STAGE :CRUDE DESLORATADINE 308553

Index
Storage: Store between 2-8º C in well-closed container
Total Crude Deslo Consumption
Total No of batches
QTY UNIT

713 Lit Ethanol RE-7104

till unconverted Loratadine content
37.5 Lit DM water SS 316 HPLC is NMT 0.5 %
150.00 Kg LORATADINE 2 KL
94.5 Kg Sodium hydroxide Charge/Heat Send sample to QC after 10 hrs. & th
Temp:25-300C/80-850C after every 90 min
hydrolysis
872.25 Lit

450 Lit DM water RE-7104

SS 316
2 KL
Cool and stir
Temp:50-550C

1322.25 Lit

RE-7104
SS 316 Rec Aq Ethanol
2 KL
Distillation u/v
till (3.5 times volume of Loratadine)
Temp:50-550C

525

450 Lit MIBK RE-7104

SS 316
2 KL
Charge and Heat
Temp:50-550C

975.00 Lit

RE-7104 Container
SS 316 Organic
 2 KL
Stir and Settle
Temp:70-750C

Aqueous laye 450.00 Lit

Container

450 Lit MIBK RE-7104

SS 316
2 KL Container
Stir and Settle Aqueous
Temp:70-750C

Organic layer 450.00 Lit

Container

1500 Lit DM water RE-7101

1500 Lit DM water SS 316
1500 Lit DM water 5 KL
Work up Container
Temp:70-750C Aqueous

975.00 Lit

RE-7101
SS 316 Rec MIBK
5 KL
Distillation u/v till (2 times volume of Loratadine)
Temp:65-700C

302.70 Lit

750 Lit Ethyl acetate RE-7101

15 Kg Activated carbon SS 316
5 KL
Charge and Heat
Temp:65-700C/75-800C

1060.2 Lit

15.00 Kg Celite SF-7104

150 Lit Heated Ethyl acetate for celite SS 316
bed washing
From GPA-6105 18"
 Filter
Temp 75-780C

Filtrate 1210.20 Lit

RE-7102
SS 316
3 KL
Cool and Stir
Temp:0-50C

1210.20 Lit

Chilled Ethyl acetate for cake wash

150 Lit CF-7101
from GPA-6106
SS 304 Container
48" ML+WML
Centrifuge
Temp 0-50C

Wet cake 112.50 Kg

VTD-7102
SS-316
till LOD content is NMT 0.5 % (send 72 Trays
sample to QC after 6 hrs. and then
after every 4 hr drying Drying
Temp 45-50C

Dry 98.28 Kg

CRUDE DESLORATADINE

Yield 0.52-0.81 Kg/Kg

Actual 0.66 Kg/Kg
well-closed container
136.5374 Kg
1.39 batches Min vol Max vol Min V Max V
Tag no Capacity UOM
QTY UNIT in lit in lit
RE-7104 2 KL
RE-7102 3 KL
712.5 872.25 4.75 5.815 RE-7101 5 KL
converted Loratadine content by
C is NMT 0.5 %
CF-7101 48 Inch
SF-7101 18 Inch
sample to QC after 10 hrs. & then CTF-7101 20 Inch
every 90 min VTD-7102 72 Trays

872.25 1322.25 5.815 8.815

525 1322.25 3.5 8.815

Aq Ethanol
652.5 Lit SOLD

5 times volume of Loratadine)

525 975 3.5 6.5

450.00 975.00 3 6.5

525 Lit
 450.00 900.00 3 6

450.00 Lit ETP

525 Lit 975.00 2475.00 6.5 16.5

4500 Lit ETP

302.7 975.00 2.018 6.5

550.4 Lit SRU

times volume of Loratadine)

302.70 1060.2 2.018 7.068

 1210.20 1210.20 8.068 8.068

997.5 Lit SRU

MOC Location Remark Usage

SS 316 10 M Half Anchor Batch charging , Reaction,Distillation

SS 316 10 M Anchor Workup ,Distillation ,Carbon, Transferring
SS 316 10 M Anchor Cooling and CF Filtration
SS 304 0M BM Not Available Transferring
SS 316 To be fit on 0 M NA Transferring
SS 316 To be fit on 0 M Not in PFD Filtration
SS 316 0M Drying
 Temp. Sensing Vol. Reaction Mass
Min. S. Vol.
With StirringWithout StirringMin. Vol. Max Vol.
15 517 645 450 1322
65 114 175 303 2475
26 190 535 1210 1210
- - - - -
- - - - -
- - - - -
- - - - -
 Batch size (For RE-7104) Reaction
Parameters UOM Plant Parameters
Equipment Capacity m3 2 Equipment Capacity
Batch size Kg 150 Batch size

