Apiaceae Nutraceuticals

Nutraceutical Potential of Apiaceae
44
Milica G. Aćimović
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1312
2 Bioactive Compounds of Apiaceae . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1313
2.1 Phenolic Compounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1313
2.2 Polyacetylenes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1316
2.3 Terpenoids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1316
3 Nutraceutical Potential of Apiaceae . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1319
3.1 Anethum graveolens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1319
3.2 Angelica archangelica . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1319
3.3 Apium graveolens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1320
3.4 Carum carvi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1320
3.5 Coriandrum sativum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1321
3.6 Cuminum cyminum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1321
3.7 Daucus carota . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1322
3.8 Foeniculum vulgare . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1322
3.9 Levisticum officinale . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1323
3.10 Pastinaca sativa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1323
3.11 Petroselinum crispum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1324
3.12 Pimpinella anisum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1325
4 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1325
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1326
Abstract
Apiaceae family is large, with over 3.000 species worldwide cultivated for many
purposes. Some plants in this family such as carrots, parsley, parsnip and celery are
common vegetable crops, while other members like anise, caraway, coriander,
cumin, fennel, lovage, angelica and dill are famous for their medicinal and
M. G. Aćimović (*)
Department of Alternative Crops and Organic Agriculture, Institute of Field and Vegetable Crops,
Novi Sad, Serbia
e-mail: acimovicbabicmilica@gmail.com
# Springer Nature Switzerland AG 2019 1311

J.-M. Mérillon, K. G. Ramawat (eds.), Bioactive Molecules in Food, Reference Series in
Phytochemistry, https://doi.org/10.1007/978-3-319-78030-6_17
1312 M. G. Aćimović
aromatic properties. Usage of these plants is very popular in everyday diet because
of their documented health benefits. Apiaceae are a very important source of
phytochemicals – chemicals with biological activity. However, phytochemicals
are non-nutritive plant chemicals, also called nutraceuticals. They are widely used
for prevention, treatment or cure of conditions or diseases. Bioactive compounds
with nutraceutical potential are polyphenolic compounds, polyacetylenes and
terpenoids. The aim of this review is to represent selected plants of Apiaceae
family currently used as nutraceuticals and describe their nutritional benefits.
Keywords
Vegetable · Spices · Biological activity · Food · Nutrition · Phenolics ·
Polyacetylenes · Terpenoids
Abbreviations
CAE Caffeic acid equivalent
CE Catechine equivalent
DW Dry weight
FW Fresh weight
GAE Gallic acid equivalents
QE Quercetin equivalent
TFC Total flavanoids content
TPC Total phenolic contents
1 Introduction
Apiaceae (Umbelliferae) family is large, with over 3.000 species worldwide culti-
vated for food, as vegetables, herbs, spices or for medicinal purposes. Some plants in
this family such as carrots, parsley, parsnip and celery are common vegetable crops,
while other members like anise, caraway, coriander, cumin, fennel, lovage, angelica
and dill are famous for their medicinal and aromatic properties [1].
The plants from Apiaceae family are mainly temperate herbaceous annual (anise,
caraway, coriander, cumin, dill, sweet fennel), biannual (carrot, parsley, parsnip,
celery) or perennial (angelica, lovage, bitter fennel). Leaves are alternate on stem or
arranged in leaf rosette (mainly in the first year of development in biannual and
perennial members). In all the mentioned species, stem is erect and hollow, and in the
upper part is branch. Each branch finishes with an inflorescence. The small and
simple flowers are generally arranged into compound umbels. They have five petals
that are usually white or yellow, with five stamens, and an ovary with two carpels.
The fruit that develops from this ovary varies considerably between the spices.
Generally the fruit are schizocarps, which contain two seeds.
All Apiaceae plants contain a well-developed secretory system in all plant parts,
such as schizogeneus secretory cavities in the root, phloem in the stem and leaves
and clearly-delimited tissue known as vittae in the fruit. These structures are
important for depositing essential oils, which give the specific odor and flavor to
44 Nutraceutical Potential of Apiaceae 1313
each plant. Due to their flavor, a large number of plants from this family are used as
vegetables or spices [2].
Plants from the Apiaceae family are a very important source of nutraceuticals.
Their usage is very popular in everyday diet because of their documented health
benefits. The figure below shows members of Apiaceae family and their parts which
are usually used. For example, caraway, cumin, aniseed are exclusively used as seed,
while dill and coriander are used as seed and leaves, and from carrot seed and root. In
case of fennel, apart from seed and leaves, succulent leaf stalks are also used. Celery
is used in a similar way. From lovage, parsley and angelica, the root is also used
together with above-ground parts (Fig. 1).
2 Bioactive Compounds of Apiaceae
Bioactive compounds can be divided into two groups: phytochemicals which are
non-nutritive plant chemicals, also called nutraceuticals, and nutrients which include
minerals, proteins, fibers, carbohydrates, fats, etc. However, nutraceuticals possess
biological activity, while nutrients affect the growth, development and function of
the human body.
Nutraceuticals can be designated as food with medical benefits; as indicated by its
name which is derived from “nutrition” and “pharmaceutics”. They include poly-
phenolic compounds, polyacetylenes and terpenoids [3]. Nutraceuticals are widely
used for prevention, treatment or cure of conditions or diseases [4, 5, 6]. The high
antioxidant activity of nutraceuticals is the basis for many potential benefits, among
which many for degenerative and chronic diseases [7].
2.1 Phenolic Compounds
Phenolic compounds, as one of major bioactive nutraceutical ingredients in plants,

are responsible for the organoleptic characteristics of plant-derived foods and bev-
erages, particularly color and taste properties and they also contribute to the nutri-
tional qualities of fruits and vegetables [8]. The phenolic metabolites include:
anthocyanins, anthochlors, benzofurans, chromones, coumarins, flavonoids,
flavonones and flavonols, isoflavonoids, lignans, phenols and phenolic acids, phe-
nolic ketones, phenylpropanoids, quinonoids, stilbenoids, tannins and xanthones [9].
The antioxidant property in many plants is related to the presence of phenolic
compounds. Nutritionally, these compounds are responsible for increasing the
shelf life of foods as well as slowing the lipid, protein and enzymatic oxidation, as
well as for providing protection against development of cancers, cardiovascular and
liver diseases, diabetes, osteoporosis and neurodegenerative diseases in humans [10,
11, 12, 13, 14]. However, the content of biologically active substances, among them
polyphenols in plants, depends on various factors such as: area in which the plant is
grown (agrochemical characteristic of soil), climatic conditions in the region during
the growing season, cultivation technology but also the variety [15]. Apart from this,
Fig. 1 Plants from Apiaceae family with their parts which are usually used in nutrition
total phenolic contents depend also on postharvest processing (fresh, dry, freeze
herb), solvents used for extraction (water, ethanol, acetone, etc.) and significantly
varies due to plant material (seed, herb, root) etc. Review of total phenolic content
according to literature is shown in Table 1.
Table 1 Phenolic compound from selected plants from Apiaceae family

Plant Phenolic compounds
Anethum TPC in dill seed methanolic extract is 773.14 mg GAE 100 g 1 dw, while
graveolens TFC is 231.84 mg QE 100 g 1 dw [16]. On the other side, TPC in fresh dill
herb acetone extract is 35.23 mg GAE g 1 dw, and content of TFC is
30.39 mg CAE g 1 dw [17]. However, TPC in dry dill herb varied from
55.46 to 71.29 mg GAE g 1 dw depend on solvents [18]. Further, fresh dill
herb acetone extract contains 19.49 mg QE g 1 dw phenolic acids, and the
dominant are chlorogenic and benzoic acids [17]
Angelica TPC in angelica roots is 11.8–17.3 mg GAE g 1 extract, while content of
archangelica coumarins is 0.91 mg 100 g 1 extract [19]. The dominant are coumarin
derivatives among which isoimperatorin, oxypeucedanin, imperatorin,
ostruthol, angelicin, bergapten, scopoletin, isopimpinellin, and xanthotoxin
[20, 21]
Apium TPC in celery seed methanol extract is 825.85 mg GAE 100 g 1 dw, and
graveolens TFC is 177.57 mg CE 100 g 1 dw, while content of tanins is 243.36 mg CE
100 g 1 dw [22]. The dominant flavonoids are apigenin, luteolin, and
kaempferol, while the dominant phenolic acids are caffeic, p-coumaric and
ferulic acid [23]
Carum carvi TPC in caraway seeds is 3.99 mg GAE g 1 dw with 42 phenolic compounds
[24]. The dominant flavonoid constituent from caraway seed is quercetin
3-glucuronide, isoquercitrin, quercetin 3-O-caffeylglucoside and kaempferol
3-glucoside [25]. Phenolic acid content in caraway seed is about 65 μg g 1
dw, with dominant chlorogenic, p-coumaric and caffeic acid [24]
Coriandrum TPC in coriander leaves extracts is 1.12 mg GAE 100 mL 1 [26], and the
sativum main flavonoids are quercetin-3-O-rutinoside, kaempferol and acacetin,
while identified phenolic acids are vanilic, ferulic and p-coumaric acid [27,
28]. Coriander seed contain TPC 0.72 g GAE 100 g 1 extract [29]. Rutin,
quercetin, chlorogenic and caffeic acid were separated and identified
flavonoids in the methanolic and ethanolic extracts of coriander seed [30]
Cuminum Acetone extract of cumin seed contains TPC between 16.50 and 18.60 mg
cyminum GAE g 1 dw, TFC between 4.99 and 5.91 mg CE g 1 dw and tannin
80.23–83.23 mg CE g 1 dw [31]. The main phenolic compounds from
cumin are quercetin, p-coumaric, rosmarinic, vanillic and trans-2-
dihydrocinnamic acids, as well as resorcinol [32]
Daucus carota TPC in the carrot root varied considerably from 19.8 to 342.2 mg GAE
100 g 1 fw depend on root color [33], and from 81.25–113.69 mg GAE kg 1
fw depend on variety [15]. However, carrot contained high amounts of
phenolic acids, flavonoids, and carotenoids. Content of ß-carotenes vary
between 24.58 and 124.28 mg kg 1 fw [15] while total ascorbic acid ranged
from 41.12 to 58.36 mg 100 g 1 fw, whereas 5-caffeolquinic acid ranged
from 30.26 to 65.39 mg 100 g 1 fw [34]
Foeniculum TPC in seed methanolic extract was 1017.29 mg GAE 100 g 1 dw, while
vulgare TFC is 695.52 mg QE 100 g 1 dw [16]. Further, also TFC in seed
methanolic extract is 9.325 mg QE g 1 dw, with dominant gallic acid
(277.131 μg g 1 dw), caffeic acid (166.062 μg g 1 dw), ellagic acid
(99.476 μg g 1 dw), quercetin (781.986 μg g 1 dw) and kaempferol
(92.856 μg g 1 dw) [35]. From the other side, fennel herb contains two
phenolic compounds, 3.4-dihydroxy-phenethylalchohol-6-O-caffeoyl-β-D-
glucopyranoside and 3΄0.8΄-binaringenin [11]
(continued)
Table 1 (continued)
Plant Phenolic compounds
Levisticum TPC in lovage leaves ranged between 359.75 and 1601.87 mg GAE 100 g 1
officinale dw, while TFC varied between 551.01–3548.33 mg CE 100 g 1 dw,
depending on postharvest treatment (fresh, frozen, dry). Phenolic
compounds present in lovage leaves are: rutine, catechin, caffeic,
chlorogenic, coumaric, sinapic, and ferulic acid [36]
Pastinaca sativa The total phenolic acid in parsnip is 5.7 mg 100 g 1 fw, while the major
soluble phenolic acid is chlorogenic acid [37]. Total content of coumarins
ranged from 115.7 to 408.5 mg 100 g 1 dw. In vegetative plant parts the
dominant are isopimpinellin and psoralen, while imperatorin was dominant
in fruit [38]
Petroselinum TPC in parsley seed is 0.62 g GAE 100 g 1 extract, while in leaves it is
crispum 0.92 g GAE 100 g 1 extract [29]. However, another study shows that TPC in
parsley leaves ranged from 15.20 to 54.20 mg CE g 1 extract, while TFC is
between 4.50 and 42.1 mg QE g 1 extract [39]. Flavonoids isolated from
aqueous extract of parsley leaves: apigenin, apigenin-7-O-glucoside or
cosmosiin, apigenin-7-O-apiosyl-(1–2)-O-glucoside or apiin and the
coumarin 2,3-dihydroxyfuranocoumarin or oxypeucedanin hydrate [40]
Pimpinella TPC in anise seed is 46.17 mg GAE 100 g 1 dw, while TFC is 17.43 mg CE
anisum 100 g 1 dw [41]. Another study shows that TPC is 42.09 mg g 1 extract, and
identified mainly flavonoids (28.08 mg g 1 extract) and phenolic acids
(14.01 mg g 1 extract). Morerover, apigenin and luteolin derivatives, as well
as caffeoylquinic acid derivatives were determined [12]
2.2 Polyacetylenes
Polyacetylenes are a group of phytochemicals that have attracted significant interest

in medicine and pharmaceutical industry in recent years due to their range of
potential health-promoting bioactivities. Polyacetylenes isolated from Apiaceae
plants include antifungal and antibacterial activity [42, 43], as well as anti-
inflamatory [44] and anticancer [45, 46] properties. They also display antidiabetic
[47] effects and have potential in the treatment of endotoxemia and inflammation
accompanied by the overproduction of NO [48]. Apart from this, they possess
neurotoxic, anti-platelet-aggregatory activity and are responsible for allergic skin
reactions [49, 50, 51]. However, polyacetylenes have a major impact on the bitter
taste in roots of parsnip, celeriac, parsley and carrot, as well as fennel bulbs [52, 53,
54, 55, 56, 57, 58, 59]. The review of polyacetilenes present in plants from Apiaceae
family according to literature is shown in Table 2.
2.3 Terpenoids
Terpenoids, especially monoterpenes and sesquiterpenes are the main constituents in

essential oils which, as volatile compounds, give fragrance to many aromatic plants
[64]. Some terpenoids are very typical for plant species from the Apiaceae family as
Table 2 Polyacetylenes from selected plants from Apiaceae family

