MCQs Pharmacology MDY3

1 The Ca2+ concentration is predominant in

A Extracellular fluid

B Intracellular fluid

C Bone

D Uterus

2 The Na+ concentration is predominant in

A Extracellular fluid

B Intracellular fluid

C Bone

D Uterus

3 The K+ concentration is predominant in

A Extracellular fluid

B Intracellular fluid

C Bone

D Uterus

4 Apoptosis is

A a programmed cellular death

B a gangrene

C a necrosis

D a hemolysis

5 Repair and healing occurs

A When tissues are necrosis

B When tissues are normal

C When tissues are damaged

D When organs are dead

6 The following phrase are related to regeneration, Choose the best answer

A Regeneration is involvement of connective tissue cells

B Regeneration is the replacement of the tissue or organ that has been damaged or lost
C Complete regeneration of a tissue or organ is frequently

D Regeneration is hyperplasia

7 The following phrase are related to regeneration, Choose the best answer

A Regeneration is involvement of connective tissue cells

B Regeneration is the involvement of apoptosis

C Complete regeneration of a tissue or organ is frequently

D Complete regeneration of a tissue or organ is rare

8 The following phrase are related to peripheral nervous system, Choose the FALSE answer

A Somatic nervous system (SNS) controls muscle movement and relays information

B Autonomic nervous system (ANS): controls involuntary bodily functions and regulates glands

C The Parasympathetic system regulates “rest and digest” functions

D The cranial nerves are not a branch of the peripheral nervous system

9 The following phrase are related to Autonomic nervous system (ANS), Choose the best answer

A Somatic nervous system (SNS) controls involuntary bodily functions and regulates glands

B Autonomic nervous system (ANS): controls muscle movement and relays information

C The Autonomic nervous system comprises three divisions: sympathetic, parasympathetic and enteric.

D The Autonomic nervous system comprises two divisions: sympathetic and parasympathetic

10 The following phrase are related to Autonomic nervous system (ANS), Choose the False answer

A The principal transmitters are acetylcholine (ACh) and noradrenaline

B The principal transmitters are GABA and dopamine

C Neurotransmitter is messengers released from a neuron, but they are released to carry a message
across a synapse

D The neuromodulator is a messenger released from a neuron that affects the transmission of the
signals between neurons

11 SPINRAZA® (nusinersen) is used to treat

A Epilepsy

B Schizophrenia

C Depressive illnesses

D Spinal muscular atrophy (SMA)

12 The followings are related to symptoms of psychosis: Choose the False answer

A Hallucination

B Delusions

C Paranoid delusion

D Epilepsy

13 Alcohol, caffeine, nicotine are called

A Psychotropic Drugs or Psychotropic substances

B Psychotic Drugs

C Opioid drug

D Epilepsy drugs

14 Antipsychotic Drugs or Psychotic drugs are used to treat, Choose the FALSE answer

A Epilepsy

B Schizophrenia

C Bipolar disorder

D Mania

15 Haldol (haloperidol) is a

A Antiepileptic

B Antipsychotic

C Central nervous stimulant

D Opioid drug

16 Thorazine (chlorpromazine) is a

A Antiepileptic

B Antipsychotic

C Central nervous stimulant

D Opioid drug

17 lithium is a

A Antiepileptic

B Antipsychotic

C Central nervous stimulant

D Mood stabilizers

18 carbamazepine is a

A Antiepileptic

B Antipsychotic

C Central nervous stimulant

D Mood stabilizers

19 Which is the main excitatory transmitters in the CNS

A Glutamate

B GABA

C GABAA

D GABAB.

20 Which is the main inhibitory transmitter in the CNS

A Glutamate

B GABA

C NMDA

D AMPA

21 The followings are related GABA receptor: Choose the False answer

A Benzodiazepines are GABA receptor agonist

B Benzodiazepines are GABA receptor antagonist

C Muscimol is a specific GABAA agonist

D bicuculline is an antagonist

22 The followings are related to Glycine: Choose the False answer

A Glycine is an inhibitory transmitter

B Glycine mainly in the spinal cord

C Strychnine is a competitive glycine agonist.

