DRUG ANALYSIS

NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING

DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: stimulate smooth  To induce or  Hypersensitivity to  Drug- CNS: seizures, coma, Use cautiously in: ● Inform patient about
Oxytocin muscle stimulate drug drug.Sympathomim neonatal brain risks and benefits of
contractions in labor etics: postpartal damage, ● previous cervical or oxytocin-induced
 Cephalopelvic
Brand Name: uterus and cervix.  To control hypertension subarachnoid uterine surgery, history labour.
disproportion.
Oxymed postpartum Thiopental hemorrhage
 Fetal distress when of uterine sepsis
Dosage: bleeding anesthetics: delayed CV: premature
 Incomplete delivery is not anesthesia induction ventricular
imminent. contractions, ● breast-feeding
10 unit/mL vial abortion Vasoconstrictors:
 Prolonged use in severe hypertension arrhythmias, neonatal patients.
Route: uterine inertia or (when given within 3 bradycardia
Injection – I.V, severe toxaemia. to 4 hours of GI: nausea, vomiting
oxytocin) GU:postpartalhemorr
I.M  Hypertonic or
 Drug-herbs. hage; pelvic
hyperactive uterine
Ephedra (ma hematoma; uterine
Frequency: pattern.
huang): increased hypertonicity, spasm,
 Unfavourable fetal hypertension or tetanic contraction;
position or abruptio placentae;
Classification: presentation that’s uterine rupture (with
Oxytocic undeliverable excessive doses)
hormones Hematologic:afibrino
without conversion.
genemiaHepatic:
 Labour induction or neonatal jaundice
Reference: augmentation when Other:
Nurses Drug vaginal delivery is hypersensitivity
Handbook 7E reactions including
contraindicated (as
UnitedVRG anaphylaxis, low 5-
in invasive cervical
minute Apgar score
cancer, active
(neonate)
genital herpes, or
total placenta
previa)

STUDENT NURSE: CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________

 NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING
DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: inhibit  Rheumato  Hypersensitivity  Drug- CNS: headache, Use cautiously in: ●Tell patient to take
Ibuprofen cyclooxygenase, id arthritis; to drug or other drug.Antihyperten dizziness, oral drug with full glass
drowsiness, DRUG
an enzyme osteoarthr NSAIDs sives, diuretics: ● severe of water, with food, or
Brand Name: itis decreased efficacy nervousness, aseptic ANALYSIS
needed for  Perioperative use cardiovascular, renal, after meals to
Advil  Mild to of these drugs meningitis
prostaglandin in coronary artery or hepatic disease; GI minimize GI upset.
Dosage: moderate Aspirin and other CV: hypertension,
synthesis. bypass graft disease; asthma;
pain NSAIDs, arrhythmias
surgery EENT: amblyopia, chronic alcohol use ● To help prevent
400 mg P.O. q  Fever corticosteroids:
reduction additive adverse blurred vision, tinnitus esophageal irritation,
4 to 6 hours
 Primary GI effects GI: nausea, vomiting, ● elderly patients instruct patient to
p.r.n. or 400 to
dysmenor Cefamandole, constipation, avoid lying down for 30
800 mg I.V.
rhea cefoperazone, dyspepsia, abdominal ● pregnant (avoid use to 60 minutes after
over 30 discomfort, GI
 Fever cefotetan, drugs after 30 weeks’ taking dose. 2Instruct
minutes q 6 reduction; affecting platelet bleeding gestation) or patient to immediately
hours pain relief function (including GU: cystitis, breastfeeding patients report irregular
abciximab, hematuria, azotemia,
heartbeats, black tarry
Route: clopidogrel, renal failure
● children younger stools, vision changes,
P.O (analgesic) eptifibatide, Hematologic:anemia
, prolonged bleeding
than age 17 (safety unusual tiredness,
ticlopidine,
P.O (anti- tirofiban), time, aplastic anemia, and efficacy not yellowing of skin or
inflamm plicamycin, neutropenia, established) eyes, change in
thrombolytics, pancytopenia, urination pattern,
Frequency: valproic acid, thrombocytopenia, difficulty breathing,
warfarin: leukopenia, finger or ankle
increased risk of agranulocytosisHepat swelling, weight gain,
bleeding ic: hepatitis itching, rash, fever, or
Classification:
Cyclosporine: Metabolic:hyperglyce
NSAIDs sore throat.
increased risk of mia,
Reference:
nephrotoxicity hypoglycemiaRespira
Nurses Drug
Digoxin: slightly tory: bronchospasm ● Caution patient to
Handbook 7E avoid driving and other
increased digoxin Skin: rash, pruritus,
UnitedVRG hazardous activities
blood level urticaria,
Lithium: increased StevensJohnson until he knows how
lithium blood level, syndrome drug affects
greater risk of Other:edema, allergic concentration,
lithium toxicity reactions including alertness, and
 Drug-diagnostic anaphylaxis balance.
tests. Alanine
amino-transferase,
● As appropriate,
alkaline
review all other
phosphatase,
aspartate significant and life-
aminotransferase, threatening adverse
blood urea reactions and
nitrogen, interactions, especially
STUDENT NURSE: CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________