Plant Polyacetylenes
Anethum Dill roots contain polyacetylenes such as panaxynol (C17H24O) and
graveolens falcarindiol (C17H24O2) [60]
Angelica Many species from genus Angelica contain polyacetylenes. For example,
archangelica polyacetylene from A. purpuraefolia is (+)-9(Z), 17-octadecadiene-
12,14-diyne-1,11,16-triol [61], while A. furcijuga contain ( )-falcarinol
and falcarindiol [62]. A. gigas contains: octadeca-1, 9-dien-4, 6-diyn-3, 8,
18-triol (1), 18-acetoxy-octadeca-1, 9-dien-4, 6-diyn-3, 8-diol (2) and 3, 8,
18-triacetoxy-octadeca-1, 9-dien-4, 6-diyn (3) [48]
Apium graveolens Celery root contains polyacetylenes: falcarindiol, falcarinol, panaxydiol
and 8-O-methylfalcarindiol [44, 49]
Carum carvi Aliphatic C17-polyacetylenes of the caraway are falcarinol, falcarindiol,
falcarinolone and falcarindione [52]
Coriandrum In coriander, polyacetylenes are detected but not identified [52]
sativum
Cuminum cyminum No data in the available literature
Daucus carota The most abundant polyacetylenes in cultivated orange carrots is
falcarindiol (16–84 mg kg 1 fw, followed by falcarinol (8–27 mg kg 1 fw)
and falcarindiol-3-acetate (8–40 mg kg 1 fw) [59]
Foeniculum The amount of polyacetylenes in fennel bulb ranged from 0.04 to 0.24 mg
vulgare g 1 of freeze-dried plant material [49]. Polyphenoles detected in fennel
bulb are falcarindiol, falcarindiol-3-acetate, and falcarinol [57]
Levisticum Polyacetylenes from lovage roots are: 3(R)-Falcarinol (3(R)-( )-
officinale 1,9-heptadecadien-4,6-diin-3-ol] (1) and 3(R)-8(S)-falcarindiol [3(R)-8
(S)-(+)-1,9-heptadecadien-4,6-diin-3,8-diol] (2) [43]
Pastinaca sativa Polyacetylene compounds from parsnip root are falcarinol and falcarindiol
occurring in the highest concentrations (1600 and 5770 mg kg 1 freeze-
dried material, respectively), followed by falcarinone and falcarinolone.
Moreover, parsnip seeds contain polyacetylenic C18 ketoaldehyde [55]
Petroselinum Polyacetylene from parsley root are falcarindiol (up to 2320 mg kg 1
crispum freeze-dried material), falcarinol, 8-O-methylfalcarindiol (350 mg kg 1
freeze-dried material) and panaxydiol (120 mg kg 1 freeze-dried
material) [55]
Pimpinella anisum Polyacetylenes have been reported to be present in some Pimpinella
species, such as falcarinol in P. pruatjan, pentadeca-2,4,6,8-tetraene (1),
2,8-decadiene-4,6-diene-1-al (2), 2,8-tridecadiene-4,6-diene-10-ol (3)
2,8,10-tridecatriene-4,6-diene (4) in P. major, and 2-tridecaene-4,6-diene-
8-ol-10-on in P. saxifraga [63]
they are the source of the familiar taste, for example carotol in carrot, trans-anethole
in anise and fennel, carvone in caraway and dill [65, 66, 67]. Due to their aromatic
qualities, these plants are used as supplements in everyday food in order to enhance
the smell, taste and biological values. For this reason this group will be in the focus.
Essential oils have been known to possess antioxidant and antimicrobial activities,
thereby serving as natural additives in foods and food products [68, 69]. Anti-
oxidative properties of essential oils are responsible for healing or improving
degradation processes in many diseases such as cancer, rheumatoid arthritis,
Table 3 Terpenoids from selected plants from Apiaceae family

Plant
Anethum Dill seed essential oil contains carvone and limonene as the dominant
graveolens compounds [73], while the main compounds in the herb essential oil are
α-phellandrene, apiole, dill ether, limonene, geraniol and p-cymene [74]
Angelica The main components of angelica roots essential oil are α-pinene,
archangelica δ-3-carene, β-phellandrene and limonene, while in seed it is β-phellandrene,
α-phellandrene, α-pinene, myrcene and α-copaene [75, 76]
Apium graveolens Celery essential oil contains limonene and selinene. However, the
important flavor constituents of the oil responsible for the typical aroma
are phtalides (3-n-butyl-4-5-dihydrophthalide (sedanenolide), 3-n-butyl
phthalide, sedanolide, and sedanonic anhydride) [77]
Carum carvi Caraway seed essential oil is comprised from carvone and limonene,
constituting more than 90% [66, 78, 79]
Coriandrum Coriander seed essential oil contains mainly linalool [80, 81, 82], while
sativum coriander herb oil has a significantly different composition with decanal,
trans-2-decenal, 2-decen-1-ol, cyclodecane and cis-2-dodecenal as the
main compounds [83]
Cuminum cyminum The distinctive flavor and aroma are originate from essential oil, the
dominant compounds of which are γ-terpinene-7-al, cumin-aldehyde,
β-pinene and γ-terpinene [84, 85, 86, 87]
Daucus carota Carrot root essential oil contains mainly geranyl, linalool, myristicine,
pentacosane, spathulenol and trans-γ-bisabolene. The major compounds of
aerial parts’ essential oil is alismol, trans-β-caryophyllene, myrcene,
α-humulene and β-ionone [88]. The major constituents of essential oil from
carrot seeds are carotol, sabinene, α-pinene followed by aromadendrene,
β-farnesene, sesquisabinene, trans-caryophyllene and myrcene [67]
Foeniculum The dominant compound in fennel seed and herb essential oil is trans-
vulgare anethole which gives them similar scent as to aniseed [89]. However,
fennel has two varieties: sweet and bitter. Sweet fennel (var. dulce) apart of
trans-anethole (more than 80%), contains estragole (less than 10%) and
fenchone (less than 7.5%). Bitter fennel (var. vulgare) apart of trans-
anethole (55–75%) contains fenchone (12–25%) [90]
Levisticum The lovage flavor, like the celery one, originates from essential oil where
officinale the dominant compound is β–phellandrene, while phthalides are present in
small amounts and give the characteristic fragrance [91]
Pastinaca sativa Root essential oil had the two major constituents, myristicine and terpinolene
[92]. Aerial parts contain essential oil with dominant cis-β-ocimene, hexyl
butanoate, trans-β-farnesene and lavandulyl acetate [93]
Petroselinum Major compounds in parsley essential oil are apiol, myristicin and
crispum β-phellandrene [94, 95]
Pimpinella anisum Anise contains essential oil with the most abundant component, trans-
anethole, above 96% which exhibits sweet and licorice taste with a herbal
anise and fennel nuance [89, 96]
cirrhosis and arteriosclerosis as well as in degenerative processes associated with

aging [70]. Essential oils also showed antimicrobial properties, which makes them
efficient alternative antibiotics and antimycotic agents [71, 72]. Review of terpe-
noids present in Apiaceae according to literature is shown in Table 3.
3 Nutraceutical Potential of Apiaceae
The aim of this review is to represent members of Apiaceae family currently used as
nutraceuticals and describe their nutritional benefits. Investigation of nutraceuticals
from this family is very attractive because of their extensive application in everyday
diet. Review of their chemical composition and biological activity highlighted their
importance as food with health benefits.
3.1 Anethum graveolens
Dill seed and leaf are the parts which are mainly used. Dill seed is used in pickled
cucumbers, bread, processed meats, sausages, cheese and condiments. Dill leaves
are used in pickles, while fresh are used for garnish or to flavor salads, vegetable
dishes, sea food, soups, yogurt and mayonnaise [2]. Dill has been used in traditional
medicines worldwide since the ancient times. It is used to relieve colic pain in babies
and flatulence in young children, as carminative (improves appetite), mild diuretic,
galactogogue, stimulant and stomachic. It is also used for treatment of diarrhoea,
astma, neuralgia, dysuria, dysmenorrhoea, gallbladder disease and insomnia [97,
98]. However, a great number of pharmacological studies show that dill possesses
significant biological activity. Because of the high antioxidative potential [18, 99],
dill can be used to improve biochemical processes in patients who suffer from
diseases in relation to metabolic syndrome [100]. Studies show that dill can be
used for managing diabetes and cardiovascular diseases because it possesses hypo-
glycemic properties [101, 102, 103]. It is documented that dill decreased total
cholesterol without any side effects [104, 105, 106]. Apart from this, dill has
hepatoprotective properties [107, 108, 109, 110, 111, 112]. Dill exhibited great
anti-cancer activity on oral cavities and breast cancer cells lines [113]. Dill is a
good antimicrobial agent [114, 115], which makes it a very significant plant in herbal
medicine, especially as a base for the development of novel antimicrobial
phytoremedies [116].
3.2 Angelica archangelica
Angelica root is used in herbal liqueurs and bitter spirits, in flavoring meat and canned
vegetables, while the seed is used in alcoholic distillates. However, chopped angelica
green parts (leaves and herb) can be added to fruit salads, fish dishes and cottage
cheese, they are used for decorating cakes and pastry and to flavor jams and jellies,
confectionaries and liqueurs [2]. The species is well known and has been cultivated
since the ancient times for treating certain diseases, such as gastrointestinal problems,
like a carminative or in flatulent colic, as well as diaphoretic and diuretic [117].
Applied externally, angelica is good as a counter-irritant, for treatment of rheumatic
diseases [118]. New investigations of this plant show that it possesses good anti-
oxidative [119, 120, 121] and antimicrobial activity [72, 75, 122, 123]. This indicates
that angelica can be used as a botanical preservative against molds, aflatoxin con-
tamination and oxidative deterioration of walnut samples [124], as well as a control
agent for plant pathogenic fungi in natural formulations [125]. Angelica root water
extraction revealed a significant antioxidant role beside its chelation potency of lead
ions, so it can be used as a natural chelator in case of lead poisoning [126]. Clinical
investigations show that angelica expressed hepatoprotective activity [119, 127] as
well as cytotoxicity in human pancreas cancer cells and mouse breast cancer cells
[128]. Angelica also shows anxiolytic activity, so it can be used for nervous disorders
and cerebral diseases, for example for epilepsy treatment [129, 130].
3.3 Apium graveolens
Celery has different forms and uses. Turnip-rooted celery, also called celeriac, is used
mainly as grated raw salad, as well as cooked vegetable in stews and soups. Leaf
celery, called smallage, is chopped and used for garnishing and flavoring, either fresh
or dried. The succulent leafstalk, often with a part of leafblade, is used for the
preparation of sauces, vegetable juices, stews, soups, salads, etc. Celery seed is
used as condiment, in pickling vegetables, salad dressings, breads, biscuits, soups,
spice mixed with salt, as bouquet garnish [2]. In traditional medicine, celery is used to
treat many diseases. Traditionaly, celery is mainly used as a diuretic and as a treatment
for arthritis and rheumatism. Celery also has sedating effect and has been used in
herbal medicine to treat nervousness, hysteria and various other conditions [131, 132].
However, investigations show that celery possesses good antioxidant activity [133,
134, 135] as well as antimicrobial activity [136, 137]. Significant hepatoprotective
activity [138, 139, 140, 141, 142], and anti-inflammatory effect of celery are reported
[143, 144]. Hypoglycemic effect of celery is also reported, as well as that its potent
role in ameliorating stressful complications accompanied by diabetes mellitus [145,
146]. Celery acts as an intestinal smooth muscle relaxant in the digestive tract [147].
Also, it has antihypertensive properties, and can be considered as an antihypertensive
agent in chronic treatment of elevated blood pressure [148]. Celery showed a signif-
icant diuretic effect that accentuates the excretion of urinary calcium [149].
3.4 Carum carvi
Caraway seed is used in creams, cakes, baked goods, cheese, confections, fresh
cabbage, meat dishes, rye bread, salads, while essential oil obtained from seed is
used to flavor chewing gum, candy, soft drinks and alcoholic beverages [2, 150].
Caraway seed essential oil has been reported to have potential therapeutic effects,
mainly due to its high antioxidant activity [151]. Considering the radical scavenging
[152] and good antioxidant profile [153, 154], it has been recommended for its
multifaceted pharmacological properties [155]. Caraway has been used to treat
digestive disorders for a long time. It can be used successfully for establishing
normal intestinal motility, for healing chronic constipation, gastric ulcer, dysbiosis,
dyspeption and heartburn [156, 157, 158, 159, 160, 161, 162]. The application of
caraway fruits significantly inhibits the increase of total cholesterol and levels of
triglycerides [163, 164, 165]. Apart from this it can be used in the treatment of
hyperglycemia [166, 167]. Caraway fruit shows strong antibacterial and antifungal
activities [168, 169, 170]. It also has anti-inflammatory properties [157] and anti-
stress activity [171]. Caraway significantly increases urine output, and the total
volume of urine excreted [172]. In addition, the aqueous extract of caraway fruits
decreases the level of glucose in serum, urea, creatinine, total urinary protein and
microalbuminuric levels. Caraway possesses strong anti-oxidant activity which pro-
vides renoprotection against diabetes and its complications [173]. It is established
that the essential oil also protects the kidneys from damage which occur as a
consequence of diabetic nephropathy [174].
3.5 Coriandrum sativum
Coriander leaf is used to make chutneys and sauces, green salsas, dips, snacks,
soups, while the seed is used in couscous, stews and salads, as a condiment in pickle
spices, seasonings, curry powders, sausages, cakes, pastries, biscuits and buns. Seed
essential oil is used in beverages, baked goods, condiments, relishes and meat
products [2]. However, leaf and seed have different aromas because of the different
chemical composition, but both oils possess good antioxidative [175, 176], as well as
antimicrobial activity [177, 178]. Studies indicated that coriander enabled develop-
ment of a novel broad spectrum of antibacterial herbal formulations, and that it has
potential for new natural antifungal formulations [179]. However, bioactive com-
pounds present in coriander are used in traditional and modern medicine, as well as
in everyday nutrition [69, 180, 181]. In folk medicine, coriander seed is used as an
aromatic, carminative, stomachic, antispasmodic and against gastrointestinal com-
plaints such as dyspepsia, flatulance and gastralgia [179]. It is often recomanded for
insomnia and anxiety [182, 183, 184]. Its use is recommended for healing the urinary
system, ie uretritis, cystitis and urinary tract infections [185]. It has also been used in
heavy metal detoxification [186]. It is used as an analgetic and antirheumatic agent
[187]. Coriander is effective against hyperlipidemia [188, 189, 190] and hypergly-
cemia [191, 192]. It also acts as a hepatoprotectant [193, 194, 195, 196, 197, 198]
and anticancer agent [199, 200, 201]. Apart from this, coriander can also be used as
an anthelmintic [202, 203].
3.6 Cuminum cyminum
Cumin seed is used as a flavoring component in beverages, confectioneries, baked

