MCQs (Antidepressants)

1. Which of the following is not an antidepressant drug?

a) Tricyclic antidepressants.
b) Monoamine oxidase inhibitors (MAOIs).
c) Selective serotonin reuptake inhibitors (SSRIs).
d) Antinoamine tritase rehibitor (ATRs).

2. Anxiolytic drugs are used to treat:

a) The symptoms of depression and mood disorder.
b) The symptoms of anxiety and stress.
c) The symptoms of psychosis and schizophrenia.
d) None of the above.

3. What is a major side effect of Prozac?

a) Loss of sexual desire.
b) Loss of hair.
c) Weight loss.
d) Weight gain.

4. Antipsychotics do which of the following?

a) Alleviate Major positive symptoms (such as thought disorder and hallucinations).
b) Alleviate Major negative symptoms (such as social withdrawal).
c) Reducing the burden of institutional care.
d) All of the above.

5. Drugs called Benzodiazepines are used to treat:

a) Depression.
b) Anxiety disorders.
c) Schizophrenia.
d) Mood disorders

6. Monoamine oxidase inhibitors (MAOIs) are effective for the treatment of:
a) Schizophrenia.
b) Major depression
c) Obsessive compulsive disorder
d) Generalized anxiety disorder.

7. Of the following, choose the antidepressant having both high sedative and high
Anticholinergic activity:
a. Imipramine
b. Amitriptyline

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c. Fluoxetine
d. Trazodone
8. The antidepressant which selectively blocks 5-hydroxytryptamine uptake is:
a. Fluoxetine
b. Imipramine
c. Bupropion
d. Venlafaxine

9. Imipramine produces the following actions EXCEPT:

a. Euphoria
b. Dryness of mouth
c. Tachycardia
d. Seizure

10. Limitations of typical tricyclic antidepressants include the following EXCEPT:

a. Narrow safety margin
b. Low oral bioavailability
c. Frequent side effects
d. Long latent period for response

11. Advantages of selective serotonin reuptake inhibitors (SSRIs) include the following
EXCEPT:
a. No interference with ejaculation and orgasm
b. Minimal sedative action
c. Unlikely to cause fall in BP
d. Lack of seizure precipitating potential

12. Currently, the selective serotonin reuptake inhibitors are the preferred drugs for
The following psychiatric disorder/disorders:
a. Phobias
b. Obsessive-compulsive disorder
c. Post-traumatic stress disorder
d. All of the above

13. Venlafaxine differs from standard tricyclic antidepressants in that it:

a. Does not inhibit 5-HT reuptake
b. Does not inhibit noradrenaline reuptake
c. Does not have anticholinergic or anti-adrenergic property
d. Has lower antidepressant efficacy

14. Which of the following is labelled as a 'serotonin and noradrenaline reuptake

Inhibitor or SNRI:
a. Amineptine
b. Venlafaxine
c. Bupropion
d. Citalopram

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 15. A patient of endogenous depression was put on imipramine therapy. After what
Interval the therapeutic effect is likely to manifest:
a. Three days
b. One week
c. Three weeks
d. Three months

16. Diabetic and other types of neuropathic pain often responds to:
a. Chlorpromazine
b. Diazepam
c. Imipramine
d. Lithium

17. NaSSAs work by increasing the amount of noradrenaline and serotonin in the
synaptic cleft and blocking some ______________ in order to treat depression.
a. Dopamine Receptors
b. Serotonin Receptors
c. Noradrenaline Receptors
d. Chemical Receptors

18. Monoamine oxidase inhibitors inhibits the action of monoamine oxidase, a

____________.
a. A protein
b. A co-enzyme
c. A brain enzyme
d. An amino acid

19. Monoamine oxidase helps break down neurotransmitters, such as serotonin. If less
serotonin is broken down, there will be _____________________.
a. More circulating serotonin.
b. Less circulating serotonin.
c. More circulating GABA
d. More circulating oxidants

20. (TCAs) are so named because there are ___________ in the chemical structure of
these medications.
a. One ring
b. Two rings
c. Three rings
d. Four rings

21. Which of the following is a common side effect of tricyclic antidepressants?

a. Increased appetite
b. Insomnia
c. Excessive sweating

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d. Weight loss

22. Which of the following is a common use for tricyclic antidepressants?

a. Treating anxiety disorders
b. Managing migraines
c. Controlling high cholesterol
d. Improving memory and cognitive function

23. Which of the following is a common use for antidepressants?

a. Treating high blood pressure
b. Managing chronic pain
c. Preventing the common cold
d. Controlling allergies

24. Noradrenaline and specific serotoninergic antidepressants are commonly known as:
a. SSRIs
b. SNRIs
c. MAOIs
d. TCAs

25. Which neurotransmitters do Noradrenaline and specific serotoninergic

antidepressants primarily affect?
a. Dopamine and GABA
b. Serotonin and norepinephrine
c. Acetylcholine and glutamate
d. Endorphins and histamine

ANTIDEPRESSANTS | by group - II