509 - Industrial Report

PRESENTATION ON
INDUSTRIAL TRAINING
PERFORMED AT MEDIWIN
PHARMA CEUTICALS, NARODA
GIDC, DIST-AHMEDABAD.
PRESENTED BY
PANARA KUSHKUMAR U.
M. Sc Organic Chemistry
(SEM-4TH)
Roll NO-16
SHRI P.H.G Muni Arts& Science College KALOL,
Boradi.
DECLARATION
I Panara Kushkumar U., hereby declare that work presented in

the industrial training report entitled in INDUSTRIAL
TRAINING PERFORMED AT MEDIWIN
PHARMASEUTICALS, NARODA GIDC, DIST-
AHMEDABAD.
It is an authentic record of work carried out by
me during 04.01.2023 to 25.01.2023 at MEDIWIN
Pharmaceuticals Naroda, under the guidance of GUJARAT
University, AHMEDABAD. Is being submitted for partial
fulfilment of the requirement for the award of MASTER
degree in Organic Chemistry. This is not been submitted
anywhere else for the award of any other degree/diploma.
Date- 25.02.2023
Place- AHMEDABAD
Submitted By- PANARA KUSHKUMAR UMESHBHAI.
Training Report | MEDIWIN PHARMA

PHARMACEUTICALS 2
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TRAINING CERTIFICATE

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ACKNOWLEGMENT
It is a matter of pleasure and happiness to make and submit

this industrial training report during course of the completion
of this industrial work. Many of the persons have offered their
valuable and enormous support.
I’m thankful to all my teachers of Shri P.H.G Muni
Arts& Science College, Kalol ,GANDHINAGAR. For
their blessings and encouragement.
I would like to express my special thanks and gratitude to
MEDIWIN PHARMACEUTICALS and Mrs.YATRI
MISTRY for providing all the essential facilities which were
required for this training.
Finally, I express my regards to my beloved parents who
inspired me throughout my studies and completion of this
training.
PANARA KUSH.
Fourth SEM
(M.Sc)
Roll no-16

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INDEX
SR. NAME OF CONTENT

NO.
1 Introduction
2 Vision, Mission and Values
3 List of Products
4 Layout
5 Tablet and Orals Introduction
6 Details about Tablet and Oral

Liquids
7 Quality Control Section
8 Equipments
9 Conclusion

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INTRODUCTION
Location- MEDIWIN PHARMACEUTICALS

Plot 128A ,Phase 1&2
,NARODA GIDC, Dist.-
Ahmedabad- 380038
India.
Site Capabilities-
 Manufacturing Facility- Vitamins & Minerals Premixes
Processing, Primary Packing, Secondary Packing, and
Sachet filling machine
 General Tablets Granulation Area, Three
Compression cubicles and three packing lines
 State of art Quality laboratory-
 Qualified and competent staff
 Separate Wet and Instrument Lab
 Microbiology Setup
 Labs are well equipped with latest infrastructure.


PHARMACEUTICALS 7
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Salient Features-
 Total Land Area- 35 Acres
 Total construction area- 24,500m2
 Four separate manufacturing facilities-
 General Tablets
 Oral liquids, Sugar coated Tablets, and
Vitamins& Minerals Premixes for Human
Nutrition Health
 Vitamins and minerals premixes for
Animal Nutrition Health
 Herbal Plant
 The company manufactures and exports cosmetics,
dietary supplements, sweeteners, OTC products,
phytochemicals, and natural extracts.
CERTIFICATIONS

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Export
With lots of hard work and effort, Mediwin has become the
manufacturer and exporter of 225 products in 20 countries. Our products
are in 3 categories- Pharmaceutical Formulation, Nutraceuticals,
Cosmetics and skin care.
In South East Asia- We export to Myanmar, Cambodia, Philippines,

Vietnam, Hong Kong, Mongolia and Srilanka.
Central Asia & CIS– Yemen, Uzbekistan, Kazakhstan, Turkmenistan,

