1) The document discusses the story of Dr. Krishnamurthy Ella, the founder of Bharat Biotech who developed the Covaxin COVID-19 vaccine. It describes his background growing up in a small village in India and his education and career path to founding Bharat Biotech.
2) It outlines the process of developing Covaxin, with Dr. Ella deciding on a killed-virus vaccine approach rather than mRNA due to practical reasons. Covaxin went through animal and human trials and was found to generate antibodies against COVID-19.
3) Covaxin was developed without any funding from the government, representing a success story for an indigenous Indian vaccine.
Original Description:
Original Title
Script Writing on Covid and Frontline Working Staff
1) The document discusses the story of Dr. Krishnamurthy Ella, the founder of Bharat Biotech who developed the Covaxin COVID-19 vaccine. It describes his background growing up in a small village in India and his education and career path to founding Bharat Biotech.
2) It outlines the process of developing Covaxin, with Dr. Ella deciding on a killed-virus vaccine approach rather than mRNA due to practical reasons. Covaxin went through animal and human trials and was found to generate antibodies against COVID-19.
3) Covaxin was developed without any funding from the government, representing a success story for an indigenous Indian vaccine.
1) The document discusses the story of Dr. Krishnamurthy Ella, the founder of Bharat Biotech who developed the Covaxin COVID-19 vaccine. It describes his background growing up in a small village in India and his education and career path to founding Bharat Biotech.
2) It outlines the process of developing Covaxin, with Dr. Ella deciding on a killed-virus vaccine approach rather than mRNA due to practical reasons. Covaxin went through animal and human trials and was found to generate antibodies against COVID-19.
3) Covaxin was developed without any funding from the government, representing a success story for an indigenous Indian vaccine.
EFFECTS OF COVID 19 PANDEMIC IN DAILY LIFE COVID-19 is a disease caused by a new strain of coronavirus. ‘CO’ stands for corona, ‘VI’ for virus, and ‘D’ for disease. Formerly, this disease was referred to as ‘2019 novel coronavirus’ or ‘2019-nCoV.On 31 December 2019, WHO was informed of cases of pneumonia of unknown cause in Wuhan City, China. A novel coronavirus was identified as the cause by Chinese authorities on 7 January 2020 and was temporarily named “2019-nCoV”. Most people who are infected with the SARS-CoV- 2 virus have respiratory symptoms. They start to feel a little bit unwell, they will have a fever, they may have a cough or a sore throat or sneeze. In some individuals, they may have gastrointestinal symptoms. Others may lose the sense of smell or the sense of taste. As time passes in a pandemic there’s a greater chance of survival for those getting infected 6 months later like September 2020 than those who got infected 6 months earlier say February 2020. The reason for this is that Doctors and scientists know more about Covid-19 now than 6 months ago and hence are able to treat patients better. I will list 5 important things that we know now that we didn’t know in February 2020 for your understanding. COVID-19 was initially thought to cause deaths due to pneumonia- a lung infection- and so Ventilators were thought to be the best way to treat sick patients who couldn’t breathe. Now we are realising that the virus causes blood clots in the blood vessels of the lungs and other parts of the body and this causes the reduced oxygenation . Now we know that just providing oxygen by ventilators will not help but we have to prevent and dissolve the micro clots in the lungs. This is why we are using drugs like Asprin and Heparin ( blood thinners that prevents clotting) as protocol in treatment regimens in June 2020. Previously patients used to drop dead on the road or even before reaching a hospital due to reduced oxygen in their blood- OXYGEN SATURATION. This was because of *HAPPY HYPOXIA*- where even though the oxygen saturation was gradually reducing the COVID-19 patients did not have symptoms until it became critically less, like sometimes even 70%. Normally we become breathless if oxygen saturation reduces below 90%. This breathlessness is not triggered in