Professional Documents
Culture Documents
Model Paper
Pharmacology
CLINICAL PHARMACOLOGY
Please use a dark pencil/pen to complete the test. Read the instructions at the
begining carefully. This is a practice test series in Clinical Pharmacology.
Please Note: There is a Negative Marking of (-1) for each incorrect response.
1. A drug which is used to treat ventricular arrhythmias
A Mexiletine
C Diltiazem
B Adenosine
D Amitryptyline
PGI2
PGE2
PGF2
TXA2
Prostacyclin
A.
B.
C.
D.
E.
steroid release
vasoconstriction
marked vasodilatation
antiaggregatory effect on platelets
prolactin release
C Carbamazepine
B Warfarin
D Itraconazole
C 3 and 4
B 2 and 3
D 2, 3 and 4
-1-
Series I-C
Model Paper
Pharmacology
C ethosuximide
B phenobarbital
D lorazepam
C Neisseria meningitidis
B Listeria monocytogenes
D Bacteroides fragilis
C benzathine penicillin
B penicillin V
C bleomycin
B neomycin
D tobramycin
11. Given below is a list that includes 'drug of choice' and clinical conditions. Match
the following drugs with their most likely indications:
A.
B.
Ibuprofen
Carbamazepine
C.
D.
E.
Ethosuximide
Sodium nitroprusside
Phentolamine
A. hypertensive emergencies
B. hyperadrenergic hypertensive
episodes
C. rheumatoid arthritis
D. simple partial seizures
E. absence seizures
C Furazolidone
B Clavulanic acid
D Clindamycin
-2-
Series I-C
Model Paper
Pharmacology
C 1 and 4
B 2 and 4
D 1 and 3
14. Drugs that are poorly bound to plasma protein (25%) include:
A Lisuride
C Haloperidol
B phenytoin
D Warfarin
C clozapine
B bromocriptine
D metoclopramide
C droperidol
B metoclopramide
D phencyclidine
17. Drug which is both lipid and water soluble and soluble in alcohol
A carbidopa
C azathioprine
B ciprofloxacin
D phencyclidine
18. Given below is a list that includes 'drug of choice' and clinical conditions. Match
the following drugs with their most likely indications:
A.
B.
C.
D.
E.
Metronidazole
Penicillin G
Itraconazole
Streptomycin
Azithromycin
A.
B.
C.
D.
E.
Chlamydial pneumonia
Tularemia
pseudomembranous enterocolitis
paracoccidioidomycosis
syphilis
C Micromonospora inyonensis
B Microsporidium ceylonensis
D Micromonospora echinospora
-3-
Series I-C
Model Paper
Pharmacology
C Diazepam
B Morphine
D Baclofen
21. Drugs that have high bioavailability (>80%) include all of the following except:
A Diazepam
C Amoxicillin
B Clavulanic acid
D Phenytoin
C monobactum antibiotics
B Carbapenems
D Aminoglycosides
C fluoxetine
B paroxetine
24. Drugs which are highly lipid soluble and have high protein binding (>90%)
includes:
A phenytoin
C fluoxetine
B propranolol
D sotalol
C propranolol + nifedipine
B nifedipine + verapamil
D diltiazem + captopril
C rifampicin
B Amoxicillin
D Ethosuximide
27. Which of the following drug has the lowest protein binding?
A loperamide
C clonidine
B sodium oxybate
D thiopentone
C Carbachol
B Pilocarpine
D Atropine
-4-
Series I-C
Model Paper
Pharmacology
C dicyclomine
B droperidol
D tubocurarine
30. Match the following drugs with their corresponding 'plasma protein binding' values:
A.
B.
C.
D.
E.
Zidovudine
Methotrexate
Phenytoin
Carbamazepine
Lamotrigine
A.
B.
C.
D.
E.
70%
55%
50%
90%
30%
32. Which of the following drug has the highest protein binding?
A lamotrigine
C rifampicin
B carbamazepine
D phenytoin
33. Which of the following drugs have a T half-life of less than <10 hrs?
A Quinidine
C Amiodarone
B Clonidine
D Tolbutamide
C phenobarbital
B talbutal
D thiopental
C butalbital
B midazolam
D methohexital
C Atenolol
B Etoricoxib
D Lorazepam
-5-
Series I-C
Model Paper
Pharmacology
C penicillamine
B chloroquine
D methotrexate
38. Which of the following drugs is an abortifacient (a substance that may induce
abortion)?
A Heparin
C Chloroquine
B Warfarin
D misoprostol
C penicillin
B neomycin
D trimethoprim
C triamcinolone
B phenytoin
D carbimazole
C Phenylbutazone
B Etomidate
D Co-trimoxazole
43. Drugs known to inhibit hepatic microsomal enzyme CYP3A4 (enzyme inhibitors):
A Methadone
C Haloperidol
B Celecoxib
D Danazol
C paromomycin
B sodium stibogluconate
D miltefosine
-6-
Series I-C
Model Paper
Pharmacology
C Alprazolam
B Chlorodiazepoxide
D Flurazepam
C Isoniazid
B Trimethoprim
D Bacitracin
C Macrolides
B Aminoglycosides
D Polymixins
48. Match the following anticancer drugs according to their correct group of origin:
A.
B.
C.
D.
E.
Azathioprine
Methotrexate
5-fluorouracil (5-FU)
Cyclophospamide
Carmustine
A.
B.
C.
D.
E.
