1.long Exam QP

3/30/22, 8:15 AM GP SEPT BATCH PROG EXAM 2 2ND SEM SY 2021-2022
All of these
4. Diminished GFR persistently less than 60ml/min/1.73 in at least 3 months from any cause *
(1 Point)
Chronic kidney disease
Acute Kidney injury
Renal tubular defects
End stage renal disease
5. Elevation of BUN and creatinine *

(1 Point)
Azotemia
Encephalopathy
Asterixis
Uremia
6. Grossly visible hematuria, diminished GFR, mild to moderate protenuria, nypertension *

(1 Point)
Nephritic Syndrome
Nephrotic Syndrome
Azotemia
Uremia
7. Heavy protenuria, hypoalbuminenia, severe edema, hyperlipidemia, lipiduria *

(1 Point)
Uremia
Azotemia
Nephritic Syndrome
Nephrotic Syndrome
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8. Acquired retention cysts which are acquired, asymptomatic and very frequently found in
cadavers
*
(1 Point)
medullary sponge kidney
cystic renal dysplasia
autosomal recessive cystic disease
simple cyst
9. Enlarged renal cysts which have mesenchyme; Usually found in newborns *

(1 Point)
autosomal dominant cystic disease
simple cyst
10. 10 month old male had history of jaundice. Liver biopsy revealed fibrosis. What condition can
be found in the kidney?
*
(1 Point)
autosomal recessive cystic disease
simple cyst
11. Split basement membrane; Progressive renal failure; Nerve deafness *

(1 Point)
The term Alport syndrome refers to a group of
Goodpasture syndrome inherited, heterogeneous disorders involving the
basement membranes of the kidney and
Alport syndrome frequently affecting the cochlea and eye as well.
These disorders are the result of mutations in
Rapidly progressing glomerulonephritis
type IV collagen genes.
Poststreptococcal GN
12. 8 year old male manifested headache and bipedal edema. He was brought to the hospital for
consult. Upon examination, BP was increased. Lab exam: increased ASO titer to more than four
fold.
*
(1 Point)
Goodpasture syndrome
Alport syndrome
13. Linear immunofluorescence caused by anti glomerular basement membrane antibodies *

(1 Point)
Goodpasture syndrome also referred to as
Alport syndrome anti-glomerular basement membrane (anti-
GBM) disease, is an autoimmune disease that
affects both the kidneys and lungs by the
Goodpasture syndrome formation of autoantibodies that attack their
basement membranes.
14. Mesangial IgA deposite may be seen in which condition? *

(1 Point)
Idiopathic IgA nephropathy of Berger's disease is
characterized by prominent and diffuse IgA
deposits in the mesangium.
Berger disease
Alport syndrome
15. Characterized by fused foot processes and lipid accumulation on renal tubular cells *
(1 Point)
Minimal Change Disease
Multiple myeloma
Focal segmental Glomerulosclerosis
Amyloidosis
16. Characterized by accumulation kappa or lambda light chains on renal tubular cells; In light
microscopy, may be seen as acellular material on cells
*
(1 Point)
Multiple myeloma
Amyloidosis
17. In light microscopy, may be seen as acellular material on cells; In polarizing microscopy,
exhibits apple green birefringence
*
(1 Point)
Amyloidosis
Multiple myeloma
18. Much more likely to obstruct and cause hematuria; Associated with ureter and bladder
carcinomas
*
(1 Point)
Adenocarcinoma
Transitional Cell Carcinoma
Squamous cell carcinoma
Renal cell carcinoma
19. A 38 year old male presented with hematuria. Incision biopsy done revealed clear tumor cells.
He underwent radical nephrectomy. Cut sections of the tumor show golden yellow ill defined
tumor.
*
(1 Point)
Adenocarcinoma
Transitional Cell Carcinoma
Renal cell carcinoma
Squamous cell carcinoma
20. The red granular appearance of the cytoplasm of oncocytoma is due to which organelle? *
(1 Point)
golgi apparatus
mitochondria
lysosome
rough endoplasmic reticulum
21. Characterized by glomerular basement membrane alterations - tram track appearance,

deposits of C3 and sometimes subendothelial deposits; Can be idiopathic or 2º to chronic
immune diseases Hep-C, alpha-1-antitrypsin, HIV
*
(1 Point)
membranoproliferative glomerulonephritis
Alport syndrome
22. The autosomal recessive renal cystic disease resemble the adult type *
(1 Point)
True
False
23. 95% of patients with acute glomerulonephritis recover *

