“ HAIR FALL ” 2023

Date :-

CERTIFICATE
Certified that AKSHANSH KUMAR (Roll No. 19013700030) has carried out the
projectwork presented in this report entitled “HAIR FALL” for the award of
Bachelor of Pharmacy from AVIPS , Shobhit University Gangoh ,undermy
Supervision . the report embodies results of original work ,and studies are
carried out by the student himself .

Supervised by
Dr. HIMANI BAJAJ

Professor
AVIPS ,Shobhit University , Gangoh ,Saharnpur

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DECLARATION
I hearby declare that the project work entitled “ HAIR FALL ”submitted to the “
Adarsh Vijendra Institute Of Pharmaceutical Science ”On the
requirement of “Shobhit University” is a record of original work done by under
the guidance of Dr. Himani Bajaj , (Professor ), Shobhit University Gangoh
(Saharanpur ).

( Akshansh Kumar )

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ACKNOWLEDGMENT
I would like to express my sincere thank you all those who have involved directly
and indirectly with successful completion of the project work.

Too many esteemed respected teacher “Dr.Himani Bajaj ” associate professor,

department of pharmaceutical chemistry. I wish to express my sincere graduate
for is continuous encouragement valuable suggestion and cooperation
throughout the project work.

I convey my gratitude and warm time to Prof. (Dr.) Madan Kaushik Director
AVIPS for his guidance and support.

I am thankful to my friend for helping me get through the difficult times and for
all the emotional support and entertainment and care they provided.

Above all, these work could not have been completed without the help, courage,
love ,synergy and moral boosting provide my parents who have invested they are
present for many future.

There is a final debt. adapt that I can never repay which I owe to Almighty God,
for the strength and guidance best owned upon me right from the beginning.

( Akshansh Kumar )

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CONTENTS
Page no
Certificate 01

Declaration 02

Acknowledgement 03

CHAPTER – 1 ABSTRACT 05
CHAPTER – 2 INTRODUCTION 06-07

CHAPTER – 3 CAUSES OF HAIR FALL 08-10

CHAPTER – 4 TYPES OF HAIR FALL 11-15

CHAPTER –5 HAIR USED IN TREATMENT OF 16- 20

ALOPECIA
CHAPTER – 6 DISADVANTES 22-22
CHAPTER – 7 CONCLUSION 23-23
CHAPTER – 8 REFERENCES 24-26

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Chapter - 01
ABSTRACT

Hairs can be defined as -"improved epithelial structure formed as a result of keratinization of

germinative cells," hairs are the outgrowths from the follicles existing on the skin. Hair is
composed of keratin with chemical constituents such as Carbon(C), Nitrogen (N), Sulfur(S), &
Oxygen (O). Hair growth varies from person to person but on average hair grows about 15-30
mm/ month. The main unbiased of present study is to treat Alopecia. Alopecia areatatis an
unpredictable hair loss - condition. Herbal drug used internally as well as externally used hair
growth to prevent premature greyish or hair loss. The claim of better growth of hair and
diminution in loss of hair. Alopecia is one of the major problems amongst urban people to
subjection to stress environmental problems etc. So, with the help of this review article, we
conclude that many herbal drugs having potency for curing alopecia with no side effects. The
various types of allopathic drugs to treat hair loss but they have many side effects.
Approximately about 80% residents recommended herbal drugs for their beneficial effects
along with fewer side effects as compared synthetic drugs .

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Chapter - 02

Introduction:

Hairs can be defined as -"improved epithelial structure formed as a result of keratinization of germinative
cells," hairs are the outgrowths from the follicles present on the skin. Hair is composed of keratin with
chemical constituents such as Carbon (C), Nitrogen (N), Sulfur(S), & Oxygen (O). Hair growth varies from
person to person but on average hair grows about 15-30 mm/ month. Hair is the one of the vital parts of the
body derived from ectoderm of the skin, and is protective appendages on the body..
Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body.
Typically at least the head is involved. The severity of hair loss can vary from a small area to the entire
body. Inflammation or scarring is not usually present.