Volume Multiplication
8.82
factor Volume Multiplication
factor
Batch volume (V1) m3 1.322 Batch volume (V1)
% occupancy 66.11 % occupancy

REACTOR (RE-7101) Water Seperation & Charcoalisation

Parameters UOM Plant Parameters
Equipment Capacity m3 5 Equipment Capacity
Batch size Kg 150 Batch size

Volume Multiplication
16.50 Volume Multiplication
factor
factor
Batch volume (V1) m3 2.475 Batch volume (V1)
% occupancy 49.50 % occupancy

REACTOR (RE-7102) MIBK Seperation & Charcoalization

Parameters UOM Plant Parameters
Equipment Capacity m3 3 Equipment Capacity
Batch size Kg 150 Batch size

Volume Multiplication
factor 8.07
Volume Multiplication
factor
Batch volume (V1) m3 1.210 Batch volume (V1)
% occupancy 40.34 % occupancy
 UOM Lab
m3 0.003
Kg 0.200

8.82

m3 0.002
58.77

oalisation
UOM Lab
m3 0.005
Kg 0.200

16.50

m3 0.003
66.00

oalization
UOM Lab
m3 0.003
Kg 0.200

8.07

m3 0.002
53.79
 Crude deslo Reaction
Parameter MPP-4 MPP-4 MPP-4
Tag No RE-7104 GPA-7102 GPA-6105
Batch size (kg) 150 17 17
Shell MOC SSR GLR GLR
Operating capacity (L) 2000 250 200
Max process volume(L) 1322.25 149.86 149.86
Shell height 1500 800 710
Shell dia 1300 640 500
Sweep dia (mm) 1200 254 254
Da/D ratio 0.92 0.40 0.51
L/D ratio 1.15 1.25 1.42
RPM 50 194 200
Tip speed (m/sec) 3.14 2.58 2.66
% Occupancy 66.1 59.9 74.9
Agitator type Anchor Half Moon Half Moon
No of baffles 4 - -
Motor HP - - -
 MIBK Seperation Charcoalisation MIBK Seperation Charcoalisation
Parameter MPP-4 MPP-4 Parameter
Tag No RE-7101 GPA-6106 Tag No
Batch size (kg) 150 17 Batch size (kg)
Shell MOC SSR GLR Shell MOC
Operating capacity (L) 5000 250 Operating capacity (L)
Max process volume(L) 2475.00 136.16 Max process volume(L)
Shell height 2200 800 Shell height
Shell dia 1730 640 Shell dia
Sweep dia (mm) 1300 254 Sweep dia (mm)
Da/D ratio 0.75 0.40 Da/D ratio
L/D ratio 1.27 1.25 L/D ratio
RPM 50 200 RPM
Tip speed (m/sec) 3.40 2.66 Tip speed (m/sec)
% Occupancy 49.5 54.5 % Occupancy
Agitator type Anchor Half Moon Agitator type
No of baffles 4 - No of baffles
Motor HP - - Motor HP
MIBK Seperation Charcoalisation
MPP-4 MPP-4
RE-7102 GPA-6106
150 17
SSR GLR
3000 250
1210.2 136.16
1865 800
1460 640
1000 254
0.68 0.40
1.28 1.25
60 200
3.14 2.66
40.3 54.5
Anchor Half Moon
4 -
- -
 REACTOR (RE-7104) Batch charging , Reaction, Distillation
Plant Energy Dissipation UOM Lab Energy Dissipation

Sweep Diameter D 1.2 m Sweep Diameter D

RPM N 50 RPS N
RPS N 0.8333333 sec^-1 Calculated RPM N
Agitator Anchor Agitator Anchor
Power number Np 0.6 Power number Np
Volume V 1.32225 m^3 Volume V
Ei 0.653 watts/kg Ei

REACTOR (RE-7101) Workup ,Distillation ,Charcoalization.

Plant Energy Dissipation UOM Lab Energy Dissipation
Sweep Diameter D 1.3 m Sweep Diameter D
RPM N 50 RPS N
RPS N 0.8333333 sec^-1 Calculated RPM N
Agitator Anchor Agitator Anchor
Power number Np 0.6 Power number Np
Volume V 1.2102 m^3 Volume V
Ei 1.07 watts/kg Ei

REACTOR (RE-7102) Cooling and CF Filtration

Plant Energy Dissipation UOM Lab Energy Dissipation
Sweep Diameter D 1 m Sweep Diameter D
RPM N 60 RPS N
RPS N 1 sec^-1 Calculated RPM N
Agitator Anchor Agitator Anchor
Power number Np 0.6 Power number Np
Volume V 1.2102 m^3 Volume V
Ei 0.50 watts/kg Ei

Flask Sweep Dia.

