A REPORT ON INDUSTRIAL VISIT

A Report Submitted to Dr. A. P. J. Abdul Kalam Technical

University in Partial
Fulfillment
of the Requirement for the Degree of

BACHELOR OF PHARMACY
By
VIVEK
(1908720500088)

UNDER THE SUPERVISION

OF
MR.SAKET VERMA
(Associate Professor )

DR. OMPRAKASH SCHOOL OF PHARMACY

NISAI, FARRUKHABAD
 ACKNOWLEDGEMENT
First, I praise God, the Almighty, merciful and passionate, for
providing me this opportunity granting me the capability to
proceed successfully.
There is no word to express the feeling of gratitude I have in my
heart for respected. Mr.Deepak Kumar(Associate Proffesor
),Mr. Alok Kumar (Director)and other faculty of Pharmacy,
Dr.Om Prakash School of Pharmacy, Nisai ,Farrukhabad, (U.P.)
Last but not the least I would also like to thank all my friends
for their support.

VIVEK SINGH
(B.Pharma 8th semester )
Roll.No,-1908720500088
 DECLARATION

I hereby declared this project entitled “Project Report on Industrial

Training” for the award of Bachelor of Pharmacy from Dr. A.P.J.K.
Technical University, Lucknow. This project embodies result of my
original work and studies and the content of the project don’t from the
basis for the award of any other degree.

VIVEK SINGH
1908720500088
Date: - April 2023
Place: - NISAI
 PREFACE

Pharmacy is the Art and Science of preparing and dispensing drug. It is

the health profession that links health sciences with chemical sciences and
aims to ensure the safe and effective use of pharmaceutical drugs. So it is
a fully technical profession where practical knowledge ismuch
more important along with theoretical knowledge.

According to curriculum of a four year integrated degree course of

BACHELOR OF PHARMACY each student has to undergo practical
training for a periods of four week in various pharmaceutical industries in
India.

I was directed to undergo my industrial training at COOPER

PHARMA LIMITED, this report containa brief description of the above
pharmaceutical industry which was observed during the training program.
 INDUSTRIAL VISIT REPORT

Date of visit : APRIL-2023

Place of visit : Cooper Pharma Limited

Faculty : Mr .SAKET VERMA

Mr .DEEPAK KAMAL

Miss. PRAGYA MAM

Miss.NIMISHA MAM

Co-ordinators : PRAGYA MAM

Participating

Students : B.Pharm 4th year

INTRODUCTION
The industrial visit of 2019 took place in Dehradun (Uttarakhand), India from 8 th
march2019 to 14 march 2019. 54 students visited 2 pharmaceutical plants viz,
Cooper Pharma Limited and Vamso biotec pvt. Ltd. The accommodation of the
students visiting was organized in Dehradun and it was 2-3 hours journey from
Massoori by the bus to the industries those were set in Dehradun.

Dehradun industrial tour is a prime attraction for biotechnology, botany, agri,

geography and petrochemical students. Many institutions of national importance like
forest Research Institute; Oil and Natural Gas Commission; Indian Military
Academy; Wild Life Institute etc. are located n Deradun which make it a place of
national importance attracting tourists in large numbers.

Surrounded on the east by River

Ganga, on the west by the Yamuna,
the doon Valley is a picturesque
region at the foothills of the
panoramic Shivakik ranges.
Dehradun serves as the gateway to
the hiss resort of mussoorie.
Nestled in the mountain ranges of
Himalayas, Dehradun is the capital
of Uttarakhand.

The name Dehradun is a collection of two words”dera” meaning camp and

”dun” meaning valley. Said to be one of the oldest cities in India, it is believed that
Lord Rama and his brotherdid penance here or killing Ravana, the demon king.
During the 17th and 18th centuries Dehradun changed hands several times: Guru Ram
Rai retreated here from Punjab, the mugal Governor Najib-ud-Daula occupied it
from 1757-1770 and the gorkhas overran it on their westward expansion before
proceding it to the British in 1815. Under the british, Dehradun became an elite town
with many a fine institutions such as the Forest Resurch Institute, Doon School and
Welham Schools for girls and boys, many more like the ONGC and Wadia Institute
of Himalayan Studies, were added in time.
Introduction:-