Definition:

Hair loss: Hair loss is the thinning of hair on the scalp. The medical term for hair loss is alopecia. Alopecia
can be temporary or permanent. The most common form of hair loss occurs gradually and is referred to as
"androgenetic alopecia," meaning that a combination of hormones (androgens are male hormones) and
heredity (genetics) is needed to develop the condition. Other types of hair loss include alopecia
areata (patches of baldness that usually grow back), telogen effluvium (rapid shedding after
childbirth, fever, or sudden weight loss); and traction alopecia (thinning from tight braids or ponytails).

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History:

Hair fall has been a common problem throughout human history. Hair loss has been documented in
ancient medical texts and was recognized as a common condition in many cultures, including
ancient Egypt, Greece, and Rome. In traditional Indian medicine, Ayurveda, hair fall was considered
a result of imbalances in the body's doshas, and various herbal remedies were prescribed to treat it.

In the 19th century, advances in medical science led to the discovery of hormones and their role in
hair growth and hair loss. The first synthetic hormone, testosterone, was synthesized in 1935, and
its effects on hair growth were studied in the following decades.

In the 20th century, hair loss became a more significant concern due to changing social norms and
the rise of the beauty industry. The development of cosmetic products, such as hair dyes and
styling tools, contributed to hair damage and hair fall. Today, hair fall continues to be a common
problem, and various treatments are available, including medication, surgery, and lifestyle changes.

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Chapter - 03
CAUSES OF HAIR LOSS:

CAUSES OF HAIR LOSS:

Most cases of hair loss can be divided into three categories: non-cicatricial alopecia, cicatricial

alopecia, and hair shaft abnormalities

1. NON-CICATRICIAL ALOPECIA:

Non-cicatricial alopecia is hair loss with chances for regrowth. Types of non-cicatricial alopecia
include telogen effluvium (TE), androgenetic alopecia (AGA), and alopecia areata (AA). Traction
alopecia (caused by pulling hair) and trichotillomania (compulsive hair-plucking) are also included in
this group. However, in chronic cases, trauma can affect the follicle stem cells (follicle midportion),
producing scarring and permanent hair loss.

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2. CICATRICIAL ALOPECIA:

Cicatricial alopecia is irreversible hair loss associated with the destruction of stem cell
reservoir located in the midportion of the follicle. Cicatricial alopecia is caused by a diverse
group of cutaneous disorders with a variety of presentations.
Common causes of cicatricial alopecia are fungal or bacterial folliculitis, discoid lupus
erythematosus, and lichen planopilaris. Other causes are skin diseases, trauma, scarring bullous
disorders (epidermolysis bullosa, bullous pemphigoid, porphyria cutanea), and neoplastic disease
(skin tumors and cutaneous metastasis). To evaluate cicatricial alopecia of unknown origin,
clinicians should start with cultures for bacteria and fungus. Diagnosis is based on a scalp biopsy, a
4-mm punch is suggested.

3. HAIR SHAFT ABNORMALITIES:

Hair shaft abnormalities produce fragile and brittle hair. Patients may present with diffuse or patchy
areas of short hair and a history of hair that will not grow beyond a certain length. Inherited
disorders (genodermatoses) and external hair shaft damage can change the hair shaft structure.
Repeated trauma to the hair shaft in the form of traction, bleaching, perming, or blow drying is most
often the cause of the hair shaft abnormality in adults.
A variety of hair shaft shapes may develop. The most commonly found hair shaft abnormality is
trichorrexis nodosa, a nodal area where the hair splits into strands. Trichorrexis nodosa is more
commonly acquired as a result of external damage, however it may be associated with genetic and
metabolic disorders that alter hair keratinization. These patients should be referred to a
dermatologist interested in hair diseases.