D Tetanus toxin acts mainly by interfering with glycine release

23 The followings are related to Noradrenaline: Choose the False answer

A Synthesis, storage and release of noradrenaline in the CNS are the same as in the periphery,
B Synthesis, storage and release of noradrenaline in the CNS are NOT the same as in the periphery

C The actions of noradrenaline are mediated through α1, α2, β1 and β2 receptors

D Noradrenergic cell bodies occur in discrete clusters, mainly in the locus coeruleus

24 Noradrenergic transmission is believed to be important in: Choose the False answer

A Blood pressure regulation

B Antihypertensive drugs (e.g. clonidine, methyldopa)

C The ‘arousal’ system, controlling wakefulness and alertness

D Noradrenergic cell bodies NOT occur mainly in the locus coeruleus

25 The followings are related to Dopamine: Choose the False answer

A Dopamine is a neurotransmitter

B Dopamine is NOT a neurotransmitter

C Dopamine is a precursor for noradrenaline

D There are five dopamine-receptor subtypes

26 The followings are related to Dopamine: Choose the False answer

A D1 receptors may be implicated in the negative symptoms of schizophrenia

B D1 receptors may be implicated in the positive symptoms of schizophrenia

C Parkinson’s disease is associated with a deficiency of nigrostriatal dopaminergic neurons

D Dopamine acts on the chemoreceptor trigger zone to cause nausea and vomiting

27 Drugs acting on serotonin receptors: Choose the False answer

A fluoxetine is a selective serotonin uptake inhibitor used to treat depression

B Buspirone is a serotonin receptor agonist

C Sumatriptan is a serotonin receptor agonist

D pizotifen is a serotonin receptors agonist used for migraine prophylaxis

28 Drugs acting on serotonin receptors: Choose the best answer

A fluoxetine is used to treat depression

B Buspirone is used to treat depression

C Sumatriptan is used to treat depression

D Pizotifen is a used to treat depression

29 The followings are related to Acetylcholine (Ach) in the CNS: Choose the False answer

A Synthesis, storage and release of ACh in the CNS are essentially the same as in the periphery

B Dementia and Parkinson’s disease, are associated with abnormalities in cholinergic pathways.

C Nicotinic receptors are mainly located pre-synaptically

D Hyoscine is a Muscarinic agonist which cause amnesia

30 The followings are related to Histamine in the CNS: Choose the False answer

A Histamine is a neurotransmitter

B H1, H2 and H3 receptors are widespread in the brain

C H1 receptor agonists are strongly sedative.

D H1 receptor antagonists are antiemetic

31 The followings are related to Melatonin: Choose the False answer

A Melatonin is synthesized mainly in the pineal gland

B Melatonin is synthesized mainly in the skin

C Secretion is controlled by light intensity, being low by day and high by night

D Melatonin is a hormone that regulates your waking and sleeping cycle

32 The followings are related to Melatonin: Choose the False answer

A Agonists at melatonin receptors induce sleep

B Agonists at melatonin receptors have antidepressant properties

C Antagonists at melatonin receptors induce sleep

D Melatonin is a hormone that regulates your waking and sleeping cycle

33 The followings are related to Nitric oxide (NO): Choose the False answer
A NO is a gaseotransmitters in the CNS

B Increased NO production raise intracellular Ca2+

C In larger amounts, NO contributes to neurotoxicity.

D NO is a laughing gas.

