MOLECULAR IMMUNOLOGY

(VAI-311)

Hussain Mustatab Wahedi, PhD Lecture 13

Department of Healthcare Biotechnology 17-Apr-2023
ASAB, NUST, Islamabad SP-2023
 Opsonization

C-Reactive Protein (CRP) → Phosphocholines and CHOs (Fc Receptor)

Activation of Complement System → Phagocytosis

Complement system → Vertebrates & Invertebrates

MBL Deficiency
Phagocytosis: How microbes are killed?

Phagosomes + Lysosomes/Granules = Phagolysosomes

Multiple mechanisms:
• ROS
• RNS
• Enzymes in lysomses
• Antimicrobial peptides
• Low pH (ATPase Proton Pump)
• Phagosomes oxidase (NADPH oxidase) oxidative burst
• Oxygen Attack (ROS & RNS)
 Oxygen Attack (ROS & RNS)

iNOS or NOS2
ROS & RNS can be released
Chronic Granulomatous Disease (CGD)
What is Pyroptosis and which PRRs can start it?