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Non-cicatricial alopecia Cicatricial alopecia Hair shaft disorders

Telogen effluvium Trauma or local surgery External agents:

Androgenetic Skin or follicular infection:
fungal, bacterial, viral
alopecia Alopecia
Autoimmune diseases:
areata Traction discoid lupus
erythematosus, lichen
alopecia planopilaris, morphea
traction bleaching,
perming, and blow
drying
Inherited disorders:
argininosuccinicaciduria,
trichothiodystrophy syndrome

Trichotillomania Neoplastic diseases:

skin tumors and
cutaneous metastases

Shedding
The most common cause of hair loss is shedding or telogen effluvium (TE), which is the
premature conversion of growth-phase hair follicles to the resting or shedding (telogen)
phase.

Androgenetic alopecia

Androgenetic alopecia (AGA) or common baldness is prominent central-pattern scalp alopecia

induced by androgens, and it may affect genetically predisposed men and women at any time
between puberty to senescence. Inheritance of AGA is controversial, it is eigther polygenic or
autosomal dominant with variable penetrance

Alopecia areata
Alopecia areata (AA) is hair loss of suspected autoimmune origin with an unpredictable prognosis.
AA causes isolated or recurrent patchy hair loss (figure 3). Multiple patches, complete scalp hair
loss (alopecia totalis), and complete scalp and body hair loss (alopecia universalis) are other clinical
presentations of AA.

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Chapter - 04
TYPES OF HAIR LOSS :

TYPES OF HAIR LOSS :

a.)Alopecia Areata (prime stage):

Alopecia areata is a common autoimmune disease that results in the loss of hair on the scalp and
else where. It usually starts with one or more small, round, non-scarring smooth patches. Mild Brief
Alopecia Areata- Patient with repeated transient alopecia areata but never converts into alopecia
totalis or universalis

b.) Temporary Alopecia Areata:

Patient with Alopecia areata in advanced phase and some of them converts into Alopecia
totalis/Alopecia universalis.

c.) Ophiasis Alopecia Areata:

Ophiasis type of alopecia areata shows a band like hair loss. It occurs generally in the progressive
or the occip ital areas of the scalp, and therefore it is more difficult to treat, as most medicines have
a de layed action on these areas.

d.) Alopecia Universalis:

Loss of hair from entire body including eyebrows and eyelashes Scar ring Alopecia Any
inflammatory process (burns, bacterial infections, ringworm, injury) necessary to cause permanent
loss of follicles, affected area known as Scarring alopecia. Trichotillomania -This type of hair loss is
known as compulsive pulling or dull selfpulling by a patient Himself or herself.

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e.)Traction Alopecia:

Hair elegance that tie hairs so tight can causes much traction at the root of hairs, and can develop
adhesion alopecia

f.) Chemotherapy and hair loss:

Chemotherapy is exclusive behavior for cancer patients but it marks normal cells and hair follicles
too. This causes hair loss and known as anagen effluvium type of alopecia.

g.) Diffuse Alopecia:

Unnecessary Loss of hair all over the scalp without creating a reinforcement. Hair loss due to side
effect of the beauty treatments- Any beauty treatments like hair colors, dye, straightening, softening,
rebounding, perming etc., which contains harsh chemicals can trigger hair loss for some individuals.
Telogen effluvium (TE) and chronic telogen effluvium- (CTE) Dietary lacks, Crash dieting High grade
fever, Anemia, Blood loss, Hormonal imbalance and pregnancy etc. can cause telogen effluvium
type of hair loss telogen word is known for latent phase of the hair and fluvium means.

h.)Traction Alopecia :

Hair elegance that tie hairs so tight can causes much traction at the root of hairs, and can develop
adhesion alopecia

i.) Chemotherapy and hair loss:

Chemotherapy is exclusive behavior for cancer patients but it marks normal cells and hair follicles
too. This causes hair loss and known as anagen effluvium type of alopecia.
j) Diffuse Alopecia :

