Sr Antibiotic Adjuvant MOA of adjuvant

no.
1 Amoxicillin Clavulanic acid Serine-β-lactamase inhibitor
2 Meropenem Aspergillomarasmine Metallo-β-lactamase inhibitor
A
3 Ampicillin Sulbactam Synergy to cover strains of bacteria
resistant to ampicillin, thus providing
broader coverage. This combo adds a
beta-lactamase inhibitor to ampicillin
to provide extended coverage
against potentially resistant bacteria
4 Sulfamethoxazole Trimethoprim blocking the reduction of
dihydrofolate to tetrahydrofolate,
the active form of folic acid, by
susceptible organisms
5 Ticarcillin Clavulanic acid Serine-β-lactamase inhibitor
6 Meropenem Clavulanic acid Serine-β-lactamase inhibitor
7 Gentamicin Fosfomycin alternative in the therapy of severe
infections due to multiresistant
Enterobacteriacae.
8 Amikacin Fosfomycin alternative in the therapy of severe
infections due to multiresistant
Enterobacteriacae.
9 Ceftazidime Fosfomycin alternative in the therapy of severe
infections due to multiresistant
Enterobacteriacae.
10 Cefepime Fosfomycin alternative in the therapy of severe
infections due to multiresistant
 Enterobacteriacae.
11 Ciprofloxacin Fosfomycin alternative in the therapy of severe
infections due to multiresistant
Enterobacteriacae.
12 Levofloxacin Fosfomycin alternative in the therapy of severe
infections due to multiresistant
Enterobacteriacae.
13 Aztreonam Fosfomycin alternative in the therapy of severe
infections due to multiresistant
Enterobacteriacae.
14 Ampicillin Tellurite Synergistically acting in E. coli
15 Cefotaxime Tellurite Synergistically acting in E. coli
16 Tetracycline Tellurite Synergistically acting in E. coli
17 Chloramphenicol Tellurite Synergistically acting in E. coli
18 Gentamicin Tellurite Synergistically acting in E. coli
19 Imipenem Cilastatin Imipenem is rapidly inactivated by
renal dehydropeptidase I (DHP-1), it
is given in combination with
cilastatin, a DHP-I inhibitor which
increases half-life and tissue
penetration of imipenem.
20 Piperacillin Tazobactam Preventing bacteria from destroying
piperacillin
21 Amikacin Menadione enhances the antibiotic activity of
drugs by cell membrane
permeabilization mechanism
22 Gentamicin Menadione enhances the antibiotic activity of
drugs by cell membrane
 permeabilization mechanism
23 Neomycin Menadione enhances the antibiotic activity of
drugs by cell membrane
permeabilization mechanism
24 Ceftriaxone Sulbactum Synergy to cover strains of bacteria
resistant to ampicillin, thus providing
broader coverage. This combo adds a
beta-lactamase inhibitor to ampicillin
to provide extended coverage
against potentially resistant bacteria
25 Ceftriaxone Tazobactum Tazobactum is a beta lactamase
inhibitor so increases duration of
action and reduces resistance to
ceftriaxone
26 Rifampicin Isoniazid Both drugs have a synergistic effect
to kill the mycobacterium involved in
tuberculosis. Rifampicin targets DNA
dependant RNA polymerase while
isoniazid targets mycolic acid
synthesis, which interferes with cell
wall synthesis
27 Ofloxacin Ornidazole Synergistic effect to kill bacteria since
Ornidazole of the 5-nitroimidazole
drug family is used to treat
protozoan and anaerobic bacterial
infections via a mechanism that
involves activation by reduction of
the nitro group, and production of
toxic derivatives and radicals and
Ofloxacin is a fluoroquinolone whose
primary mechanism of action is
inhibition of bacterial DNA gyrase