Angela

Quismundo
Creative Portfolio
 Years of Experience
English tutor for 2 years both online and
face-to-face classes.
Angela Handled Beginner students,intermediate,
University student, and Business class
Quismundo student

Notable Achievements to Share

Creative
Attended several pieces of training.
Portfolio
 Education

High School
I save lives under the
I graduated from Holy College microscope.
Angel University,
Angeles Pampanga Pre-med course
Bachelor of Science in
Medical Laboratory
Sciences.
University of Baguio
 CANCER AS A
MITOCHONDRIAL
METABOLIC
DISEASE
Dr. Thomas Seyfried
Lesson Outline

Cancer

Specific Types of Cancer

Managing Cancer
I'd like to start this off basically to present a report card on
our approach to managing cancer and as I said
I'm going to speak to you today about cancer in
general and also focus on specific types of cancer
in particular glioblastoma as kind of an illustrative
example of our approach to managing the
disease.
Glioblastoma- also referred to as a grade IV astrocytoma, is a fast-
growing and aggressive brain tumor. It invades the nearby brain
tissue but generally does not spread to distant organs. GBMs can
arise in the brain de novo or evolve from lower-grade astrocytoma.
These are the numbers that we can take from the American
Cancer Society published every year data, Dr. Seyfried compiled
the last five years' data from the year 2013 to 2017, and you can
see these are pretty sobering numbers
"pretty sobering numbers"
Sobering
Adjective
creating a more serious,
sensible, or solemn mood.
You'll notice that the deaths per day and year exceed that of
the new cases are not good just to put things into perspective
the population increased in the United States over the same
period of time.

It was about 2.9 percent so you know how is this war on cancer
going right you look at the numbers you can make your own
decision these are numbers you don't see on TV, OPDIVO and
Katroo - and it's not kind of stuff but you don't see the
constant increase in deaths per day so the question we have
to ask ourselves, you know what's going on here, you know how
can we're not getting success here.
 This is a failure of monumental proportions right the
Numbers, these are large numbers in China's 8,000 over 8,000 a day. In
China dying from cancer. Cancer is already superseded heart disease in
China, so you know we go out and we raise money for cancer right you all
know run, jump I don't know if you do Cross Fit for cancer but everybody
raises money for cancer makes them feel good. Nobody asks how much of
the money we raise goes to cancer research and what's more important
kind of research you're doing with all that money the federal government
spending millions of dollars on cancer research, and people are raising
money to stand up to cancer.
Look at more, the more money we raise for cancer the more cancer
we get
 su·per·sede
Verb
Take the place of (a person or thing previously in
authority or use)

Example: "The older models have now been

superseded"
Synonyms: Replace, supplant, take the place of, take
over from, substitute for.
FUNDAMENTAL MISUNDERSTANDING

so you have to say what is going on here

how do you explain this, it has to do with a
fundamental misunderstanding of what
the nature of this disease is we've been led
to believe that this is a genetic disease and
I'll present evidence to say that it's NOT.
 FUNDAMENTAL MISUNDERSTANDING

And we know that there's a simple

cartoon of a cell with a nucleus and
mitochondria and cell membrane so we
know there are mutations in the nucleus
but we also know that in the
mitochondria their defects as well.
 NUCLEUS

A nucleus, as related to genomics,

is the membrane-enclosed
organelle within a cell that
contains the chromosomes.

An array of holes, or pores, in the

nuclear membrane allows for the
selective passage of certain
molecules (such as proteins and
nucleic acids) into and out of the
nucleus.
 MITOCHONDRIA

Mitochondria are
membrane-bound cell
organelles that generate
most of the chemical
energy needed to power the
cell's biochemical reactions.

known as the "Power house

of the cell"
 FUNDAMENTAL MISUNDERSTANDING

And I'll be showing you data that shows that

the origin of this disease is a mitochondrial
metabolic abnormality it's not a nuclear
genetic disease and the mutations that you
see in the nucleus are actually coming from
reactive oxygen species produced by the
mitochondria so what the entire field has
been doing over the last six or seven decades
is chasing red herrings consequently you
have sixteen hundred people a day dying
from the disease.
 Did You Know?
The current Dogma is cancer, a genetic
disease and this is solidified in this major
paper hallmarks of Cancer by Hannah and
Weinberg.

Dog. ma
noun
a principle or set of principles laid down by an authority as
incontrovertibly true.

 Did You Know?

Hannah and Weinberg wrote highly cited
papers in the entire cancer field and what they
say is "cancer cells carry the oncogenic and
tumor suppressor mutations" that define
cancer as a genetic disease.
And we say it's a Dogma because it's presented as if
it's an irrefutable truth something that said dogmas
are no longer questioned it's at this solidified
viewpoint

 THANK YOU FOR LISTENING

IF YOU HAVE QUESTIONS AND
CLARIFICATIONS
, DON'T HESITATE TO ASK :)
 Learning Outcomes

Name the scientists who discovered DNA's structure.

Cite the characteristics of DNA.

Explain the primary function of DNA.

 CHARACTERISTICS OF DNA

Hydrogen bonds between complementary bases hold DNA's two polynucleotide chains.

Base Pairs

Adenine (A) bonds with thymine (T).

Cytosine (C) bonds with guanine (G).

 FUNCTION OF DNA

It stores genetic information necessary for

organisms to develop, survive, and reproduce.

Damage to DNA may cause cells to stop

dividing, cell death, or become malignant.
 SUMMARY

DNA Characteristics
The Discovery DNA is made of nucleotide monomers.
The double-helical The four bases are adenosine, thymine,
model came from cytosine, and guanine.
the combined work
of Watson, Crick,
Franklin, and Wilkins.
DNA Function
DNA stores an organism's genetic information.
 ASSIGNMENT

How does DNA replication occur?

Use a graphic organizer to show
the step-by-step process.
 REFERENCE

CK-12. "DNA Structure and Replication."

Retrieved November 30, 2022 from
https://flexbooks.ck12.org/cbook/ck-12-biology-
flexbook-2.0/section/4.3/primary/lesson/dna-
structure-and-replication-bio/#modality-title
 Use these elements and illustrations in your Canva Presentation.
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