DRUG ANALYSIS

NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING

DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Antibiotic such as > Moderate to > Hypersensitivity to Drug-drug. GI: nausea, vomiting, Use cautiously in: > Advise patient to
Cefuroxime cefuroxime is severe cephalosporins or diarrhea, abdominal immediately report
axetil important for infections antacids such as: pain, dyspepsia,
penicillins rash or bleeding
Brand Name: preventing wound >Carnitine deficiency aluminum hydroxide tendency. .
infection and intra-
Dosage: abdominal
750 mg IM q 8 abscess following calcium carbonate > Teach patient how to
hours appendectomy. It recognize signs and
magnesium symptoms of
is used to treat
hydroxide
bacterial infections superinfection. Instruct
in many different him to report these
sodium bicarbonate
parts of the body. right away.
which may affect the
It belongs to the
absorption of
class of medicines
cefuroxime > As appropriate,
known as
cephalosporin review all other
immunosuppressant significant and life-
antibiotics. It s, such as
works by killing threatening adverse
mycophenolate
bacteria or mofetil or reactions and
preventing their mycophenolic acid interactions, especially
growth. those related to the
Drug-food. Moderate- drugs, tests, and foods
or high-fat meal: mentioned above
increased drug
bioavailability
STUDENT NURSE: CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR:

DRUG ANALYSIS
 NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING
DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Destroys gram- > Serious Hypersensitivity to  Drug-drug. CNS: dizziness, Use cautiously in: >Teach patient to
Gentamicin negative bacteria infections drug or other Acyclovir, vertigo, tremors, recognize and
sulfate caused by amphotericin B, numbness,
by irreversibly Pseudomonas
aminoglycosides >neuromuscular immediately report
binding to 30S carboplatin, depression, disease, renal signs and symptoms of
aeruginosa,
Brand Name: cephalosporins, confusion, lethargy,
subunit ofbacterial Escherichia impairment, hearing hypersensitivity
Gentacidin coli, and cisplatin, loop headache,
ribosomes and impairment reaction, infection,
Dosage: Proteus, diuretics, paresthesia,
blocking protein vancomycin, other neuromuscular unusual tiredness,
Klebsiella,
synthesis, Serratia, ototoxic or blockade, seizures, >sulfite sensitivity (with yellowing of skin or
Route:
I.V, I.M, Topical, resulting in Enterobacter, nephrotoxic drugs: neurotoxicity parenteral use) eyes, and muscle
misreading of Citrobacter, or increased risk of EENT: visual twitching. >Advise
Ophthalmic
Staphylococcu > obese patients
genetic code and ototoxicity and disturbances, dry patient to report signs
s species
Frequency: separation of > Endocarditis nephrotoxicity eyes, nystagmus, and symptoms of
ribosomes from Dimenhydrinate, photophobia, >elderly patients ototoxicity (hearing
prophylaxis
messenger RNA. other antiemetics: ototoxicity, hearing loss, ringing in ears,
before
masking of loss, tinnitus > pregnant or
Classification: surgery vertigo). >Instruct
ototoxicity GI: nausea, vomiting,
Aminoglycoside > External breastfeeding patients patient to drink plenty
symptoms General stomatitis, increased
ocular of fluids to ensure
infections anesthetics, salivation,
neuromuscular splenomegaly, >infants, neonates, adequate urine output.
Reference: caused by and premature infants.
susceptible blockers: increased anorexia GU:
Nurses Drug > Tell patient to
organisms activity of these increased urinary
Handbook 7E
> Treatment drugs Indomethacin: casts, polyuria, monitor urine output
UnitedVRG
and increased dysuria, erectile and report significant
prevention of gentamicin peak dysfunction, changes. >Caution
superficial and trough levels azotemia, patient to avoid driving
burns Penicillins (such nephrotoxicity and other hazardous
caused by as ampicillin, Hematologic: activities until he
susceptible ticarcillin): eosinophilia,
knows how drug
bacteria synergistic effect leukemoid reaction, affects concentration
hemolyticanemia,
Tacrolimus: and alertness. > As
aplastic anemia,
nephrotoxicity neutropenia, appropriate, review all
 Drug-diagnostic agranulocytosis, other significant and
tests. Alanine leukopenia, life-threatening
aminotransferase, thrombocytopenia, adverse reactions and
aspartate pancytopenia
aminotransferase, interactions, especially
Hepatic:
bilirubin, blood urea those related to the
hepatomegaly,
nitrogen (BUN), drugs and tests
hepatotoxicity,
creatinine, lactate hepatic mentioned above.
dehydrogenase: necrosisMusculosk
increased values eletal: joint pain,
Granulocytes, muscle twitching
hemoglobin, Respiratory:apnea
STUDENT NURSE: CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________
 DRUG ANALYSIS

NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING

DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Relaxes vascular Hypertension > Hypersensitivity to Drug- CNS: dizziness, Use cautiously in: >Monitor CBC, lupus
Hydralazine smooth muscles drug or tartrazine drug.Antihypertensive drowsiness, > suspected CV or erythematosus cell
of arteries and > Coronary artery s, nitrates: additive headache, peripheral cerebrovascular studies, and
Brand Name: arterioles, causing disease hypotension neuritis disease, severe renal antinuclear antibody
Apresoline Epinephrine: reduced CV: tachycardia,
peripheral > Mitral valvular or hepatic disease titers before and
Dosage: pressor response to angina, orthostatic
vasodilation and rheumatic heart > pregnant or periodically during
10 mg P.O. epinephrine hypotension,
decreasing disease Metoprolol, arrhythmias breastfeeding patients therapy.
q.i.d. After 2 to
4 days, may peripheral propranolol: increased EENT: lacrimation, > children > Monitor blood
increase to 25 vascular blood levels of both nasal congestion pressure, pulse rate
mg P.O. resistance. These drugs MAO inhibitors: GI: nausea, vomiting, and regularity, and
actions decrease increased hypotension diarrhea, daily weight.
Route: blood pressure Drug-diagnostic constipation, anorexia > To avoid rapid blood
P.O, I.V, I.M and increase heart tests. Coombs’ test: Metabolic: sodium pressure, drop, taper
rate, stroke positive result retention dosage gradually
Frequency: Granulocytes, Musculoskeletal:
volume, and before discontinuing.
hemoglobin, joint pain, arthritis
cardiac output. 2Assess for lupuslike
neutrophils, platelets, Skin: rash, blisters,
red blood cells, white flushing, pruritus, signs and symptoms,
Classification: including joint pain,
blood cells: decreased urticaria
Peripheral
levels Other: chills, fever, fever, myalgia,
vasodilator
Drug-behaviors. lymphadenopathy, pharyngitis, and
Alcohol use: additive edema, lupuslike splenomegaly.
hypotensive response syndrome > Watch for peripheral
Reference:
McGraw-Hill neuritis. If it occurs,
Nurse’s Drug expect to give
Handbook 7th pyridoxine
Edition,
STUDENT NURSE: CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________
 NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING
DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Increases osmotic ● Hypermagnesemia Drug-drug. CNS (with I.V. use): Use cautiously in: When giving prolonged
Magnesium Mild DRUG
gradient in small ● Heart block Aminoquinolones, confusion, ● renal insufficiency, or repeated I.V.
Sulfate magnesium ANALYSIS
intestine, which ● Myocardial damage nitrofurantoin, decreased reflexes, abdominal pain, infusions, assess
draws water into deficiency ● Active labor or penicillamine, dizziness, syncope, nausea and vomiting, patellar reflex and
Brand Name: intestines and within 2 hours of tetracyclines: sedation, rectal bleeding, anuria, monitor for respiratory
MgSO4 Severe
causes distention. delivery decreased hypothermia, hypocalcemia rate of 16
Dosage:
These effects hypomagnese absorption of these paralysis CV (with ● pregnant patients. breaths/minute or
8-24-
stimulate mia drugs (with oral I.V. use): more.
mEqaddedto
TPN solution peristalsis and magnesium) CNS hypotension, With I.V. use, monitor
bowel evacuation. Hypomagnese depressants: arrhythmias, blood magnesium level
Route: In antacid action, mia treatment additive effects circulatory collapse (desired level is 3 to 6
P.O, I.V, I.M reacts with Digoxin: heart block, GI: nausea, mg/ dl or 2.5 to 5
hydrochloric acid Hypomagnese conduction changes vomiting, cramps, mEq/L). Check for
Frequency: in stomach to form mia (with I.V. use) flatulence, anorexia signs
water and prophylaxis Enteric-coated Metabolic: and symptoms of
Classification: increase gastric drugs: faster hypermagnesemia, magnesium toxicity
Mineral Supplemental
pH. In dissolution of these hypocalcemia (hypotension, nausea,
magnesium in
anticonvulsant drugs Musculoskeletal vomiting, ECG
total
action, depresses Neuromuscular (with I.V. use): changes, muscle
Reference: parenteral
CNS and blocks blockers: increased muscle weakness, weakness, mental or
McGraw-Hill nutrition
Nurse’s Drug transmission of effects of these flaccidity respiratory depression,
Handbook 7th peripheral drugs (with I.V. use) Respiratory: coma). Keep injectable
Constipation
Edition, p. 742- neuromuscular Drug-diagnostic respiratory calcium on hand to
744. impulses. Indigestion tests. Calcium, paralysis Skin: counteract magnesium
magnesium: diaphoresis Other: toxicity.
increased levels allergic reaction, ● Monitor urine output,
(with I.V. use injection site which should measure
reaction, laxative 100 ml or more every
dependence (with 4 hours. 2If I.V.
repeated or magnesium was given
prolonged use) before delivery, assess
neonate for signs and
symptoms of
magnesium toxicity,
such as
neuromuscular or
respiratory depression.
● Monitor electrolyte
levels and liver
function tests.
STUDENT NURSE: CUI, MARK CHRISTIAN T.. CLINICAL INSTRUCTOR: __________________________________