Georgia.
Africa- Nigeria, Ghana, Zambia, Kenya.
Latin America- Bolivia, Chile, Ecuador, Honduras, Guatemala
Western Asia- Azerbaijan

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VISION, MISSION & VALUES
Vision-
MEDIWIN Pharmaceuticals Solutions are the leading
healthcare professionals with a top ranking position in
(INDIAN DRUG MANUFACTURING
ASSOCIATION). MEDIWIN Pharmaceuticals are
leading manufacturer in Vitamins and Minerals
Premixes and Exporter of the same.
Mission-
We Shall ensure the Quality, reliability, and innovation
thereby enhancing the sustainability and values for all
stakeholders. We are currently exporting 225 products
in 20 countries and are targeting to export 350+
products in 50 countries by 2030.
Values-
 Knowledge- Expertise and Innovation

 Action- Entrepreneurship and Integrity
 Care- Trusteeship and Humiluty
 Impact- Performance and Resilience
The values that guide our culture are embodied in

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our purpose-
“Doing Well and Doing Good ”

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LIST OF PRODUCTS
1. Bactrim Syrup
2. Becozym C Forte
3. Paraxin Suspension

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4. Basiton C forte with Biotin Tablet
5. Bayers Tonic
6. Vitamin C Chewable

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7. Saridon Tablets
8. Benadon Tablets
9. Phosformin Tonic

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Layout

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Layout Of Orals Manufacturing Section

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Layout Of Tablet Manufacturing

Section

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Tablet and Oral Liquids
Tablets: Tablets is a pharmaceutical dosage form.

Tablets may be defined as the solid unit dosage form of
medicaments with or without diluents and prepared by
molding or compression. It comprises of active
substances and excipients. Usually in prepared powder
form, Pressed, or compacted from a powder into a solid
state. The excipients can include diluents, binders,
granulating , lubricating ,to ensure the efficient tableting.
Sweetners to give the flavor, disintegrants to promote the
break of tablet in stomach, and so on. The polymer
coating is done to make the tablet swallow easily.
The compressed tablet is most popular dosage form used

today. About two third of all prescriptions are dispensed
as solid dosage forms, and half of these are compressed
tablets. A tablet can be formulated to deliver an accurate
dosage to specific site. It is usually taken orally but can
be administered sublingually, buccally, rectally, or
intravaginally.
Advantages of Tablets:
1. Cost is lowest of all oral solid dosage forms

2. Lighter and compact.

PHARMACEUTICALS 19
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3. Easiest and cheapest to package and strip.

4. Sustained released product is possible by
enteric coating.
5. They are unit dosage forms and offer the greatest
capabilities of all oral dosage form for greatest
dose precision and the least content variability.
Disadvantages of Tablets:
1. Difficult to swallow in case of childrens and
unconsious patients.
2. Some drugs resist compression into dense
compacts, owing to amorphous nature, low density
character.
Orals Liquids: Oral liquids are the homogeneous

liquid preparations, usually contains a solution, an
emulsion or a suspension or one or more active
ingredients in a suitable liquid base. They are prepared for
oral administration rather as such or after dilution. They
may contain other substances such as suitable dispersing,
solubilizing, wetting, emulsifying, stabilizing, and
antimicrobial substances for preservation.
They may also contain suitable sweetening agents,
flavoring agents and permitted colored agents. If sodium
saccharin or potassium saccharin is used for sweetening,
then its concentration in pediatric preparations should not
be more than 5 mg per kg of body weight

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Types of Oral Liquids:

1. Syrup
2. Oral Suspension
3. Oral Solution
4. Oral Drops
5. Oral Emulsion
6. Mixture
7. Linctus
8. Elixir
Advantages of Oral Liquids:

1. Immediate available for absorption.
2. Easy administration
3. Bitter drugs can be given by this route
Disadvantages of Oral Liquids:

1. Less stable compare to solid dosage forms.
2. They are bulky and difficult for store and transport.
3. Incompatibility is more.

