Chapter 13: Carbohydrate Storage and Synthesis in

Liver and Muscle

Main pathways of carbohydrates metabolism

Structure of glycogen

Pathways of glycogenesis and glycogenolysis

Regulation of glycogenesis and glycogenolysis

Glycogen storage diseases and medical cases

 Carbohydrate Storage and Synthesis in
Liver and Muscle

ATP
Carbohydrate Storage and Synthesis in
Liver and Muscle
Glycogenesis vs Glycogenolysis

GLUT2
Glycogenesis

GLUT2
Glycogenolysis
 Hormonal Regulation of Hepatic Glycogenolysis

There are three major hormonal activators of glycogenolysis: glucagon, epinephrine (adrenaline), and cortisol.
Hormonal Regulation of Hepatic Glycogenolysis by Glucagon
Hormonal Regulation of Hepatic Glycogenolysis by Glucagon
 Hormonal Regulation of Hepatic Glycogenolysis by Epinephrine

α-adrenergic receptor

Activation of
Glycogenolysis
Hormonal Regulation of Glycogenesis by Insulin
Glycogen Storage Diseases (GSDs)