24-FEB 2020(2): KAPS ARABIC Group

1.What is the acid that is not used to extract materials:

A.HCL
B. Sulphoric acid
C. Nitric acid
D. Alginic acid

2.Not affect on the mortality in HF treatments:

Digoxin

3.Perindopril and celecoxib both are affecting on kidney:

Nephrotoxicity
ACEI+ NSAIDS=Renal failure

4.Chloramphenicol 90%+gentamycin 5%
Adjust only for Chloramphenicol

5.Most causes Cholestatic hepatitis

Amoxicillin with Clavulanic acid

6.Aminoglycosides S.E:
Nephrotoxicity ‫هنا الي جه‬
Ototoxicity

7.How much Boric acid FD =0.288 (2% ) :‫ مساله ال‬APEC

Answer: 322.5 mg

8.Need loading dose for parenteral route:

Digoxin
9.Lisinopril Max dose:
40 mg
10. warfarin:
48-72 hrs
11.ACEI cause:
Increase urea

12.patient is taking Rosuvastatin and other statin ??and Amitriptyline, Thiamine,

Acamprosate, alcohol he has a main complaint:
!!!!!!!!!
1-which drug cause confusion according to his complain
Amitriptyline
2-Acamprosate dose and B/D or O/D: (treatment of alcoholism)
333 mg three times ‫الي موجود منهم صح‬
666 mg two times
999 mg one time a day
For at least three months

13.preventive in Asthma:
A. B2 agonist
B. inhaled corticosteroids

14. child 10-12 years old got an adverse effect related to Asthma:
A. Long term oral corticosteroids
B. Inhaled corticosteroids
15. phenylethylamine structure:

16.Which is gastric protective:

Sucralfate

17.Most effect on insulin production is:

A. Glucose
B. para

18.Which cause hyperglycemia:

A. Ezetimibe
B. Clozapine

19. medroxyprogesterone: ----------------

20. Quetiapine most side effects:

A. weight gain
B. used in bipolar

21.Acute overdose of nortriptyline (least)

A. Hyperpyrexia
B. convulsion
C. confusion
D. constipation

22.Not used in open angle glaucoma treatment:

A. pilocarpine
B. Latanoprost
C. Bimatoprost
D. Tropicamide

23.Not used as Antiemetic:

Sumatriptan

24.Antagonise muscarinic receptor:

Atropine

25. 5α-reductase inhibitor:

A. Finasteride
B. Alprostadil

26.sporcidal:
A. Benzalkonium chloride
B. Thiomersal
C. Chlorbutanol
27. Imipramine structure:

28.penicillin structure:

29.Histamine structure:
Answer: B
Piperacillin structure:

30.Which of the following do not use in Aspirin toxicity:

A. Ca. edetate
B. Kcl
C. Charcoal

31.Not form of biotransformation:

Esterification

32. NE to E metabolism:
Methylation
‫و بيجيب االستركشرات بتاعتهم‬

NE to E
33.Angle of H bond:
104.5°

34.Warfarin clotting factors

II, VII, IX and X

35.Chondrocyte:
A. RA
B. OA

36. Do not do vasodilatation in angina:

A. Metoprolol
B. Nifedipine
C. Nitrates

37. Not symptoms of Organophosphorus toxicity

A. Nausea, vomiting, Diarrhea
B. Dry mouth
C. Tachycardia

38. Pyrrole structure:

39. phenothiazine structure:

40.Flucloxacillin structure:

41. Giant living organism 0.5% salt in 1.5% salt and no permeability what is happened
after 1 hr:

A. No change

B. Burst

C. Shrink

42.Acamprostat mechanism of action:

GABA analogue

43. Least drug for alcohol:

A. Diazepam
B. Naloxone
C. Disulfiram
D. Acamprosate

44. Doxycycline:
100 mg for 4 weeks after coming back from malaria place

45.Aminoglycoside causes more:

A. least Nephrotoxic
B. More Nephrotoxic
C. potent neuromuscular blocker

46.Which increase K level:

A. Frusemide
B. Bumetanide
C. Amiloride
D. Indapamide

47. Theophylline dose adjustment is required in:

Hepatic impairment

48.Amiodarone which is most appropriate:

X-ray

49.protein is metabolized by:

A. Deamination
B. Hydrolysis
C. Oxidation
D. Esterification

50. Protein is damaged by:

A. Deamination
B. Hydrolysis
C. Oxidation
D. Esterification

51.Calculations:
1077 ml CPR
157 mmole --------No dilution
Digoxin -----------6 days
936 ------CPR
40 gm----------2 mmole
0.61 , 40% F=0.16
MTX----260 tablets