goods, meat and meat products, condiments and relishes, gravies, snack foods,
gelatins and puddings [2]. It is generally used as a food additive, popular spice,
and flavoring agent in many cuisines [204]. Cumin seeds have also been widely used
in traditional medicine for treatment of several health disorders and diseases, such as
toothaches, dyspepsia, diarrhea, epilepsy and jaundice. Hovewer, the literature pre-
sents ample evidence for the biological and biomedical activities of cumin, among
which strong antioxidative [205, 206] and antimicrobial activity [207, 208]. Because
of this, it is an important natural food preservative. Further, there is scientific proof
that cumin shows antistress, antioxidant, and memory-enhancing activities, that its
traditional use as a culinary spice in foods is beneficial in combating stress and
related disorders [209]. Cumin possesses hypolipidemic [210, 211], as well as
hypoglycaemic potential [212, 213]. Investigations show that cumin possesses
hepatoprotective properties against drugs and chemically induced hepatotoxicities,
by increasing the level of antioxidant enzymes in the liver [214, 215, 216]. The
finding also suggests that it possesses anticancer activity against several carncer cell
lines. These studies convey the use of cumin as a helper in the therapy or the control
of colon, liver and prostrate cancer. Also, the use of cumin in diet may reduce the risk
of cancer [217, 218]. Apart from this, phytochemical constituents from cumin seed
show analgesic and anti-inflammatory activities [219].
3.7 Daucus carota
The carrot is mainly consumed as a root vegetable, primarily raw, in juices, salads, or
for pickling, while it is used cooked in soups and stews, as well as for cakes. Carrot
seed is used for essential oil distillation. Obtained oil contains carotol as the
dominant compound, and is used as a flavoring agent in food products, mainly in
beverages, baked goods, condiments, relishes and meat products [2]. Lately, a
number of studies pointed out that the aerial parts are also a source of phytochem-
icals and could be economically important, for example antioxidants and for blood
pressure lowering [220, 221, 222]. The ethnobotanical uses of this species also
included applications in the treatment of cough, diarrhea, dysentery, cancer, malaria,
tumors, as an antiseptic, abortifacient, aphrodisiac, carminative, stimulant, sto-
machic and tonic [223]. Studies show that root, as the part mainly used, act as an
antioxidant [224, 225, 226], hepatoprotectant [227, 228, 229] and gastroprotectant
[230, 231, 232, 233, 234]. Carrot is a good antiinflammatory [235, 236] and
anticancer agent [46, 237, 238, 239, 240]. Also, it possesses hypoglycaemic and
hypolipidemic properties [47, 241, 242, 243]. Carrot seeds appear to be a promising
candidate for improving memory and it would be worthwhile to explore the potential
of this plant in the management of Alzheimer patients [243]. Apart from this, carrot
seed shows antinoceptive and antiinflamatory [244], as well as hypoglycaemic and
hypolipidemic properties [245, 246, 247].
3.8 Foeniculum vulgare
Fennel seed is used in meat dishes, curries, spice blends, soups, vegetables, breads.
Fresh and chopped leaves can be used as garnish for fish dishes, sauces, salads, stews
and curries. Leaf stalk, also called pseudobulb, is used raw in salads, stuffing, soups,
sauces; it can be baked or blanched. Seed and herb essential oil is used in beverages,
condiments, relishes, baked goods, frozen dairy, gelatines, puddings, meat products
and candies [2]. Fennel has a wide range of bioactivity and has proved to be a good
source for traditional medicine. Mainly, it is used as galactagogue and emmenagogue.
Because of its diuretic activity, it is useful for kidney and bladder diseases. It is also
relieves nausea and vomiting. It is useful for chronic fever and eliminates obstruc-
tions of internal organs especially those in liver, intestine and respiratory tract [248].
It provides a noteworthy basis in pharmaceutical biology for the development and
formulation of new drugs and future clinical uses [249, 250]. However, investigations
show that fennel has efficient antimicrobial activity against bacteria [35, 251, 252],
fungi [253, 254, 255] and viruses [256]. Fennel also possesses good antioxidative
potential [257, 258], because of hat it is used as food additive to provide protection
against oxidative degradation of foods by free radicals, but also used to protect
humans from oxidative stress damage [249, 259]. Fennel also possesses anti-
inflammatory [260, 261], anticancer [262] and hepatoprotective activity [263, 264].
Further, hypolipidemic and hypoglycaemic potential are also proven [263, 265], as
well as diuretic potential and beneficial effect on renal function [266, 267].
3.9 Levisticum officinale
The lovage root is used for producing soup seasonings, finished flavorings in
liqueurs; the leaf is used for seasoning sauces, meat dishes, while the seed is used
as spice, for flavoring cakes, soups, salads, for pickled vegetables (especially
cabbage and cucumbers) [2]. Lovage has the strong, characteristic seasoning-like
principle of the herb, aromatic odor and taste [268]. Lovage is one of the herbs that
have been traditionally used for treatment of many diseases, as diaphoretic, expec-
torant, stomachic and stimulant [269]. Apart from this, lovage is used in treatment of
kidney stones and urinary tract infections [270]. These uses are approved by
pharmacological studies, i.e. lovage significantly decreased levels of urine cysteine,
creatinine and volume [271]. Hovewer, clinical experience shows that lovage in
combination with other plants can be used for treatment of urogenital and gestroin-
testinal diseases [272]. Lovage exhibited significant antimicrobial [43, 273, 274] and
antioxidative activity [36, 275]. Investigations show that lovage is an inexpensive
source of natural antibacterial substances for use in pathogenic systems to prevent
the growth of bacteria and extend the shelf life of processed foods [276]. Apart from
this, lovage possesses anticancer activity, i.e. inhibits human head and neck squa-
mous carcinoma cells growth [277] as well as human liver cancer cell and breast
cancer cell lines [278]. Lovage also shows neuroprotective activities, i.e. alcoholic
extract has both repair and restoration effects on peripheral nerves [270], as well as
antiinflamatory activity [278].
3.10 Pastinaca sativa
The parsnip is a root vegetable resembling white carrot. The root is used in soups,
stews, cakes, pies and puddings, while leaves and young leafstalks can be used
cooked with other greens as a vegetable or added to soups. The seed is used as a
condiment in making beer, wine or distilled spirits [91, 279]. Parsnip has a sweet,
distinct, aromatic flavor, similar to nutmeg and cinnamon. This plant is used in
traditional medicine worldwide, mainly as a carminative, spasmolytic and diuretic.
Also, their usage in treatment of epilepsy is mentioned. Investigations show that
parsnip shows anticonvulsant activity due to the presence of a furanocoumarin
compound, xanthotoxin [280]. Apart from this, parsnip has anticancer activity,
because it contains falcarinol which proved to be the most active compound with a
pronounced toxicity against acute lymphoblastic leukemia cell line [49]. Also,
parsnip possesses antimicrobial activity against the most common human gastroin-
testinal pathogenic microbial strains [93]. Parsnip shows significant antibacterial
activities on phytopathogenic bacteria, so it might potentially be used as a biological
pesticide [92]. The results showed that the addition of parsnip could effectively
reduce lipid oxidation, maintain or improve sensory attributes and extend the shelf-
life of beef burgers during refrigerated storage. Therefore, it is suggested that
parsnip, as a natural herb, could be used to extend the shelf-life of meat products,
providing the consumer with food containing natural additives, which might be seen
as a healthier option than those of synthetic origin [281].
3.11 Petroselinum crispum
Parsley, like celery, has different forms and uses. Roothy form is mainly used as a
vegetable, while the leafy form has two varieties, broad-leaved and curly-leaved.
The parsley root is used as a vegetable to enhance flavor in soups, stews and
condiments, while the leaf is used as a garnish (for salads, soups, boiled potatoes
and egg dishes), blended in dips and cooked sauces. Seed is usually used for
essential oil extraction. Obtained oil is used to flavor meat sauces, pickles, spice
blends, baked goods, oils and fats, processed vegetables, soups, gelatines and
puddings [2]. Parsley can be used fresh and dried. Parsley has a pungent, warm,
spicy, herbaceous-scent. However, smell and taste in dried spices are different from
the fresh ones due to changes in volatile profile during the drying process [282].
Parsley is mainly used in food industry as a vegetable and spice, while in etnophar-
macology application as an appetizer, carminative and diuretic. However, investi-
gations show that parsley shows potential to prevent oxidative stress-related
diseases and can be developed into functional food or alternative natural antioxi-
dants [283, 284]. Parsley showed a hepatoprotective effect against acute liver injury
induced by chemical agents [285, 286, 287, 288], as well as injuries due to the
complication of diabetes [289] or chronic changes induced in non-alcoholic fatty
liver disease [290]. Parsley is a good diuretic and has antihypertensive effect [291,
292]. Apart from this, parsley shows antiurolithic effects against calcium oxalate
stones [293].
3.12 Pimpinella anisum
Anise is used in beverages, baked goods, condiments, relishes, oils and fats, frozen
dairy, gravies, meat products and soft candy. Seed essential oil is used in chewing
gums, gelatines, puddings, soft and hard candies [2, 150]. Anise, like fennel, has an
aromatic and sweet taste. It is used in folk medicine in many countries for treatment
of digestive, respiratory and neurological diseases, as well as natural estrogen [294,
295]. New investigations show that anise is rich in phytochemical contents, which
possess high antioxidant [296, 297] and antimicrobial activities [71, 299]. A new
interesting approach to develop plants as natural source and preservative for the food
industry is considered. Treatment with anise is effective in reducing the level of some
of biochemical parameters and ameliorate behavior of intoxicated by lead [298].
Apart from this, anise possesses strong anticancer activity on human prostate cancer
cell line [300], as well as on gastric cancer cell line [301]. Thus, anise could be one of
the foods that attribute to cancer prevention and treatment. It could also be a natural
source of novel anticancer compounds with anti proliferative and/or apoptotic
properties. Anise also possesses hypoglycaemic and hypolipidemic properties
[302, 303]. Investigation shows hepatoprotective activity, too [304, 305]. High
range of active potentials leads to various applications of anise, such as health
supplement and pharmaceutical benefits [41]. This is conditioned by significant
content of synergistic action of the bioactive compounds present in the seed [12, 306].
4 Conclusion
Phytochemical screening of spices and vegetables which are usually used in diet,
shows that they possess bioactive constituents of pharmaceutical importance. Ther-
apeutic activity is especially important in prevention and treatment of modern
diseases which are directly related to oxidative stress, such as aging, cancer etc.
Nutritionally induced acute and chronic diseases such as diabetes, hyperlipidemia,
liver diseases and others, can be prevented or relieved by using plants. Thereby,
promoting optimal health, longevity and quality of life can all be achieved by plants,
i.e. nutraceuticals present in them.
It is known that many plants have been used as food additives and in folk
medicine for treating numerous diseases worldwide since the ancient times. How-
ever, only recently has there been a huge number of pharmacological and clinical
studies about the positive effects that plants have on the human health. These studies
have awakened people’s interest in the plant’s usage. Plants from Apiaceae family
are used in almost all national cuisines, both as a vegetable (carrot, celery, parsley,
parsnip, fennel) or as spice or condiment (dill, cumin, anise, coriander, lovage,
angelica). Due to the complex chemical composition, they show significant thera-
peutic activity, while their aromatic properties enable their wide application in
everyday nutrition. All economic studies imply that nutraceuticals will play an
important role in the future development of food with therapeutic properties.
References
1. Tunçtürk M, Özgökçe F (2015) Chemical composition of some Apiaceae plants commonly
used in herby cheese in eastern Anatolia. Turk J Agric For 39:55–62
2. Aćimović M, Milić N (2017) Perspectives of the Apiaceae hepatoprotective effects – a review.
Nat Prod Commun 12:309–317
3. Huang WY, Cai YZ, Zhang Y (2010) Natural phenolic compounds from medicinal herbs and
dietary plants: potential use for cancer prevention. Nutr Cancer 62:1–20
4. Siró I, Kápolna E, Kápolna B, Lugasi A (2008) Functional food. Product development,
marketing and consumer acceptance – a review. Appetite 51:456–467
5. Jain N, Ramawat K (2013) Nutraceuticals and antioxidants in prevention of diseases. In:
Ramawat KG, Mérillon JM (eds) Natural products, Phytochemistry, botany and metabolism of
alkaloids, Phenolics and terpenes. Springer, Berlin/Heidelberg
6. Wang J, Guleria S, Koffas M, Yan Y (2016) Microbial production of value-added
nutraceuticals. Curr Opin Biotechnol 37:97–104
7. Cornelli U (2009) Antioxidant use in nutraceuticals. Clin Dermatol 27:175–194
8. Tapas AR, Sakarkar DM, Kakde RB (2008) Flavonoids as nutraceuticals: a review. Trop J
Pharm Res 7:1089–1099
9. Dillard C, German B (2000) Review phytochemicals: nutraceuticals and human health. J Sci
Food Agric 80:1744–1756
10. Pandey KB, Rizvi SI (2009) Plant polyphenols as dietary antioxidants in human health and
disease. Oxidative Med Cell Longev 2:270–278
11. Ghanem M, Radwan H, Mahdy ES, Elkholy Y, Hassanein H, Shahat A (2012) Phenolic
compounds from Foeniculum vulgare (Subsp. piperitum) (Apiaceae) herb and evaluation of
hepatoprotective antioxidant activity. Pharm Res 4:104–108
12. Martins N, Barros L, Santos-Buelgac C, Ferreira I (2016) Antioxidant potential of two
Apiaceae plant extracts: a comparative study focused on the phenolic composition. Ind Crop
Prod 79:188–194
13. Ereifej KI, Feng H, Rababah TM, Tashtoush SH, Al-U’datt MH, Gammoh S, Al-Rabadi GJ
(2016) Effect of extractant and temperature on phenolic compounds and antioxidant activity of
selected spices. Food Nutr Sci 7:362–370
14. Saleem F, Sarkar D, Ankolekar C, Shetty K (2017) Phenolic bioactives and associated
antioxidant and anti-hyperglycemic functions of select species of Apiaceae Family targeting
for type 2 diabetes relevant nutraceuticals. Ind Crop Prod. https://doi.org/10.1016/j.
indcrop.2017.06.023
15. Bystrická J, Kavalcová P, Musilová J, Vollmannová A, Tóth T, Lenková M (2015) Carrot
(Daucus carota L. ssp. sativus (Hoffm.) Arcang.) as source of antioxidants. Acta Agri
Slovenica 105:303–311
16. Nagy M, Tofană M, Socaci SA, Pop AV, Bors MD, Farcas A, Moldovan O (2014) Total
phenolic, flavonoids and antioxidant capacity of some medicinal and aromatic plants. Bull
UASVM Food Sci Technol 71:209–210
17. Świeca M, Gawlik-Dziki U (2008) Influence of thermal processing on phenolics compounds
level and antiradical activity of dill (Anethum graveolens L.) Herba Polonica 54:59–69
18. Isbilir SS, Sagiroglu A (2011) Antioxidant potential of different dill (Anethum graveolens L.)
leaf extracts. Int J Food Prop 14:894–902
19. Molnar M, Jerković I, Suknović D, Bilić-Rajs B, Aladić K, Šubarić D, Jokić S (2017)
Screening of six medicinal plant extracts obtained by two conventional methods and super-
critical CO2 extraction targeted on coumarin content, 2,2-diphenyl-1-picrylhydrazyl radical
scavenging capacity and total phenols content. Molecules 22:348. https://doi.org/10.3390/
molecules22030348
20. Harmala P, Vuorela H (1990) Optimization of the high-performance liquid chromatography of

