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    This document discusses molecular immunology topics including: 1) Regulated cell death mechanisms like NETosis and pyroptosis that contribute to pathogen elimination. 2) Pyroptosis is triggered by NLRs and its molecular mechanism involves canonical and non-canonical inflammasomes. 3) Innate lymphoid cells like NK cells that kill pathogens through cytotoxicity, cytokine release like IFN-gamma, and antibody-dependent cytotoxicity.

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    LECTURE-14 (26-04-2023)

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    This document discusses molecular immunology topics including: 1) Regulated cell death mechanisms like NETosis and pyroptosis that contribute to pathogen elimination. 2) Pyroptosis is triggered by NLRs and its molecular mechanism involves canonical and non-canonical inflammasomes. 3) Innate lymphoid cells like NK cells that kill pathogens through cytotoxicity, cytokine release like IFN-gamma, and antibody-dependent cytotoxicity.

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    13 views11 pages

    Lecture-14 (26-04-2023)

    Uploaded by

    maha
    This document discusses molecular immunology topics including: 1) Regulated cell death mechanisms like NETosis and pyroptosis that contribute to pathogen elimination. 2) Pyroptosis is triggered by NLRs and its molecular mechanism involves canonical and non-canonical inflammasomes. 3) Innate lymphoid cells like NK cells that kill pathogens through cytotoxicity, cytokine release like IFN-gamma, and antibody-dependent cytotoxicity.

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    © All Rights Reserved
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    of 11

    MOLECULAR IMMUNOLOGY

    (VAI-311)

    Hussain Mustatab Wahedi, PhD Lecture 14


    Department of Healthcare Biotechnology 26-Apr-2023
    ASAB, NUST, Islamabad SP-2023
    Regulated Cell Death Contributes to Pathogen elimination
    • Neutrophil extracellular traps (NET & NETosis)
    • Pyroptosis - NLRs
    NETs and NETosis
    What is Pyroptosis and which PRRs can start it?
    Pyroptosis: Molecular Mechanism
    Canonical Inflammasome Non-Canonical Inflammasome
    Innate Lymphoid Cells
    Innate Lymphoid Cells: NK cells
    NK cells Effector Mechanisms
    • Cytotoxicity via degranulation (KARs vs KIRs)
    Innate Lymphoid Cells: NK cells
    NK cells Effector Mechanisms
    • Cytotoxicity via degranulation (KARs vs KIRs)
    Innate Lymphoid Cells: NK cells
    NK cells Effector Mechanisms
    • Cytotoxicity via degranulation (KARs vs KIRs)
    • Release of cytokines: IFN-gamma induces phagocytosis
    Innate Lymphoid Cells: NK cells
    NK cells Effector Mechanisms
    • Cytotoxicity via degranulation (KARs vs KIRs)
    • Release of cytokines: IFN-gamma induces phagocytosis
    • Antibody-dependent cell-mediated cytotoxicity
    Microbiome
    • Resident microbiota

    • Microorganisms that live in the skin and mucous


    membranes of healthy normal persons.

    e.g. mice lacking certain species of bacteria develop auto-


    immune disorders of infections

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