Q-Need 10000 unit add 17 ml water to produce 500unit/ml , u have 300 unit/ml vial ,
how much water in each vial
Answer: 10 ml
52.Sildenafil dose:
50-100 mg 1 hr before sexual intercourse
53.Cephalexin resistant against:
A. E.Coli
B. Staph
C. Strept
D. Campylo jejune

54. Rivaroxaban about cyp:

Cyp3A4
55. Roxithromycin max dose:
300 mg

56.Cyp:
Smoking--------1A2
Diltiazem -------3A4

57.Greatest absorption:
A. Lower intestine
B. Upper intestine –dudenum—jujenum---illeum

58.paracetamol child dose : 300 mg

Phenytoin dose :
Phenytoin
Epilepsy (oral)
4–5 mg/kg daily, increased by 30 mg daily once every 2 weeks according to response
Usual range, 200–500 mg daily once daily or in 3 divided doses
Status epilepticus (IV)
15–20 mg/kg

Uv : 200-400

59.Dronabinol:
is a synthetic form of delta-9-tetrahydrocannabinol
60.Sterioisomers:
=16

61.Fats:
Are esters of fatty acids and glycerol

62.Side effects of Hydroxychloroquine:

Retinopathy

63.Drug do not go acetylation:

A. Gentamycin

B. Vancomycin

64.Ibuprofen metabolism:
Glucuronidation

65.ACEIs effect on Urea:

Increase urea so do not use with high urea

66.Ascorbic acid contain which ring:

A. Aromatic ring
B. Unsaturated lactone

67. Q 86 from pharmacy review:

68.What will advise patient is taking Glyceryl trinitrate tablets:
A. Store in fridge.
B. Store in Amber bottle and Store in Tightly stoppered container.

69. Ranitidine + Itraconazole why Ranitidine decrease Itraconazole activity:

A. Due to more absorption because of decrease PH
B. Ranitidine decrease metabolism
C. Less absorption because ranitidine increases PH and Itra needs acidic media

70. Why Omeprazole has long activity:

A. Due to formulation
B. Due to long half life
C. Irreversible inhibitor of proton pump.

71. Giving structure and asking what is this: phenothiazine

Structure of thioguanine and asking it is used as: antimetabolite

Answer E (not)
Answer: E
‫ س باالمتحان بطلو يجيبوه هيك غيرو االختيارات ف بتختارو‬antimetabolite

72. Sartan counselling:

A. sitting to decrease feeling of dizziness
B. Do not take K supplements
C. Renal monitoring
D. All of the above is right

73. Irbesartan:
Once daily

74. Verapamil + Atenolol:

A. AV block
B. Tachyarrhythmia
C. Bradycardia

75.Disopyramide
ACH side effects
76.Ezetimibe:
Will not decrease absorption of other drugs
77. Amiloride:
Hyperkalemia

78. Ca + FO’s
Chelation

79. Formoterol:
B2 agonist long acting

80. Patient Profile:

Lady has hip replacement operation she is given drugs as Heparin, Midazolam,
Prothrombin. On next day Naloxone during surgery Morphine
1-Why Midazolam:
Anesthesia
2- Why prothrombin?
To counteract the coagulation action of Heparin
3-How withdraw Heparin activity:
A. Prothrombin time or APTT
B. INR
4-Why Naloxone?
To save respiratory depression of morphine

81. 17α-Estradiol st class:

Steroid
82. What happened after ACEI s is given:
A. Increase Sr Cr and increase K
B. Increase Sr Cr and decrease K
C. increase Sr Cr and decrease Ca

83. Aspirin toxicity with which cytotoxic drug:

MTX

84. Which cytotoxic drug cause more nausea and vomiting:

Cisplatin

85. MTX class:

A. Alkylating
B. Antimetabolites

86. MTX toxicity:

Folinic

87. 0.5 1 1.5% salt

0.5

Shrink

88.
89.
90. Gm(-ve) bacteria:
Ciprofloxacin
91. Rectal dosage form incorrect:
Base solubility and melting is NOT important
92. UTI inappropriate which is not true:
E.coli is not a common cause of UTI
93. S.C or IM is best absorption rate because:
A. Increase lipid solubility
B. Increase partition coefficient

94. For isotonic solution most appropriate:

A. Nasal spray
B. Mouth wash
C. Skin
D. Liniment

95. Need loading dose for parenteral route:

A. Digoxin---------------need only in arrythmia
B. Phenytoin ----------in seizures

96. Case study:

Patient with HF+HTN+ depression and she is menopausal what drug can be given to
her for HF:
-she has problem when she surge she has only urinary slightly every time
Drug dose adjustment

97.Doxyrubicin:
Cardiac damage
98. Dimorphism:
change from hyphae to yeast
99. Not factor for oral absorption:
t1/2+MWT both are not factors