coumarins in Angelica archangelica with reference to molecular structure. J Chromatogr
507:367–380
21. Kumar D, Bhat ZA, Kumar V, Shah MY (2013) Coumarins from Angelica archangelica Linn.
And their effects on anxiety-like behavior. Prog Neuro-Psychopharmacol Biol Psychiatry
40:180–186
22. Dellal A, Benali FT, Hamel A, Dif MM, Bouazza S, Douaoui A, Rahmani H (2016)
Optimization of the extraction conditions of phenolic compounds from (Apium graveolens)
seeds by response surface methodology. Adv Environ Biol 10:155–163
23. Yao Y, Sang W, Zhou M, Ren G (2010) Phenolic composition and antioxidant activities of 11
celery cultivars. J Food Sci 75:C9–13
24. Vallverdú-Queralt A, Regueiro J, Alvarenga JFR, Martinez-Huelamo M, Leal LN, Lamuela-
Raventos RM (2015) Characterization of the phenolic and antioxidant profiles of selected
culinary herbs and spices: caraway, turmeric, dill, marjoram and nutmeg. Food Sci Technol
Campinas 35:189–195
25. Kunzemann J, Herrmann K (1977) Isolation and identification of flavon(ol)-O-glycosides in
caraway (Carum carvi L.), fennel (Foeniculum vulgare mill.), anise (Pimpinella anisum L.),
and coriander (Coriandrum sativum L.), and of flavon-C-glycosides in anise. I. Phenolics of
spices. Z Lebensm Unters Forsch 164:194–200
26. Al-Juhaimi F, Ghafoor K (2011) Total phenols and antioxidant activities of leaf and stem
extracts from coriander, mint and parsley grown in Saudi Arabia. Pak J Bot 43:2235–2237
27. Nambiar VS, Daniel M, Guin P (2010) Characterization of polyphenols from coriander leaves
(Coriandrum sativum), red amaranthus (A. paniculatus) and green amaranthus
(A. frumentaceus) using paper chromatography: and their health implications. J Herb Med
Toxicol 4:173–177
28. Barros L, Dueñas M, Dias MI, Sousa MJ, Santos-Buelga C, ICFR F (2012) Phenolic profiles
of in vivo and in vitro grown Coriandrum sativum L. Food Chem 132:841–848
29. Farah H, Elbadrawy E, Al-Atoom AA (2015) Evaluation of antioxidant and antimicrobial
activities of ethanolic extracts of parsley (Petroselinum crispum) and coriander (Coriandrum
sativum) plants grown in Saudi Arabia. Int J Adv Res 3:1244–1255
30. Rajeshwari U, Andallu B (2011) Isolation and simultaneous detection of flavonoids in the
methanolic and ethanolic extracts of Coriandrum sativum L. seeds by RP-HPLC. Pak J Food
Sci 21:13–21
31. Bettaieb-Rebey I, Bourgou S, Debez IBS, Jabri-Karoui I, Sellami IH, Msaada K, Limam F,
Marzouk B (2012) Effects of extraction solvents and provenances on phenolic contents and
antioxidant activities of cumin (Cuminum cyminum L.) seeds. Food Bioprocess Technol
5:2827–2836
32. Bettaieb I, Bourgou S, Wannes WA, Hamrouni I, Limam F, Marzouk B (2010) Essential oils,
phenolics, and antioxidant activities of different parts of cumin (Cuminum cyminum L.) J Agric
Food Chem 58:10410–10418
33. Leja M, Kamińska I, Kramer M, Maksylewicz-Kaul A, Kammerer D, Carle R, Baranski R
(2013) The content of phenolic compounds and radical scavenging activity varies with carrot
origin and root color. Plant Foods Hum Nutr 68:163–170
34. Faisal NA, Chatha SAS, Hussain AI, Ikram M, Bukhari SA (2016) Liaison of phenolic acids
and biological activity of escalating cultivars of Daucus carota. Int J Food Prop. https://doi.
org/10.1080/10942912.2016.1252390
35. Dua A, Garg G, Mahajan R (2013) Polyphenols, flavonoids and antimicrobial properties of
methanolic extract of fennel (Foeniculum vulgare miller). Eur J Exp Biol 3:203–208
36. Tomsone L, Kruma Z, Talou T, Zhao TM (2015) Natural antioxidants of horseradish and
lovage extracted by accelerated solvent extraction. J Hyg Eng Desig 10:16–24
37. Kaushik P, Andújar I, Vilanova S, Plazas M, Gramazio P, Herraiz FJ, Brar NS, Prohens J
(2015) Breeding vegetables with increased content in bioactive phenolic acids. Molecules
20:18464–18481
38. Ekiert H, Gomółka E (2000) Furanocoumarins in Pastinaca Sativa L. in vitro culture.
Pharmazie 55:618–620
39. Trifunschi S, Ardelean D (2012) Quantification of phenolics and flavonoids from Petroselinum
crispum extracts. J Med Ar 15:83–86
40. Chaves D, Frattani F, Assafim M, de Almeida AP, Zingali R, Costa S (2011) Phenolic chemical
composition of Petroselinum crispum extract and its effect on haemostasis. Nat Prod Comm
6:961–964
41. Christova-Bagdassarian VL, Bagdassarian KS, Atanassova MS (2013) Phenolic compounds
and antioxidant capacity in Bulgarian plans (dry seeds). Int J Adv Res 1:186–197
42. Garrod B, Lewis BG, Coxon DT (1978) Cis-heptadeca-1,9-diene-4,6-diyne-3,8-diol, an anti-
fungal polyacetylene from carrot root tissue. Physiol Plant Pathol 13:241–246
43. Schinkovitz A, Stavri M, Gibbons S, Bucar F (2008) Antimycobacterial polyacetylenes from
Levisticum officinale. Phytother Res 22:681–684
44. Metzger B, Waksmonski J, Thompson A, Barnes D (2013) Supercritical fluid extraction (SFE)
of anti-inflammatory polyacetylenes from celeriac (Apium graveolens L.) FASEB J
27:1079.34
45. Dembitsky V, Levitsky D (2006) Acetylenic terrestrial anticancer agents. Nat Prod Commun
1:405–429
46. Zaini RG, Brandt K, Clench MR, Le Maitre CL (2012) Effects of bioactive compounds from
carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid
leukaemia cells. Anti Cancer Agents Med Chem 12:640–652
47. El-Houri RB, Kotowska D, Christensen KB, Bhattacharya S, Oksbjerg N, Wolber G,
Kristiansen K, Christensen LP (2015) Polyacetylenes from carrots (Daucus carota) improve
glucose uptake in vitro in adipocytes and myotubes. Food Funct 6:2135–2144
48. Choi YE, Ahn H, Ryu JH (2000) Polyacetylenes from Angelica gigas and their inhibitory
activity on nitric oxide synthesis in activated macrophages. Biol Pharm Bull 23:884–886
49. Zidorn C, Jöhrer K, Ganzera M, Schubert B, Sigmund EM, Mader J, Greil R, Ellmerer EP,
Stuppner H (2005) Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley,
and parsnip and their cytotoxic activities. J Agric Food Chem 53:2518–2523
50. Christensen LP (2011) Aliphatic C(17)-polyacetylenes of the falcarinol type as potential health
promoting compounds in food plants of the Apiaceae Family. Recent Pat Food Nutr Agric 3:64–77
51. Chen Y, Peng S, Luo Q, Zhang J, Guo Q, Zhang Y, Chai X (2015) Chemical and pharmaco-
logical progress on polyacetylenes isolated from the family Apiaceae. Chem Biodivers
12:474–502
52. Christensen LP, Brandt K (2006) Bioactive polyacetylenes in food plants of the Apiaceae
Family: occurrence, bioactivity and analysis. J Pharm Biomed Anal 41:683–693
53. Kreutzmann S, Christensen L, Edelenbos M (2008) Investigation of bitterness in carrots
(Daucus carota L.) based on quantitative chemical and sensory analyses. LWT 41:193–205
54. Schulz-Witte J, Nothnagel T, Schulz H (2010) Comparison of different clean-up methods for
simultaneous HPLC determination of carotenoids and polyacetylenes in carrot root. J Appl Bot
Food Qual 83:123–127
55. Roman M, Baranski R, Baranska M (2011) Nondestructive Raman analysis of polyacetylenes
in Apiaceae vegetables. J Agric Food Chem 59:7647–7653
56. Kramer M, Bufler G, Nothnagel T, Carle R, Kammerer DR (2012) Effects of cultivation
conditions and cold storage on the polyacetylene contents of carrot (Daucus carota L.) and
parsnip (Pastinaca sativa L.) J Hortic Sci Biotechnol 87:101–106
57. Rawson A, Hossain M, Patras A, Tuohy M, Brunton N (2013) Effect of boiling and roasting on
the polyacetylene and polyphenol content of fennel (Foeniculum vulgare) bulb. Food Res Int
50:513–518
58. Petrache P, Rodino S, Butu M, Pribac G, Pentea M, Butnariu M (2014) Polyacetylene and
carotenes from Petroselinum sativum root. Dig J Nanomater Biostruct 9:1523–1527
59. Dawid C, Dunemann F, Schwab W, Nothnagel T, Hofmann T (2015) Bioactive C17-poly-
acetylenes in carrots (Daucus carota L.): current knowledge and future perspectives. J Agric
Food Chem 63:9211–9222
60. Nakano Y, Matsunaga H, Saita T, Mori M, Katano M, Okabe H (1998) Antiproliferative

constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae
plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii.
Biol Pharm Bull 21:257–261
61. Min BS (2006) Coumarins and a polyacetylene from the roots of Angelica purpuraefolia. Nat
Prod Sci 12:129–133
62. Matsuda H, Kageura T, Ninomiya K, Toguchida I, Nishida N, Yoshikawa M (1998)
Hepatoprotective and nitric oxide production inhibitory activities of coumarin and poly-
acetylene constituents from the roots of Angelica furcijuga. Bioorg Med Chem Lett
8:2191–2196
63. Nurcahyanti A, Nasser I, Sporer F, Graf J, Bermawie N, Reichling J, Wink M (2016) Chemical
composition of the essential oil from aerial parts of Javanian Pimpinella pruatjan Molk. And
its molecular phylogeny. Diversity 8:15. https://doi.org/10.3390/d8030015
64. El Sohaimy SA (2012) Functional foods and nutraceuticals-modern approach to food science.
World Appl Sci J 20:691–708
65. Aćimović M, Korać J, Jaćimović G, Oljača S, Đukanović L, Vuga-Janjatov V (2014a)
Influence of ecological conditions on seeds traits and essential oil contents in anise (Pimpinella
anisum L.) Not Bot Horti Agrobot Cluj Napoca 42:232–238
66. Aćimović M, Oljača S, Tešević V, Todosijević M, Đisalov J (2014b) Evaluation of caraway
essential oil from different production areas of Serbia. Hort Sci (Prague) 41:122–130
67. Aćimović M, Stanković J, Cvetković M, Ignjatov M, Lj N (2016b) Chemical characteriza-
tion of essential oil from seeds of wild and cultivated carrots from Serbia. Bot Serb
40:55–60
68. Tongnuanchan P, Benjakul S (2014) Essential oils: extraction, bioactivities, and their uses for
food preservation. J Food Sci 79:1231–1249
69. Aćimović M, Lj K, Popović S, Dojčinović N (2015a) Apiaceae seeds as functional food. J
Agric Sci (Belgrade) 60:237–246
70. Saleh MA, Clark S, Woodard B, Deolu-Sobogun SA (2010) Antioxidant and free radical
scavenging activities of essential oils. Ethn Dis 20:78–82
71. Kosalec I, Pepeljnjak S, Kuštrak D (2005) Antifungal activity of fluid extract and essential oil
from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharma 55:377–385
72. Fraternale D, Flamini G, Ricci D (2014) Essential oil composition and antimicrobial activity of
Angelica archangelica L. (Apiaceae) roots. J Med Food 17:1043–1047
73. Bailer J, Aichinger T, Hackl G, de Hueber K, Dachler M (2001) Essential oil content and
composition in commercially available dill cultivars in comparison to caraway. Ind Crop Prod
14:229–239
74. Rana VS, Blazquez AM (2014) Chemical composition of the essential oil of Anethum
graveolens aerial parts. J Essent Oil Bear Pl 17:1219–1223
75. Aćimović M, Pavlović S, Varga A, Filipović V, Cvetković M, Stanković J, Čabarkapa I
(2017a) Chemical composition and antibacterial activity of Angelica archangelica root essen-
tial oil. Nat Prod Commun 12:205–206
76. Aćimović M, Cvetković M, Stanković J, Filipović V, Nikolić L, Dojčinović N (2017b)
Analysis of volatile compounds from Angelica seeds obtained by headspace method.
AJMAP 3:10–17
77. Sowbhagya HB (2014) Chemistry, technology, and nutraceutical functions of celery (Apium
graveolens L.): an overview. Crit Rev Food Sci Nutr 54:389–398
78. Meshkatalsadat MH, Salahvarzi S, Aminiradpoor R, Abdollahi A (2012) Identification of
essential oil constituents of caraway (Carum carvi) using ultrasonic assist with headspace solid
phase microextraction (UA-HS-SPME). Dig J Nanomater Biostruct 7:637–640
79. Seidler-Łożykowska K, Kędzia B, Karpińska E, Bocianowski J (2013) Microbiological
activity of caraway (Carum carvi L.) essential oil obtained from different origin. Acta Sci
Agron 35:495–500
80. Aćimović M, Oljača S, Jaćimović G, Dražić S, Tasić S (2011) Benefits of environmental

conditions for growing coriander in Banat region, Serbia. Nat Prod Commun 6:1465–1468
81. Aćimović M, Stanković J, Cvetković M (2016) Effect of weather conditions, location and
fertilization on coriander fruit essential oil quality. J Essent Oil Bear Plant 19:1208–1215
82. Aćimović M, Grahovac M, Stanković J, Cvetković M, Maširević S (2016) Essential oil
composition of different coriander (Coriandrum sativum L.) accessions and their influence
on mycelial growth of Colletotrichum ssp. Acta Scientiarum Polonorum Hortorum Cultus
15:35–44
83. Mandal S, Mandal M (2015) Coriander (Coriandrum sativum L.) essential oil: chemistry and
biological activity. Asian Pac J Trop Biomed 5:421–428
84. Aliniana S, Razmjooa J, Zeinali H (2016) Flavonoids, anthocyanins, phenolics and essential
oil produced in cumin (Cuminum cyminum L.) accessions under different irrigation regimes.
Ind Crop Prod 81:49–55
85. Ma M, Mu T, Sun H, Zhang M, Chen J, Yan Z (2015) Optimization of extraction efficiency by
shear emulsifying assisted enzymatic hydrolysis and functional properties of dietary fiber from
deoiled cumin (Cuminum cyminum L.) Food Chem 179:270–277
86. Topal U, Sasaki M, Goto M, Otles S (2008) Chemical compositions and antioxidant properties
of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide
extraction and steam distillation. Int J Food Sci Nutr 59:619–634
87. Wanner J, Bail S, Jirovetz L, Buchbauer G, Schmidt E, Gochev V, Girova T, Atanasova T,
Stoyanova A (2010) Chemical composition and antimicrobial activity of cumin oil (Cuminum
cyminum, Apiaceae). Nat Prod Commun 5:1355–1358
88. Zatla AT, Dib MEA, Djabou N, Tabti B, Meliani N, Costa J, Muselli A (2017) Chemical
variability of essential oil of Daucus carota subsp. sativus from Algeria. J Herbs Spices Med
Plant 23:216–230
89. Aćimović M, Tešević V, Todosijević M, Đisalov J, Oljača S (2015c) Compositional charac-
teristics of the essential oil of Pimpinella anisum and Foeniculum vulgare grown in Serbia. Bot
Serb 39:9–14
90. Aćimović M, Lj K, Stanković J, Cvetković M, Filipović V (2015) Essential oil composition
from sweet and bitter fennel fruits from Serbia. Med Raw Mat 35:121–129
91. Aćimović M, Cvetković M, Stanković J, Malenčić Đ, Kostadinović L (2015b) Compound
analysis of essential oils from lovage and celery fruits obtained by headspace extraction. Ann
Agron (Novi Sad) 39:44–51
92. Nikolić M, Markovic T, Ćirić A, Glamočlija J, Marković D, Soković M (2015) Susceptibility
of oral Candida spp. reference strains and clinical isolates to selected essential oils of Apiaceae
species. Med Raw Mat 35:151–162
93. Matejić J, Džamić A, Mihajilov-Krstev T, Ranđelović V, Krivošej Z, Marin P (2014) Antimi-
crobial potential of essential oil from Pastinaca sativa L. Biologica Nyssana 5:31–35
94. Linde GA, Gazim ZC, Cardoso BK, Jorge LF, Tešević V, Glamoćlija J, Soković M, Colauto
NB (2016) Antifungal and antibacterial activities of Petroselinum crispum essential oil. Genet
Mol Res 15(3). https://doi.org/10.4238/gmr.15038538
95. Borges IB, Cardoso BK, Silva ES, de Oliveira JS, da Silva RF, de Rezende CM, Gonçalves JE,
Junior RP, de Souza SGH, Gazim ZC (2016) Evaluation of performance and chemical
composition of Petroselinum Crispum essential oil under different conditions of water deficit.
Afr J Agric Res 11:480–486
96. Gende LB, Maggi MD, Fritz R, Eguaras MJ, Bailac PN, Ponzi MI (2009) Antimicrobial
activity of Pimpinella anisum and Foeniculum vulgare essential oils against Paenibacillus
larvae. J Essent Oil Res 21:91–93
97. Jana S, Shekhawat GS (2010) Anethum graveolens: an Indian traditional medicinal herb and
spice. Pharmacogn Rev 4:179–184
98. Aćimović M, Milić N (2015) Dill in traditional medicine and modern phytotherapy. Med Raw
Mat 35:23–35
99. El Mansouri L, Bousta D, Balouiri M, Ouedrhiri W, Elyoubi-El HA (2015) Antioxidant