Unnecessary Loss of hair all over the scalp without creating a reinforcement. Hair loss due to side
effect of the beauty treatments- Any beauty treatments like hair colors, dye, straightening, softening,
rebounding, perming etc., which contains harsh chemicals can trigger hair loss for some individuals.
Telogen effluvium (TE) and chronic telogen effluvium- (CTE) Dietary lacks, Crash dieting High grade
fever, Anemia, Blood loss, Hormonal imbalance and pregnancy etc. can cause telogen effluvium
type of hair loss telogen word is known for latent phase of the hair and fluvium means.

k.)Alopecia Totalis: Loss of hair from whole Scalp.

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2. Hair Growth Cycle and Its Mechanism :

The hair growth undergoes a tiresome cycle where the anagen phase followed by the catagen and
the telogen phase [7]. In the anagen phase, the hair is actively growing while in the catagen phase
it is characterized by the degeneration and resorption of the lower region of the hair follicle. The
resting phase, where the hair is inactive, is called telogen phase after this phase the growth of the
hair follicle resumes in the scalp, a hair growth cycle has three main phases: Anagen, catagen,
and telogen. The anagen phase is the growth cycle typically lasts 3-5 years. On a healthy scalp,
there are approximately 1,000,000 hair and 90% of the follicles are continually in the anagen
phase of hair growth. The catagen stage follows the end of the growth period when a follicle begins
to become dormant. The telogen stage is a dormant or resting period that lasts 3-4 months. When
the dormant phase ends, an old hair falls out. A hair follicle then returns to the anagen stage, and
a new hair begins to grow.

An average rate of hair growth is about half an inch per month depending on hair follicles and age of
an individual. On average, 50-60 scalp hairs are lost daily in a normal hair growth cycle and new
hairs begin to grow from these follicles. Hair loss begins when less new hair begins the re-growth
stage.

3. Symptoms of Hair Loss:

There are several factors for the hair loss; some of the main factors are given below -

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4. The Herbs Used in The Treatment of Alopecia Provide One of the

Following :
1. Nutritional support.
2. DHT blockers and 5-α-Reductase blockers.
3. Aromatherapy and improved scalp blood Circulation.

1. Nutritional Support:

Minerals such as calcium, copper, chromium, iodine, zinc, and magnesium are necessary to
maintain healthy hair growth. Mineral deficiency will reduce the chance to regulate the blood
circulation that promotes healthy hair growth and thyroid hormones that prevent dry hair and hair
loss as well as defects in hair color. Too much iron is toxic to your body. Be sure to talk to your
doctor before taking any mineral supplement. B vitamins (especially B6, B3, B5 and folic acid), biotin
(anti-oxidant, sources of biotin is: whole grains, egg yolks, liver, rice and milk. Vitamin A is important
for over-all good health. It’s also beneficial to hair follicles, as it keeps the hair root lubricated.
Vitamin E acts as an antioxidant that aids real circulation in the scalp due to increased oxygen
uptake in blood, therefore it plays an important role in promoting hair growth and preventing hair
loss.

2. DHT Blockers and 5-α-Reductase blockers 7, 8, 9, 10:

After knowing the well-established role of DHT in hair loss, it is recommended that the use of herbs
that have pronounced DHT or 5-α-Reductase blocking activity can be used for the treatment of
Alopecia (especiallyAndrogenetic). There are some herbs that have proved DHT blocking activity
like Pygeum africanum, Seneroa repens, Urtica dioica and others with potential 5- α-Reductase
inhibiting ability like Camellia sinensis, Panax ginseng etc.