(1 Point)
True
False
24. 28 year old female. Hypertensive. Small kidneys on ultrasound (non cystic). No hematuria or
lipiduria.
*
(1 Point)
Renal artery stenosis
Glomerulonephritis
Nephrotic Syndrome
Renal Failure
25. On autopsy of a gunshot wound victim, a well delineated pale wedge shaped lesion on one of
the kidneys is noted.
*
(1 Point)
Renal Infarct
Nephrolithiasis
Hypoplasia
Urolithiasis
26. Most common congenital anomaly of the pancreas caused by a failure of fusion of the fetal
duct systems of the dorsal and ventral pancreatic primordia
*
(1 Point)
Agenesis
Ectopic Pancreas
Annular Pancreas
Pancreas Divisum
27. Ring of normal pancreatic tissue that completely encircles the second portion of the
duodenum
*
(1 Point)
Pancreas Divisum
Annular Pancreas
Ectopic Pancreas
Agenesis
28. Aberrantly situated, found in about 2% of routine postmortem examinations. *

(1 Point)
Ectopic Pancreas
Annular Pancreas
Agenesis
Pancreas Divisum
29. Pancreas fails to develop. *

(1 Point)
Ectopic Pancreas
Agenesis
Pancreas Divisum
Annular Pancreas
30. Agenesis of the pancreas is caused by *

(1 Point)
CFTR
SPINK1
PDX1
PRSS1
31. Culprit of hereditary pancreatitis except *

(1 Point)
SPINK1
PDX1
PRSS1
CFTR
32. Which does not describe acute pancreatitis? *

(1 Point)
inflammatory
none
usually caused by gallstone
Alcohol related
irreversible
33. Mechanism of alcohol induced injury of the pancreas *

(1 Point)
all
Defective intracellular transport of proenzymes within cells
Primary acinar cell injury
Pancreatic duct obstruction
34. Mechanism of CFTR gene defect to pancreas *

(1 Point)
decreased bicarbonate secretion by pancreatic ductal cells, thereby promoting protein

plugging and duct obstruction
alteration of calcium level
prevent self inactivation of trypsin
increases trypsin activity
35. Which does not describe chronic pancreatitis? *

(1 Point)
loss of pancreatic parenchyma
no exception
fibrosis
loss of exocrine and endocrine function
risk of pseudocyst
36. Described as duct-centric mixed inflammatory cell infiltrate, venulitis, and increased numbers
of IgG4-secreting plasma cells
*
(1 Point)
autoimmune pancreatitis
chronic pancreatitis
cyst
acute pancreatitis
37. Described as hard gland , sometimes with visibly dilated ducts containing calcified concretions.
Acinar loss is a constant feature
*
(1 Point)
cyst
autoimmune pancreatitis
acute pancreatitis
chronic pancreatitis
38. A 70 year old female underwent partial pancreatectomy for tumor in the tail of pancreas.
Tumor is composed of glycogen-rich cuboidal cells, contain clear, thin, straw-colored fluid.
*
(1 Point)
Solid pseudopapillary neoplasm
Intraductal papillary neoplasm
Serous cystic neoplasm
Mucinous cystic neoplasm
39. Painless, slow-growing mass. The cystic cavities are large, filled with thick, tenacious mucin and
lined by a columnar mucin producing epithelium associated with a dense stroma
*
(1 Point)
40. A 24 year old female presented with abdominal pain and dyspepsia. CT scan showed large well
circumscribed pancreatic mass. On histologic sections, solid sheets and pseudopapillary
projections are seen with hemorrhagic debris.
*
(1 Point)
41. 57 year old male undergoes annual check up. Incidental finding is a pancreatic head mass
involving the duct of Santorini. Which of the following best matches the clinical findings?
*
(1 Point)
42. Most frequently altered oncogene in pancreatic cancer and activates a number of downstream
pathways that augment cell growth and survival, most notably the MAPK and PI3K/AKT
pathways
*
(1 Point)
SMAD4
CDKN2A
KRAS
TP53
43. Rarely inactivated in other cell types *

