The whole brain multiscale organization of the functional

brain network in adolescent PTSD

David Corredor , Shailendra Segobin, Thomas Hinaut, Francis Eustache, Jaques Dayan, Bérengère
Guillery-Girard, Mikaël Naveau*

We were interested in studying the brain functional

network of adolescent PTSD without apriori biases,
neither regarding regions of interest nor the
communities' composition and topological scale.
This way, we avoided blurring population-specific
characteristics and missing relevant information
beyond commonly associated brain regions to PTSD.

INTRODUCTION
• The brain is a complex system meaning that its functional
properties arise from the interaction among its constituents,
including indirect connections between regions (Avena-
Koenigsberger et al., 2018;).
• The study of the functional brain organization in PTSD has been
mostly carried out using regions of interest and population-
independent functional atlases (e.g., the Yeo atlas).

METHODS
• 14 PTSD patients and 24 controls were included in the analyses

• We built on the network neuroscience framework and specifically in

multisubject community analysis (Betzel et al., 2019) to unravel
multiscale functional communities in PTSD
.
• To investigate the node-to-node specificities, we compared the frequency [Insert figure heading here]
at which any two nodes were allocated to the same community (AM). To
compare the groups, we subtracted the AM of PTSD subjects from the AM
of the control group (DiffAM) (figure 1).

• To compute statistics, we ran 10000 times the analysis using permuted

versions of subjects' group identities to create an empirical null
distribution

RESULTS
• In PTSD, we found a set of hyper-colocalized nodes (red edges in
3) in the occipital and pericentral communities for the three
topological scales. Moreover, we found a set of hypo-colocalized
nodes (blue edges in figure 3) in the frontal, lateral, and medial
anteroposterior communities.

DUSCUSSION
• The results presented here suggest an imbalance in the large-
scale cortical organization in PTSD

• The analyses presented here could be applied to task-related

paradigms to investigate the reconfiguration in functional
communities constrained by a sensory or thought-related task.
Furthermore, coupled with structural connectivity data (the
connectome), the analyses presented here could be used to
investigate brain dynamics associated with this imbalance across
sensory-to-association areas
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References
Betzel, R. F., Bertolero,… & Bassett, D. S. (2019). The community structure of functional brain
networks exhibits scale-specific patterns of inter- and intra-subject variability. NeuroImage
David Corredor
Avena-Koenigsberger, A., Misic, B., & Sporns, O. (2018). Communication dynamics in complex brain
networks. Nature Reviews Neuroscience,

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