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3. Aromatherapy:

Aromatherapy can be used as a supplement to treat alopecia. It uses highly concentrated extracts
which are derived from the flowers, leaves, bark and the roots of various plants like Arnica montana,
Cedrus atlantica, Lavandula agustifolia, Oscimum sanctum, Pilocarpus jabarondi, Rosmarinus
officinalis, Thyme vulgaris etc., (table 2). In aromatherapy, the essential oils enter the body through
the olfactory system (inhalation) and/or through your skin. As with herbs that are taken orally, the
essential oils reach the circulatory system (the blood) where they bind to receptors and change the
chemical composition. These oils work not only on a cellular level to strengthen/calm the nervous
system, but also on a spiritual one, providing with a sense of wellbeing.

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Chapter - 05

Here’s Used in Treatment of Alopecia:

a. Ginkgo biloba (Ginkgoaceae) :

Chemical constituents: Ginkgolides A, B, C, J, M, bioflavin, sitosterol, lactones and

anthrocyanins.

Mode of Application: The drug is extracted in coconut oil and is massaged for at least 2
minutes.

Reason: The drug is known to improves cerebral microcirculation and hence increases oxygen
supply

b. Phyllanthus embelica (Euphorbeaceae):

Constituents : Vitamin C, phyllemblin, tannin, phosphorous, iron, calcium.

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Mode of Application :

Indian gooseberry oil, prepared by boiling dry pieces of Indian gooseberry in coconut oil, is
considered a valuable hair tonic for enriching hair growth. A mixture of an equal quantity of fresh
Indian gooseberry juice and lime juice, used as a shampoo also stimulates hair growth and
prevents hair loss.

Reason :

Iron is involved in the oxygenation of your body’s red blood cells. It is essential for normal hair
growth and maintaining healthy hair. If the amount of iron cannot be replaced with food intake, iron
deficiency will cause hair loss because of oxygen deficiency.

c. Allium cepa L. (Liliaceae)

Constituents :

Protein (albumin), allyl propyl disulphide, diallyl sulphide, alliin, allicin. It also Contains some mineral like
potassium, zinc, calcium, magnesium and traces of chromium.

Mode of Application :

Onion has also been found beneficial in patchy baldness .The affected part should be rubbed with onion
juice morning and evening till it is red. It should be rubbed with honey afterwards.

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Reason :
Zinc helps to secrete the scalp with much needed oil and avoid dandruff that may cause hair loss.
Iron is involved in the oxygenation of your body’s red blood cells. It is essential for normal hair
growth and maintaining healthy hair

d. Rosmarinus officinalis (Labiatae) and Lavandula:

Constituents:
angustifolia Miller (Labiatae) Rosmary constitutes 1-2% volatile oil containing 0.8-6% of esters and
8-20% of alcohols, The principal constituents are 1, 8- cineole, borneol, camphor, bornyl acetate and
monoterpene hydrocarbons. The chief constituents of lavender oil are Lavenanlol, linalyl acetate,
linalol, lavendulyl acetate, terpineol and cineol.

Mode of Application : These oils were massaged into the scalp for a minimum of 2 minutes
daily for seven months.

Reason:
The essential oils enter your system through the olfactory system (inhalation) and/or through your
skin and reach your circulatory system (the blood) where they bind to receptors and change the
chemical composition.

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e. Juglans regia L. 27 (Juglandaceae)

Constituents :

Fatty acids, linoleic acid (50.58 - 66.60%) are the predominant fatty acid followed by oleic acid
(14.88 - 28.71%) and linolenic acid (9.16 -16.42%). The other fatty acids were found in trace
contents. The macronutrient contents of walnut are 100 g-1 for K (911.0 - 684.3), P (434.7 - 356.2),
Ca (756.7 - 388.2), Mg (444.0 - 330.8) and Na (48.9 - 26.1) while micronutrient contents of walnut
are Fe (6.6 - 4.3), Cu (2.8 - 1.8), Mn (5.7 - 2.7) and Zn (4.3 - 2.7). The potassium contents were
found to be higher than those of the other minerals in all kernels of the walnuts.

Mode of Application :

The application of walnut oil all over the scalp and massaging it into the hair roots is also beneficial
in the treatment of hair loss. It nourishes the hair and promotes hair growth.