Cooper Pharma is a global pharmaceutical manufacturing company, which is

renowned internationally for its quality standards and efficacy of the products. We
are committed to making the world a healthier place through the development,
production, and marketing of excellent pharmaceutical products. We strive to
achieve this objective by developing innovative products, which suit the needs of the
patients globally and are superior in terms of quality, packaging, and stability. We
have a range of more than 500 molecules across segments and dosage forms. Our
state of the art manufacturing facility has been appreciated and approved globally
by various regulatory authorities. We are a WHO-GMP, ISO certified company &
Government recognized Export House. We are also cGMP/ PICS/ USFDA/
UKMHRA/ TGA/ EUGMP compliant and maintain the highest quality standards.

It is one of the oldest and top pharma companies in India. We are a global
pharmaceutical manufacturing company, exporting to more than 25 countries across
the globe. We are involved in the manufacturing of pharmaceuticals, pharmaceutical
distribution, marketing, and exports.

We are a part of the prestigious Cooper group, which was established in the year
1959.

Its manufacturing unit is located in the lush green environs of Dehradun,

Uttarakhand in North India. Our corporate office is located in the capital city of
Delhi, India. We have huge capacities to manufacture tablets, capsules, syrups,
ointments, sterile powder injectables and liquid injectables.
 They have constantly strived for a sustainable growth since our inception. This
strategy is achieved by planning key alliances with leading global partners for
marketing and distribution. We aim to improve the health of patients worldwide
through continuous innovation in the formulation, effective marketing,
manufacturing facilities, broad product portfolio, in-depth understanding of
pharmaceutical regulations, partnerships and affiliations. As a recognized WHO
GMP approved and PICS compliant manufacturer for pharmaceuticals, we strive not
only adhere but also exceed the WHO / PICS quality standards.

The goal is to maintain and exceed quality parameters through the eyes of the
medical fraternity. We strive for continuous innovation and development of new
health products and to make them available at all pharmacies worldwide. In all our
efforts towards the same, we follow our primary values of excellence, integrity,
quality, and teamwork.

Among pharma manufacturers in India, Cooper Pharma Limited is a leading

manufacturer of generic & ethical medicines headquartered in Delhi, the capital city
of India. Our organization believes in fulfilling the social responsibilities,
maintaining the core values and extending support to the society beyond the business
motives. As a pharmaceutical manufacturing company in India, we have a genuine
endeavour to alleviate the sufferings of mankind and make the medicines available
to all at affordable prices. We do so without any discrimination and strive to improve
the quality of the drugs.

Cooper Pharma Limited is a part of the Cooper Pharma Group which was
founded in 1959 by a renowned and visionary pharmacist Dr O.S. Bhargava in Delhi.
As a leading pharmaceutical manufacturing company in India, Cooper has gradually
but vastly spread the reach. It is selling branded generics and ethical segments across
25 states of India. The company has achieved hallmark of quality and efficacy for
its 450 distributors and 8,000 retailers. Being one of the topmost drug manufacturers
in India, it began exports in the year 1991 with an extensive range of specialized
products that were categorized across segments and dosage forms. Eventually,
within a couple of years, exports rose and soon accounted for 60% of the total
turnover of the organization
Overview of Cooper Pharma

Cooper Pharma is a global pharmaceutical manufacturing company, which is

renowned internationally for its quality standards and efficacy of the products. We
are committed to making the world a healthier place through the development,
production, and marketing of excellent pharmaceutical products. We strive to
achieve this objective by developing innovative products, which suit the needs of the
patients globally and are superior in terms of quality, packaging, and stability. We
have a range of more than 500 molecules across segments and dosage forms. Our
state of the art manufacturing facility has been appreciated and approved globally by
various regulatory authorities. We are a WHO-GMP, ISO certified company &
Government recognized Export House. We are also cGMP/ PICS/ USFDA/
UKMHRA/ TGA/ EUGMP compliant and maintain the highest quality standards.

We are one of the oldest and top pharma companies in India. We are a global
pharmaceutical manufacturing company, exporting to more than 25 countries across
the globe. We are involved in the manufacturing of pharmaceuticals, pharmaceutical
distribution, marketing, and exports.

