SEMESTER-III

UNIT-1 PATHOLOGY-I
“WOUND HEALING”

PRESENTED BY

MR. SACHIN SHARMA

 YOU WILL LEARN ABOUT

W H AT I S R E G E R AT I O N A N D R E PA I R ?
INTRODUCTION

DEFINITION

TYPES OF WOUND HEALING

FACTOR INFLUENCING HEALING

COMPLICATION OF HEALING

MR. SACHIN SHARMA(M.Sc. N.)

INTRODUCTION

• Healing relies on formation of granulation tissue made up of

fibroblasts bounded by extracellular matrix, blood vessels (newly
formed), macrophages, and other inflammatory cells
• Macrophages present in wound remove debris, involve more
fibroblasts andangio blasts, and stimulate production of
extracellular matrix. The macro phages secrete collagenases and
other lytic enzymes which help in scar remodeling.
• Simultaneously, they also secrete metalloproteinases inhibitors
which act against the lytic enzymes, thus, facilitating uniform
remodeling.
• Healing takes place by the following two processes:
1. Regeneration
2. Repair

MR. SACHIN SHARMA(M.Sc. N.)

Regeneration and Repair
1. Regeneration: It results in complete restoration of the
original tissue by the proliferation of parenchymal
cells.
2. Repair: It results in fibrosis and scarring by the
proliferation of connective tissue elements.

The process of regeneration and repair occurs

simultaneously.

MR. SACHIN SHARMA(M.Sc. N.)

MR. SACHIN SHARMA(M.Sc. N.)
DEFINITION
• Healing is defined as the response of body
against an injury in order to restore normal
structure and function.

MR. SACHIN SHARMA(M.Sc. N.)

 TYPES OF WOUND HEALING

PRIMARY UNION

SECONDARY UNION

MR. SACHIN SHARMA(M.Sc. N.)

 Initial haemorrhage

Acute inflammatory response

Epithelial changes

Organisation

Suture tracks

PRIMARY UNION
MR. SACHIN SHARMA(M.Sc. N.)
 Initial haemorrhage

Inflammatory Phase

Granulation tissue

Wound contraction

Presence of infection

SECONDARY UNION
MR. SACHIN SHARMA(M.Sc. N.)
 LOCAL FACTOR SYSTEMIC FACTOR

LOCAL FACTOR AGE

POOR BLOOD SUPPLY NUTIRION

MOVEMENT SYSTEMIC INFECTION

EXPOSURE TO IONISING ADMINISTRATION OF

RADIATION GLUCOCORTIOCOIDS
EXPOSURE TO UV UNCONTROLLED
LIGHT DIABETICS
TYPE,SIZE AND HEMATOLOGIC
LOCATION ABNORMALITIES

FACTOR INFLUENCING HEALING

MR. SACHIN SHARMA(M.Sc. N.)
 Infection

Implantation cyst

Pigmentation

Deficient scar formation

Incision hernia
Hypertrophied scars and
keloid formation
Excessive contraction

Neoplasia

COMPLICATION OF HEALING
MR. SACHIN SHARMA(M.Sc. N.)
 Video time

MR. SACHIN SHARMA(M.Sc. N.)

 THANK
YOU

MR. SACHIN SHARMA(M.Sc. N.)