Covid patients and so we we’re getting the sick patients very late to the hospitals in February 2020. Now since knowing about happy hypoxia we are monitoring oxygen saturation of all covid patients with a simple home use pulse oxymeter and getting them to hospital if their oxygen saturation drops to 93% or less*. This gives more time for doctors to correct the oxygen deficiency in the blood and a better survival chance in June 2020 We did not have drugs to fight the corona virus in February 2020. We were only treating the complications caused by it… hypoxia. Hence most patients became severely infected. Now we have 2 important medicines FAVIPIRAVIR & REMDESIVI Which are ANTIVIRALS that can kill the corona virus . By using these two medicines we can prevent patients from becoming severely infected and therefore cure them BEFORE THEY GO TO HYPOXIA. This knowledge we have in September 2020… not in February 2020. Many Covid-19 patients die not just because of the virus but also due the patients own immune system responding In an exaggerated manner called *CYTOKINE STORM*. This stormy strong immune response not only kills the virus but also kills the patients. In February 2020 we didn’t know how to prevent it from happening. Now in September 2020, we know that easily available medicines called Steroids, that doctors around the world have been using for almost 80 years can be used to prevent the cytokine storm in some patients. Now we also know that people with hypoxia became better just by making them lie down on their belly- known as prone position Apart from this a few days ago Israeli scientists have discovered that a chemical known as Alpha Defensin produced by the patients White blood cells can cause the micro clots in blood vessels of the lungs and this could possibly be prevented by a drug called Colchicine used over many decades in the treatment of Gout. So now we know for sure that patients have a better chance at surviving the COVID-19 infection now in September 2020 than in February 2020 for sure. India has not peaked in March or April because of the lockdown. This strategy has postponed the Covid-19 pandemic in INDIA by 3 crucial months that has enabled us to save thousands of lives. Going forward there’s nothing to panic about Covid- 19, if we remember that a person who gets infected, later has a better chance at survival than one who got infected early feet distancing from others .Wear proper masks Work from home whenever possible Order home delivery of food groceries and vegetables Stay at home during lockdown . Hand wash & hygiene The most important thing is if you lie down on your stomach, then there is more Oxygen flow to your Lungs. So your breathing will be lot easier With this we can beat the virus . If someone tells you every one is going to get infected, tell them that you are willing to wait to be the last person… who knows by then we might even have a Vaccine.
The Story of Covaxin
On the border between Tamil nadu and erstwhile Andhra Pradesh, lies the temple town of Thiruthani, one of the six famed abodes of Lord Muruga. Krishnamurthy Ella was born in 1969, in an agricultural family to middle class parents. No one could have imagined his trajectory. Perhaps because of his background, Krishna wanted to study agriculture. His father wasn’t pleased - he told his son “Nobody becomes a farmer by just studying agriculture” . Unfazed, Krishna joined University of Agricultural sciences in Bangalore. His passion and hardwork earned him a gold medal. Unlike “ordinary” gold medalists, he wasn’t content to get a job. Nevertheless he supported himself after undergrad by working briefly in the agricultural division of Bayer Pharma. He longed for more. He got a rotary scholarship which enabled him to move to the US, to do his PhD in University of Wisconsin. The scholarship was the wind under his wings. There was no looking back. His speciality was molecular biology. While in the US, he met Suchitra, an economics graduate and married her. Average Indians in US would dream of a green card for themselves. Dr Krishna dreamt for millions of people - freedom from diseases. His solution - low cost vaccine for neglected diseases. He wanted his dreams to become reality in India. He started Bharat Biotech in Hyderabad in the newly formed Genome Valley. The first