We are a part of the prestigious Cooper group, which was established in the year
1959.
Our manufacturing unit is located in the lush green environs of Dehradun,
Uttarakhand in North India. Our corporate office is located in the capital city of
Delhi, India. We have huge capacities to manufacture tablets, capsules, syrups,
ointments, sterile powder injectables and liquid injectables.

We have constantly strived for a sustainable growth since our inception. This
strategy is achieved by planning key alliances with leading global partners for
marketing and distribution. We aim to improve the health of patients worldwide
through continuous innovation in the formulation, effective marketing,
manufacturing facilities, broad product portfolio, in-depth understanding of
pharmaceutical regulations, partnerships and affiliations. As a recognized WHO
GMP approved and PICS compliant manufacturer for pharmaceuticals, we strive not
only adhere but also exceed the WHO / PICS quality standards.

Our goal is to maintain and exceed quality parameters through the eyes of the
medical fraternity. We strive for continuous innovation and development of new
health products and to make them available at all pharmacies worldwide. In all our
efforts towards the same, we follow our primary values of excellence, integrity,
quality, and teamwork.

Facilities
Corporate Office is located in Delhi, the capital of India. Our plant is located in
Dehradun, the capital of the picturesque hill state of Uttarakhand. Dehradun is
255km away from Delhi and can be reached by Air, Train & Bus.

Key features include:

❖ Area of over 7,000 sq meters with separate buildings for Manufacturing,

Office & Utility.
❖ Based on uniflow concept with separate entries for each production area both
for man and material.
❖ Eco-friendly and egronomic design of the Building & Premises.
❖ Latest and best in class HVAC, Water and other Utility Systems.
❖ Effective water and waste management.
❖ Good Manufacturing Process Records.
 ❖ Over 10,000 sq ft area dedicated for Quality Control and Quality
Assurance Activity.

Quality Control
Cooper Pharma Ltd is a WHO-GMP and ISO Certified global pharmaceutical
company, which has been serving customers in more than 25 countries since 1959.
We are USFDA, UKMHRA and TGA compliant and abide by the highest standards
of quality.

At Cooper Pharma, the mission is to provide reliable, safe and affordable

medicines to patients worldwide, thus helping people to live healthier lives. Right
from the procurement to the completed formulations, our stringent procedures
ensure that the products are safe, effective and compliant with the International
standards.

Efforts are underway to get our fully equipped laboratories accredited as the
Research & Development Center by the Government of India.

• Quality policy

Our quality policy stands committed to maintaining the good manufacturing

practices, conform to the International standards and ensure a timely supply of goods
with cost-effectiveness. We believe in achieving the highest level of customer
satisfaction and market leadership in domestic, as well as overseas markets, by
implementing the Quality Management Systems (QMS) on a continual basis.

• Quality Control

Quality control begins at the time of

material planning and continues through the
process of receiving the APIs and other material
for the production, which is sourced from
approved, reputed vendors. The process of
monitoring the stability of the product during the
shelf life continues until the release of the
finished goods for sale and expiry of the product.
We have an in-house modern testing laboratory, which is equipped with all the
necessary instruments and a highly-qualified technical staff. An area of over 10,000
sq ft and a team of over 25 skilled employees is dedicated especially for QC
activities.

With an aim to preserve the high quality of the products, we do not compromise on
the APIs. We import quality raw materials from reliable sources in Germany, Italy,
and other European countries. We operate in total compliance with the G.M.P. norms
set by the W.H.O. and the latest international guidelines set by the USFDA/
UKMHRA/ EUGMP. These norms are controlled by superior quality laboratories
that are divided into three sections:

❖ Chemical Laboratory: Has adequate, qualified technical staff and well-laid out
Standard Operating Procedures (SoPs) for operation
❖ Instrumentation Laboratory: The fully equipped QC department has the latest
state-of-the-art equipment, such as 6 HPLCs, 2 IRs, GCs, ToC, 4 stability
chambers & incubators among instruments

Microbiological Laboratory: The products are subjected to a series of microbial

tests during production and post production. The environment and utilities are
continuously monitored on a real-time basis here.

We have achieved many awards and acclamations at the state, national and
international levels for keeping our promise of excellent quality.

Quality Management and Assurance

We use ultra-modern technology and strict operating procedures. The

technically skilled team maintains the highest standards of safety and utilizes
environmentally-friendly and clean processes for quality management.