34 The followings are related to cholinergic drugs: Choose the False answer

A Cholinergic drug are called parasympathomimetic drugs

B Cholinergic agonists is one class of cholinergic drugs

C Cholinesterase drugs is one class of cholinergic drugs

D Anticholinesterase drugs is one class of cholinergic drugs

35 The followings are related to cholinergic drugs: Choose the False answer

A Cholinergic drug are called parasympathomimetic drugs

B Cholinergic agonists is one class of cholinergic drugs

C Cholinesterase drugs is one class of cholinergic drugs

D Anticholinesterase drugs is one class of cholinergic drugs

36 Pilocarpine is, Choose the best answer

A Cholinergic drug

B Cholinergic antagonists

C Cholinesterase drugs

D Anticholinesterase drugs

37 The followings are related to actions of cholinergic drugs: Choose the False answer

A Produce salivation

B Bradycardia

C Dilation of blood vessels

D Dilation of the bronchioles

cholinergic drugs

38 The indications of cholinergic drugs: Choose the false answer

A Treat atonic bladder conditions

B To treat postoperative abdominal distention and Gastro Intestinal atony

C Reduce eye pressure

D Treat salivary gland hyperfunction

39 Pilocarpine is, Choose the best answer

A Muscarinic agonist

B Muscarinic antagonists

C Cholinesterase drugs

D Anticholinesterase drugs

40 Atropine is, Choose the best answer

A Muscarinic agonist

B Muscarinic antagonists

C Cholinesterase drugs

D Anticholinesterase drugs

41 Nicotine is, Choose the best answer

A Muscarinic agonist

B Muscarinic antagonists

C Ganglion-stimulating drugs

D Anticholinesterase drugs

42 Tubocurarine is, Choose the best answer

A Muscarinic agonist

B Ganglion-blocking drugs

C Ganglion-stimulating drugs

D Anticholinesterase drugs

43 Neostigmine is, Choose the best answer

A Muscarinic agonist

B Ganglion-blocking drugs

C Reversible Anticholinesterase drugs

D Irreversible Anticholinesterase drugs

44 Echothiophate is, Choose the best answer

A Muscarinic agonist

B Ganglion-blocking drugs

C Reversible Anticholinesterase drugs

D Irreversible Anticholinesterase drugs

45 Phenylephrine is, Choose the best answer

A Selective α1 agonists

B Selective α2 agonists

C Selective α1 antagonists

D Selective β1 antagonists

46 Clonidine is, Choose the best answer

A Selective α1 agonists

B Selective α2 agonists

C Selective α1 antagonists

D Selective β1 antagonists

47 Dobutamine is, Choose the best answer

A Selective α1 agonists

B Selective α2 agonists

C Selective β 1 agonists

D Selective β2 agonists

48 Dobutamine is, Choose the best answer

A Bronchodilator drugs

B Increase hypotension

C to treat cardiogenic shock or anaphylaxis

D Vasodilation drugs

49 Salbutamol is, Choose the best answer

A Selective α1 agonists

B Selective α2 agonists

C Selective β 1 agonists

D Selective β2 agonists
50 Salbutamol is, Choose the best answer

A Bronchodilator drugs

B Bronchoconstriction drugs

C Vasoconstriction drugs

D Vasodilation drugs

51 Tamsulosin is, Choose the best answer

A Selective α1 antagonists

B Selective α2 antagonists

C Selective β 1 antagonists

D Selective β2 antagonists

52 Tamsulosin is, Choose the best answer

A to treat benign prostatic hypertrophy

B to treat prostatic cancer

C to treat cardiogenic shock or anaphylaxis

D to treat asthma

52 Atenolol is, Choose the best answer

A Selective α1 antagonists

B Selective α2 antagonists

C Selective β 1 antagonists

D Selective β2 antagonists

53 Atenolol is, Choose the best answer

A to treat benign prostatic hypertrophy

B to treat asthma

C to treat cardiogenic shock or anaphylaxis

D to treat angina pectoris or hypertension

54 Adrenergic drugs (sympathomimetic drugs) can affect, Choose the WRONG answer

A alpha-adrenergic receptors

B beta-adrenergic receptors

C dopamine receptors
D cholinergic receptor

55 The following are adrenergic drugs (sympathomimetic drugs), Choose the WRONG answer

A Catecholamines:

B norepinephrine and epinephrine

C dopamine, dobutamine

D Atenolol

56 Adrenergic drugs is, Choose the WRONG answer

A Inotrope: they make the heart contract more forcefully

B Positive chronotropic effect (cause the heart to beat faster)

C To treat cardiogenic shock or anaphylaxis

D To treat hypertension

57 Ephedrine is, Choose the BEST answer

A catecholamine drugs

B Non-catecholamine drugs

C Dopamine drugs

D Dobutamine drugs

58 Non-catecholamine drugs is, Choose the WRONG answer

A Stimulating alpha receptor

B stimulating beta2 receptors

C smooth-muscle relaxation (terbutaline)