product was caesium free Hepatitis B vaccine - the first in the world. His work caught the attention of Bill& Melinda Gates foundation - whose funds enabled Bharat Biotech to develop Rotavirus vaccine and conjugate Typhoid vaccine - again for the first time in the world. It took 16 long years to make the rotavirus vaccine a reality. The vaccine costs 85 dollars in the western world, but Krishna had brought its price down to an astounding 1 dollar ! The vaccines are available in 70 countries and Dr Krishna and team have 140 patents to their name. Then covid happened. The race for the vaccine started. The virus was new. No one knew what would work for sure - and everyone was hedging bets. Meanwhile, Adar Poonawalla , the billionaire CEO of the world’s largest vaccine manufacturing company was in talks with Oxford and Astra for manufacturing a adenovirus vaccine. Half a dozen companies from India tried, but realistically our collective fate depended on these two men. They couldn’t have been more different. Poonawalla was a born billionaire, young and dashing, dressed in immaculate tuxedos, driving luxury cars and flying private jets to London. Krishna was a scientist from a family of farmers, a salt of the earth man who had risen through sheer hardwork and grit. The global race to develop a vaccine had many approaches simultaneously. It’s a little like betting on many horses at the same time. Krishna realised that the vaccines should not just be safe and effective, but also practical. That meant no difficult storage conditions. So mRNA vaccines were out. The adenovirus vaccines trick the body into believing that it has infection by sending just the spike protein the virus uses to enter the cell. The immune system once primed, remembers this and when the real virus attacks, is able to protect us. There was one glitch - the protection wasn’t full, at least in the early stages when they tested in chimpanzees . Krishna toyed with the idea of modified rabies virus as a vector, but it didn’t work out. His projects with University of Wisconsin , his alma mater and Thomas Jefferson Institute too didn’t yield much results. When the rest of the world went for cutting edge mRNA tech, Dr Krishna decided to go the retro route. Sometimes, old is gold. And he struck gold with the killed virus vaccine , developed in association with ICMR. It had to be tested though - initially in mice and guineapigs and then in humans. There were numerous struggles in phase 1 and 2 trials. This was a race against time. Corona was killing people. The previous vaccine had taken long years of research. Will covaxin work? Will it be safe? Were the foremost questions in everyone’s mind. With the help of India’s virologists , they shortened the testing phase. They gave the vaccine to volunteers and in 28 days - their blood sample was taken. It was tested in a high biosafety lab with the deadly virus. If the vaccine had worked, the antibodies in the blood sample, would neutralise the virus and there won’t be any growth. To their ecstasy, the vaccine worked brilliantly. At long last, he had developed a vaccine that was made in India, but for the world. Covaxin was born. Amazingly, Krishna Ella had achieved this without a single rupee from the government !There were further struggles ahead - in human testing. The pandemic had created a virtual Babel of tongues, magnified a million times by social media - with every Tom, Dick and Harry raising doubts about the vaccine in every stage. Indian regulatory authorities were sane for once - they expedited the process. India became the only third world country to develop a vaccine. With the Vaccine Maitri initiative, it gave vaccines to many countries. It was an incredible achievement. In the 60s, President Kennedy announced that America will put a man on the moon within a decade - eventhough no one knew how. It came to be known as the “moonshot”. Covaxin is India’s moonshot moment or perhaps a “coroshot” moment, achieved not in a decade, but within one year. It’s our own success in the war against an invisible foe. The fruits of this victory, will be shared - with the poorest of countries. They say, seeing is believing. Great men reverse this adage. They believe with such intensity that they bring to life and see what they believe. Believing is seeing.