We have received approvals from various ministries of health & regulatory agencies
for the sales & distribution of our products.

Key elements for effective quality controls:-

 ❖ Our state-of-the-art manufacturing facilities are cGMP compliant (current
Good Manufacturing Practices) and conform to national and international
standards. Our hi-tech machineries are designed to achieve a high level of
precision.
❖ Our quality control laboratories have the latest equipment that
offer excellence at every stage of processing. We have a dedicated pool of
talent that consistently retains the safety standards.
❖ We maintain world-class quality for our products and services across
domestic and overseas markets, thus ensuring that every patient has access to
the best medicines in the world.
❖ We upgrade our manufacturing facilities, adapt to the technological
innovations and provide medicines at an affordable price.

ABOUT COOPER PHARM PVT. LTD

Cooper Pharma Limited is a Public incorporated on 02 February 1989. It is classified as
Non-govt company and is registered at Registrar of Companies, Delhi. Its authorized share
capital is Rs. 30,000,000 and its paid up capital is Rs. 10,000,000. It is inolved in
Manufacture of other chemical products Cooper Pharma Limited's Annual General
Meeting (AGM) was last held on 05 September 2018 and as per records from Ministry of
Corporate Affairs (MCA), its balance sheet was last filed on 31 March 2018.

Directors of Cooper Pharma Limited are Abhishek Bhargava, Rakesh Bhargava,

Mhd Bassam Naassan, Ashok Kumar Pandey, Abhijit Sengupta, Nagendra Prasad
Bramhadev Upadhyay.

Cooper Pharma Limited's Corporate Identification Number is (CIN)

U24231DL1989PLC034902 and its registration number is 34902.Its Email address is
accountsdel@cooperpharma.com and its registered address is 12/12, SHAKTI NAGAR
DELHI DL 110007 IN .

Current status of Cooper Pharma Limited is – Active.

Company Details :-

CIN U24231DL1989PLC034902
Company Name COOPER PHARMA LIMITED
Company Status Active
RoC RoC-Delhi
Registration Number 34902
Company Category Company limited by Shares
Company Sub Category Non-govt company

Class of Company Public

Date of Incorporation 02 February 1989

Age of Company 30 years, 2 month, 11 days

History of company:-
In the year 1959, noted pharmacist Late Shri O.S.Bhargava felt the need to establish
a world-class pharmaceutical manufacturing company and follow the visionary
principles of our national leaders of self-reliance. It was the beginning of a long and
eventful journey into the pharmaceutical sector. Cooper Pharma was founded in the
year 1959 in Delhi. Since its inception, the vision has been to provide quality &
affordable medicines to all and make them available at all leading pharmacies across
the nation.
Cooper Pharma has evolved from a manufacturer serving the Indian patients
to catering to people across the globe. The facilities are continuously expanded and
integrated with the development of the latest products. Exports were started in the
year 1991 and have increased ever since. In 2007, a new export-oriented
manufacturing facility was set up in Dehradun, capital of Uttarakhand in North India.
Over the years, we have been awarded and have earned acclaim for the quality
standards and services, both in India and across the globe.
Thus, we are strong technically, commercially and morally. In our pursuit of
growth with internationally approved healthcare products and our flight for
excellence, each achievement is just another milestone in our journey and is not the
ultimate destination. Growth, which is based on excellence and integrity, is a
continuous process in our company.
MILESTONES

• 1959

The first plant set up in Delhi. Only a few products manufactured and sold in the
Northern states of India.

• 1959-1991

Products available at major pharmacy chains across the country, thanks to the
continuous expansion.

• 1991

Exports started with nearby Asian countries.

• 1991-2007

Expansion of exports, with products available in bigger markets in Asia, Africa, and
other countries.

• 2007
New unit set up in Dehradun. Equipped with state-of-the-art manufacturing facilities
across dosage forms.

• 2007 Onwards

Expansion of markets and development of the latest pharmaceutical formulations.

Products now available in more than 25 countries and on leading online pharmacies.