activity of aqueous seed extract of Anethum graveolens L. Int J Pharm Sci Res 7:1219–1223
100. Mansouri M, Nayebi N, Keshtkar A, Hasani-Ranjbar S, Taheri E, Larijani B (2012) The effect
of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic
syndrome; a randomized double blind controlled trial. Daru 20:47. https://doi.org/10.1186/
2008-2231-20-47
101. Mishra N (2013) Haematological and hypoglycemic potential Anethum graveolens seeds
extract in normal and diabetic Swiss albino mice. Vet World 6:502–507
102. Goodarzi MT, Khodadadi I, Tavilani H, Oshaghi EA (2016) The role of Anethum graveolens
L. (dill) in the management of diabetes. J Trop Med 2016:1098916. https://doi.org/10.1155/
2016/1098916
103. Mobasseri M, Payahoo L, Ostadrahimi A, Bishak YK, Jafarabadi MA, Mahluji S (2014)
Anethum graveolens supplementation improves insulin sensitivity and lipid abnormality in
type 2 diabetic patients. Pharm sci 20:40–45
104. Yazdanparast R, Bahramikia S (2008) Evaluation of the effect of Anethum graveolens L. crude
extracts on serum lipids and lipoproteins profiles in hypercholesterolaemic rats. Daru
16:88–94
105. Bano F, Ikram H, Akhtar N (2013) Aqueous extract of Anethum graveolens L. seeds decrease
LDL-C:HDL-C ratio in over weight rats. Pak J Biochem Mol Biol 46:26–29
106. Mirhosseini M, Baradaran A, Rafieian-Kopaei M (2014) Anethum graveolens and hyperlip-
idemia: a randomized clinical trial. J Res Med Sci 19:758–761
107. Yazdanparast R, Alavi M (2001) Antihyperlipidaemic and antihypercholesterolaemic effects
of Anethum graveolens leaves after removal of furocoumarins. Cytobios 105:185–191
108. Tamilarasi R, Sivanesan D, Kanimozhi P (2012) Hepatoprotective and antioxidant efficacy of
Anethum graveolens Linn in carbon tetrachloride induced hepatotoxicity in albino rats. J Chem
Pharm Res 4:1885–1888
109. Thuppia A, Jitvaropas R, Saenthaweesuk S, Somparn N, Kaulpiboon J (2011)
Hepatoprotective effect of the ethanolic extract of Anethum graveolens L. on paracetamol-
induced hepatic damage in rats. Planta Med 77:PF18
110. Ali WSH (2013) Hypolipidemic and antioxidant activities of Anethum graveolens against
acetaminophen induced liver damage in rats. WJMS 8:387–392
111. Rabeh NM, Aboraya AO (2014) Hepatoprotective effect of dill (Anethum graveolens L.) and
fennel (Foeniculum vulgare) oil on hepatotoxic rats. PJN 13:303–309
112. Oshaghi EA, Khodadadi I, Tavilani H, Goodarzi MT (2016) Effect of dill tablet (Anethum
graveolens L) on antioxidant status and biochemical factors on carbon tetrachloride-induced
liver damage on rat. Int J App Basic Med Res 6:111–114
113. Peerakam N, Wattanathorn J, Punjaisee S, Buamongkol S, Sirisa P, Chansakaow S (2014)
Chemical profiling of essential oil composition and biological evaluation of Anethum
graveolens L. (seed) grown in Thailand. J Nat Sci Res 4:34–41
114. Kaur GJ, Arora DS (2009) Antibacterial and phytochemical screening of Anethum graveolens,
Foeniculum vulgare and Trachyspermum ammi. BMC Complement Altern Med 9:30. https://
doi.org/10.1186/1472-6882-9-30
115. Chen Y, Zeng H, Tian J, Ban X, Ma B, Wang Y (2013) Antifungal mechanism of essential
oil from Anethum graveolens seeds against Candida albicans. J Med Microbiol
62:1175–1183
116. Dahiya P, Purkayastha S (2012) Phytochemical analysis and antibacterial efficacy of dill seed
oil against multi-drug resistant clinical isolates. Asian J Pharm Clin Res 5:62–64
117. Sava-Sand C, Antofie MM (2016) New improvements in plant quality of Angelica
archangelica l. as a crop species of food and pharmaceutical interest. Sci Paper Series
Manag Eco Eng Agri Rural Develop 16:477–480
118. Bhat ZA, Kumar D, Shah MY (2011) Angelica archangelica Linn. Is an angel on earth for the
treatment of diseases. Int J Nutri Pharmacol Neurol Diseases 1:36–50
119. Elgohary AA, Shafaa MW, Raafat BM, Rizk RA, Metwally FG, Saleh AM (2009) Prophy-
lactic effect of Angelica archangelica against acute lead toxicity in albino rabbits. Romanian. J
Biophys 19:259–275
120. Wojcikowski K, Stevenson L, Leach D, Wohlmuth H, Gobe G (2007) Antioxidant capacity of
55 medicinal herbs traditionally used to treat the urinary system: a comparison using a
sequential three-solvent extraction process. J Alternat Complement Med 13:103–109
121. Sezer-Senol F, Skalicka-Woźniak K, Khan MTH, Orhan IE, Głowniak K (2011) An in vitro
and in silico approach to cholinesterase inhibitory and antioxidant effects of the methanol
extract, furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits.
Phytochem Lett 4:462–467
122. Nemeth S, Paşca B, Teodorescu A, Coita I, Teaha D (2015) Coumarins isolated from the dry
roots of Angelica archangelica L. and their antibacterial activity. Analele Universităţii din
Oradea, Fascicula: Ecotoxicologie, Zootehnie şi Tehnologii de Industrie Alimntară B
14:355–362
123. Rather RA, Rehman SU, Naseer S, Lone SH, Bhat KA, Chouhan A (2013) Flash chromatog-
raphy guided fractionation and antibacterial activity studies of Angelica archangelica root
extracts. IOSR-JAC 4:34–38
124. Prakash B, Singh P, Goni R, Raina AK, Dubey NK (2015) Efficacy of Angelica archangelica
essential oil, phenyl ethyl alcohol and α- terpineol against isolated molds from walnut and their
antiaflatoxigenic and antioxidant activity. J Food Sci Technol 52:2220–2228
125. Fraternale D, Flamini G, Ricci D (2016) Essential oil composition of Angelica archangelica L.
(Apiaceae) roots and its antifungal activity against plant pathogenic fungi. Plant Biosyst
150:558–563
126. Raafat BM, Zahrany SM, Al-Zahrani AS, Tawifiek E, Al-Omery AM (2012) Angelica
Archangelica roots water extraction as a natural antioxidant tolerating ROS production in
lead poisoning. RJPBCS 3:795–806
127. Yeh ML, Liu CF, Huang CL, Huang TC (2003) Hepatoprotective effect of Angelica
archangelica in chronically ethanol-treated mice. Pharmacology 68:70–73
128. Sigurdsson S, Ogmundsdottir HM, Gudbjarnason S (2005) The cytotoxic effect of two
chemotypes of essential oils from the fruits of Angelica archangelica L. Anticancer Res
25:1877–1880
129. Kumar D, Ali Bhat Z (2012) Anti-anxiety activity of methanolic extracts of different parts of
Angelica archangelica Linn. J Tradit Complement Med 2:235–241
130. Pathak S, Wanjari MM, Jain SK, Tripathi M (2010) Evaluation of antiseizure activity of
essential oil from roots of Angelica archangelica Linn. In mice. Indian J Pharm Sci
72:371–375
131. Asif HM, Akram M, Usmanghani K, Akhtar N, Shah PA, Uzair M, Ramzan M, Ali Shah SM,
Rehman R (2011) Monograph of Apium graveolens Linn. JMPR 5:1494–1496
132. Fazal SS, Singla RK (2012) Review on the pharmacognostical and pharmacological charac-
terization of Apium Graveolens Linn. IGJPS 2:36–42
133. Kooti W, Daraei N (2017) A review of the antioxidant activity of celery (Apium graveolens
L.). J Evid Based Complementary Altern Med. https://doi.org/10.1177/2156587217717415
134. Sameh B, Ibtissem B, Mahmoud A, Boukef K, Boughattas NA (2011) Antioxidant activity of
Apium graveolens extracts. JBAPN 1:340–343
135. Kooti W, Ali-Akbari S, Asadi-Samani M, Ghadery H, Ashtary-Larky D (2014) A review on
medicinal plant of Apium graveolens. Adv Herb Med 1:48–59
136. Shanmugapriya R, Ushadevi T (2014) In vitro antibacterial and antioxidant activities of Apium
graveolens L. seed extracts. Int J Drug Dev Res 6:165–170
137. Uddin Z, Shad AA, Bakht J, Ullah I, Jan S (2015) In vitro antimicrobial, antioxidant activity
and phytochemical screening of Apium Graveolens. Pak J Pharm Sci 28:1699–1704
138. Singh A, Handa SS (1995) Hepatoprotective activity of Apium graveolens and Hygrophila
auriculata against paracetamol and thioacetamide intoxication in rats. J Ethnopharmacol
49:119–126
139. Sultana S, Ahmed S, Jahangir T, Sharma S (2005) Inhibitory effect of celery seeds extract on
chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and
altered hepatic foci development. Cancer Lett 221:11–20
140. Kolarovic J, Popovic M, Mikov M, Mitic R, Gvozdenovic L (2009) Protective effects of celery
juice in treatments with doxorubicin. Molecules 14:1627–1638
141. Belal NM (2011) Hepatoprotective effect of feeding celery leaves mixed with chicory leaves
and barley grains to hypercholesterolemic rats. Asian J Clin Nutri 3:14–24
142. Osman N (2013) The role of antioxidant properties of celery against lead acetate induced
hepatotoxicity and oxidative stress in irradiated rats. Arab J Nucl Sci Appl 46:339–346
143. Ramezani M, Nasri S, Yassa N (2009) Antinociceptive and anti-inflammatory effects of
isolated fractions from Apium graveolens seeds in mice. Pharm Biol 49:740–743
144. Choosri N, Tanasawet S, Chonpathompikunlert P, Sukketsiri W (2017) Apium graveolens
extract attenuates adjuvant induced arthritis by reducing oxidative stress. J Food Biochem 41
(1):12276. https://doi.org/10.1111/jfbc.12276
145. Mansi K, Abushoffa AM, Disi A, Aburjai T (2009) Hypolipidemic effects of seed extract of
celery (Apium graveolens) in rats. Phcog Mag 5:301–305
146. Al-Saaidi JAA, Alrodhan MNA, Ismael AK (2012) Antioxidant activity of n-butanol extract of
celery (Apium Graveolens) seed in streptozotocin-induced diabetic male rats. Res Pharmaceut
Biotechnol 4:24–29
147. Branković S, Gočmanac-Ignjatović M, Kostić M, Veljković M, Miladinović B, Milutinović M,
Radenković M (2015) Spasmolytic activity of the aqueous and ethanol celery leaves (Apium
graveolens l.) extracts on the contraction of isolated rat ileum. Acta Medica Medianae
54:11–16
148. Moghadam MH, Imenshahidi M, Mohajeri SA (2013) Antihypertensive effect of celery seed
on rat blood pressure in chronic administration. J Med Food 16:558–563
149. Al Jawad FH, Al Razzuqi RAM, Al Jeboori AA (2011) Apium Graveolens accentuates urinary
ca+2 excretions in experimental model of nephrocalcinosis. Int J Green Pharm 5:100–102
150. Aćimović M, Dolijanović Ž, Oljača S, Kovačević D, Oljača M (2015) Effect of organic and
mineral fertilizers on essential oil content in caraway, anise and coriander fruits. Acta
Scientiarum Polonorum Hortorum Cultus 14(1):95–103
151. Najda A, Dyduch J, Brzozowski N (2008) Flavonoid content and antioxidant activity of
caraway roots (Carum carvi L.) Veget Crops Res Bull 68:127–133
152. Foti MC, Ingold KU (2003) Mechanism of inhibition of lipid peroxidation by γ-terpinene,
an unusual and potentially useful hydrocarbon antioxidant. J Agric Food Chem 51:
2758–2765
153. Damašius J, Šk_emait_e M, Kirkilait_e G, Vinauskien_e R, Venskutonis PR (2007) Antioxidant
and antimicrobial properties of caraway (Carum carvi L.) and cumin (Cuminum cyminum L.)
extracts. Vet Med Zoot 40:9–13
154. Samojlik I, Lakić N, Mimica-Dukić N, Đaković-Švajcer K, Božin B (2010) Antioxidant nad
hepatoprotective potential of essential oils of coriander (Coriandrum sativum L.) and caraway
(Carum carvi L.) (Apiaceae). J Agric Food Chem 58:8848–8853
155. Johri KR (2011) Cuminum cyminum and Carum carvi: an update. Pharmacogn Rev 5:63–72
156. Hawerelak JA, Cattley T, Myers SP (2009) Essential oils in the treatment of intestinal
dysbiosis: a preliminary in vitro study. Altern Med Rev 14:380–384
157. Keshavarz A, Minaiyan M, Ghannadi A, Mahzouni P (2013) Effects of Carum carvi L.
(caraway) extract and essential oil on TNBS-induced colitis in rats. Resеаrch in pharmaceu-
tical. Science 8:1–8
158. Khayyal MT, Seif-El-Nasr M, El-Ghazaly MA, Okpanyi SN, Kelber O, Weiser D (2006)
Mechanisms involved in the gastro-protective effect of STW5 (Iberogast ®) and its components
against ulcers and rebound acidity. Phytomedicine 13:56–66
159. Al-Essa MK, Shafagoj YA, Mohammed FI, Afifi FU (2010) Relaxant effect of ethanol extr act
of Carum carvi on dispersed intestinal smooth muscle cells of the guinea pig. Pharm Biol
48:76–80
160. Sadeghian S, Neyestani T, Shirazi MH, Ranjabarian P (2005) Bacteriostatic effect of dill,
fennel, caraway and cinnamon extracts against Helicobacter pylori. J Nutr Environ Med
15:47–55
161. Villarini M, Fatigoni C, Cerbone B, Dominici L, Moretti M, Pagiotti R (2011) In vitro testing
of a laxative herbal food supplement for genotoxic and antigentoxic properties. J Med Plants
Res 5:2533–2539
162. Yosefi SS, Sadeghpour O, Sohrabvand F, Atarod Z, Askarfarashah M, Ateni TR, Yekta NH
(2014) Effectiveness of Carum carvi on early return of bowel motility after caesarean section.
Eur. J Exp Biol 4:258–262
163. Haidari F, Sayed-Sadjadi N, Taha-Jalali M, Mohammed-Shahi M (2011) The effect of oral
administration of Carum carvi on weight, serum glucose, and lipid profile in streptozotocin-
induced diabetic rats. Saudi Med J 32:695–700
164. Lemhadri A, Hajji L, Michel JB, Eddouks M (2006) Cholesterol and triglycerides lowering
activities of caraway fruits in normal and streptozotocin diabetic rats. J Ethnopharmacol
106:321–326
165. Saghir MR, Sadiq S, Nayak S, Tahir MU (2012) Hypolipidemic effect of aqueous extract of
Carum carvi (black zeera) seeds in diet induced hyperlipidemic rats. Pak J Pharm Sci
25:333–337
166. Eidi A, Eidi M, Rohani HA, Basati F (2010) Hypoglycemic effect of ethanolic extract of
Carum carvi L. seeds in normal and streptozotocin-induced diabetic rats. J Med Plants
9:106–113
167. Moubarz G, Taha MM, Mahdy-Abdallah H (2014) Antioxidant effect of Carum carvi on the
immune status of streptozotocin-induced diabetic rats infested with Staphylococcus aureus.
World Appl Sci J 30:63–69
168. Iacobellis NS, Cantore PL, Capasso F, Senatore F (2005) Antibacterial activity of Cuminum
cyminum L. and Carum carvi L. essential oils. J Agric Food Chem 53:57–61
169. Simic A, Rančić A, Sokolović MD, Ristić M, Grujić-Jovanović S, Vukojevic J, Marin PD
(2008) Essential oil composition of Cymbopogon winterianus and Carum carvi and their
antimicrobial activities. Pharm Biol 46:437–441
170. Škrinjar M, Mandić A, Mišan A, Sakač M, Lj Š, Zec M (2009) Effect of mint (Mentha piprita
L.) and caraway (Carum carvi L.) on growth of some toxigenic Aspergillus species and
aflatoxin B1 production. J Nat Sci Matica Srpska Novi Sad 116:131–139
171. Koppula S, Kopalli SR, Sreemantula S (2009) Adaptogenic and nootropic activities of
aqueous extracts of Carum carvi Linn (caraway) fruit: an experimental study in Wistar rats.
Aus J Med Herbal 21:72–78
172. Lahlou S, Tahraoui A, Israili Z, Lyoussi B (2007) Diuretic activity of the aqueous extracts of
Carum carvi and Tanacetum vulgare in normal rats. J Ethnopharmacol 110:458–463
173. Sadiq S, Nagi AH, Shahzad M, Zia A (2010) The reno-protective effect of aqueous extract of
Carum carvi (black zeera) seeds in streptozotocin induced diabetic nephropathy in rodents.
Saudi J Kidney Dis Transpl 21:1058–1065
174. El-Soud NH, El-Lithy NA, El-Saeed G, Wahby MS, Khalil MY, Morsy F, Shaffie N (2014)
Renoprotective effects of caraway (Carum carvi L.) essential oil in streptozotocin induced
diabetic rats. J Appl Pharmaceut Sci 4:27–33
175. Marangoni C, de Moura NF (2011) Antioxidant activity of essential oil from Coriandrum
sativum L. in Italian salami. Ciênc Tecnol Aliment 31:124–128
176. Darughe F, Barzegar M, Sahari MA (2012) Antioxidant and antifungal activity of coriander
(Coriandrum sativum L.) essential oil in cake. Int Food Res J 19:1253–1260
177. Matasyoh JC, Maiyo ZC, Ngure RM, Chepkorir R (2009) Chemical composition and
antimicrobial activity of the essential oil of Coriandrum sativum. Food Chem 113:
526–529
178. Silva F, Ferreira S, Queiroz JA, Domingues FC (2011) Coriander (Coriandrum sativum L.)
essential oil: its antibacterial activity and mode of action evaluated by flow cytometry. J Med
Microbiol 60:1479–1486
179. Aćimović M, Oljača S, Dražić S (2012) Uses of coriander (Coriandrum sativum L.) Med Raw
Mat 31:67–82
180. Aćimović M, Kostadinović L, Puvača N, Popović S, Urošević M (2016a) Phytochemical
constituents of selected plants from Apiaceae family and their biological effects in poultry.
Food Feed Res 43:35–41
181. Momin AH, Acharya SS, Gajjar AV (2012) Coriandrum sativum – review of advances in
phytopharmacology. IJPSR 3:1233–1239
182. Emamghoreishi M, Heidari-Hamedani GH (2008) Effect of extract and essential oil of
Coriandrum sativum seed against pentylenetetrazole-induced seizure. Pharm Sci 7:1–10
183. Mahendra P, Bisht S (2011) Anti-anxiety activity of Coriandrum Sativum assessed using
different experimental anxiety models. Indian J Pharmacol 43:574–577
184. Pathan AR, Kothawade KA, Logade MN (2011) Anxiolytic and analgetic effect of seeds of
Coriandrum Sativum Linn. International journal of research in pharmacy and. Chemistry
1:1087–1099
185. Aissaoui A, El-Hilaly J, Israili ZH, Lyoussi B (2008) Acute diuretic effect of continuous
intravenous infusion of an aqueous extract of Coriandrum sativum L. in anesthetized rats. J
Ethnopharmacol 115:89–95
186. Millet J (2005) Cilantro, chlorella, and heavy metals. Med Herbal 14:17–20
187. Rajeshwari U, Andallu B (2011) Medicinal benefits of coriander (Coriandrum sativum L.)
Spatula DD 1:51–58
188. Lal AA, Kumar T, Murthy PB, Pillai KS (2004) Hypolipidemic effect of Coriandrum sativum
L. in triton-induced hyperlipidemic rats. Indian J Exp Biol 42:909–912
189. Dhanapakiam P, Mini Joseph J, Ramaswamy VK, Moorthi M, Senthil Kumar A (2008) The
cholesterol lowering property of coriander seeds (Coriandrum sativum): mechanism of action.
J Environ Biol 29:53–56
190. Joshi SC, Sharma N, Sharma P (2012) Antioxidant and lipid lowering effects of Coriandrum
sativum in cholesterol fed rabbits. Int J Pharm Pharm Sci 4:231–234
191. Yibru E, Menon MKC, Belayneh Y, Seyifu D (2015) The effect of Coriandrum sativum seed
extract on hyperglycemia, lipid profile and renal function in streptozotocin induced type- 2
diabetic Swiss albino mice. IJHSR 5:166–177
192. Aissaoui A, Zizi S, Israili ZH, Lyoussi B (2011) Hypoglycemic and hypolipidemic effects of
Coriandrum sativum L. in Meriones Shawi rats. J Ethnopharmacol 137:652–661
193. Kansal L, Sharma V, Sharma A, Lodi S, Sharma SH (2011) Protective role of Coriandrum
sativum (coriander) extracts against lead nitrate induced oxidative stress and tissue damage in
the liver and kidney in male mice. Int J Appl Biol Pharm 2:65–83
194. John NAA, Shobana G, Keerthana K (2014) Protective effect of Coriander sativum L. on
cadmium induced toxicity in albino rats. World J Pharm Pharm Sci 3:525–534
195. Moustafa AH, Ali EMM, Moselhey SS, Tousson E, El-Said KS (2014) Effect of coriander on
thioacetamide-induced hepatotoxicity in rats. Toxicol Ind Health 30:621–629
196. Sreelatha S, Padma PR, Umadevi M (2009) Protective effects of Coriandrum sativum extracts
on carbon tetrachloride-induced hepatotoxicity in rats. Food Chem Toxicol 47:702–708
197. Ramadan MM, Algader NNEA, El-Kamali HH, Ghanem KZ, Farrag ARH (2013) Chemopre-
ventive effect of Coriandrum sativum fruits on hepatic toxicity in male rats. WJMS 8:322–333
198. Pandey A, Bigoniya P, Raj V, Patel KK (2011) Pharmacological screening of Coriandrum
sativum Linn. For hepatoprotective activity. J Pharm Bioallied Sci 3:435–441
199. Nithya TG, Sumalatha D (2014) Evaluation of invitro anti-oxidant and anticancer activity of
Coriandrum sativum against human colon cancer HT-29 cell lines. Int J Pharm Pharm Sci
6:421–424
200. Tang EL, Rajarajeswaran J, Fung SY, Kanthimathi MS (2013) Antioxidant activity of
Coriandrum sativum and protection against DNA damage and cancer cell migration. BMC
Complement Altern Med 13:347. https://doi.org/10.1186/1472-6882-13-347
201. Gomez-Flores R, Hernández-Martínez H, Tamez-Guerra P, Tamez-Guerra R, Quintanilla-
Licea R, Monreal-Cuevas E, Rodríguez-Padilla C (2010) Antitumor and immunomodulating
potential of Coriandrum sativum, Piper nigrum and Cinnamomum zeylanicum. J Nat Prod
3:54–63
202. Chandan HS, Tapas AR, Sakarkar DM (2011) Anthelmintic activity of extracts of Coriandrum
Sativum Linn. In Indian earthworm. Int J Phytomed 3:36–40
203. Eguale T, Tilahun G, Debella A, Feleke A, Makonnen E (2007) In vitro and in vivo
anthelmintic activity of crude extracts of Coriandrum Sativum against Haemonchus contortus.
J Ethnopharmacol 110:428–343
204. Mnif S, Aifa S (2015) Cumin (Cuminum cyminum L.) from traditional uses to potential
biomedical applications. Chem Biodivers 12:733–742
205. Moghadam ARL (2016) Chemical composition and antioxidant activity Cuminum cyminum L.
essential oils. Int J Food Prop 19:438–442
206. Rebey IB, Zakhama N, Karoui IJ, Marzouk B (2012) Polyphenol composition and antioxidant
activity of cumin (Cuminum cyminum L.) seed extract under drought. J Food Sci 77:
C734–C739
207. Abbaszadegan A, Gholami A, Ghahramani Y, Ghareghan R, Ghareghan M, Kazemi A, Iraji A,
Ghasemi Y (2016) Antimicrobial and cytotoxic activity of Cuminum cyminum as an intracanal
medicament compared to chlorhexidine gel. Iran Endod J 11:44–50
208. Saee Y, Dadashi M, Eslami G, Goudarzi H, Taheri S, Fallah F (2016) Evaluation of antimi-
crobial activity of Cuminum cyminum essential oil and extract against bacterial strains isolated
from patients with symptomatic urinary tract infection. NBM 4:147–152
209. Koppula S, Choi DK (2011) Cuminum Cyminum extract attenuates scopolamine-induced
memory loss and stress-induced urinary biochemical changes in rats: a noninvasive biochem-
ical approach. Pharm Biol 49:702–708
210. Dhandapani S, Subramanian VR, Rajagopal S, Namasivayam N (2002) Hypolipidemic effect
of Cuminum cyminum L. on alloxan-induced diabetic rats. Pharmacol Res 46:251–255
211. Srivastava V, Dubey S, Sharma SB, Chaddha V (2013) Studies on hypolipidemic activity of
seeds of Cuminum cyminum Linn. Indo am. J Pharm Res 3:8260–8265
212. Willatgamuwa SA, Platel K, Saraswathi G, Srinivasan K (1998) Antidiabetic influence of
dietary cumin seeds (Cuminum cyminum) in streptozotocin induced diabetic rats. Nutr Res
18:131–142
213. Keihan GS, Gharib MH, Momeni A, Hemati Z, Sedighin R (2016) A comparison between the
effect of Cuminum cyminum and vitamin E on the level of leptin, paraoxonase 1, HbA1c and
oxidized LDL in diabetic patients. Int J Mol Cell Med 5:229–235
214. Mushtaq A, Ahmad M, Jabeen Q, Saqib A, Wajid M, Akram MA (2014) Hepatoprotective
investigations of Cuminum cyminum dried seeds in nimesulide intoxicated albino rats by
phytochemical and biochemical methods. Int J Pharm Pharm Sci 6:506–510
215. Abbas N, Naz M, Alyousef L, Ahmed ES, Begum A (2017) Comparative study of
hepatoprotective effect produced by Cuminum cyminum, fruits of Phyllanthus emblicus and
silymarin against cisplatin-induced hepatotoxicity. Int J Pharm Sci Res 8:2026–2032
216. Kumar A, Kumar R, Kumar N, Nath A, Singh JK, Ali M (2011) Protective effect of Cuminum
cyminum and Coriandrum sativum on profenofos induced liver toxicity. Int J Pharm Biol Arch
2:1405–1409
217. Mekawey AAI, Mokhtar MM, Farrag RM (2009) Antitumor and antibacterial activities of [1-
(2-ethyl, 6-Heptyl) phenol] from Cuminum cyminum seeds. J Appl Scis Res 5:1881–1888
218. Prakash E, Gupta DK (2014) Cytotoxic activity of ethanolic extract of Cuminum cyminum
Linn against seven human cancer cell line. Univers J Agric Res 2:27–30
219. Bhat SP, Rizvi W, Kumar A (2014) Effect of Cuminum cyminum L. seed extracts on pain and
inflammation. J Nat Remedies 14:186–192
220. Gilani AH, Shaheen E, Saeed SA, Bibi S, Irfanullah SM, Faizi S (2000) Hypotensive action of
coumarin glycosides from Daucus carota. Phytomedicine 7:423–426
221. Sudewi S, Wahyuono S, Astuti P (2014) Isolation and identification of free radicals scavenger
from Daucus carota L leaves. Trad Med J 19:142–148
222. Mohammedi H, Mecherara-Idjeri S, Foudil-Cherif Y, Hassani A (2015) Chemical composition