Reason :

The fruit contains essential minerals which are helpful in the growth of healthy hair. Iron increases
blood circulation and oxygen supply as stated earlier. Zinc helps to secrete the scalp with much
needed oil and avoid dandruff that may cause hair loss

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f. Glycyrrhiza glabra Linn. (Leguminosae):

Constituents :
The chief constituents are glycyrrhizin, potassium and calcium salt of glycyrrhizinic acid.

Mode of Application :

The paste of liquorice, made by grinding the pieces in milk with a pinch of saffron, is another
valuable remedy for patchy baldness. This paste should be applied over the bald patches at night
before going to bed.

Reason : The extract of liquorice has proved to possess

Some Scientific Studies:

[1] . Naryan et al. investigated the therapeutic potential of Psidium guajava and its polyherbal
formulation on chemotherapy induced alopecia. The hydroalcoholic extract of Psidium guajava at
the dose of 300mg/kg were tested for its hair growth activity in mice. Alkaline phosphatase level in
control was 93.66U/L and this level was decreased in toxic group. Psidium guajava extract at the
dose of 300mg/kg orally and 5% solution topically increased the level of Alkaline phosphatase and
hair density in chemotherapy induced alopecia mice33.

[2]. Dixit et al. investigated hair growth activity of a mixture of Eclipta alba hassak, citrullus
colocynthisshared and Tridex procumbens34

[3]. The methanolic extract of Eclipta alba were screened for its hair growth promoting activity in
C57/BL6 mice by kanika et al. Methanolic extract of Eclipta alba at the dose of 3.2 mg/15cm2 and
1.6mg/15cm2 was applied in mice and compared with standard drug minoxidil

[4]. Green tea contains a high amount of purine alkaloids, flavonoids, caffic acid derivative, volatile
oil and catechins including epigallocatechin gallate. Epigallocatechin gallate isolated from the leaves
of Camellia sinensis and investigated for its effect on human dermal papilla cells in vivo and in vitro.

[5] . Ethanolic extract and petroleum ether extract of Citrullus colocynthis were evaluated for hair, growth
activity on albino rats by Roy et al. 2% and 5% of ethanolic and petroleum ether extract ointment were
applied on the skin of rats. The hair growth initiation was found on 4th day with5% and 5th day with 2%
petrolium ether extract group while hair growth initiation was found on the 6th with menoxidil treated
group.

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Allopathic Medicine for Hair Fall:

Allopathic medicine offers several treatment options for hair fall, including:

Minoxidil: It is a topical solution that can be applied to the scalp to promote hair growth. Minoxidil
is believed to increase blood flow to hair follicles and prolong the anagen (growth) phase of the hair
cycle. It is available over-the-counter and in prescription strength.

Finasteride: It is an oral medication that is used to treat male-pattern baldness. Finasteride works
by blocking the conversion of testosterone to dihydrotestosterone (DHT), which is a hormone that
contributes to hair loss in men. It is available only by prescription.

Corticosteroids: These are anti-inflammatory drugs that can be injected into the scalp to treat
alopecia areata, which is an autoimmune condition that causes patchy hair loss. Corticosteroids
work by suppressing the immune system and reducing inflammation.

Hair transplant surgery: It involves removing small plugs of hair from areas where hair is still
growing and transplanting them to areas where hair has stopped growing. This procedure can be
done in a doctor's office under local anesthesia.

Platelet-rich plasma (PRP) therapy: It involves injecting a patient's own blood plasma, which
is rich in growth factors, into the scalp to promote hair growth. PRP therapy is still considered
experimental and is not yet widely available.

It is important to consult a doctor or dermatologist before starting any allopathic treatment for hair
fall, as they can assess the underlying cause of hair loss and recommend the most appropriate
treatment.

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Chapter – 06
Di sadvantges

1. Hair transplant surgery:

The most expensive solution. Costs typically ranges from $4,000 to $40,000 depending on who the
surgeon is.Incredibly invasive, involves scarring, the removing of strips of skin or plugs of skin.

