Medicinal Chemistry-III (MCQs)

Q. Which are the narrow spectrum antibiotic?

a. Penicillin
b. Streptomycin
c. Erythromycin
d. All of the above
Q. Which is the synthetic antibiotic?
a. Cephalothin
b. Chloramphenicol
c. Tetracycline
d. Penicillin G
Q. Which antibiotic is bacterial cell wall synthesis inhibitor?
a. Cephalosporins
b. Macrolide antibiotics
c. Amino glycosides
d. All of the above
Q. Which antibiotic is protein synthesis inhibitor?
a. Penicillin
b. Cephalosporins
c. Erythromycin
d. Rifampin
Q. Which antibiotic interferes with nucleic acid biosynthesis?
a. Lincomycin
b. Rifampin
c. Tetracycline
d. Streptomycin
Q. Penicillin was discovered by scientist ___________
a. Paul Ehrlich
b. Gerhard Domagk
c. Alexander Fleming
d. None of the above
Q. Which heterocyclic ring is present in the chemical structure of penicillin?
a. Thiazolidine
b. Pyrrolidine
c. Pyrazolidine
d. Thiazole
Q. Which basic ring is present in penicillin?
a. Cepham ring
b. Penam ring
c. Cephem ring
1
 d. None of the above
Q. Different penicillin are derivatives of ____________
a. 6-nitro penicillanic acid
b. 7-amino penicillanic acid
c. 6-amino penicillanic acid
d. 7-nitro penicillanic acid
Q. Penicillin are degraded by ___________
a. Acid
b. Alkali
c. Penicillinase
d. All of the above
Q. On acid degradation, penicillin is converted into ___________
a. Penicilloic acid
b. Penillic acid
c. Penilloic acid
d. Penicillamine
Q. On alkali degradation, penicillin is converted into ____________
a. Penicilloic acid
b. Penillic acid
c. Penilloic acid
d. Penicillamine
Q. Identify the given structure of penicillin.

a. Penicillin V
b. Penicillin G
c. Methicillin
d. Cloxacillin
Q. Which penicillin is a penicillinase susceptible?
a. Methicillin
b. Cloxacillin
c. Oxacillin
d. Penicillin V
Q. Penicillin V is also known as:
a. Phenoxy methyl penicillin
b. Benzyl penicillin
c. Cloxacillin
2
 d. Carbenicillin

Q. Penicillin G is also known as:

a. Benzyl penicillin
b. Natural penicillin
c. Phenoxy methyl penicillin
d. Both a and b
Q. Identify the structure of penicillin.

a. Ampicillin
b. Methicillin
c. Cloxacillin
d. Oxacillin
Q. Identify the chemical class of given penicillin.

a. Amino penicillin
b. Carboxy penicillin
c. Ureido penicillin
d. None of the above
Q. Which is the beta lactamase inhibitor?
a. Clavulanic acid
b. Salbactam
c. Tazobactam
d. All of the above
Q. Penicillins interfere with synthesis of __________?
a. Bacterial cell wall
b. Bacterial protein
c. Nucleic acid
d. All of the above
Q. Penicillin inhibit bacterial cell wall by inhibiting enzyme _________

3
 a. Penicillinase
b. Transpeptidase
c. Lactamase
d. All of the above
Q. In penicillin, beta lactam ring is fused with:
a. Thiazolidine
b. Piperidine
c. Pyrrolidine
d. Pyrimidine
Q. Penicillin can be derived from ________
a. Penicillium notatum
b. Penicillium crysogenum
c. Both a and b
d. None of the above
Q. Primarily, penicillin are effective against strains of ________
a. Gram negative bacteria
b. Gram positive bacteria
c. Both a and b
d. None of the above
Q. Stability of benzyl penicillin can be increased by substitution of _______
a. Electron doating group
b. Electron withdrawing group
c. Electron releasing group
d. None of the above
Q. Which of the following statements about penicillin is false?
a. Ticarcillin is resistant to beta lactamase
b. Penicillin are bacteriostatic in effect
c. Penicillin V is available in oral, i.v. and i.m. route
d. All of the above
Q. Which of the following penicillin drugs is a drug?
a. Ticarcillin
b. Bacampicillin
c. Ampicillin
d. Carbenicillin
Q. Which does not describe penicillin?
a. Bactericidal
b. Inhibit cell wall synthesis
c. Broad spectrum
d. Cause bacteria to die from cell lysis
Q. Ring system present in the Diloxanide furoate:

4
 a. Furan
b. Quinoline
c. Imidazole
d. Triazole

Q. Ethambutol act by a inhibiting the synthesis of:

a. Arabinogalactone
b. Mycolic acid
c. DNA dependent RNA polymerase enzyme
d. RNA dependent RNA polymerase enzyme
Q. 2-ethyl thio isonicotinamide is IUPAC name of:
a. Pyrazinamide
b. Isoniazid
c. Ethionamide
d. Sulphonamides
Q. Pyrazinamide acts by:
a. By decreasing pH of medium of M. tuberculosis
b. By inhibiting mycolic acid synthesis
c. Inhibiting DNA dependent RNA polymerase
d. Cell lysis
Q. Isoniazid, Rifampin, Ethambutol, Pyrazinamide is used in combination in case of:
a. Patient suffering from Diabetes
b. Patient suffering from Hypertension
c. Patient suffering from viral infection
d. Patient suffering from TB
Q. Sulphamethoxazole used in treatment of:
a. Urinary tract infections
b. Respiratory tract infections
c. Eye infections
d. Heart Injury
Q. Rifampin is derivative of:
a. Rifamycin B
b. Gentamicin B
c. Paracetamol
d. Ibuprofen
Q. Chemical name of Amoxicillin is:
a. 4-[D-(-)amino p-hydroxy phenyl acetamido] penicillanic acid
b. 6-[D-(-)-amino p-hydroxy phenyl acetamido] penicillanic acid
c. Hydroxy analogue o-Benzyl penicillin
d. Carboxy benzyl penicillin

5
Q. Chemically, Primaquine is:
a. 8-[4-amino-1-ethylbutylamino]-6-methoxy quinoline
b. 8-[4-amino-1-methylbutylamino]-6-methoxy quinoline
c. 8-[2-amino-1-methybutylamino]-6-methoxy quinoline
d. 8-[2-amino -1-ethy1butyl 1-amino]-6-ethoxy quinoline

Q. Cephalosporin is obtained by
a. P. acremonium
b. P. Notatum
c. S. Venezuela
d. None of the above
Q. The antimicrobial activity of penicillin is due to
a. Thiazolidine
b. 6-APA
c. Beta-lactam ring
d. None of the above
Q. Antiviral action of purine analogues is primarily related to the followings:
a. Inhibition of RNA synthesis
b. Inhibition of DNA polymerase
c. Immunomodulation
d. Inhibition of viral penetration
Choose the correct option:
A. R is correct and Q is incorrect
B. Q is correct and S is incorrect
C. P is correct and R is incorrect
D. S is correct and P is incorrect
Q. ___________ is symmetrical tricyclic amine?
a. Ganciclovir
b. Vidarabine
c. Amantadine
d. Idoxuridine
Q. What kind of antibacterial agent is erythromycin?
a. A macrolide
b. A penicillin
c. A cephalosporin
d. A tetracycline
Q. Penicillin is obtained from
a. Bacteria
b. Fungi
c. Virus
6
 d. Protozoa
Q. Which one of the following statements is FALSE for fluoroquinolones?
a. These are highly effective by oral and parenteral routes
b. These are relatively more susceptible to development of resistance
c. These are effective against those bacteria that are resistant to β-lactam and
aminoglycoside antibiotics
d. These are bactericidal with broad spectrum of activity
Q. Penicillin ring system is derived from two of the following amino acids:
a. Alanine and methionine
b. Cysteine and valine
c. Glycine and cysteine
d. Methionine and leucine
Q. Some statements are given for clavulanic acid sulbactam and tazobactam:
A. All three lack the 6-acylamino side chain
B. All are potent inhibitors of the enzyme β-lactamase
C. All are prodrugs of penicillin
D. All have weak antibacterial activity
Choose the correct combination of statements.
a. A, B and C are true while D is false
b. B, C and D are true while A is false
c. A, C and D are true while B is false
d. A, B and D are true while C is false
Q. Which of the following approach is considered under the ‘Ligand based drug designing’ ?
a. Molecular docking
b. Pharmacophore modeling
c. QSAR Modeling
d. b and c both
Q. Solid phase synthesis is frequently used in combinatorial chemistry. What is meant by solid
phase synthesis?
a. Reactions are carried out without solvent.
b. Reagents and reactants are attached to a solid phase support.
c. Reagents are used in the solid phase.
d. Molecules are constructed on a solid phase support.
Q. What term is used for a molecular unit which is attached to the solid support and which
contains a reactive functional group that allows attachment of a starting material?
a. Resin activator
b. Hook
c. Linker
d. Joiner
Q. Patients with penicillin allergies are frequently allergic to another which class of antibiotics?