Manufacturing
❖ Instruments used in production:-
➢ Octagonal blender - granule mixture
➢ Plenta 100 - Capsule filling machine
➢ AE 120 (10001/5001)- used for Aerosol
➢ Neocota, Autocota – Coating machine
➢ Tablet granulator- FBE 500

❖ Quality Control section:-

There are four section in QC, Raw material section, Instrument section, Finished
product section, Stability section. The instruments used are:-
➢ Dissolution test apparatus.
➢ Disintegration tube.
➢ Tablet hardness tester.
➢ Friability tester.
➢ Karl Fisher moisture titrator.
➢ Melting point apparatus.
➢ Leak test apparatus.
➢ High Performance Liquid Chromatography (normal and reverseHPLC).

❖ Packaging Types-
➢ Blister packing
➢ Strip packing
➢ Container packing
➢ Aerosol packing
Products Manufactured List
Sr. No. COMPOSITION TYPE
Antibiotics-ARV
1 Cimetidine 400mg Tablet
2 Linezolid 600mg Tablet
3 Ceftriaxone 500mg Sulbactam 250mg Injection
4 Ceftriaxone 250mg Sulbactam 125mg Tablet
5 Ceftriaxone 1gm Sulbactam 500mg Injection
6 Amoxicillin Sodium 500mg and Sulbactam Injection
Sodium 250mg
7 Cefoperazone 500mg Sulbactam 500mg Injection
8 Cefoperazone 1gm Sulbactam 1gm Injection
9 Sulphaguanidine Tablet
10 Oxacillin 1gm Injection
Antidiabetic
1 Gliclazide 80mg Tablet
2 Sitagliptin 50mg, 100mg Tablet
3 Pioglitazone 15mg Tablet
4 Pioglitazone 15mg Metformin 500mg Tablet
5 Glibenclamide 5mg Tablet
6 Metformin HCI 500mg and Glimepiride Tablet
1gm
7 Glimepiride 1mg, 2mg, 3mg, 4mg Tablet
Antimalarials
1 Artesunate 100mg Amodiaquine 270mg Tablet
2 Artesunate 50mg Amodiaquine 135mg Tablet
3 Artesunate 25mg Amodiaquine 67.5mg Tablet
4 Artesunate 60mg, 120mg Injection
5 Artemether 20mg Lumefantrine 120mg Tablet
6 artemether 80 mg Injection
7 Artemether 40mg Lumefantrine 240mg Tablet
8 Artemether 80mg Lumefantrine 480mg Tablet
9 α-β Arteether 75mg, 150mg, 300mg Injection
10 Amodiaquine Hydrochloride 200mg Tablet
NSAIDs
1 Ketorolac Tromethamine 30mg Tablet
2 Tramadol HCI 50mg, 100mg, 200mg and Tablet
225mg
3 Tramadol HCI 37.5mg and Paracetamol Tablet
325mg
4 Aspirin 500mg Caffeine 50mg Tablet
5 Tramadol HCL 50mg,100mg Injection
6 Nimesulide 100mg Paracetamol 325mg Tablet
7 Nimesulide 100mg Tablet
8 Aspirin 75mg Tablet
9 Lidocaine 2% Injection
10 Celecoxib 200mg Tablet
11 Celecoxib 200mg Capsule
12 Ibuprofen 200mg, 400mg, 600mg, 800mg Tablet
13 Epinephrine 1mg Injection
14 Diclofenac Sodium 50mg Tablet
15 Fentanyl 50mcg Injection
Cardiology
1 Spironolactone 50mg and Furosemide Tablet
20mg
2 Spironolactone 25mg Tablet
3 Valsartan 40mg, 80mg, 160mg Tablet
4 Ranolazine 500mg, 1000mg Tablet
5 Olmesartan 40mg and Amlodipine 5 Tablet
6 Olmesartan 20mg and Amlodipine 5 Tablet
7 Enalapril 5mg, 10mg Tablet
8 Metoprolol 25mg, 50mg, 100mg Tablet
9 Simvastatin 5mg, 10mg, 20mg Tablet
10 Aspirin 75mg Tablet
11 Losartan Potassium 50mg Tablet
Hydrochlorothiazide 12.5mg
12 Losartan Potassium 25mg, 50mg Tablet
13 Telmisartan 40mg, 80mg Tablet
14 Olmesartan 10mg, 20mg, 40mg Tablet
Cns-Neuro
1 Sumatriptan 50mg Tablet
2 Olanzapine 10mg Tablet
3 Pregabalin 75mg Tablet
4 Methylcobalamin 500mcg, 1000mcg and Tablet
1500mcg
5 Chlorpromazine 25mg Tablet
6 Alprazolam 0.5mg Tablet
 Gastrointestinal
1 Sucralfate 1mg Syrup Syrup
2 Omeprazole 40mg Injection
3 Pyrantel Pamoate 250mg Tablet
4 Pyrantel Pamoate 250mg Syrup Syrup
5 Pantoprazole 40mg Tablet