(Litre) (mm)

3 85
5 120
3 85
on
y Dissipation UOM TYPICAL CHARACTERISTICS OF SOME IMPELLERS

0.085 m AGITATOR Power number Flow Number

(Np) (Nq)

7.563722 sec^-1 Propeller 0.8 0.5

454 Flat blade turbine 5 0.7
Anchor Pitch blade turbine 1.3 0.8
0.6 Anchor 0.6 0.5
0.001763 m^3 Retreat Curve(RCI) 0.4 0.3
0.653 watts/kg Curved Blade Turbine 1 0.6
Intermig 0.35

on. Length 600 mm QTY

y Dissipation UOM 77 mm 1
0.12 m 85 mm 1
6.17506 sec^-1 95 mm 1
Anchor
371 120 mm 1
Anchor 125 mm 1
0.6 140 mm 1
0.0033 m^3
1.07 watts/kg
Length 450 mm QTY
70 mm 1
RCI
75 mm 1
y Dissipation UOM
0.085 m
6.698045 sec^-1 Length 45 48 60
402 PBT 85 90 85
Anchor QTY 1 1 1
0.6
0.001614 m^3
0.50 watts/kg
60
100
1
 CF G-force RPM calculator (CF-7101) filtration
Parameters Plant UOM Lab UOM
Diameter 48 inch Diameter 6 inch
Rotor Radius 60.96 cm Rotor Radius 7.62 cm
Feeding Stroke First
RPM 990
RPM 350
G-force 83 G-force 83

CF G-force RPM calculator (CF-7101) filtration

Parameters Plant UOM Lab UOM
Diameter 48 inch Diameter 6 inch
Rotor Radius 60.96 cm Rotor Radius 7.62 cm
Spinning Stroke Second
RPM 1584
RPM 560
G-force 214 G-force 214

CF G-force RPM calculator (CF-7101) filtration

Parameters Plant UOM Lab UOM
Diameter 48 inch Diameter 6 inch
Rotor Radius 60.96 cm Rotor Radius 7.62 cm
Washing Stroke First'
RPM 990
RPM 350
G-force 83 G-force 83

CF G-force RPM calculator (CF-7101) filtration

Parameters Plant UOM Lab UOM
Diameter 48 inch Diameter 6 inch
Rotor Radius 60.96 cm Rotor Radius 7.62 cm
Final Spinning Stroke Second
RPM 2121
RPM 750
G-force 383 G-force 383
  RCF = 1.118 * 10-5 * r * (rpm)2 CF cap rotor radius
48 60.96
Feeding First 350 36 45.72
Spinning Second 560 60 152.4
Washing First' 350 48 121.92
Final Spinning Third 950 36 91.44
 Dryer tray loading scale down
Plant
Wet Cake 112.5 Kg
Bulk density 0.5 Kg/Litre
Wet cake Volume 0.23 KL
No. of Lots 1
Effective wet cake 112.5 Kg
Dryer Tag No. VTD-7102
Tray/RVD dimensions
Length 0.945 m
Width 0.355 m
Height 0.055 m
RPM 0
Area of each tray 0.81395 m2
No. of trays/capacity 48 trays/Litre
Overall area 39.0696 m2
Wet cake/m2 2.88 Kg/m2
RVD occupancy - %
Volume of each tray 18.45 Litre
Each tray max capacity 9.23 Kg
Utility temp 45-50 °C

Rota vapour No . Of trays Length

0.5 1 0.05
1 2 0.1
1.5 3 0.15
0.2
Plant name
MPP-1
MPP-2
MPP-3
MPP-4
MPP-5 VTD-8103 (PPA)
MPP-6 VTD-8102
MPP-7 VTD-7103
MPP-8 VTD-7102
MPP-9 VTD-8107 (PPA)
CSP-1 VTD-8105
CSP-2A VTD-8104
CSP-2B VTD-8108
CMPP VTD-8101
DSP-2 VTD-8109
SD-4101 (PPA)
SD-7101 (PPA)
SD-7103 (PPA)
SD-7102 (PPA)
RVD-7101
RVD-8101
RVD-1301
RVD-1401
VTD-1401C
VTD-1401D
VTD-1401E
VTD-1401F
VTD-1401G
RVD-2201 (PPA)
RVD-2202
ANFD-2201(PPA)
FBD-2201(PPA)