and antioxidant activity of essential oils from Algerian Daucus carota L. subsp. carota aerial
parts. J Essent Oil Bear Pl 18:873–883
223. Al-Snafi AE (2017) Nutritional and therapeutic importance of Daucus Carota- a review. IOSR
J Pharm 7:72–88
224. Zhang D, Hamauzu Y (2004) Phenolic compounds and their antioxidant properties in different
tissues of carrots (Daucus carota L.) J Food Agric Environ 2:95–100
225. Sun T, Simon PW, Tanumihardjo SA (2009) Antioxidant phytochemicals and antioxidant
capacity of biofortified carrots (Daucus carota L.) of various colors. J Agric Food Chem
57:4142–4147
226. Mueller L, Boehm V (2011) Antioxidant activity of β-carotene compounds in different in vitro
assays. Molecules 16:1055–1069
227. Shoba S, Patil PA, Vivek V (2008) Hepatoprotective activity of Daucus carota L. aqueous
extract against paracetamol, isoniazid and alcohol induced hepatotoxicity in male Wistar rats.
Pharmacologyonline 3:776–787
228. Jain PK, Khurana N, Pounikar Y, Patil S, Gajbhiye A (2012) Hepatoprotective effect of carrot
(Daucus carota L.) on paracetamol intoxicated rats. IJPPT 1:115–120
229. Singh K, Singh N, Chandy A, Manigauha A (2012) In vivo antioxidant and hepatoprotective
activity of methanolic extracts of Daucus carota seeds in experimental animals. Asian Pac J
Trop Biomed 2:385–388
230. Khatib N, Angel G, Nayna H, Kumar JR (2010) Gastroprotective activity of the aqueous
extract from the roots of Daucus carota L in rats. IJRAP 1:112–119
231. Jiin WH, Hidayat EM, Lukman K (2014) Gastroprotective effect of carrot (Daucus carota L.)
juice in rat models. Althea Medical Journal 1:35–39
232. Patil MV, Kandhare A, Bhise S (2012) Anti-inflammatory effect of Daucus carota root on
experimental colitis in rats. Int J Pharm Pharm Sci 4:337–343
233. Chandra P, Kishore K, Ghosh AK (2015) Assessment of antisecretory, gastroprotective, and
in-vitro antacid potential of Daucus carota in experimental rats. Osong Public Health Res
Perspect 6:329–335
234. Wehbe K, Mroueh M, Daher CF (2009) The potential role of Daucus carota aqueous and
methanolic extracts on inflammation and gastric ulcers in rats. J Complement Integr Med
6(1):7. https://doi.org/10.2202/1553-3840.1159
235. Valente J, Resende R, Zuzarte M, Goncalves MJ, Lopes MC, Cavaleiro C, Pereira C, Saiguerio
L, Cruz MT (2015) Bioactivity and safety profile of Daucus carota subsp. maximus essential
oil. Ind Crop Prod 77:218–224
236. Kamiloglu S, Grootaert C, Capanoglu E, Ozkan C, Smagghe G, Raes K, Van Camp J (2016)
Anti-inflammatory potential of black carrot (Daucus carota L.) polyphenols in a co-culture
model of intestinal Caco-2 and endothelial EA.hy926 cells. Mol Nutr Food Res 00:1–11.
https://doi.org/10.1002/mnfr.201600455
237. Diab-Assaf M, El-Sharif S, Mroueh M (2007) Evaluation of anti-cancer effect of Daucus
carota on the human promyelocytic leukemia HL-60 cells. Clin Cancer Res 13:56
238. Najm PI (2014) The anti-cancer activity of 2 himachalene-6-ol extracted from Daucus carota
ssp. carota. Dissertation, Lebanese American University
239. Shebaby WN, El-Sibai M, Smith KB, Karam MC, Mroueh M, Daher CF (2013) The
antioxidant and anticancer effects of wild carrot oil extract. Phytother Res 27:737–744
240. Shebaby WN, Mroueh M, Bodman-Smith K, Mansour A, Taleb RI, Daher CF, El-Sibai M
(2014) Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in
MDA-MB-231 breast cancer cells. BMC Complement Altern Med 14:387. https://doi.org/
10.1186/1472-6882-14-387.
241. Ranjbar B, Pouraboli I, Mehrabani M, Dabiri S, Javadi A (2010) Effect of the methanolic
extract of Daucus carota seeds on the carbohydrate metabolism and morphology of pancreas
in type I diabetic male rats. Physiol Pharmacol 14:85–93
242. Vasudevan M, Parle M (2006) Pharmacological evidence for the potential of Daucus carota in
the management of cognitive dysfunctions. Biol Pharm Bull 29:1154–1161
243. Jaffat HS, Semysim EA (2016) Hypo-lipidemic effects of aqueous extract of Daucus carota
seeds (Daucus carota L.) induced atherogenic diet in wister male rats. Res J Pharm Biol Chem
Sci 7:2714–2720
244. Mani V, Parle M, Ramasamy K, Majeed ABA (2010) Anti-dementia potential of Daucus
carota seed extract in rats. Pharmacologyonline 1:552–565
245. Vasudevan M, Gunnam KK, Parle M (2006) Antinociceptive and anti-imflammatory proper-
ties of Daucus carota seeds extract. J Health Sci 52:598–606
246. Pouraboli I, Ranjbar B (2015) The effect of Daucus carota seeds extract on lipid profile, LFT
and kidney function indicators in streptozocin-induced diabetic rats. Int J Plant Sci Ecol
1:84–87
247. Singh K, Dhongade H, Singh N, Kashyap P (2010) Hypolipidemic activity of ethanolic extract
of Daucus carota seeds in normal rats. IJBAR 1:73–80
248. Rahimi R, Ardekani MR (2013) Medicinal properties of Foeniculum Vulgare mill. In tradi-
tional Iranian medicine and modern phytotherapy. Chin J Integr Med 19:73–79
249. Badgujar SB, Patel VV, Bandivdekar AH (2014) Foeniculum vulgare mill: a review of its
botany, phytochemistry, pharmacology, contemporary application, and toxicology. Biomed
Res Int 2014:842674. https://doi.org/10.1155/2014/842674
250. Rather MA, Dar BA, Sofi SN, Bhat BA, Qurishi MA (2016) Foeniculum vulgare: a compre-
hensive review of its traditional use, phytochemistry, pharmacology, and safety. Arab J Chem
9:S1574–S1583
251. Diao WR, QP H, Zhang H, JG X (2014) Chemical composition, antibacterial activity and
mechanism of action of essential oil from seeds of fennel (Foeniculum vulgare mill.) Food
Control 35:109–116
252. Mota AS, Martins MR, Arantes S, Lopes VR, Bettencourt E, Pombal S, Gomes AC, Silva LA
(2015) Antimicrobial activity and chemical composition of the essential oils of Portuguese
Foeniculum vulgare fruits. Nat Prod Commun 10:673–676
253. Mimica-Dukić N, Kujundžić S, Soković M, Couladis M (2003) Essential oil composition and
antifungal activity of Foeniculum vulgare mill. Obtained by different distillation conditions.
Phytother Res 17:368–371
254. Skrobonja J, Delić D, Karaman M, Matavulj M, Bogavac M (2013) Antifungal properties of
Foeniculum vulgare, Carum carvi and Eucalyptus sp. essential oils against Candida albicans
strains. J Nat Sci Matica Srpska Novi Sad 124:195–202
255. Thakur N, Sareen N, Shama B, Jagota K (2013) Studies on in vitro antifungal activity of
Foeniculum vulgare Mill. against spoilage fungi. GJBB 2:427–430
256. Shukla HS, Dubey P, Chaturvedi RV (1989) Antiviral properties of essential oils of
Foeniculum vulgare and Pimpinella anisum L. Agron EDP Sci 9:277–279
257. Shahat AA, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh
MA (2011) Chemical composition, antimicrobial and antioxidant activities of essential oils
from organically cultivated fennel cultivars. Molecules 16:1366–1377
258. Chang S, Bassiri A, Jalali H (2013) Evaluation of antioxidant activity of fennel (Foeniculum
vulgare) seed extract on oxidative stability of olive oil. JCHR 3:53–61
259. El Ouariachi E, Lahhit N, Bouyanzer A, Hammouti B, Paolini J, Majidi L, Desjobert JM,
Costa J (2014) Chemical composition and antioxidant activity of essential oils and solvent
extracts of Foeniculum Vulgare mill. From Morocco. J Chem Pharm Res 6:743–748
260. Choi EM, Hwang JK (2004) Antiinflammatory, analgesic and antioxidant activities of the fruit
of Foeniculum vulgare. Fitoterapia 75:557–565
261. Yang IJ, Lee DU, Shin HM (2015) Anti-inflammatory and antioxidant effects of coumarins
isolated from Foeniculum vulgare in lipopolysaccharide-stimulated macrophages and 12-O-
tetradecanoylphorbol-13-acetate-stimulated mice. Immunopharmacol Immunotoxicol
37:308–317
262. Mohamad RH, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy
SM, El-Merzabani MM (2011) Antioxidant and anticarcinogenic effects of methanolic extract
and volatile oil of fennel seeds (Foeniculum vulgare). J Med Food 14:986–1001
263. Özbek H, Ugras S, Dulger H, Bayram I, Tuncer I, Ozturk G, Ozturk A (2003)
Hepatoprotective effect of Foeniculum vulgare essential oil. Fitoterapia 74:317–319
264. Özbek H, Ugras S, Bayram I, Uygan I, Erdogan E, Öztürk A, Huyut Z (2004)
Hepatoprotective effect of Foeniculum vulgare essential oil: a carbon-tetrachloride induced
liver fibrosis model in rats. Scand J Lab Anim Sci 1:9–17
265. Parsaeyan N (2016) The effect of Foeniculum vulgare (fennel) extract on lipid profile, lipid
peroxidation and liver enzymes of diabetic rat. IJDO 8:24–29
266. Beaux D, Fleurentin J, Mortier F (1997) Diuretic action of hydroalcohol extracts of
Foeniculum vulgare var dulce (D.C.) roots in rats. Phytother Res 11:320–322
267. Sadrefozalayi S, Farokhi F (2014) Effect of the aqueous extract of Foeniculum vulgare
(fennel) on the kidney in experimental PCOS female rats. Avicenna J Phytomed 4:
110–117
268. Blank I, Schieberle P (1993) Analysis of the seasoning-like flavour substances of a commercial
lovage extract (Levisticum officinale Koch.) Flav Frag J 8:191–195
269. Reza VRM, Abbas H (2007) The essential oil composition of Levisticum Officinale from Iran.
Asian J Biochem 2:161–163
270. Mahmoudzehi S, Dorrazehi GM, Jamalzehi S, Khabbaz AHH, Ghorbani F, Hooti A, Dadkani
AG, Souran MM (2017) The neuroprotective effects of alcoholic extract of Levisticum
officinale on alpha motoneurons’ degeneration after sciatic nerve compression in male rats.
Biomed Pharmacol J 10:633–640
271. Mohammadi M, Parvaneh E, Ghamari ZT (2016) Clinical investigation of Levisticum
officinale (lovage) effectiveness’ in patients with cystinuria. J Urol Res 3:1071
272. Naber KG (2013) Efficacy and safety of the phytotherapeutic drug Canephron ® N in preven-
tion and treatment of urogenital and gestational disease: review of clinical experience in
Eastern Europe and Central Asia. Res Rep Urol 5:39–46
273. Mirjalili MH, Salehi P, Sonboli A, Hadian J, Ebrahimi SN, Yousefzadi M (2010) The
composition and antibacterial activity of the essential oil of Levisticum officinale Koch flowers
and fruits at different developmental stages. J Serb Chem Soc 75:1661–1669
274. Ebrahimi A, Eshraghi A, Mahzoonieh MR, Lotfalian S (2016) Antibacterial and antibiotic-
potentiation activities of Levisticum officinale L. extracts on pathogenic bacteria. Int J Inf
Secur 4:e38768. https://doi.org/10.17795/iji-38768
275. Mohamadi N, Rajaei P, Moradalizadeh M, Amiri MS (2017) Essential oil composition and
antioxidant activity of Levisticum officinale Koch. At various phenological stages. J Med
Plants 16:45–55
276. Mirjalili MH, Salehi P, Sonboli A, Hadian J, Ebrahimi SN, Yousefzadi M (2010) The
composition and antibacterial activity of the essential oil of Levisticum Officinale Koch
flowers and fruits at different developmental stages. J Serb Chem Soc 75:1661–1669
277. Sertel S, Eichhorn T, Plinkert P, Efferth T (2011) Chemical composition and antiproliferative
activity of essential oil from the l of a medicinal herb, Levisticum officinale, against UMSCC1
head and neck squamous carcinoma cells. Anticancer Res 31:185–192
278. El-Hamid SRA, Abeer YI, Hendawy SF (2009) Anti-inflammatory, antioxidant, anti-tumor
and physiological studies on Levisticum officinale Koch plant. Planta Med 75:PE62. https://
doi.org/10.1055/s-0029-1234623
279. Cain N, Darbyshire SJ, Francis A, Nurse RE, Simard MJ (2010) The biology of Canadian
weeds. 144. Pastinaca sativa L. Can J Plant Sci 90:217–240
280. Skalicka-Woźniak K, Zagaja M, Głowniak K, Łuszczki J (2014) Purification and anticonvul-
sant activity of xanthotoxin (8-methoxypsoralen). Cent Eur J Biol 9:431–436
281. Akbarmivehie M, Baghaei H (2016) The effect of addition parsnip herb and its extract on
momtaze hamburger shelf life. Eur Online J Nat Soc Sci 5:132–146
282. Mangkoltriluk W, Srzednicki G, Craske J (2005) Preservation of flavour components in