PHARMACEUTICALS 21
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DETAILS OF TABLET AND ORAL

LIQUODS
Tablet Manufacturing:
Manufacturing of the tableting blend:
In the tablet pressing process, the main guideline is to ensure

that the appropriate amount of the active ingredient is in each
tablet. Hence all the ingredients should be mix well. If the
sufficiently homogeneous mixture of the components cannot
be obtained with simple blending processes, the ingredients
must be granulated prior to compression to assure an even
distribution of the active compound in the final tablet. Two
basic techniques are used to granulate the powders for
granulation into the tablets. Wet granulation and Dry
granulation. Powders that can be mixed welled do not require
granulation and can be compressed into tablets through direct
compression.
1. Wet granulation
Introduction:
The most widely used process of agglomeration in a

pharmaceutical industry is wet granulation. Wet
granulation process simply involve the wet mass of the
powder blend with a granulating liquid. Wetting size
and
PHARMACEUTICALS 22
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drying are important steps in involved in the wet

granulation.
Process:
1. Mixing of the drugs and excipients.

2. Preparation of the binder solution
3. Mixing of the binder solution with powder solution to
form wet mass.
4. Drying of the moist granules.
5. Mixing of the screened granules with disintegrant,
lubricant and glidant.
The wet granulation technique has

some limitations.
2. Dry
granulation:
Introduction:
In dry granulation process the powder mixture is

compressed without the use of solvent and heat. It is the
least desirable of all method of granulation. The two
basic procedures are to form compact of material by
compression and then mill to the compact to obtain a
granules. Two methods are used for dry granulation.
PHARMACEUTICALS 23
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The most widely used method is slugging where the
powder

PHARMACEUTICALS 24
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is recompressed and the resulting tablet or slug are

milled to yield the granules. The other method is to
precompress the powder with the powder with
pressure rolls using a machine such as Chilosonator.
Roller compaction:
The roller compaction of powder by means of pressure

roll can also be accompanied by machine called
Chilosonator. Unlike tablet machine the chilosonator
turns out a compacted mass in a steady continuous flow.
The powder is fed down between the powder into the
compaction zone like slugs. The aggregates are milled or
screened out for the production into granules.
Processing Steps:
1. Selection of raw materials

2. Weighing
3. Size Reduction
4. Mixing (Precompression or slugging)
5. Screening
6. Lubrication
7. Compression
This method has also some advantages and
disadvantages too.

PHARMACEUTICALS 25
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3. Direct compression:
This method is used when a group of ingredients can be

blended and placed in a tablet press to make tablet
without any of the ingredients having to be changed.
This is not very common because many tablets have
active pharmaceutical ingredients which will not allow
for direct compression due to their concentration or
excipients used in formulations are not conductive to
direct compression. Granulation is the process of
collecting particles together by creating bonds between
them.
This method is utilize simple operation it requires mixed
all the ingredients then go for the direct compression
using compressor machine. This method used when the
small dose of drug is directly used with diluent.
Manufacturing of Tablet:
First the powder is filled into the die from above. The
mass of powder is determined by the position of the
lower punch in the die, the cross section area of the die,
and the powder density. At this stage adjustment to the
tablet weight are normally made by repositioning the
lower punch. After the die filling upper punch is lowered
into the die and the powder is uniaxially compressed to a
porosity of between 5 and 20%. The compression can
takes place in one or two stages and for commercial
production occurs very fast. Finally the upper punch is
pulled up and out of the die and the tablet is ejected from
the die by lifting the lower punch until its upper surface

PHARMACEUTICALS 26
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is flush with the top face of the die. Ths process

is repeated for each tablet.
Common problems encounter in during tablet

manufacturing operation include:
 Fluctuations in tablet weight, usually caused by uneven
powder flow into the die due to poor powder flow
properties.
 Fluctuations in dosage of the active pharmaceutical
ingredient, caused by uneven distribution of the API
in the tableting blend.
 Sticking, mottling ,orange pill effect ,capping,
lamination, etc., are the problems were encounter in the
tablet manufacturing.
Tablet Coating:
An application of coating material to the exterior of tablet
with the intension of conferring benefit and properties to the
dosage form over uncoated variety.
Objective:
 To mask color, odor and taste of drug.
 To provide physical and chemical protection to drug.
 To control release of drug from the tablet.
 To provide physical elegance.