7
 a. Fluoroquinolones
b. Macrolides
c. Aminoglycosides
d. Cephalosporins
Q. Streptomycin is produced by which organism?
a. Streptomyces noursei
b. Streptomycin nodosus
c. Streptomycin griseus
d. Streptomycin fradiae
Q. Antibiotic produced from Streptomyces rimosus is:
a. Chlortetracycline
b. Tetracycline
c. Oxytetracycline
d. Doxycycline
Q. Which reaction is catalyzed by beta-lactamase enzyme?
a. Final cross-linking reaction to form bacterial cell wall
b. Hydrolysis to acyl side chain from penicillin structures
c. Hydrolysis of four membered ring present in penicillin
d. Biosynthesis of penicillin structure form amino acids valine and cysteine
Q. What is the target for clavulanic acid?
a. β-lactamase
b. L-ala racemase
c. Transpeptidase
d. Penicillin acylase
Q. Aminoglycosides are most effective against which kind of microorganisms?
a. Aerobic gram-negative bacteria
b. Anaerobic gram-negative bacteria
c. Aerobic gram-positive bacteria
d. Anaerobic gram-positive bacteria
Q. Aminoglycosides work by irreversibly binding to the __________ ribosomal subunit?
a. 50s
b. 30s
c. Both
d. None
Q. Which of the following drugs is not an aminoglycoside?
a. Streptomycin
b. Neomycin
c. Amikacin
d. Azithromycin
Q. Chemically tetracycline is a derivative of:

8
 a. Purine
b. Pyrimidine
c. Octahydro Naphthacene
d. Phenanthrene
Q. Chemically cephalosporins is:
a. 7-amino acid
b. 7-aminocephalosporanic acid
c. 5-aminocephalosporanic acid
d. 6-amino acid
Q. Examples of Ureido penicillin are:
a. Mezlocillin & Piperacillin
b. Carbenicillin & Ticarcillin
c. Ampicillin & Bacampicillin
d. None of the above
Q. Examples of Monobactam antibiotic is:
a. Ampicillin & Bacampicillin
b. Carbenicillin & Ticarcillin
c. Sulbactam & Tazobactam
d. Aztreonam & Tigemonam
Q. Basic nucleus of Macrolide antibiotics is:
a. Macrocyclic Lactone (spiroketal group)
b. Microcyclic ring
c. Lactam ring
d. Beta lactam ring
Q. Identification of a new chemical entity as a potential therapeutic agent (From Hit to Lead)
is known as:
a. Drug development
b. Drug discovery
c. Both of the above
d. None of the above
Q. Process of bringing new pharmaceutical drug to the market once the lead compound has
been identified through the process of drug discovery. From Lead to NDA is known as:
a. Drug development
b. Drug discovery
c. Both of the above
d. None of the above
Q. Natural products or derivatives or synthetic substances with good binding ability in Drug
discovery is known as:
a. Lead
b. NDA
c. IND
9
 d. Hit
Q. Compound with good activity and selectivity in screening during drug discovery is known
as:
a. Lead
b. NDA
c. IND
d. Hit
Q. Identification of a lead nucleus depends on the consideration of:
a. Molecular structure
b. Geometry of receptor
c. Drug receptor interaction
d. Observed biological responses
e. All of the above
Q. Drug design may be considered as an integrated whole approach which essentially involeves
which step/steps:
a. Chemical synthesis
b. Evaluation for activity-spectrum
c. Toxicological studies
d. Drug metabolism
e. All of the above
Q. Which of the following method used for virtual screening?
a. ADMET analysis
b. QSAR modeling
c. Pharmacophore modeling
d. All of the above
Q. Drug discovery is a process of finding:
a. Disease etiology
b. Target identification
c. Lead discovery/optimization
d. All of the above
Q. Drug discovered accidently or by unexpected results/action is called as:
a. Serendipitous pathway
b. Screening pathway
c. Chemical modification pathway
d. Rational pathway
Q. Lipinski’ rule of 5 is used for:
a. Docking
b. Similarity search
c. Drug likeness
d. Dynamics simulation

10
Q. Biological activity of most drugs is related to the combination of physicochemical
properties. This statement is relevant to:
a. Hammett’s substituent constant
b. Hansch analysis
c. Tafts steric constant
d. Free Wilson analysis
Q. DYLOMMS (Dynamic Lattice-Oriented Molecular Modeling System) is related to:
a. 2D-QSAR
b. 3D-QSAR
c. SAR
d. Docking
Q. What does symbol P represent in QSAR equation?
a. pH
b. Plasma concentration
c. Partition coefficient
d. Prodrug
Q. What is the symbol π represent in a QSAR equation?
a. Hydrophobicity of the molecule
b. Electronic effect of the substituent
c. Substituent hydrophobicity constant
d. Measure of steric properties for a substituent
Q. What does MR represent in QSAR equation?
a. Molar refractivity is a stereoelectronic factor
b. Molar refractivity is an electronic factor
c. Molar refractivity is a hydrophobic factor
d. Molar refractivity is a steric factor
Q. What does a negative value of σ signify for a substituent?
a. Electron withdrawing
b. Electron donating
c. Neutral
d. Hydrophobic

11