parsley (Petroselinum crispum) by heat pump and cabinet drying. Pol J Food Nutr Sci
14:63–66
283. Zhang H, Chen F, Wang X, Yao HY (2006) Evaluation of antioxidant activity of parsley
(Petroselinum crispum) essential oil and identification of its antioxidant constituents. Food Res
Int 39:833–839
284. Tang EL, Rajarajeswaran J, Fung S, Kanthimathi MS (2015) Petroselinum crispum has
antioxidant properties, protects against DNA damage and inhibits proliferation and migration
of cancer cells. J Sci Food Agric 95:2763–2771
285. Al-Howiriny TA, Al-Sohaibani MO, El-Tahir KH, Rafatullah S (2003) Preliminary evaluation
of the anti-inflammatory and anti-hepatotoxic activities of ‘parsley’ Petroselinum crispum in
rats. J Nat Remedies 3:54–62
286. Kamal T, Abd-Elhady E, Sadek K, Shukry M (2014) Effect of parsley (Petroselium crispum)
on carbon tetrachloride-induced acute hepatotoxicity in rats. Res J Pharm Biol Chem Sci
5:1524–1534
287. Troncoso L, Guija E (2007) Petroselinum sativum (perejil) antioxidant and hepatoprotective
effects in rats with paracetamol-induced hepatic intoxication. Anales de la Facultad de
Medicina Universidad Nacional Mayor de San Marcos 68:333–343
288. Jassim AM (2013) Protective effect of Petroselinum crispum (parsley) extract on histopatho-
logical changes in liver, kidney and pancreas induced by sodium valproate in male rats. Kufa J
Veteri Med Sci 4:20–27
289. Bolkent S, Yanardag R, Ozsoy-Sacan O, Karabulut-Bulan O (2004) Effects of parsley
(Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study.
Phytother Res 18:996–999
290. Nair VY, Balakrishanan N, Antony Santiago JV (2015) Petroselinum crispum extract attenu-
ates hepatic steatosis in rats fed with fructose enriched diet. Bratislava Med J 116:547–553
291. Campos KE, Balbi APC, Alves MJQF (2009) Diuretic and hipotensive activity of aqueous
extract of parsley seeds (Petroselinum sativum Hoffm.) in rats. Rev Bras Farmacogn 19:41–45
292. Vargas JLZ, Lujan EGT, Pachas LCC, Lujan EPT, Lujan MT, Lujan PE (2016) Determination
of diuretic activity of Petroselinum sativum (parsley). J Hypertens 34:431. https://doi.org/
10.1097/01.hjh.0000501115.12030.e5
293. Moram GSE (2016) Evaluation of anti-urolithiatic effect of aqueous extract of parsley
(Petroselinum sativum) using ethylene glycol-induced renal calculi. WJPR 5:1721–1735
294. Shojaii A, Fard MA (2012) Review of pharmacological properties and chemical constituents
of Pimpinella anisum. ISRN Pharmaceutics. https://doi.org/10.5402/2012/510795
295. Aćimović M, Dojčinović N (2014) A review of pharmacological properties of anise
(Pimpinella anisum L.) Med Raw Mat 34:3–17
296. Gülçın I, Oktay M, Kıreçcı E, Küfrevıoǧlu I (2003) Screening of antioxidant and antimicrobial
activities of anise (Pimpinella anisum L.) seed extracts. Food Chem 83:371–382
297. Tavallali V, Rahmati S, Bahmanzadegan A (2017) Antioxidant activity, polyphenolic contents
and essential oil composition of Pimpinella Anisum L. as affected by zinc fertilizer. J Sci Food
Agric. https://doi.org/10.1002/jsfa.8360
298. Bekara A, Aithamadouhe N, Kahloula K, Sadi N, Aoues AK (2016) Effect of Pimpinella
anisum L aqueous extract against oxidative stress induced by lead exposure in young rats
brain. J Appl Environ Biol Sci 6:85–93
299. Akhtar A, Deshmukh AA, Bhonsle AV, Kshirsagar PM, Kolekar MA (2008) In vitro anti-
bacterial activity of Pimpinella anisum fruit extracts against some pathogenic bacteria. Vet
World 1:272–274
300. Kadan S, Rayan M, Rayan A (2013) Anticancer activity of anise (Pimpinella anisum L.) seed
extract. Open Nutraceuticals J 6:1–5
301. Rahamooz-Haghighi S, Asadi MH (2016) Anti-proliferative effect of the extracts and essential
oil of Pimpinella Anisum on gastric cancer cells. J Herb Med Pharmacol 5:157–161
302. Shobha RI, Rajeshwari CU, Andallu B (2013) Anti-peroxidative and anti diabetic activities of
aniseeds (Pimpinella anisum l) and identification of bioactive compounds. AJPCT 1:516–527
303. Rajeshwari U, Shobha I, Andallu B (2011) Comparison of aniseeds and coriander seeds for
antidiabetic, hypolipidemic and antioxidant activities. Spatula DD 1:9–16
304. El-Sayed MGA, Elkomy A, Sahar S, El-Banna AH (2015) Hepatoprotective effect of
Pimpinella anisum and Foeniculum vulgare against carbon tetrachloride induced fibrosis in
rats. World. J Pharm Sci 4:78–88
305. Jamshidzadeh A, Heidari R, Razmjou M, Karimi F, Moein MR, Farshad O, Akbarizadeh AR,
Shayesteh MRH (2015) An in vivo and in vitro investigation on hepatoprotective effects of
Pimpinella anisum seed essential oil and extracts against carbon tetrachloride-induced toxicity.
Iran J Basic Med Sci 18:205–211
306. Aćimović M, Tešević V, Mara D, Stanković J, Cvetković M, Djuragić O (2016) Influence of
fertilization on total polyphenole content in aniseed postdistillation waste material. AJMAP
3:57–67

Apiaceae Nutraceuticals

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Nutraceutical Potential of Apiaceae

# Springer Nature Switzerland AG 2019 1311

2 Bioactive Compounds of Apiaceae

2.1 Phenolic Compounds

Phenolic compounds, as one of major bioactive nutraceutical ingredients in plants,

Table 1 Phenolic compound from selected plants from Apiaceae family

Polyacetylenes are a group of phytochemicals that have attracted signiﬁcant interest

Terpenoids, especially monoterpenes and sesquiterpenes are the main constituents in

Table 2 Polyacetylenes from selected plants from Apiaceae family

Table 3 Terpenoids from selected plants from Apiaceae family

cirrhosis and arteriosclerosis as well as in degenerative processes associated with

3 Nutraceutical Potential of Apiaceae

3.1 Anethum graveolens

3.2 Angelica archangelica

3.3 Apium graveolens

3.4 Carum carvi

3.5 Coriandrum sativum

3.6 Cuminum cyminum

Cumin seed is used as a ﬂavoring component in beverages, confectioneries, baked

3.7 Daucus carota

3.8 Foeniculum vulgare

3.9 Levisticum officinale

3.10 Pastinaca sativa

3.11 Petroselinum crispum

3.12 Pimpinella anisum

20. Harmala P, Vuorela H (1990) Optimization of the high-performance liquid chromatography of

60. Nakano Y, Matsunaga H, Saita T, Mori M, Katano M, Okabe H (1998) Antiproliferative

80. Aćimović M, Oljača S, Jaćimović G, Dražić S, Tasić S (2011) Beneﬁts of environmental

99. El Mansouri L, Bousta D, Balouiri M, Ouedrhiri W, Elyoubi-El HA (2015) Antioxidant

222. Mohammedi H, Mecherara-Idjeri S, Foudil-Cherif Y, Hassani A (2015) Chemical composition

282. Mangkoltriluk W, Srzednicki G, Craske J (2005) Preservation of ﬂavour components in

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