D cholinergic drugs

59 Adrenergic blocking drugs (sympatholytic drugs) is

A Cholinergic drug

B Muscarinic drugs

C Vasoconstrictive drugs

D Vasodilation drugs

60 Beta-adrenergic blockers, can be prescribed, Choose the WRONG answer

A To treat angina OR heart failure OR heart attack

B To treat hypertension
C To treat hypotension

D To treat cardiomyopathy

61 The following are neurodegenerative disorders, EXCEPT

A Ischemic brain damage or Stroke

B Alzheimer’s disease

C Parkinson’s disease

D Cardiomyopathy

62 The following is related to Alzeimer' s disease, Choose the WRONG answer

A Familial Alzeimer' s disease is frequent

B Alzheimer’s disease symptoms often include changes in memory, thinking and reasoning skills

C While dementia is a general term, Alzheimer's disease is a specific brain disease

D AD is a common age-related dementia, distinct from vascular dementia

63The following is related to Parkinson’s disease, Choose the WRONG answer

A Degenerative disease of the basal ganglia

B Tremor at rest and muscle rigidity

C Associated with degeneration of dopaminergic nigrostriatal neurons

D Is a chronic, progressive, sensitive disorder

64 The following is related to Levodopa and Parkinsonism, Choose the WRONG answer

A Levodopa is a pro-drug which is converted to dopamine in the body

B Levodopa cross the blood–brain barrier.

C Levodopa is taken up by the surviving nigrostriatal neurons

D Parkinsonism is due to dopamine deficiency, so dopamine is therapeutic value

65 The following is related Amantadine, Choose the WRONG answer

A is used in mild cases of parkinsonism

B It can also be used along with L.dopa

C Is an antibiotic drug

D Large doses produce insomnia

66 The following is related Huntington's disease, Choose the WRONG answer

A Huntington's disease is an inherited disorder

B It causes severe motor symptoms in the form of choreiform

C Dopamine was slightly increased

D Dopamine was decreased

67 Drugs used to alleviate the motor symptoms of Huntington's disease, Choose the WRONG answer

A Tetrabenazine that reduces dopamine storage

B Chlorpromazine.

C Haloperidol

D Dopamine

68 Drug treatment of multiple sclerosis, Choose the WRONG answer

A Baclofen for muscle spasticity

B Amitriptyline for emotional problem

C Natalizumab or alemtuzumab may be considered in those with more active disease

D Levodopa

69 The following is related to Local anesthetics, Choose the WRONG answer

A Local anesthetics block sodium channels

B Local anesthetics are drugs that block nerve conduction

C Local anesthetics are drugs that increases nerve conduction

D Local anesthetics can cause both sensory and motor paralysis

70 The following is related to Local anesthetics, Choose the WRONG answer

A Local anesthetic is exploited in the therapy of cardiac dysrhythmias and epilepsy

B Local anesthetic block conduction in peripheral nerves

C Local anesthetics block nociceptive and sympathetic transmission

D Local anesthetics increase nociceptive and sympathetic transmission

71 Classification of Local anesthetics, Choose the BEST answer

A Procaine is injectable and long acting

B Procaine is injectable and surface anesthetic

C Cocaine is injectable
D Lignocaine is surface anesthetic

72 Unwanted effects of Local anesthetics, Choose the WRONG answer

A Due mainly to escape of LA into the systemic circulation.

B Occasional hypersensitivity reactions

C Co-administration of a vasoconstrictor (e.g. adrenaline) prolongs the local effect

D Fall in blood pressure

73 Uses of Local anesthetics, Choose the WRONG answer

A Surface anesthesia

B Infiltration anesthesia

C Field Block

D There is loss of consciousness

74 Inhalation general anesthetics, Choose the Best answer

A Ketamine

B Halothane

C Thiopental

D Etomidate

75 Intravenous general anesthetic agents, Choose the Best answer

A Ketamine

B Halothane

C Ether

D Nitrous Oxide (N2O)

76 Preanesthetic medication of general anesthetic, Choose the WRONG answer

A Decrease anxiety

B Relieve preoperative pain if present

C Increase gastric acidity fluid

D Reduce gastric acidity fluid

77 Clinical uses of general anesthetic, Choose the WRONG answer

A Inhalational anesthetics are used for maintenance of anesthesia

B Nitrous oxide must always be given with oxygen

C Nitrous oxide must always be given NO oxygen

D Need preanesthetic medication

78 The following is related to anxiolytic and hypnotic drugs, Choose the BEST answer

A Anxiolytic drugs induces sleep resembling natural sleep.