DRUG ANALYSIS
 NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING
DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Stimulates CNS ● Hypersensitivity to Drug-drug. CNS: headache, Use cautiously in: ● Obtain direct
Methyldopa alpha-adrenergic Hypertension drug or its Adrenergics, MAO asthenia, ● heart failure, edema, Coombs’ test before
receptors, components inhibitors: excessive weakness, hemolyticanemia, therapy starts and 6
Brand Name: decreasing ● Pheochromocytoma sympathetic dizziness, sedation, hypotension, severe and 12 months later.
Aldomet sympathetic ● Active hepatic stimulation decreased mental bilateral ● Monitor periodic
Dosage:
stimulation to disease or history of Amphetamines, acuity, depression, cerebrovascular blood counts to detect
250mg
heart and blood methyldopa- barbiturates, paresthesia disease adverse hematologic
POb.i.dtot.i.
vessels. Also associated hepatic nonsteroidal anti- parkinsonism, Bell’s ● dialysis patients reactions.
Route: reduces arterial disorders ● MAO inflammatory drugs, palsy, involuntary ● elderly patients ● Monitor liver function
P.O, I.V pressure and inhibitor uses within phenothiazines, choreoathetotic ● pregnant or tests and check for
plasma renin. past 14 days tricyclic movements CV: breastfeeding patients. signs and symptoms of
Frequency: antidepressants: bradycardia, hepatic dysfunction
Once a day decreased edema, orthostatic (particularly during first
antihypertensive hypotension, 6 to 12 weeks of
Classification: effect Anesthetic’s, myocarditis EENT: therapy).
Centrally acting antihypertensives, nasal congestion ● Check for edema or
antiadrenergic
nitrates: additive GI: nausea, weight gain to help
hypotension Ferrous vomiting, diarrhea, determine if diuretic
gluconate, ferrous constipation, should be added to
Reference:
McGraw-Hill sulfate: decreased abdominal regimen.
Nurse’s Drug methyldopa blood distention, colitis, ● Monitor blood
Handbook 7th level Haloperidol: dry mouth, pressure. Drug
Edition, p. 781 increased sialadenitis, sore or tolerance may occur
haloperidol effects, black tongue, during second and
increased risk of pancreatitis GU: third months of
psychoses breast enlargement, therapy.
Levodopa: additive gynecomastia,
hypotension and failure to ejaculate,
CNS toxicity erectile dysfunction
Lithium: increased Hematologic:
risk of lithium toxicity eosinophilia,
Nonselective beta- hemolyticanemia
adrenergic blockers: Hepatic: hepatitis
paradoxical Other: fever
hypertension
Tolbutamide:
increased
tolbutamide effects
Drug-diagnostic
tests. Alanine
aminotransferase,
STUDENT NURSE: CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________
 DRUG ANALYSIS

NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING

DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: ➣ Essential ➣ Treatment of ➣Hypersensitivity to DRUG: Antacids may Large doses may Peptic ulcer, regional >Assess nutritional
Ferrous Sulfate component in Iron Deficiency iron salts. decrease absorption aggravate existing enteritis, ulcerative status, dietary history.
formation of Hgb, Anemia Hemochromatosis, of ferrous compounds. GI tract disease colitis, pts receiving Question history of
Brand Name: myoglobin, hemolyticanemias. May decrease (peptic ulcer, frequent blood hemochromatosis,
Fer-Iron enzymes. Promotes ➣ Used to absorption of hemolyticanemia,
regional enteritis, transfusions.
Dosage: effective prevent Iron bisphosphonates (e.g., ulcerative colitis.
Deficiency ulcerative colitis). Question use of
Oral Solution: erythropoiesis and risedronate), cefdinir,
quinolones, Severe iron antacids, calcium
75 mg/mL (15 transport, utilization
of oxygen. tetracyclines. poisoning occurs supplements.
mg/mL
most often in ➣ Monitor serum iron,
elemental total iron-binding
HERBAL: None children,
iron). Tablets: capacity, reticulocyte
significant. manifested as
325 mg (65 count, Hgb, ferritin.
vomiting, severe Monitor daily pattern of
mg elemental FOOD: Cereal, coffee, abdominal pain, bowel activity, stool
iron). Syrup: dietary fiber, eggs, consistency. Assess for
diarrhea,
300 mg/5 mL milk, and tea decrease clinical improvement,
dehydration,
(60 mg absorption. record relief of iron-
followed by deficiency symptoms
elemental iron
hyperventilation, (fatigue, irritability, pallor,
per 5 mL). LAB VALUES: May
pallor, cyanosis, paresthesia of
increase serum extremities, headache).
bilirubin, iron. May cardiovascular
Route: ➣ Expect stool color to
P.O decrease serum collapse.
darken. • Oral liquid may
calcium. stain teeth. • To prevent
Frequency: mucous membrane and
teeth staining with liquid
preparation, use dropper
or straw and allow
Classification: solution to drop on back
Prevention, of tongue. • If GI
treatment of discomfort occurs, take
iron-deficiency after meals or with food.
anemia • Do not take within 2 hrs
of other medication or
Reference:
eggs, milk, tea, coffee,
Nursing 2020 cereal. • Do not take
Drug Handbook antacids or OTC calcium
supplements.
STUDENT NURSE: CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________
 DRUG ANALYSIS

NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING

DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: >Stimulates > > Contraindicated in >No information >Altered sleep >Use cautiously in >Administer orally if at all
Folic Acid production of red Recommende pernicious, aplastic, provided pattern, malaise, breastfeeding patients possible. With severe GI
and white blood d dietary or normocytic anemia poor concentration, malabsorption or very
Brand Name: cells and platelets allowance impaired judgment, severe disease, give IM,
Folvite IV, or subcutaneously.
in some hyperactivity,
Dosage: >Megaloblasti
megaloblasticane anorexia, nausea,
canemia >Test using Schilling test
mias related to flatulence, bitter and serum vitamin B12
Route:
P.O
taste, allergic levels to rule out
reaction (including pernicious anemia.
Frequency: rash, pruritus, Therapy may mask signs
erythema), of pernicious anemia
Classification: bronchospasm while the neurologic
Tablets: 0.4 deterioration continues.
mg, 0.8 mg, 1
mg >WARNING: Use caution
when giving the
parenteral preparations
Reference: to premature infants.
Nurses Drug These preparations
Handbook 7E contain benzyl alcohol
UnitedVRG and may produce a fatal
gasping syndrome in
premature infants.

>WARNING: Monitor
patient for
hypersensitivity
reactions, especially if
drug previously taken.
Keep supportive
equipment and
emergency drugs readily
available in case of
serious allergic
response.
STUDENT NURSE: CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________
 NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING
DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Disturbs DNA ➣Trichomoniasis > Hypersensitivity to >Drug-drug. CNS: dizziness, Use cautiously in: ● Advise patient to
Metronidazole synthesis in ➣ Bacterial drug, other Azathioprine, headache, ataxia, take drug with food if it
infections fluorouracil: increased vertigo, DRUG
susceptible nitroimidazole > severe hepatic causes GI upset.
Brand Name: ➣Amebiasis risk of leukopenia incoordination, ANALYSIS
bacterial derivatives, or impairment However, instruct him
Flagyl ➣Amebic liver Cimetidine: insomnia, fatigue
organisms parabens (topical to take extended-
Dosage: abscess decreased EENT: rhinitis,
form only) > history of blood release tablets 1 hour
>Bacterial ➣ Bacterial metronidazole sinusitis, pharyngitis
vaginosis >First-trimester metabolism, GI: nausea, vomiting, dyscrasias, seizures, before or 2 hours after
infections
Adults: Initially, ➣ Perioperative pregnancy in patients increased risk of diarrhea, abdominal or other neurologic meals.
15 mg/kg I.V., prophylaxis in with trichomoniasis toxicity Disulfiram: pain, furry tongue, problems
followed by 7.5 colorectal acute psychosis and glossitis, dry mouth, ● Tell patient with
mg/kg I.V. q 6 surgery
confusion Lithium: anorexia > breastfeeding trichomoniasis to
hours, not to ➣ Rosacea
increased lithium GU: dysuria, dark patients refrain from sexual
exceed 4 g/day
for 7 to 10 day blood level urine, incontinence intercourse or to have
Phenobarbital: Hematologic:leukop > children male partner wear a
Route: increased enia
condom to prevent
P.O, I.V, metronidazole Skin: rash, urticaria,
reinfection. Explain
Topical, Vaginal metabolism, burning, mild skin
decreased efficacy dryness, skin that asymptomatic sex
Warfarin: increased irritation, transient partners should be
Frequency: treated
warfarin effects redness (with topical
>Drug-diagnostic forms) simultaneously.
tests. Alanine Other: unpleasant or
Classification: aminotransferase, metallic taste, ● Advise patient to
Nitroimidazole aspartate superinfection, report fever, sore
derivative aminotransferase, phlebitis at I.V. site throat, bleeding, or
lactate
bruising.
dehydrogenase:
Reference: altered levels
Nurses Drug >Drug-behaviours. ● Inform patient that
Handbook 7E Alcohol use: drug may cause
UnitedVRG disulfiram-like metallic taste and may
reaction discolor urine deep
brownish-red.

● Tell patient using

topical form to clean
area thoroughly with
mild cleanser before
use and then wait 15
to 20 minutes before
applying drug. Tell her
she may apply
cosmetics to skin after
STUDENT NURSE:CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________