VTD-6101
VTD-6104
VTD-5101
VTD-5103 (PPA)
VTD-8106 (PPA)
VTD-6103 (PPA)
VTD-9502 (PPA)
RVD-6102
VTD-9101
VTD-9102 (PPA)
VTD-9202
VTD-9203 (PPA)
RVD-9201
ANFD-9101
VTD-9301(PPA)
VTD-9302(PPA)
VTD-9304
VTD-9305
RVD-9301
VTD-9501
VTD-9504(PPA)
VTD-9505(PPA)
VTD-9601
VTD-9602
VTD-9603 (PPA)
RVD-9502
RVD-9601
RVD-9602
ANFD-9501
VTD-9701(PPA)
VTD-9801
VTD-9802
VTD-9804(PPA)
VTD-9805(PPA)
 RVD-9701
RVD-9801
VTD-9401
VTD-9402
VTD-9403 (PPA)
VTD-9404(PPA)
VTD-9405(PPA)
VTD-9406(PPA)
VTD-9407
VTD-8401
VTD-8402
VTD-8403
VTD-8404(PPA)
VTD-8502(PPA)
VTD-8503
VTD-8501
RVD-8401
RVD-8501
ANFD-8401

T1
NO. OF
PLANT TYPE OF DRYER TAG NO TRAYS/ MOC of Trays
CAPACITY
VTD-1501A 48 SS
VTD-1501B 48 SS
MPP-1 Vaccum Tray Dryer
MPP-1 Vaccum Tray Dryer
VTD-1551 6 SS
VTD-1501C (PPA) 24 SS
VTD-8103 (PPA) 48 SS
VTD-8102 48 SS
VTD-7103 48 SS
VTD-7102 48 SS
VTD-8107 (PPA) 12 SS
Vaccum Tray Dryer
VTD-8105 6 SS
VTD-8104 6 SS
VTD-8108 48 SS
MPP-4
VTD-8101 6 SS
VTD-8109 48 SS
SD-4101 (PPA) 10Kg/Hr N.A
SD-7101 (PPA) 15 Kg/Hr N.A
Spray Dryer
SD-7103 (PPA) 45Kg/Hr N.A
SD-7102 (PPA) 25Kg/Hr N.A
RVD-7101 1.5 KL N.A
Rotary Vaccum Dryer
RVD-8101 1.5 KL N.A
CSP-1 Rotary Drum Dryer RVD-1301 1.8 KL N.A
CSP-2A Rotary Vaccum Dryer RVD-1401 2 KL N.A
VTD-1401C 48 SS
VTD-1401D 48 SS
CSP-2B Vaccum Tray Dryer
VTD-1401E 48 SS
VTD-1401F 48 SS
VTD-1401G 48 SS
RVD-2201 (PPA) 2KL N.A
Rotary Vaccum Dryer
RVD-2202 2KL N.A
DSP-2
ANDF ANFD-2201(PPA) 5KL N.A
FBD FBD-2201(PPA) 340L N.A
VTD-1401A 48 SS
VTD3105 64 SS
VTD-4102 48 SS
Vaccum Tray Dryer
VTD-4104 (PPA) 48 SS
VTD-3106 (PPA) 64 SS
MPP-2
VTD-3107 (PPA) 64 SS
RVD-3103 1.5 KL N.A
RVD-4105 1.5 KL N.A
Rotary Vaccum Dryer
RVD-4101 1.5KL N.A
RVD-3108 2 KL N.A
VTD-6101 48 SS
VTD-6104 64 SS
VTD-5101 48 SS
Vaccum Tray Dryer VTD-5103 (PPA) 48 SS
MPP-3
VTD-8106 (PPA) 6 SS
VTD-6103 (PPA) 48 SS
VTD-9502 (PPA) 48 SS
Rotary Vaccum Dryer RVD-6102 1.5KL N.A
VTD-9101 48 SS