(1 Point)
SMAD4
KRAS
TP53
CDKN2A
44. Secreted by exocrine pancreas *

(1 Point)
somatostatin
trypsin
insulin
glucagon
45. Autoimmune pancreatitis characteristics *

(1 Point)
duct-centric mixed inflammatory cell infiltrate, venulitis, and increased numbers of IgG4-
secreting plasma cells.
all
a form of chronic pancreatitis
fibrosis, loss of pancreatic parenchyma, loss of exocrine and endocrine function, and high risk
of developing pseudocysts
46. Associated with transcriptional silencing of these genes and loss of their function. *
(1 Point)
CDKN2A
TP53
Hedgehog signaling pathway
DNA Methylation Abnormalities
47. Morphology of chronic pancreatitis *

(1 Point)
fibrosis, atrophy and dropout of acini, and variable dilation of pancreatic ducts
acute inflammation, microvascular leak and edema
fat necrosis
destruction of pancreatic parenchyma, destruction of blood vessels and interstitial

hemorrhage.
48. virtually always associated with hyperactivation of the Wnt signaling pathway due to acquired
activating mutations of the CTNNB1 (β-catenin) oncogene.
*
(1 Point)
49. Frequent mutations in the GNAS and KRAS oncogenes and the TP53, SMAD4, and RNF43
tumor suppressor genes have been reported
*
(1 Point)
50. Which autoimmune disease is characterized by immune complex deposition in the skin, kidney,
and lung?
*
(1 Point)
C. Sjogren syndrome
D. Progressive scleroderma
E. SLE
B. Graft versus host disease
A. CREST
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3/30/22, 8:15 AM GP SEPT BATCH PROG EXAM 2 2ND SEM SY 2021-2022

Chronic kidney disease

Acute Kidney injury

Renal tubular defects

End stage renal disease

5. Elevation of BUN and creatinine *

6. Grossly visible hematuria, diminished GFR, mild to moderate protenuria, nypertension *

7. Heavy protenuria, hypoalbuminenia, severe edema, hyperlipidemia, lipiduria *

medullary sponge kidney

cystic renal dysplasia

autosomal recessive cystic disease

9. Enlarged renal cysts which have mesenchyme; Usually found in newborns *

autosomal dominant cystic disease

medullary sponge kidney

cystic renal dysplasia

cystic renal dysplasia

autosomal recessive cystic disease

medullary sponge kidney

11. Split basement membrane; Progressive renal failure; Nerve deafness *

Rapidly progressing glomerulonephritis

13. Linear immunofluorescence caused by anti glomerular basement membrane antibodies *

14. Mesangial IgA deposite may be seen in which condition? *

Minimal Change Disease

Focal segmental Glomerulosclerosis

Focal segmental Glomerulosclerosis

Minimal Change Disease

Minimal Change Disease

Focal segmental Glomerulosclerosis

Transitional Cell Carcinoma

Squamous cell carcinoma

Renal cell carcinoma

Transitional Cell Carcinoma

Renal cell carcinoma

Squamous cell carcinoma

rough endoplasmic reticulum

21. Characterized by glomerular basement membrane alterations - tram track appearance,

23. 95% of patients with acute glomerulonephritis recover *

Renal artery stenosis

28. Aberrantly situated, found in about 2% of routine postmortem examinations. *

29. Pancreas fails to develop. *

30. Agenesis of the pancreas is caused by *

31. Culprit of hereditary pancreatitis except *

32. Which does not describe acute pancreatitis? *

usually caused by gallstone

33. Mechanism of alcohol induced injury of the pancreas *

Defective intracellular transport of proenzymes within cells

Primary acinar cell injury

Pancreatic duct obstruction

34. Mechanism of CFTR gene defect to pancreas *

decreased bicarbonate secretion by pancreatic ductal cells, thereby promoting protein

alteration of calcium level

prevent self inactivation of trypsin

increases trypsin activity

35. Which does not describe chronic pancreatitis? *

loss of pancreatic parenchyma

loss of exocrine and endocrine function

Solid pseudopapillary neoplasm

Intraductal papillary neoplasm

Serous cystic neoplasm

Mucinous cystic neoplasm

Mucinous cystic neoplasm

Serous cystic neoplasm

Solid pseudopapillary neoplasm