B Hypnotic drugs aimed at treating patients with panic disorders, generalized anxiety

C There was overlap between these two groups anxiolytic and hypnotic drugs

D Nitrous oxide is an anxiolytic and hypnotic drug

79 Actions of benzodiazepines, Choose the WRONG answer

A Sedation and hypnosis

B Reduction in anxiety

C Muscle relaxation and anticonvulsant effects

D Muscle contraction

80 The following is benzodiazepines drugs, Choose the BEST answer

A Diazepam

B Phenobarbitone

C Mephobarbitone

D Halothane

81 Actions of barbiturate, Choose the WRONG answer

A Sedation and hypnosis

B Reduction in anxiety

C Anticonvulsant: used in the treatment of epilepsy

D Muscle contraction

82 The following is barbiturate drugs, Choose the BEST answer

A Diazepam

B Phenobarbitone

C Lorazepam

D Halothane

83 The following are hypnotic drugs groups, Choose the WRONG answer

A Benzodiazepine
B Melatonin receptor agonists.

C Surface anesthesia

D Antihistamines:

84 The following are the emotional symptoms of depression , Choose the WRONG answer

A low self-esteem

B loss of motivation

C sleep disturbance and loss of appetite

D pessimism

85 Choose the BEST answer of biological symptoms of depression (mood disorder),

A low self-esteem

B loss of motivation

C sleep disturbance and loss of appetite

D pessimism

86 The following are related to nature of depression (mood disorder), Choose the BEST answer

A Unipolar depression, in which the mood changes are only one time

B Bipolar disorder, in which depression changes are only two times

C Bipolar disorder, in which depression alternates with mania.

D Unipolar depression, in which depression alternates with epilepsy

87 The following are Essential medicines for depressive disorders, Choose the WRONG answer

A Carbamazepine

B Lithium carbonate

C Valproic acid

D Diazepam

88 Choose the BEST answer of medicines for depressive disorders,

A Amitriptyline

B Carbamazepine

C Lithium carbonate

D Valproic acid

89 The following are mood-stabilizing drugs, Choose the WRONG answer

A Olanzapine (a typical antipsychotic drugs)

B Carbamazepine

C Lithium carbonate

D Barbiturate

90 The following are antipsychotic drugs, Choose the WRONG answer

A Neuroleptic drug

B Anti schizophrenic drugs

C Psychomotor stimulants

D Major tranquillizers drugs

91 The following are positive symptoms of Schizophrenia Choose the WRONG answer

A Delusions (often paranoid in nature)

B Hallucinations (often in the form of voices)

C Thought disorder

D Withdrawal from social contacts

92 Choose the BEST answer of negative symptoms of Schizophrenia

A Delusions (often paranoid in nature)

B Hallucinations (often in the form of voices)

C Thought disorder

D Flattening of emotional responses

93 The following are first-generation of antipsychotic drugs, Choose the WRONG answer

A Chlorpromazine

B Haloperidol

C Fluphenazine

D Clozapine

94 Choose the BEST answer of second-generation of antipsychotic drugs

A Chlorpromazine

B Haloperidol

C Fluphenazine

D Clozapine
95 The following are Antipsychotic-induced motor disturbances, Choose the WRONG answer

A Acute, reversible dystonia

B Parkinson-like symptoms

C Hypertension

D Tardive dyskinesia

96 Choose the BEST answer of antipsychotic sides effects,

A Hypertension

B Sedation, hypotension and weight gain

C Weight loss

D Insomnia

97 The following are related to Neuroleptic malignant syndrome (NMS) Choose the WRONG answer

A is a life-threatening idiosyncratic reaction to AP drugs

B is idiopathic

C occur rarely

D unpredictably

98 The following are related to Generalized seizures, Choose the WRONG answer

A Absence seizure (petit mal)

B Myoclonic seizure

C Partial Seizures with/no impairment of consciousness

D Atonic seizure (drop attack) or Tonic clonic seizure (grand mal epilepsy)

99 Partial Seizures, Choose the BEST answer

A Absence seizure (petit mal)

B Myoclonic seizure

C Partial Seizures with/no impairment of consciousness

D Atonic seizure (drop attack) or Tonic clonic seizure (grand mal epilepsy)