Vaccum Tray Dryer

MPP-5
 VTD-9102 (PPA) 24 SS
Vaccum Tray Dryer
VTD-9202 24 SS
MPP-5
VTD-9203 (PPA) 24 SS
Rotary Vaccum Dryer RVD-9201 1 KL N.A
ANFD ANFD-9101 500 L N.A
VTD-9301(PPA) 48 SS
VTD-9302(PPA) 48 SS
Vaccum Tray Dryer
CMPP VTD-9304 72 SS
VTD-9305 72 SS
Rotary Vaccum Dryer RVD-9301 1.6 KL N.A
VTD-9501 64 SS
VTD-9504(PPA) 72 SS
VTD-9505(PPA) 72 SS
Vaccum Tray Dryer
VTD-9601 64 SS
VTD-9602 48 SS
MPP-6
VTD-9603 (PPA) 48 SS
RVD-9502 2 KL N.A
Rotary Vaccum Dryer RVD-9601 1.5 KL N.A
RVD-9602 1.5 KL N.A
ANFD ANFD-9501 1 KL N.A
VTD-9701(PPA) 48 SS
VTD-9801 64 SS
Vaccum Tray Dryer VTD-9802 64 SS
MPP-7 VTD-9804(PPA) 72 PP
VTD-9805(PPA) 96 PP
RVD-9701 1.5 KL N.A
Rotary Vaccum Dryer
RVD-9801 1.5 KL N.A
VTD-9401 64 SS-316
VTD-9402 64 SS-316
VTD-9403 (PPA) 96 SS
MPP-8 Vacuum Tray Dryer VTD-9404(PPA) 96 SS
VTD-9405(PPA) 96 SS
VTD-9406(PPA) 96 SS
VTD-9407 48 SS
VTD-8401 72 PP
VTD-8402 64 SS/PP
VTD-8403 64 PP
Vacuum Tray Dryer
VTD-8404(PPA) 48 SS
MPP-9 VTD-8502(PPA) 48 SS
VTD-8501 48 SS
Rotary Vaccum Dryer RVD-8401 1.5 KL N.A
RVD-8501 1.5KL N.A
ANFD ANFD-8401 1.5 KL N.A
 Dryer tray loading scale down
Lab
Wet Cake 0.169 Kg Expected wet cake
Bulk density 0.5 Kg/Litre
Wet cake Volume 0.34 Litre
No. of Lots 1
Effective wet cake 0.169 Kg
Tray/Rota Vapour dimensions
Length 0.15 m
Width 0.125 m
Height 0.05 m
RPM 0
Area of each tray 0.065 m2
No. of trays 1
Overall area 0.065 m2
Wet cake/m2 2.60 Kg/m2
Roto vapour capacity Litre
RVD occupancy - %
Volume of each tray 0.94 Litre
Each tray max capacity 0.47 Kg
Utility temp 45-50 °C

Width Height RPM

0.05 0.05 6
0.08 8
0.125
0.15
 NO. OF
TRAYS/
CAPACIT
Y
VTD-1501A 48
VTD-1501B 48
MPP-1 Vaccum Tray Dryer
VTD-1551 6
VTD-1501C (PPA) 24
VTD-8103 (PPA) 48
VTD-8102 48
VTD-7103 48
VTD-7102 48
VTD-8107 (PPA) 12
Vaccum Tray Dryer
VTD-8105 6
VTD-8104 6
VTD-8108 48
MPP-4
VTD-8101 6
VTD-8109 48
SD-4101 (PPA) 10
SD-7101 (PPA) 15
Spray Dryer
SD-7103 (PPA) 45
SD-7102 (PPA) 25
RVD-7101 1.5
Rotary Vaccum Dryer
RVD-8101 1.5
CSP-1 Rotary Drum Dryer RVD-1301 1.8
CSP-2A Rotary Vaccum Dryer RVD-1401 2
VTD-1401C 48
VTD-1401D 48
CSP-2B Vaccum Tray Dryer
VTD-1401E 48
VTD-1401F 48
VTD-1401G 48
 RVD-2201 (PPA) 2
Rotary Vaccum Dryer
RVD-2202 2
DSP-2
ANDF ANFD-2201(PPA) 5
FBD FBD-2201(PPA) 0.34
VTD-1401A 48
VTD3105 64
VTD-4102 48
Vaccum Tray Dryer
VTD-4104 (PPA) 48
VTD-3106 (PPA) 64
MPP-2
VTD-3107 (PPA) 64
RVD-3103 1.5
RVD-4105 1.5
Rotary Vaccum Dryer
RVD-4101 1.5
RVD-3108 2
VTD-6101 48
VTD-6104 64
VTD-5101 48
Vaccum Tray Dryer VTD-5103 (PPA) 48
MPP-3
VTD-8106 (PPA) 6
VTD-6103 (PPA) 48
VTD-9502 (PPA) 48
Rotary Vaccum Dryer RVD-6102 1.5
VTD-9101 48
VTD-9102 (PPA) 24
Vaccum Tray Dryer
VTD-9202 24
MPP-5
VTD-9203 (PPA) 24
Rotary Vaccum Dryer RVD-9201 1
ANFD ANFD-9101 0.5
VTD-9301(PPA) 48
VTD-9302(PPA) 48
Vaccum Tray Dryer
CMPP VTD-9304 72
VTD-9305 72
Rotary Vaccum Dryer RVD-9301 1.6
VTD-9501 64
VTD-9504(PPA) 72
VTD-9505(PPA) 72
Vaccum Tray Dryer
VTD-9601 64
VTD-9602 48
MPP-6
VTD-9603 (PPA) 48
RVD-9502 2
Rotary Vaccum Dryer RVD-9601 1.5
RVD-9602 1.5
ANFD ANFD-9501 1
VTD-9701(PPA) 48
VTD-9801 64
Vaccum Tray Dryer VTD-9802 64
MPP-7 VTD-9804(PPA) 72
VTD-9805(PPA) 96
 MPP-7