6 Pantoprazole 40mg and Domperidone Tablet
30mg
7 Rabeprazole 20mg Domperidone 10mg Tablet
8 Rabeprazole 20mg Domperidone 10mg Capsule
9 Rabeprazole 20mg and Itopride 150mg Tablet
Hormones
1 Trenbolone Enanthate 100mg Injection
2 Stanozolol 100mg Injection
3 Stanozolol 5mg/10mg Tablet
4 Stanozolol 50mg Injection
5 Turinabol 10mg Tablet
6 Trenbolone cyclohehylmethylcar 76mg Injection
7 Trenbolone Acetate 100mg Injection
8 Trenbolone Suspension AQ 50mg Injection
9 Trenbolone Enanthate 100mg, 200mg Injection
10 Testosterone Base 100mg Injection
11 Mifeoristone 200mg Tablet
12 Trenbolone Hexahydrobenzylcarbonate Injection
76.5mg
13 Testosterone Compound 250mg Injection
14 Testosterone Propionate 100mg Injection
Ointment
1 SCAR CLEAN Ointment
2 PAINBLOW Ointment
3 FUSILON Ointment
4 DYACHE GEL Ointment
5 DURNOL Ointment
6 DUBIC PLUS GEL Ointment
7 CORTIS Ointment
8 COPZOLE Ointment
9 COPICIN Ointment
10 COPDIN-M Ointment
11 COGEN Ointment
12 CLINDA Ointment
13 CLEANITIZER Ointment
14 ALOE WERA Ointment
Respiratory-Antiallergies
1 Cetirizine 10mg Tablet
2 Loratadine 10mg Tablet
3 Levocetirizine 5mg and Montelukast 10mg Tablet
4 Levocetirizine 5mg Tablet
5 Montelukast Sodium 10mg Tablet
Urology-Infertility
1 Tamsulosin HCI 0.4mg and Finasteride Tablet
5mg
2 Tamsulosin HCI 0.2mg, 0.4mg Tablet
3 Tamsulosin 0.4mg prolonged release Capsules
4 Sildenafil Citrate 100mg, Tablet
5 Vardenafil 20mg Tablet
6 Finasteride 5mg Tablet
Health-Supplements
1 Multivitamin with Vitamin B1, B2, B3, B6 Tablet
and Vitamin C
2 RIBOFLAVIN Tablet
3 Pyridoxine Hydrochloride 50mg Injection
4 Ferrous Sulphate 150mg and Folic Acid Capsule
1.5mg
5 Vitamin B1, B6 and B12 Injection
6 Methylcobalamin 500mcg, 1000mcg and Injection
1500mcg
 CONCLUSION

I have undergone industrial visit at Dehradun. During this visit I have seen
various production & Quality control departments of “COOPER PHARMA
LIMITED ,In this company I saw the different production section like Tablet,
Capsule & Liquid Section including Packaging Section, QA & QC sections
respectively during industrial visit.

I found that production was carried out on job flow & Batch production system.
All the companies were reflecting the standard modes of manufacturing & other
process involved in production.

As being a budding scientist in pharmacy discipline, I cultivated my knowledge

with taking in my account of best methodologies in that functional operational
system of companies in my Seven days visit by interacting with people over
there and come to know how social practical & intellectual relation in full
fledged manner.

G.M.P. & S.O.P. methodologies of the company was reflecting the standard mode
of manufacturing, maintenance of machinery & other process involved in
production & quality control. Quality control department is fully equipped with
highly sophisticated & modern analytical instrument for presenting a authentic
perspective of product quality which is responsible for goodwill of company.

Last but not least, I made myself highly profile by governing the knowledge in
connection & coordination which the company transaction which will be
incredibility lucrative in my professional regard & of coarse given me a
accelerated drift to serve the society & acting as a panacea for mortality &
reducing the morbidity of human health ailment & providing long lasting life
safe guard to them.