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    The document describes a study that used machine learning techniques to predict metastasis in gastric cancer patients. Researchers collected data on patient characteristics and outcomes from 471 non-metastatic and 262 metastatic cases. They preprocessed the data and developed models using logistic regression, neural networks, random forests, naive Bayes, decision trees, and support vector machines. The models were trained and tested using k-fold cross validation, with the balanced dataset achieving sensitivities over 90% and AUCs over .85 for predicting metastasis. The study demonstrated that machine learning methods show promise for developing clinical tools to predict cancer progression using routine patient data.

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    The document describes a study that used machine learning techniques to predict metastasis in gastric cancer patients. Researchers collected data on patient characteristics and outcomes from 471 non-metastatic and 262 metastatic cases. They preprocessed the data and developed models using logistic regression, neural networks, random forests, naive Bayes, decision trees, and support vector machines. The models were trained and tested using k-fold cross validation, with the balanced dataset achieving sensitivities over 90% and AUCs over .85 for predicting metastasis. The study demonstrated that machine learning methods show promise for developing clinical tools to predict cancer progression using routine patient data.

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    © All Rights Reserved
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    2 views12 pages

    Advanced Machine Learning Group 6

    Uploaded by

    Hadi
    The document describes a study that used machine learning techniques to predict metastasis in gastric cancer patients. Researchers collected data on patient characteristics and outcomes from 471 non-metastatic and 262 metastatic cases. They preprocessed the data and developed models using logistic regression, neural networks, random forests, naive Bayes, decision trees, and support vector machines. The models were trained and tested using k-fold cross validation, with the balanced dataset achieving sensitivities over 90% and AUCs over .85 for predicting metastasis. The study demonstrated that machine learning methods show promise for developing clinical tools to predict cancer progression using routine patient data.

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    of 12

    Advanced Machine Learning

    Predicting Metastasis in Gastric Cancer Patients:


    Machine Learning-Based Approaches
    Background


    Data Collection

    Data Preprocessing


    Model Development


    Statistical Analysis


    1. Baseline features of GC patients classified as metastatic or non-metastatic. 2. Model performance in ML techniques using k-fold cross validation with both data.

    Metastasis P value Models Dataset Sensitivity% Specificity% Precision% F1 AUC


    No Yes
    LR Original data Train .86 .86 .76 .81 .93
    (n = 471) (n = 262)
    Test .86 .78 .77 .81 .88*
    Age, mean (SD) 59.53 (12.56) 60.02 (13.18) .616
    Sex, n (%) Balanced data Train .93 .83 .88 .87 .93
    Female 130 (61.6) 81 (38.4) .342
    Test .90 .78 .84 .84 .86
    Male 341 (65.3) 181 (34.7)
    Marital Status, n (%) NN Original data Train .93 .93 .88 .88 .98*
    Married 461 (64.0) 259 (36.0) .398
    Test .76 .78 .75 .77 .86
    Single 10 (76.9) 3 (23.1)
    BMI, n (%) Balanced data Train .98-3 .87 .95 .95 .99*
    Underweight 99 (62.7) 59 (37.3) .321
    Test .91 .81-2 .86 .86* .87*
    Normal 285 (63.6) 163 (36.4)
    Overweight 60 (67.4) 29 (32.6) RF Original data Train .89 .95 .92 .90 .98*
    Obese 27 (71.1) 11 (28.9)
    Test .80 .83 .80 .80 .87
    Smoking, n (%)
    Never used 306 (66.2) 156 (33.8) .145 Balanced data Train .98-3 .95 .96 .96 .99*
    Previous or current user 165 (60.9) 106 (39.1)
    Family history, n (%) Test .91 .78 .85 .85 .87*
    No 340 (61.8) 210 (38.2) .017 NB Original data Train .83 .85 .74 .79 .90
    Yes 131 (71.6) 52 (28.4)
    Grade of tumour, n (%) Test .89 .78 .77 .83 .88*
    Poorly 157 (78.5) 43 (21.5) < .001 Balanced data Train .87 .84 .86 .86 .91
    Moderately 114 (83.2) 23 (16.8)
    Well 85 (76.6) 26 (23.4) Test .86 .81-2 .83 .83 .86
    Undifferentiated 115 (40.4) 170 (59.6) DT Original data Train .82 .97 .94 .88 .96
    Number of involved lymph node, n (%)
    N1 154 (73.3) 56 (26.7) .007 Test .58 .78 .69 .63 .75
    N2 251 (60.2) 166 (39.8) Balanced data Train .94 .96 .95 .95 .98
    N3 66 (62.3) 40 (37.7)
    Tumour size, n (%) Test .80 .81 .80 .80 .83
    T1 25 (89.3) 3 (10.7) < .001
    SVM Original data Train .94 .86 .77 .84 .94
    T2 68 (93.2) 5 (6.8)
    T3 276 (94.8) 15 (5.2) Test .92 .76 .76 .85 .85
    T4 102 (29.9) 239 (70.1) Balanced data Train .98-3 .87 .93 .92 .93
    Type of treatment, n (%)
    Other treatments 366 (81.9) 81 (18.1) < .001 Test .93 .80 .87 .86* .85
    Surgery 105 (36.7) 181 (63.3)

    Models Dataset Precision-recall


    curve AUC

    LR Balanced data Train .91

    Test .81

    NN Balanced data Train .98

    Test .84

    RF Balanced data Train .99

    Test .86

    NB Balanced data Train .89

    Test .81

    DT Balanced data Train .98

    Test .79

    SVM Balanced data Train .87

    Test .76
    Results


    Conclusion / Question?


    Answer


    Citations
     Atefeh Talebi, Carlos A. Celis-Morales, Nasrin Borumandnia, Somayeh Abbasi,
    Mohamad Amin, Pourhoseingholi, Abolfazl Akbari & Javad Yousefi.

     Link:- https://www.nature.com/articles/s41598-023-31272-w

     Link:- https://www.freecodecamp.org/news/svm-machine-learning-tutorial-what-is-
    the-support-vector-machine-algorithm-explained-with-code-
    examples/#:~:text=SVMs%20are%20different%20from%20other,the%20maximum
    %20margin%20hyper%20plane.


    Thank you

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