic effects of anticholinergics agents in Parkinson’s disease is mainly

 all of the above

43. it acts to reduce the peripheral conversion of levodopa to dopamine

 carbidopa

44. entacapone may be of value in patients being treated with levodopa-carbidopa because it
 decreases formation of 3-O-methyldopa

45. in parkinsonian patients who have urinary retention and signs of gastrointestinal obstruction, great caution
must be exercised in the use of this drug
 benztropine

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