04/10/2017 Medical ozone therapy for the inner ear acoustic trauma - ScienceDirect

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Outline

Abstract
Keywords
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusion
Funding
Conflict of interest
Acknowledgements
References

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International Journal of Pediatric Otorhinolaryngology

Volume 77, Issue 9, September 2013, Pages 1512-1517

Medical ozone therapy for the inner ear acoustic trauma

Alper Yenigun a , Fadlullah Aksoy b, Remzi Dogan b, Fahrettin Yilmaz c, Bayram Veyseller b, Orhan Ozturan b,
Burak Ozturk d

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04/10/2017 Medical ozone therapy for the inner ear acoustic trauma - ScienceDirect

https://doi.org/10.1016/j.ijporl.2013.06.020 Get rights and content

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Abstract

Objectives
The goal of the study was to look at the potential protective effect of ozone therapy by
studying its antioxidant and vasodilatation effects against hearing loss caused by acoustic
trauma.

Methods
Thirty-two male Wistar Albino rats were divided into four groups of eight. The 1st group was
exposed to acoustic trauma, the 2nd group was treated with ozone initially, and was
exposed to acoustic trauma 24 h later, the 3rd group received ozone without trauma, while
the 4th group was the control group. The 1st and 2nd groups were exposed to acoustic
trauma with 105 dB SPL white band noise for 4 h. DPOAE and ABR tests were conducted in
all groups on the 1st, 5th, and 10th days after trauma.

Results
In the 1st group, the effects of acoustic trauma continued on days 1, 5 and 10. The 2nd
group's DPOAE and ABR results on days 5 and 10 showed significant improvement at all
frequencies compared to deterioration on day 1, and the readings were comparable to
baseline measurements.

Conclusion
Acoustic trauma is a pathology that is experienced frequently and leads to many problems
in terms of health and cost. Ozone was demonstrated to be a reparative substance against
acoustic trauma and, in addition, it can be supplied and applied easily.

Keywords
Acoustic trauma; Ozone therapy; Inner ear; Otoacoustic emission; Auditory brainstem
response

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