PHARMACEUTICALS 27
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Types of Tablet Coating

 Sugar coating
 Film coating
 Press coating.
The materials used for coating may largely comprise

sucrose, water soluble film coating polymers or
substances which are soluble in intestinal secretions
but not in those of the stomach. This types of coating
can be applied by the pan or fluid bed processes. The
compression coating technique is suitable for sugar
and enteric coatings but not for film. The tablet
coating contains use of polymer , coloring agent, etc.

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Orals Liquids
Steps for manufacturing of oral liquids;
1. Planning of Material Requirement

2. Liquid Preparation
3. Filling
4. Labeling
5. Packaging
6. Sales of Drug Products
The above mentioned steps are usually involved in

the manufacturing of the oral liquids formulations in
stepwise manner. Each step has its unique role in the
process of manufacturing of the pharmaceutical oral
liquid dosage form.
The most important step in the manufacturing is the
planning of material requirement it usually done by the
quality peoples. By the proper planning one can set the
benchmark for the manufacturing. Liquid preparation is
another step which is play important role. Here the 75%
of work is done of the manufacturing of oral liquid.
Then filling and labeling are also done with the help of
labor assign to the same purpose.
After labeling packing is done to ensures the products
used for the mankind. Lastly the most important phase
of the oral liquid manufacturing is get performed called
sales of the drug products.

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List of the equipments used in the manufacturing:
1. Mixing and storage tank

2. Portable mixer
3. Colloid mill
4. Filter press
5. Semi automatic bottle filling machine
6. Water still
7. Labeling Machine
Formulation of Oral Liquids:
1 .Drug and range of excipients includes

a) The vehicle: purified water and oil
2. Co-solvents: Propylene glycol and glycerine
3. Surfactants: To enhance the surface activity
4. Preservatives: Used against microbial contamination
5. Sweetening agents: Glucose, saccharin, aspartame
6. Buffering agents: To regulate the pH of formulation
7. Antioxidants: BHA and BHT

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Evaluation of Oral Liquids:

1. Uniformity of content
2. Uniformity of weight and volume
3. Test for bacterial endotoxin
4. Leaker test
5. Pyrogen test
6. Clarity of solution.

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Quality Control Section
It is the essay method in substance such as drugs,

packing, material , raw material, adjuvant , containers are
checked according to the monograph as per standards
given to the pharmacopoeia.
Following are the equipments used in QC section:
1. Magnetic stirrer
2. Electronic and simple balance
3. Capsule disintegration tester
4. Dissolution test apparatus
5. pH meter
6. Autoclave
7. UV and visible spectrophotometer
8. Leaker test apparatus
9. HPLC

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1. Autoclave: Autoclave is a device used to sterilize the

equipment and supply by subjecting them to high
pressure saturated at 121 degree Celsius for around 10-15
minutes.
Autoclave
2. pH meter: A pH meter is an electronic device used for

the measuring the pH of liquid formulation. A typical
pH meter consist of a special measuring probe connected
to an electronic meter that measure the display the pH
reading.

PHARMACEUTICALS 33
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pH Meter
3. Dissolution Test Apparatus: In this apparatus the

dissolution study of tablet is carried out . A single tablet
is taken and placed in wire mesh basket connected to
variable speed motor by means of a shaft this basket is
immersed in the dissolution medium contain in 100ml;
flask. The flask is maintained at 37+-0.5 degree Celsius
by means of constant temp bath. Motor is adjusted to
specified speed and samples of fluid are withdrawn at
regular time interval to determine the amount of drug in
the solution.