RVD-9701 1.5
Rotary Vaccum Dryer
RVD-9801 1.5
VTD-9401 64
VTD-9402 64
VTD-9403 (PPA) 96
MPP-8 Vacuum Tray Dryer VTD-9404(PPA) 96
VTD-9405(PPA) 96
VTD-9406(PPA) 96
VTD-9407 48
VTD-8401 72
VTD-8402 64
VTD-8403 64
Vacuum Tray Dryer VTD-8404(PPA) 48
VTD-8502(PPA) 48
MPP-9
VTD-8503 72
VTD-8501 48
Rotary Vaccum Dryer RVD-8401 1.5
RVD-8501 1.5
ANFD ANFD-8401 1.5

T1
MOC LOCATION width height volume

SS-316 0 MTR 0.39 0.05 #REF!

SS-316 0 MTR 0.39 0.05 #REF!
SS-316 0 MTR
SS-316 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS-304 0 MTR 0.355 0.055 #REF!
SS-316 0 MTR 0.38 0.045 #REF!
SS-316 0 MTR 0.41 0.05 #REF!
SS-316 O MTR 0.41 0.05 #REF!
SS-316 O MTR 0.41 0.05 #REF!
SS-316 0 MTR 0.41 0.05 #REF!
SS-316 O MTR 0.38 0.045 #REF!
SS 0 MTR
SS 0 MTR
SS-316 0 MTR
SS 0 MTR
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR
SS-304 0 MTR 0.4 0.05 #REF!
SS-304 0 MTR 0.4 0.05 #REF!
SS-304 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR 0.38 0.045 #REF!
SS-316 0 MTR 0.4 0.05 #REF!
HALAR 0 MTR 0.405 0.05 #REF!
SS-316 0 MTR 0.38 0.055 #REF!
SS-316 0 MTR 0.37 0.045 #REF!
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR 0.41 0.05 #REF!
SS-316 0 MTR 0.39 0.05 #REF!
SS-316 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR 0.41 0.05 #REF!
SS-316 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR
SS-316 0 MTR 0.375 0.05 #REF!
SS-316 0 MTR 0.4 0.05 #REF!
Halar 0 MTR 0.37 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR 0.37 0.045 #REF!
SS-316 0 MTR 0.38 0.04 #REF!
SS-316 0 MTR 0.38 0.04 #REF!
SS-316 0 MTR 0.38 0.045 #REF!
SS-316 0 MTR
SS-316 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR 0.37 0.055 #REF!
SS-316 0 MTR 0.37 0.055 #REF!
SS-316 0 MTR 0.37 0.05 #REF!
SS-316 0 MTR 0.37 0.05 #REF!
SS-316 0 MTR 0.37 0.05 #REF!
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR
SS-316
SS-316 0 MTR 0.4 0.05 #REF!
SS-316 0 MTR 0.381 0.05 #REF!
SS-316 0 MTR 0.36 0.05 #REF!
SS 0 MTR 0.385 0.05 #REF!
SS 0 MTR 0.385 0.05 #REF!
SS-316 0 MTR
SS-316 0 MTR
SS-316 0 MTR 0.381 0.05 #REF!
SS-316 0 MTR 0.381 0.05 #REF!
SS-316 0 MTR 0.381 0.05 #REF!
SS-316 0 MTR 0.381 0.05 #REF!
SS-316 0 MTR 0.381 0.05 #REF!
SS-316 0 MTR 0.381 0.05 #REF!
SS-316 0 MTR 0.381 0.05 #REF!
Halar 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS-316 0 MTR 0.375 0.05 #REF!
SS-316 0 MTR 0.38 0.05 #REF!
SS 0 MTR
SS 0 MTR
S.S 5 MTR
Expected wet cake

VTD tray specification in lab

L W H
10 5 5
10 8 5
15 12 5
20 15 5
R.P.M length width height volume

1 0.39 0.05 19.5

1 0.39 0.05 19.5

0.95 0.4 0.05 19

0.955 0.38 0.05 18.145
0.955 0.38 0.05 18.145
0.955 0.38 0.05 18.145
0.945 0.355 0.055 18.45113
0.96 0.38 0.045 16.416
0.81 0.41 0.05 16.605
0.81 0.41 0.05 16.605
0.81 0.41 0.05 16.605
0.81 0.41 0.05 16.605
0.96 0.38 0.045 16.416

6
6
8
6
0.9 0.4 0.05 18
0.9 0.4 0.05 18
0.9 0.4 0.05 18
0.9 0.4 0.05 18
0.9 0.4 0.05 18
6
6
10