100. H.pylori:
Combination therapy

101. Does not need loading dose:

A. morphine
B. Digoxin

102. which antibacterial suspension is withstanding at 121c … mints:

A. Benzyl penicillin
B. Fluoroquinolone
C. Amoxiclav

103. Non albican vaginal agent :

A. C.glabrate
B. C.krusi
C. Aspergillus
D. sarco…

104.Which is not active immunity: = passive Hep B + antitoxin

A. Tetanus antitoxin
B. Dtap

105.what is true about colloidal silver:

Miscellaneous Ag

106. cyclophosphamide prevent hemorrhage cystitis

MESNA+ drink a lot of water

107.If MTX is taken with Leflunomide:

Hepatotoxicity

108. which is osmotic diuretic:

A. sorbitol
B. Mannitol
C. Frusemide

109. Not for Aminoglycosides:

A. CI in breastfeeding
B. Effective against M.Avium in HIV
C. Effective in chlamydia and least in …..
D. Have a good oral absorption

110.Allopurinol mechanism of action

is an inhibitor of the enzyme xanthine oxidase

111.Spironolcatone
Aldosterone antagonist

112.Most effect on conduction:

A. Verapamil
B. Nifedipine
113. flupentixol route of administration:
IM
114.Drig is given as a Depot:
A. Quetiapine
B. Olanzapine

115.IV bolus:
Salbutamol

116.which gives O/W:

A. Na lauryl sulfate
B. cetyl alcohol
C. Sorbitol
117. phenytoin dose in Status Epilepticus:
Status epilepticus (IV)
15–20 mg/kg

118.Lisinopril in HF dose:
Heart failure
2.5 - 20 mg once daily. Maximum 40 mg daily.
In HTN
Hypertension
5 – 20 mg once daily. Maximum 40 mg daily.

119. Atropine and diphenoxylate will not cause:

A. Dry mouth
B. Drowsiness’
C. Bronchospasm
D. Urinary retention
120. Patient has prosthetic Heart surgery, which antibiotic for dental surgery pain:
A. cephalosporin
B. fluoroquinolones
C. Amoxicillin
D. cephalexin

121. what of the following cause most hypoglycemic symptoms:

A. Glimepiride
B. Metformin
C. Repaglinide
D. Thiazolidinedione

122.Hydrophilic:
A. Water miscible
B. Water soluble

123. Agonist means:

A. favors action and no intrinsic activity.
B. favors action and intrinsic activity
C. Not favor action

124. counselling for lice:

…………
125.Case study on Acamprosate, patient with alcohol dependence, hyperlipidemia,
insomnia …..
Which drug cause insomnia side effects:
A. Naloxone
B. Acamprosate
C. Esomeprazole
D. Benzodiazepines

126. which drug is reasonable for most of Side effects:

A. Acamprosate
B. Esomeprazole
C. Naloxone
D. DSPM

127. Least likely to occur with Acamprosate:

128. No active metabolite:

Nifedipine
129. Ophthalmic solution preservative:
Benzalkonium chloride 0.5%

130. clindamycin preparation: ……..

131. New Q : Extemporaneous compound ………

132. Cephalosporin should be monitored for:

Renal toxicity

133. Best drug against protozoa:

Metronidazole

134. Ibuprofen metabolism:

Glucuronidation

135. Ibuprofen get elimination:

A. Unchanged in urine
B. Unchanged in bile
C. Active metabolite
136. Metabolic acidosis:
A. Diarrhea
B. Vomiting

137. Least true of Vitamin D:

Used in Hyperthyroidisms

138. Li:
Hypothyroidism

139. Vitamin E:
A. include tocopherol
B. Important for male

140. which vitamin structure related to steroids:

Vitamin D

141. Which drug does not cause nausea:

A. promethazine
B. Cetirizine
142. Cannot be mixed in aqueous solution:
A. Phenytoin
B. Digoxin

143. Does not cause rhabdomyolysis:

A. Ezetimibe
B. Isotretinoin

144. Given as IV infusion for hypertensive crisis:

A. Doxazosin
B. Hydralazine
C.

145. After chronic oral dose plateau is based on:

A. Dose
B. clearance
C. Elimination half life
D. Half-life+ dose

146. Which process has the least ATP:

A. Citric acid cycle
B. Fatty acid
C. Electro transport chain
D. protease phosphate pathway

147. Most common metabolic pathway:

A. Hydrolysis
B. Oxidation
C. Reduction

148. Oestrogen uses:

149. Azo reduction to:

hydrazo then amine

150. Creatinine is excreted in renal tubule:

A. 10%
B. 25%

151. Warfarin is antagonized by:

A. Ginko
B. Omeprazole
C. St. jone wart
D. levothyroxine

152. Mg hydroxide:
A. Enzyme agent
B. physical agent
C. Chemical agent

153. Drug is used in treatment of vertigo:

A. Metoclopramide
B. Benzodiazepine
C. Scopolamine
D. Prochlorperazine
If prochlorperazine in options, choose it first then metoclopramide
154. Not active immunity:
HepB + Antitoxin