DRUG ANALYSIS
 NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING
DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: used to relieve >Moderately >Hypersensitivity to Drug-drug. CNS: drowsiness, Use cautiously in: >Monitor for adverse
Ketorolac moderately severe severe acute drug, its components, Anticoagulants: headache, dizziness >mild to moderate renal reactions, especially
pain, usually after aspirin, or other NSAIDs prolonged prothrombin CV: hypertension impairment, prolonged bleeding time
pain
surgery. Ketorolac is >Concurrent use of time Aspirin: altered EENT: tinnitus cardiovascular disease and CNS reactions.
Brand Name: in a class of aspirin, other NSAIDs, ketorolac distribution, GI: nausea, vomiting, >Check I.M. injection site
>elderly patients
medications called or probenecid metabolism, and diarrhea, >pregnant patients for hematoma and
Dosage: NSAIDs. It works >Peptic ulcer disease excretion; increased constipation, >children bleeding.
30 mg IM q 8 by stopping the >GI bleeding or risk of serious adverse flatulence, dyspepsia, >Monitor fluid intake and
hours body's production perforation reactions epigastric pain, output.
of a substance that >Advanced renal Cholestyramine: stomatitis
causes pain, fever, impairment, risk of renal decreased ketorolac Hematologic:
and inflammation. failure absorption thrombocytopenia
>Increased risk of Corticosteroids, other Skin: rash, pruritus,
bleeding, suspected or NSAIDs: additive diaphoresis
confirmed adverse GI effects Other: excessive
cerebrovascular Diuretics: decreased thirst, edema,
bleeding, hemorrhagic diuretic effect injection site pain
diathesis, incomplete Hydantoins, lithium:
hemostasis increased blood levels
>Prophylactic use and greater risk of
before major surgery, toxicity of
intraoperative use when these drugs
hemostasis is critical Probenecid: increased
>Labor and delivery risk of ketorolac
>Breastfeeding toxicity
STUDENT NURSE:CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________

NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING

DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Reduces gastric >Active >Hypersensitivity to Drug-drug. Antacids: CNS: headache, Use cautiously in: >Assess vital signs.
Ranitidine acid secretion and duodenal ulcer drug or its components decreased ranitidine agitation, anxiety >renal or hepatic
increases gastric >Alcohol intolerance absorptionPropantheli GI: nausea, vomiting, impairment, heart rhythm >Monitor CBC and
mucus and >To maintain (with some oral ne: delayed ranitidine diarrhea, disturbances, liver function tests DRUG
Brand Name:
healing of products) absorption and constipation, phenylketonuria
Zantac bicarbonate ANALYSIS
duodenal ulcers >History of acute increased peak blood abdominal discomfort (effervescent tablets)
Dosage: production, porphyria level or pain >elderly patients
Adults: 150 mg creating a Drug-diagnostic Hematologic: >pregnant or
or 10 ml P.O. protective coating tests. Creatinine: reversible breastfeeding patients.
b.i.d., or 300 mg on gastric mucosa slight elevation granulocytopeniaan
or 20 ml P.O. Hepatic enzymes: d thrombocytopenia
daily, or 50 mg increased levels Urine Hepatic: hepatitis
I.V. or I.M. q 6 protein tests using Skin: rash
to 8 hours Multistix: false- Other: pain at I.M.
negative results injection site, burning
Route: Drug-herbs. Yerba or itching at I.V. site,
I.V maté: decreased drug hypersensitivity
clearance reaction
Drug-behaviors.
Frequency:
Smoking: decreased
Up to a ranitidine effects
maximum of
50mg every 6 to
8 hours