0.95 0.4 0.05 19

0.955 0.38 0.045 16.3305
0.94 0.4 0.05 18.8
0.8 0.405 0.05 16.2
0.945 0.38 0.055 19.7505
0.945 0.37 0.045 15.73425
8
7
10
9
0.8 0.4 0.05 16
0.8 0.41 0.05 16.4
0.85 0.39 0.05 16.575
0.8 0.4 0.05 16
0.81 0.41 0.05 16.605
0.8 0.4 0.05 16
0.945 0.38 0.05 17.955
6
0.9525 0.375 0.05 17.85938
0.95 0.4 0.05 19
0.94 0.37 0.05 17.39
0.955 0.38 0.05 18.145
9

0.94 0.37 0.045 15.651

0.95 0.38 0.04 14.44
0.95 0.38 0.04 14.44
0.965 0.38 0.045 16.5015
10
0.9225 0.38 0.05 17.5275
0.953 0.37 0.055 19.39355
0.953 0.37 0.055 19.39355
0.943 0.37 0.05 17.4455
0.945 0.37 0.05 17.4825
0.9544 0.37 0.05 17.6564
7
7
7

0.94488 0.4 0.05 18.8976

0.9525 0.381 0.05 18.14513
0.9525 0.36 0.05 17.145
0.955 0.385 0.05 18.38375
0.955 0.385 0.05 18.38375
9
9
0.9525 0.381 0.05 18.14513
0.9525 0.381 0.05 18.14513
0.9525 0.381 0.05 18.14513
0.9525 0.381 0.05 18.14513
0.9525 0.381 0.05 18.14513
0.9525 0.381 0.05 18.14513
0.94488 0.381 0.05 17.99996
0.952 0.38 0.05 18.088
0.96 0.38 0.05 18.24
0.952 0.38 0.05 18.088
0.952 0.38 0.05 18.088
0.952 0.375 0.05 17.85
0.952 0.38 0.05 18.088
0.952 0.38 0.05 18.088
10
8
 Reaction
Reactor Details (RE-7104)
Parameter Plant Lab Remarks
Batch size 150 kg 0.220 kg
Flask size 2 kl 3L
Occupancy 66.11 58.77
Agitator Anchor Anchor
Sweep Diameter 1200 mm 85 mm
RPM 50 454 Ei = 0.653 watt/kg

Water Washing & Charcoalization

Reactor Details (RE-7101)
Parameter Plant Lab Remarks
Batch size 150 kg 0.220 kg
Flask size 5 KL 5L
Occupancy 49.50 66.00
Agitator Anchor Anchor
Sweep Diameter 1300 mm 120 mm
RPM 50 371 Ei = 1.07 watt/kg

Cooling and CF Filtration

Reactor Details (RE-7102)
Parameter Plant Lab Remarks
Batch size 150 kg 0.220 kg
Flask size 3 KL 3L
Occupancy 40.34 53.79
Agitator Anchor Anchor
Sweep Diameter 1000 mm 85 mm
RPM 60 402 Ei = 0.5 watt/kg

CF Details (CF-7101) filtration

Parameters Plant Lab Time (mins) Remarks
Equipment size 42" 6" NA
Filter reaction mass 350 990 60 g-force = 83

Spinning 560 1584 30 g-force = 214

Washing 350 990 35 g-force = 83
Spin Dry 750 2121 60 g-force = 383
Unloading NA NA 60 -
 Dryer Details VTD-7102
Parameters Plant Lab Remarks
Length (m) 0.945 0.15 No of trays 1
Width (m) 0.355 0.125
Height (m) 0.055 0.05

