Glycogenesis

Presenters:
Casilang, Michelle Anne Marina
Ferrer, Julia Sophia
Untalan, Jonalyn
Ydeo, Revenne
What is Glycogenesis?
It is the process of storing excess glucose
for use by the body at a later time.
Glycogenolysis occurs when the body,
which prefers glucose as an energy
source, needs energy.
The glycogen previously stored by the
liver is broken down to glucose and
dispersed throughout the body.
 STEPS IN GLYCOGENESIS
Glc-6-P to Glc-1-P Attachment of UDP-Glc Glycogen Branches
conversion to Glycogen Primer formation

01 02 03 04 0505 06
Glucose Attachment of UTP Glycogen synthesis by
Phosphorylation to Glc-1-P Glycogen synthase
Step 1: Glucose Phosphorylation
Step 2: Glc-6-P to Glc-1-P conversion
Step 3: Attachment of UTP to Glc-1-P
Step 4: Attachment of
UDP-Glc to Glycogen Primer
Step 5: Glycogen synthesis by Glycogen synthase
Step 6: Glycogen Branches formation
Biomedical Importance
The function of muscle glycogen is to act as a
readily available source of hexose units for
glycolysis within the muscle itself. Liver glycogen
is largely concerned with storage and export of
hexose units for maintenance of blood glucose,
particularly between meals. After 12-18 hours of

02
fasting, the liver becomes almost totally depleted
of glycogen, whereas muscle glycogen is only
depleted significantly after prolonged vigorous
exercise. Glycogen storage diseases are a group
of inherited disorders characterized by deficient
mobilization of glycogen or deposition of
abnormal forms of glycogen, leading to muscular
weakness or even death.
 SUMMARY:
- Glycogen represents the principal storage form of carbohydrate in the
mammalian buddy, present mainly in the liver and muscle.
- In the liver, its major function is to service the other tissues via for
nation of blood glucose.
- In muscle, it serves the needs of that organ, as a ready source of
metabolic fuel.
- Glycogen is synthesized from glucose and other precursors by the
pathway of glycogenesis.
REFERENCES:

● Harper’s Biochemistry, 24th ed.

● https://biochemden.com/carbohydrat
e-metabolism-glycogenesis/
THANKS FOR
LISTENING