Classification:
H2 blockers

Reference:
Nurses Drug
Handbook 7E
UnitedVRG
STUDENT NURSE:CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________
 NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING
DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: Blocks dopamine >To facilitate >Hypersensitivity to Drug-drug. CNS: drowsiness, Use cautiously in: >Monitor blood pressure
Metoclopramide receptors by small-bowel drug Anticholinergics, restlessness, anxiety, >diabetes mellitus, renal during I.V.
disrupting CNS intubation; >Pheochromocytoma opioids: antagonism of depression, irritability, dysfunction administration. DRUG
chemoreceptor radiologic >Parkinson’s disease metoclopramide’s GI fatigue, lassitude, >history of depression >Stay alert for ANALYSIS
Brand Name:
examination >Suspected GI motility effect insomnia, tardive >elderly patients depression and other
Reglan and trigger zone,
when delayed obstruction, perforation, Antidepressants, dyskinesia, >pregnant or adverse CNS effects.
Metozoly ODT increasing gastric emptying or hemorrhage antihistamines, other parkinsonian-like breastfeeding patients Watch for
Dosage: peristalsis and interferes >History of seizure CNS depressants reactions, >children extrapyramidal
Adults and promoting gastric disorders (such as opioids, extrapyramidal reactions, which
children emptying >Diabetic sedative-hypnotics): reactions, akathisia, usually occur within
older than gastroparesis additive CNS dystonia
first 24 to 48 hours of
age 14: depression CV: hypertension,
Cimetidine, digoxin: hypotension, therapy. To reverse
10 mg I.V. as these symptoms, give
decreased blood arrhythmias,
a single dose levels of these drugs diphenhydramine 50
Children ages neuroleptic
General anesthestics: malignant mg I.M. or benztropine
6 to 14: 2.5 to 5 exaggerated 1 to 2 mg I.M., as
mg I.V. syndrome
hypotension GI: nausea, prescribed.
as a single Haloperidol, >Check for development
dose constipation,
phenothiazines: diarrhea, dry mouth of parkinsonian-like
Children increased risk of symptoms, which may
younger than GU: gynecomastia
extrapyramidal occur within first 6
age 6: 0.1 mg/ reactions Levodopa: months of therapy and
kg I.V. as a decreased usually subside within 2
single dose metoclopramide to 3 months after
efficacy MAO withdrawal.
Route: inhibitors: increased With long-term use,
P.O, I.V, I.M catecholamine release assess patient for
Drug-diagnostic tardive dyskinesia and
tests. Aldosterone,
Frequency: discontinue drug if
prolactin: increased
levels signs or symptoms of
Drug-behaviors. tardive dyskinesia
Alcohol use: increased develop. Avoid
Classification:
blood alcohol level, treatment for longer
Prokinetic
increased CNS than 12 weeks in all
agents depression but rare cases in which
therapeutic benefit
outweighs risk of
Reference: developing tardive
Nurses Drug dyskinesia.
Handbook 7E >Monitor patient
UnitedVRG closely for signs and
symptoms of
neuroleptic malignant
syndrome
(hyperthermia, muscle
rigidity, altered
consciousness, and
STUDENT NURSE:CUI, MARK CHRISTIAN T. CLINICAL INSTRUCTOR: __________________________________

NAME OF SPECIFIC INDICATION CONTRAINDICATIO DRUG ADVERSE SPECIFIC NURSING

DRUG ACTION N INTERACTION REACTION PRECAUTION RESPONSIBILITIES
Generic Name: used to  Very high >Hypersensitivity to Drug-drug. CNS: drowsiness, Use cautiously in: >Monitor blood pressure
Paracetamol temporarily relieve fever, drug Antidepressants, restlessness, anxiety, >diabetes mellitus, renal during I.V.
mild-to-moderate >History of seizure antihistamines, other depression, irritability, dysfunction administration.
only when disorders CNS depressants fatigue, lassitude, >Stay alert for
pain and fever. It >history of depression
Brand Name: oral Cimetidine, digoxin: insomnia, tardive depression and other
is not clear exactly administr decreased blood dyskinesia, adverse CNS effects.
Dosage: how paracetamol
ation is levels of these drugs parkinsonian-like Watch for
works. However, it General anesthestics: reactions,
not extrapyramidal
is thought to work exaggerated extrapyramidal
300 mg q 4 possible reactions, which
by blocking hypotension reactions, akathisia,
hours  Mild pain, usually occur within
chemical Drug-behaviors. dystonia
first 24 to 48 hours of
messengers in the only when Alcohol use: increased CV: hypertension,
therapy. To reverse
Frequency: brain that let us oral blood alcohol level, hypotension,
increased CNS GI: nausea, these symptoms, give
know when we're administr diphenhydramine 50
in pain and by depression constipation,
ation is diarrhea, dry mouth mg I.M. or benztropine
affecting the not GU: gynecomastia 1 to 2 mg I.M., as
chemical possible prescribed.
messengers that
>Monitor patient
regulate our body
closely for signs and
temperature.
symptoms of
neuroleptic malignant
syndrome
(hyperthermia, muscle
rigidity, altered
consciousness, and
evidence of autonomic
instability [irregular
pulse or blood
pressure, tachycardia,
diaphoresis, and
cardiac arrhythmias]);
immediately
discontinue drug if
these symptoms
occur.