PHARMACEUTICALS 34
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Dissolution Test Apparatus
4. UV-Visible Spectrophotometer: UV Visible

spectrophotometer is used in pharmaceutical industry due
to its various applications. It is one useful in detection of
impurities, Food industry, forensic science, qualitative
and quantitative analysis are carried out with the help of
the same.
UV-Visible Spectrophotometer
PHARMACEUTICALS 35
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CONCLUSION
In the end I am glad to tell you that training in
MEDIWIN PHARMACEUTICALS NARODA DIST-
AHMEDABAD was an excellent and fabulous experience.
During the training I actually learned about the
pharmaceutical company and above its working the
theoretical knowledge is worth for getting a degree, and it
is accessible in the book. We can only imagine about the
thing we read, but practical life is always different and
excellent one. During My training period, I had seen the
various instruments and apparatus in the industry. The
highly sophisticated instruments that work precisely must
be operated with intense care for optimum use. We could
acquire a lot of information regarding the latest instruments
and their working procedures.
Similarly from practical point of view a
pharmaceutical company is very difficult. During the
training session I tried to my level best to gain practical
knowledge as much as I can. I improved my basic classified
doubts and also understood the importance of maintaining
of quality of products at Pharmaceutical company.
I was successfully able to complete my short venture
of training. Lastly I hope that my training report fulfill
the intended requirements.
- Regards
PANARA KUSH U.
Second Year M.Sc
(Sem-4th)

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PHARMACEUTICALS 37
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Notes

PHARMACEUTICALS 38

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PRESENTATION ON

I Panara Kushkumar U., hereby declare that work presented in

Training Report | MEDIWIN PHARMA

Training Report | MEDIWIN PHARMA

It is a matter of pleasure and happiness to make and submit

Training Report | MEDIWIN PHARMA

Training Report | MEDIWIN PHARMA

SR. NAME OF CONTENT

2 Vision, Mission and Values

5 Tablet and Orals Introduction

6 Details about Tablet and Oral

Training Report | MEDIWIN PHARMA

Location- MEDIWIN PHARMACEUTICALS

Training Report | MEDIWIN PHARMA

Training Report | MEDIWIN PHARMA

In South East Asia- We export to Myanmar, Cambodia, Philippines,

Central Asia & CIS– Yemen, Uzbekistan, Kazakhstan, Turkmenistan,

Africa- Nigeria, Ghana, Zambia, Kenya.

Latin America- Bolivia, Chile, Ecuador, Honduras, Guatemala

Western Asia- Azerbaijan

Training Report | MEDIWIN PHARMA

Training Report | MEDIWIN PHARMA

VISION, MISSION & VALUES

 Knowledge- Expertise and Innovation

The values that guide our culture are embodied in

Training Report | MEDIWIN PHARMA

Training Report | MEDIWIN PHARMA

4. Basiton C forte with Biotin Tablet

Training Report | MEDIWIN PHARMA

Training Report | MEDIWIN PHARMA

Training Report | MEDIWIN PHARMA

Layout Of Orals Manufacturing Section

Training Report | MEDIWIN PHARMA

Layout Of Tablet Manufacturing

Training Report | MEDIWIN PHARMA

Tablet and Oral Liquids

Tablets: Tablets is a pharmaceutical dosage form.

The compressed tablet is most popular dosage form used

1. Cost is lowest of all oral solid dosage forms

Training Report | MEDIWIN PHARMA

3. Easiest and cheapest to package and strip.

Orals Liquids: Oral liquids are the homogeneous

Training Report | MEDIWIN PHARMA

Types of Oral Liquids:

Advantages of Oral Liquids:

Disadvantages of Oral Liquids:

Training Report | MEDIWIN PHARMA

DETAILS OF TABLET AND ORAL

In the tablet pressing process, the main guideline is to ensure

The most widely used process of agglomeration in a

drying are important steps in involved in the wet

1. Mixing of the drugs and excipients.

The wet granulation technique has

In dry granulation process the powder mixture is

Training Report | MEDIWIN PHARMA

is recompressed and the resulting tablet or slug are

The roller compaction of powder by means of pressure

1. Selection of raw materials

Training Report | MEDIWIN PHARMA

This method is used when a group of ingredients can be

Training Report | MEDIWIN PHARMA

is flush with the top face of the die. Ths process

Common problems encounter in during tablet