2. Hair treatment systems:

A new name for hair piece, toupee, and wig (glued or not glued).Expensive hair systems can cost quite bit,
a up to $2000. Cost of bonding can be high.Maintenance to keep replacing the membrane.Hair stylist visits
for hair trimming to keep the system looking good.

3. Drugs and topical treatments

Expensive, on average $40 to $300 a month.Does not work for everybody. Everyone will not experience
the same hair regrowth.May cause sexual side effects, such as decreased sexual desire, and difficulty in
achieving an erection.
You must continue the treatment long term. It will be quickly reverse if treatment is discontinued. You will
lose the hair you have gained within 12 months of stopping the treatment.

4. Scalp micropigmentation:
Expensive depending on the amount of area that needs to be worked on, touch ups can be a few hundred
dollars to full scalp treatments ranging from $2500 to $5000.Will fade in time, especially if you do not follow
the aftercare instructions.
Always choose your technicians carefully. Seek those with multiple certifications from reputable programs.
Untrained SMP technicians doing the procedure will result in disappointment.

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Chapter - 07
CONCLUSION

Alopecia is one of the main problems amongst urban people to domination to stress environmental
problems etc. So, with the help of this review article, we conclude that many herbal drugs having
potency for curing alopecia with no side effects.

The various types of allopathic drugs to treat hair loss but they have many side effects. Herbs are
starting material for any medication research. Approximately about 80% residents recommended
herbal drugs for their beneficial effects along with fewer side effects as compared synthetic drugs.

The present study has factually established the high prevalence of hair related problems among
men of age group 18-50 years and has also identified some of the risk factors associated. This study
has also shown that the awareness of treatment options among the common population is not
adequate. It also clearly emphasises on the need for more focus on hair related problems in the
Community. Health education material on the management of common hair related problems should
be made available in the primary healthcare centres so that people can readily utilise the existing
treatment options without going through needless stress for a modifiable problem. Awareness
campaigns could also be conducted in remote villages where there is limited access to healthcare
facilities.

In summary, hair loss comes in many different ways. Alopecia is usually treatable or self-limited,
however, it may be permanent or cicatricial. Careful diagnosis of the type of hair loss will aid in
selecting effective treatment. Reassurance is an important component of any treatment regimen

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Chapter - 08
REFERENCES

[1]. Coglio G and Bosio A. Alopecia and its treatment- the reality of new chances of success in
clinical study of NuHair: first food supplement with great scientific impact, How & Why in Medicine;
Dermatology supplement May 2002.

[2]. Muradoglu F, Oguz HI, Yildiz k and Yilmaz H: Some chemical composition of walnut (Juglans
regia L.) selections from Eastern Turkey. African Journal of Agricultural Research 2010; 5(17): 2379-
2385.

[3]. Hay IC, Jamieson M and Ormerod AD: Randomized trial of aromatherapy. Successful treatment
for alopecia areata. Archieves of dermatology 1999 May; 135(5):602-3.

[4]. Sharquie KE and Al-Obaidi HK: Onion juice (Allium cepa L.), a new topical treatment for
alopecia areata. The Journal of dermatology 2002 Jun; 29(6):343-6.

[5]. Liao S and Hiipakka RA: Selective inhibition of steroid 5αreductase isozymes by tea epicatechin-
3-gallate and epigallocatechin-3- gallate. Biochemical and Biophysical Research Communication
1995; 25:214; 833-838.

[6]. Prager N, Bickett K, French N and Marcovici G: A randomized, double-blind, placebo- controlled
trial to determine the effectiveness of botanically derived inhibitors of 5- alphareductase in the
treatment of androgenetic alopecia.Journal of alternative and complementary medicines (New York,
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[7]. Esfandiari A and Kelley P: The effects of tea polyphenolic compounds on hair loss among
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