Nitrosourea
Purine antagonist
Alkylating agent
Folate antagonist
Pyrimidine antagonist
C Irinotecan
B Praziquantel
D Penciclovir
C atenolol + amplodipine
B propranolol + losartan
D metoprolol + enalapril
C gentamicin
B oral contraceptives
D probenecid
-7-
Series I-C
Model Paper
Pharmacology
C Propofol
B Midazolam
D Ketamine
54. One of the following anesthetic agent causes marked respiratory depression, low
blood pressure, and reduced cardiac output:
A Ketamine
C Halothane
B Ether
D Isoflurane
C azithromycin
B penicillin
D tetracycline
B Pseudomonas aeruginosa
C Ampicillin
B Amoxicillin
D Erythromycin
C Doxycycline
B Ceftriaxone
D Benzatheine penicillin
59. Match the following anti-diabetic drugs with their corresponding mechanism of
actions:
A.
Pioglitazone
B.
C.
D.
E.
Metformin
Repaglinide
Acarbose
Glibenclamide
C Benserazide
B Ropinirole
D Chlorpheniramine
-8-
Series I-C
Model Paper
Pharmacology
61. Which one of the following drugs has a better absorption following oral
administration?
A tigecycline
C doxyclycine
B demeclocycline
D chlortetracycline
C ampicillin
B isotretinoin
63. Regarding drugs that undergo enterohepatic circulation, pick the incorrect
statement(s):
A they are mostly excreted in the
bile
64. All of the following drugs are associated with occurrence of Torsades de pointes
except:
A disopyramide
C terfenadine
B fexofenadine
D amitryptyline
65. Drugs that are primarily excreted unchanged in the urine include:
A fexofenadine
C chloramphenicol
B flurazepam
D nadolol
C clarithromycin
B doxycycline
D clindamycin
67. Concurrent use of which of the following two drugs may precipitate ventricular
arrhythmia?
A Norfloxacin + Theophylline
C Fluconazole + Carbamazepine
B Cotrimoxazole + Phenytoin
D Erythromycin + Terfenadine
C lamotrigine
B trimethadione
D vigabratin
-9-
Series I-C
Model Paper
Pharmacology
C Streptomycin
B Ethambutol
D Clarithromycin
70. Which of the following statements about lumefantrine is/are not true?
A plasma protein binding is 99%
C it is highly lipophilic
C cardiac failure
B endotoxic shock
D severe trauma
C 30 mcg/dL
B 45 mcg/dL
D 10 mcg/dL
C 1 and 2
B 2 and 4
D 3 and 4
C Metoprolol
B Dobutamine
D Salbutamol
C Atropine
B Amiodarone
D Epinephrine
C mechlorethamine
B cyclosphosphamide
D carmustine
- 10 -
Series I-C
Model Paper
Pharmacology
78. Match the following teratogens with their corresponding effects in fetus/neonates:
A.
B.
C.
D.
E.
Penicillamine
Chlorpropamide
Carbamazepine
Lithium
Misoprostol
A.
B.
C.
D.
E.
neonatal hypoglycemia
Cutis laxa
Ebstein's anomaly
Mobius sequence
neural tube defects
C chlorambucil
B cyclosphosphamide
D busulfan
C Neostigmine
B Pilocarpine
D Echothiophate
C Potassium
B Magnesium
D Amiodarone
C Gancyclovir
B Lamivudine
D Stavudine
83. Which of the following fluoroquinolones has the highest oral bioavailability?
A Norfloxacin
C Sparfloxacin
B Levofloxacin
D Ciprofloxacin
84. Dimercaprol is effective against poisoning due to all of the following metals except:
A Arsenic
C Iron
B Copper
D Mercury
- 11 -
Series I-C
Model Paper
Pharmacology
C Penicillamine
B Ca Na2 EDTA
D Dimercaprol (BAL)
86. To be effective, all of the following agents/drugs must be given parenterally (i.v.)
except:
A Vancomycin
B Carbenicillin
D Drotaverine
C midazolam
B thiopental
D ketamine
C Propofol
B Ketamine
D Alfentanyl
C droperidol + fentanyl
B fluphenazine + midazolam
D haloperidol + lorazepam
90. Drug used in Parkinson's disease that promotes synthesis and release of
dopamine from the presynaptic neurons:
A Amantadine
C L-DOPA
B Selegiline
D Entacapone
B suppresses hepatic
gluconeogenesis
C Methotrexate
B Cisplatin
D Fuorouracil
- 12 -
Series I-C
Model Paper
Pharmacology
C Atropine
B Neostigmine
D Donepezil
C Prolastin
B Ipratropium bromide
D Montelukast
C dihydrofolate reductase
B thymidylate synthase
D cytidylate synthase
96. Which of the following drug classified as a BRM (biologic response modifier) is
used to treat rheumatoid arthritis?
A Infliximab
B Leflunomide
D Chloroquine
C Carbamazepine
B Imipramine
D Phenytoin
C Amitriptyline
B Fluoxetine
D Moclobemide
C Fluoxetine
B Imipramine
D Reboxetine
C Itraconazole
B Cotrimazole
D Diloxanide furoate
- 13 -
Series I-C
Model Paper
Pharmacology
Disclaimer: Every attempt has been made to validate each and every
question/answers. Any remaining error is regretted. Author will not be held responsible
for any errors. Please consult standard textbooks given in the reference section for any
discrepancy. Questions with wrong answers may better be left unattempted/
unanswered. This is a practice series available free to download designed for the
benefit of prospective PG candidates and UG medical students.
Reference Textbooks:
1. Essentials of Medical Pharmacology, 7th Edition, KD Tripathi
2. Basic & Clinical Pharmacology, 13th Edition, Katzung & Trevor
3. A Textbook of Clinical Pharmacology and Therapeutics, 5th Edition, Ritter, Lewis,
Mant & Ferro
- 14 -