155. Not associated with cardiac toxicity:

A. Valproic acid
B. Doxorubicin
C. Mebeverine
D. Doxepin

156. Cause hepatotoxicity:

A. MTX+ leflunomide
B. MTX + hydroxy chloroquine
C. MTX + Allopurinol

157. Least interaction with Warfarine :

Allopurinol
158. Amino acid bind with small oart of RNA:
A. t RNA
B. m RNA
C. r RNA

159. Not be used regarding Rivaroxaban:

Ketoconazole

160. In respiratory alkalosis how the renal compensate this:

H and HCO3
161. Estradiol metabolism to:
Estradiol is also metabolized via hydroxylation into catechol estrogens

162. Paracetamol toxicity lack of what…….

163. Parenteral emulsifier is:

Egg lecithin

164. Case study: Perindopril + Celecoxib

165. if patient has allergy to sulfa which drug cannot be used:

Celecoxib

166. For postpartum pain what is least likely to take:

A. Codeine
B. Tramadol
C. Paracetamol
D. Diclofenac

167. Pain Killer is used for RA:

A. Omega 3
B. Paracetamol+ Codeine

168. INR for warfarin:

2-3
169. Piperacillin structure:

Sulfonamide structure:

170. cisplatin and position of 2 Cl group:

171. patient has sore throat and allergic to penicillin which drug should be give:
A. Erythromycin
B. Tetracycline
C. Cotrimoxazole
172. Vomiting is not induced by:
A. CTZ
B. Baroreceptor of carotid
C. Emotion
D. something in inner ear

173. Insulin dosing (new options)

174. Digoxin is used in all of these:

A. Ventricular
B. Arrythmia
C. AF and HF
D. SVT

175. Acid stable and ph resistant:

Dicloxacillin

176. Treatment of travelers’ diarrhea:

Norfloxacin

177. Most warfarin interaction with:

A. Tramadol
B. Celecoxib
C. Spironolactone

178. What is wrong about Opioid:

A. Codeine is metabolized to morphine
B. Pholcodine has no analgesic effect
C. Morphine is weak base.
D. Morphine metabolite is excreted by hepatic
179. Haloperidol:

Ibuprofen

Neostigmine structure:

180. LH is secreted by:

gonadotropic cells in the anterior pituitary gland

181. Which vitamin deficiency dose not effect on eye:

Vitamin K
Vitamin is important for male:
Vitamin A

181. cretinism is caused by:

Iodine deficiency

182. Why Omeprazole dose not be taken for long time:

A. Less Ca absorption
B. suppression of PPI leads to cancer

183. Tocopherol:
Antioxidant

184. Brinzolamide is used in:

Glaucoma
185. Bisacodyl produce:
Laxative dependence

186. Pethidine
Less addictive than codeine
187. Nifedipine mechanism of action:
Block entry of Ca into smooth muscle

188. Least used for CMV:

Famciclovir

189. Drug of choice in genital Herpes:

Acyclovir
190. What is the weight of …… in 12 suppositories
450

191. Dry heat by hot air oven temp 160 For 2 hrs
A. Fat
B. Oil
C. Powder

192:

193. Procaine is metabolized by:

Hydrolysis

194. Not antacid:

CaCl2
195. Not need renal adjustment:
A. Morphine C. Diltiazem
B. Dioxine D. Acyclovir
196. Gentamycine against :
A. Strepto
B. Bacteriod
C. Viridan

197. Should not be taken in the third trimester:

A. Nifedipine
B. Diltiazem

198. salicylic acid is weak acid if increase PKa above PH what will be happen:
A. partition coefficient is reduced
B. Ionization is reduced
C. partition coefficient is increased

199. Most useful eye drops at neutral PH how can get a solution for optical preparation
by using:
A. Strong base C. Weak base
B. Strong Acid D. Weak acid

200.Chondrocyte cause:
OA

201. Atropine side effects:

Mydriasis
202. should not be taken during trimester
Diclofenac
203. Sucralfate form:
Protective layer
204. Least safe drug in pregnancy:
A. Amoxicillin
B. Cephalexin
C. Erythromycin
D. ciprofloxacin

Not for ascorbic acid:

A. Rapidly absorbed from GIT
B. Utilized at increased rate during common cold&influenza
C. Reversibly oxidized to oxalic acid
D. Daily dose is 75_150 mg
Answer: D

‫الحمد هلل رب العالمين‬