100 The following are related to Phenytoin, Choose the WRONG answer

A Phenytoin is an anticonvulsant

B Phenytoin blockade of the sodium channels

C Phenytoin stabilizes the neuronal membrane

D Phenytoin is not effective against partial seizure

101 The following are related to Adverse effects of Phenytoin, Choose the WRONG answer

A Peripheral neuropathy

B Hyperglycemia

C Hypoglycemia

D hypocalcemia

102 The following are related to Adverse effects of Phenytoin, Choose the WRONG answer

A Ataxia

B Hyperglycemia

C Hypercalcemia

D Hypocalcemia

103 The following are related to Phenobarbitone, Choose the WRONG answer

A was the first effective antiepileptic drug

B Raises the seizure threshold

C Decrease the seizure threshold

D Enhance the inhibitory activity of GABA in the CNS.

104 The following are related to Carbamazepine, Choose the WRONG answer

A Carbamazepine is used to treat bipolar mood disorder

B Carbamazepine has NOT anti-seizure activity.

C Carbamazepine blocks sodium channels.

D Carbamazepine is useful in the treatment of trigeminal neuralgia and glossopharyngeal neuralgia

105 The following are related to Baclofen, Choose the WRONG answer

A Treatment of spasticity associated with multiple sclerosis or spinal injury.

B Used in the treatment of spasticity associated with multiple sclerosis or spinal injury

C It is useful in epilepsy

D It is ineffective in cerebral spasticity caused by birth injury.

106 The following are included to psychoactive drug, Choose the WRONG answer

A Anesthetic

B Anxiolytic
C Beta Blocker

D Antidepressant drugs

107 Actions of Amphetamines, Choose the WRONG answer

A increased motor activity

B euphoria and excitement

C Amphetamine psychosis, which closely resembles schizophrenia, can NOT develop after prolonged use

D insomnia, and anorexia

108 The following are included to Psychomotor stimulants, EXCEPT

A Amphetamines

B Cocaine

C MDMA (ecstasy)

D LSD

109 Which is Psychomotor stimulants Drugs, Choose the BEST answer

A Nitrous oxide

B Cocaine

C LSD

D Ketamine

110The following are included to Psychedelic Drugs, Choose the WRONG answer

A Psychedelic Drugs referred to as hallucinogenic

B Psychedelic Drugs referred to as psychotomimetic

C Psychedelic Drugs referred to as Psychomotor stimulants

D Psychedelic drugs do not cause dependence

111 Which is Psychedelic Drugs, Choose the BEST answer

A Amphetamines

B Cocaine

C MDMA (ecstasy)

D Ketamine

112 Effects of ethanol, Choose the WRONG answer

A Reduced antidiuretic hormone secretion

B Increased antidiuretic hormone secretion

C Causing cutaneous vasodilatation

D Causing Neurological degeneration, dementia and peripheral neuropathies

113The following are related to Cannabis, Choose the WRONG answer

A Tetrahydrocannabinol (THC) is the main active principle of cannabis

B Specific cannabinoid receptors termed CB receptors

C Peripheral actions include vasoconstriction

D Endogenous ligands named endocannabinoids

114 The following are related to Cannabis actions, Choose the WRONG answer

A Both depressant and psychotomimetic effects.

B Subjective experiences include euphoria and a feeling of relaxation

C Bronchoconstriction

D Analgesic and antiemetic activity

115 The following are related to synthetic cannabinoids , Choose the WRONG answer

A User often become ‘zombie-like’ or cataleptic

B Quite harmful and can induce hallucinations, psychotic episodes, seizures and death

C Are NOT commonly sprayed on herbal material and smoked

D Named Spic K2 or Black Mamba

116 The following are related to nicotine, Choose the WRONG answer

A At the behavioral level, nicotine produces a mixture of inhibitory and excitatory effects.

B Learning, particularly under stress, is facilitated by nicotine

C Learning, particularly under stress, is reduced by nicotine

D Tachycardia, increased blood pressure and reduced gastrointestinal motility

117 The following are related to tobacco smoking, Choose the WRONG answer

A Smoking account for more than 10% of deaths worldwide

B tars are responsible; chronic bronchitis

C Use of e-cigarettes (vaping) increase the inhalation of tar and carbon monoxide

D Use of e-cigarettes (vaping) avoids the inhalation of tar and carbon monoxide