SITUATION OF DOCTORS DURING THE
PANDEMIC Doctors form an essential part of an effective response to the COVID-19 pandemic. We argue they have a duty to participate in pandemic response due to their special skills, but these skills vary between different doctors, and their duties are constrained by other competing rights. We conclude that while doctors should be encouraged to meet the demand for medical aid in the pandemic, those who make the sacrifices and increased efforts are owed reciprocal obligations in return. When reciprocal obligations are not met, doctors are further justified in opting out of specific tasks, as long as this is proportionate to the unmet obligation. They have critical roles in diagnosis, containment and treatment, and their commitment to treat despite increased personal risks is essential for a successful public health response. Frontline workers have been experiencing high work volume, personal risk and societal pressure to meet extraordinary demands for healthcare. Despite this traditional public health ethics has paid little attention to the protection of the rights of doctors. While we have so far looked at the duty of care of doctors, this is not a homogenous group. All doctors have a duty (within limitations) to care for their patients, but an acutely unwell and infectious patient might not be within the normal range of practice of some specialties. If we compare an infectious disease physician with an ophthalmic surgeon, two arguments could be made for the greater duty of the infectious disease physician: this could arise from both their greater skill in managing patients with COVID-19 and by their choice of specialty. It could be argued that by choosing to train in the management of infectious diseases they have implicitly agreed to accept a predetermined level of risk, and therefore, frontline pandemic work may fall within the scope of agreed duties. In short, the obligation to participate in frontline work is higher for those who chose to ‘opt in’ to higher risk work at specialty training, than for those who chose to ‘opt out’. This neither implies the infectious disease doctor has an absolute duty to participate in frontline work regardless of personal risk or that the ophthalmic surgeon has no duty, rather that the degree of obligation may vary between specialties within certain constraints. Licensed doctors may not be the only doctors asked to help care for patients during the pandemic. In the UK, the government called for recent retirees and senior medical students to volunteer in the response to COVID-19. This leads to the question of when professional or vocational obligations start and end. As medical students’ training is subsidised by the UK government, this could be grounds for the start of a duty to society, with this only being able to be realised later in medical school when students may have skills that could aid in the response. Although the age of most medical students means they are likely to be low risk for complications of COVID- 19, it is not clear that the skills medical students have are sufficiently useful to counter the perhaps greater risks of psychological and emotional distress in those who have not developed resilience by working in the health system. The duty to return for retirees, or those that have chosen to leave medicine, should not be grounded in their choice to be a doctor. It would be an unduly extensive duty if understood as a lifelong commitment lasting beyond a professional career. However, as recent retirees in acute care specialties could be extremely skilled staff, this duty could be ground in a ‘duty of easy rescue’. This means that ‘if it is in your power to save a life or prevent something bad from happening where the cost to you is negligible, very less, or has comparable moral importance, you are morally obliged to do it’. However, in the case of COVID-19 retirees are by their age at risk of death and serious illness, challenging the idea that the cost is eligible or this an ‘easy rescue’. Furthermore, intensive care unit beds and ventilators (as well as doctors) are a finite resource. Putting retirees on the front line may generate a net harm, rather than a net benefit. From both an ethical and pragmatic perspective, doctors must be viewed in the context of rich lives with multiple competing demands. We should encourage doctors to meet the demand for medical aid in the pandemic, but those who make the sacrifices and increased efforts are owed reciprocal obligations in return. When reciprocal obligations are not met, doctors are further justified in opting out of specific tasks, as long as this is proportionate to the unmet obligation. To encourage doctors to meet the demand for healthcare provision and to prevent structural injustices undermining reciprocal obligations owed to doctors, it is important to explicitly define the reciprocal obligations owed to doctors. Further work is required to define these professional standards that should take into account the capacity for structural factors that may influence doctor’s agency and should aim to meet these reciprocal obligations.