Thickness (Kg/m2) 2.8 2.6

Project: Desloratadine
Stage: Crude Desloratadine
Batch
150 Kg
size

Sr. No Unit Operation Qty in plant Unit

1 Charge Ethanol 713 L

2 Charge Purified water 37.5 L
3 Charge Loratadine 150 Kg
4 Charge Sodium hydroxide 94.5 Kg
5 Heat the reaction mass NA NA
6 Stir the reaction mass & Check Loratidine Content NA NA
7 cool the reaction mass NA NA
8 Charge Purified Water 450 L
9 Stir the mass NA NA
10 distilled out Aqueous Ethanol u/vacuum Approx. 652.5 L
11 Charge Methyl isobutyl ketone 450 L
12 Heat the reaction mass. NA NA
13 Stir the mass NA NA
14 Stop the agitator and settle the mass. NA NA
15 Separate bottom Aqueous layer & Kept In vessel NA NA
16 Transfer organic layer to RE-7101 NA NA
17 Start agitator and charge Aqueous layer NA NA
18 Charge Methyl isobutyl ketone 450 L
19 Stir the mass NA NA
20 Stop the agitator and settle the mass. NA NA
21 Separate bottom Aqueous layer & Kept In vessel NA NA
22 Transfer organic layer to RE-7101 NA NA
23 Workup NA NA
24 Start the agitator & charge the total quantity of organic layer in RE NA NA
25 Charge Purified Water 750+750 L
26 Stir the mass NA NA
27 Stop the agitator and settle the mass. NA NA
28 Separate bottom Aqueous layer & Kept In vessel NA NA
29 Start the agitator and charge Purified Water 750 + 750 L
30 Stir the mass NA NA
31 Stop the agitator and settle the mass. NA NA
32 Separate bottom Aqueous layer & Kept In vessel NA NA
33 Start the agitator and charge Purified Water 750+750 L
34 Stir the mass NA NA
35 Stop the agitator and settle the mass. NA NA
36 Separate bottom Aqueous layer & Kept In vessel NA NA
37 Start the agitator & Distill out MIBK u/vacuum Approx. 450 L
38 Charge Ethyl Acetate 3 L
39 Charge Celite 15 Kg
40 Recirculate trough sparkler filter & prepare bed NA NA
41 Heat the reaction mass NA NA
42 Stir the mass NA NA
43 Add Activated Carbon 15 Kg
44 Stir the mass NA NA
45 Recirculate Reaction mass through SF-7104 till clear NA NA
46 Filter the mass & collect in RE-7102 NA NA
47 Charge Ethyl acetate in RE-7101 & wash Carbon bed with Ethyl acetate 150 L
48 Cool the mass NA NA
49 Stir the mass. NA NA
50 Filtration (CF-7101) NA NA
51 Feeding NA NA
52 Spinning NA NA
53 Charge ethyl in RE-7101 and Wash the wet cake with Ethyl Acetate 150 L
54 Spinning NA NA
55 Unloading NA NA
56 Drying VTD-8105 NA NA
57 Wet cake charging in VTD tray NA NA
58 Apply vacuum NA NA
59 Vacuum dry the product NA NA
60 Apply hot water and achieve the hot water temp. required for drying NA NA
61 Dry the product with hot water till LOD NMT 0.50% NA NA
62 Unload the dryer NA NA
Expected dry Wt.: 78-121.5 Kg
Actual yield= 0.66 kg/kg
Yield=0.52-0.81 kg
 Sweep
Plant Time Std.Time (In Flask
Temp. (°C) Agitator Dia. RPM
(in Min.) Min.) Capacity
(mm)
60-120 NA NA
20-30 NA 25-30
60-90 NA 25-30
60-90 NA 25-30
90-120 NA 80-85
775 680-810 80-85
40-60 NA 50-55
60-90 NA 50-55
15 15 50-55
720-780 NA NMT 55
40-60 NA NMT 55
3 Litre Anchor 85 mm 454
50-60 NA 70-75
15 15 70-75
30 15-30 70-75
40-60 NA 70-75
40-60 NA 70-75
40-60 NA 70-75
40-60 NA 70-75
15 15 70-75
30 15-30 70-75
40-60 NA NA
40-60 NA NA
NA NA NA NA NA NA
15-20 NA 70-75
55-60 NA 70-75
15 15 70-75
30 15-30 70-75
25-30 NA 70-75
55-60 NA 70-75
15 15 70-75
30 15-30 70-75
25-30 NA 70-75
55-60 NA 70-75
15 15 70-75 5 Litre Anchor 120 mm 371
30 15-30 70-75
25-30 NA 70-75
540-600 NA NMT70
 5 Litre Anchor 120 mm 371

40-60 NA NMT70
15-20 NA NMT70
30-60 NA NMT70
130-150 NA 75-80
15 15 75-80
15-20 NA 75-80
30 30 75-80
30-60 NA 75-78 FILTRATION
40-60 NA 75-80
20-25 NA 75-80
3 Litre Anchor 85 mm 402
130-180 NLT 60 0-5
60 60 0-5
NA NA NA NA NA NA
50-60 NA 0-5 350
30 NA NA 560
20-25 NA 0-5 48 Inch NA 350
60 NA NA 750
25-30 NA NA NA
NA NA NA NA NA NA
40 NA NA
60-65 NA NA
60 60 NA
72 Trays NA NA
55-60 NA 45-50
940 540-1140 NA
30 NA NA
No. of Baffles Utility used Remark

CW

2 NA
HOT WATER / Vacuum

NA

NA NA NA

Hot Water

4 NA

Hot Water / vacuum

 4 NA

Hot Water / vacuum

Hot Water

FILTRATION

4 CHW/CHBR NA

NA NA NA

NA Nitrogen

NA NA NA

NA Nitrogen, Hot Water