Police during the time of
COVID – 19 pandemic The last major pandemic that devastated the subcontinent was the Spanish flu in 1918 that took away the life of 15 million Indians. It was reported to have come in India through the Bombay port, the first ones to be admitted to the hospital with “the Bombay fever” were the seven police sepoys who were posted at the Bombay dock. Now again when India stops in track to break the Covid-19 pandemic chain, the police have come again in the frontline for the enforcement of the lockdown. The experience of police of crowd control, public order management, investigation of criminal acts, and deterrence of the law-breaking behaviour was utilized at the time of pandemic for enforcement of lockdown. The task of enforcing a rule compliant behaviour and tracing of people who are infected with the virus are the tasks which are required skills in which only the police have experience. With the extension of lockdown, the role of police in the pandemic also extended, like helping the poor and the helpless who need urgent help to reach the hospital, supply of the essential commodity, etc. Even in some cases, when no one was available to claim the dead body, police helped in the ferrying of dead bodies and facilitating the last rites. Also, during the lockdown police were seen with the megaphones, informing the crowd about the Corona virus i.e. a job that security guards could have done, today there is a variety of tasks performed by the police that can be done by private guards under supervision. Enforcement of the lockdown and maintenance of public order As the imposition of lockdown brings big lifestyle change among the people, the police struggle to find out ways of implementing such changes. In order to restrict the spread of the virus across the country, police have taken steps to enforce lockdown properly from the first day of the lockdown on 24th March, 2020. The imposition of lockdown becomes difficult because of the closely connected community life, along with street cultures of everyday life, the climatic adjustments to a hot and humid climate where access to open spaces becomes a necessity and the panic of closing of essential services shop leads to the crowd on streets despite the stay at home orders. All this brought pressure on the police force to implement the restrictions as some started obeying the rules while others still remained or still remain defiant. In order to impose the restrictions, the police force was deployed across the nation in patrolling vans and foot patrols from the first day of the lockdown. The majority of police forces achieved success in the imposition of lockdown through strict access control and movement restriction without the use of coercive force. In India police personnel right from the starting of a police career get socialized into a policing job role where public order management and crowd control functions are taken as the most essential skill in policing and this skill of police has come to use in the present case of a pandemic related lockdown. Assistance to the vulnerable during crisis Due to the lockdown, the increased presence of police on the roads led police to face misery, vulnerability, and poverty much more than any other professional group apart from the health functionaries. This was also experienced by the poor urban migrant workers who started returning to their village on foot and the distress of those workers who survive on a daily wage basis and have left with no source for food or other survival needs. The restriction of any other actors on the field leads the police to take this responsibility and to address this vulnerability. To affect the movement restriction of the lockdown, most of the police forces started feeding programs for the poor either by becoming a bridge between the kitchens run by the government or at many places by organizing a drive-by police staff themselves for feeding the poor on the sidelines of their job. As more and more charities and public donations approached the police to distribute or engage in feeding programs, the police started partnering with other government and non-governmental agencies in relief work. As the public started seeing the police interface with relief work, their service orientation, and their connectivity with those who needed help, the trust of the public that police would deliver and reach out became stronger. Utilization of police skills for public health outcomes The police force has experience in investigation and this skill of police is required for tracing the people affected with the virus, this contact tracing has been and still is very important in this time of the rapid spread of the infective virus as the health sector struggles to manage its resources and reach. The police have done contact tracing by drawing the backward and forward linkages of the affected people, by decoding the pattern of catching the virus, and by identifying those coming in contact with the affected persons. In the investigation of contact tracing of the COVID-19 affected persons, the basic investigation skills of police have proved as a valuable resource. In order to trace the contacts from the affected persons, the CDR analysis related to the call detail records of the mobile phones of the affected person, along with other cyber forensic tools have been used by the police force. To decipher contact histories and draw models of spread, it’s the cyber police wings and the district police setups that are working with the health professionals. To do contact tracing, police all over India are using their investigation skill, cyber forensic tools, and digital investigation skills. The role of police doesn’t stop at contact tracing; it extends to physically tracing these individuals and helping the health staff to reach out and convince the identified persons to be tested, hospitalized, or quarantined as per the health advisor. Overall drop in crime due to pandemic In the time of lockdown what helped police was the fact that the roads were empty and there was zero traffic on major highways, which ensured a reduction in traffic accidents and fatalities caused by such accidents. Trespass and burglary also became a more difficult crime to commit in this time as anti-social elements are confined to their homes. During the lockdown period, a drop in crime level has been found in major cities that generally report a high number of crimes. Between April 1 and 15 , Delhi police reported a 70% fall in heinous crime i.e. murders and rape as compared to the same period last year. From March 25 – April 15 the number of crimes dropped by 79% in Chennai over the February 25 – March 15 period. The police force can be proud that it managed to keep the peace during difficult times such as the pandemic. Conclusion For our fight against the COVID-19 pandemic, the frontline staffs either in the police or health sector are great resources. The urgent need of this time is the realization of their value and worth and making rapid provisions for their safety and motivation. In order to maximize the efficiency of the police in pandemic management and at the same time keeping the police force safe and motivated, risk factors are needed to be framed into policies.